5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase

LOCUS       NP_710092                488 aa            linear   CON 24-AUG-2016
            [Shigella flexneri 2a str. 301].
ACCESSION   NP_710092
VERSION     NP_710092.1
DBLINK      BioProject: PRJNA62907
            Assembly: GCF_000006925.2
DBSOURCE    REFSEQ: accession NC_004337.2
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri 2a str. 301
  ORGANISM  Shigella flexneri 2a str. 301
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Jin,Q., Yuan,Z., Xu,J., Wang,Y., Shen,Y., Lu,W., Wang,J., Liu,H.,
            Yang,J., Yang,F., Zhang,X., Zhang,J., Yang,G., Wu,H., Qu,D.,
            Dong,J., Sun,L., Xue,Y., Zhao,A., Gao,Y., Zhu,J., Kan,B., Ding,K.,
            Chen,S., Cheng,H., Yao,Z., He,B., Chen,R., Ma,D., Qiang,B., Wen,Y.,
            Hou,Y. and Yu,J.
  TITLE     Genome sequence of Shigella flexneri 2a: insights into
            pathogenicity through comparison with genomes of Escherichia coli
            K12 and O157
  JOURNAL   Nucleic Acids Res. 30 (20), 4432-4441 (2002)
   PUBMED   12384590
REFERENCE   2  (residues 1 to 488)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (26-AUG-2011) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B.,
            Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y.,
            Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y.,
            Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2011) State Key Laboratory for Moleclular
            Virology and Genetic Engineering, Microbial Genome Center of
            Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA,
            Beijing 100176, P.R.China
  REMARK    Sequence update by submitter
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B.,
            Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y.,
            Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y.,
            Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-DEC-2004) State Key Laboratory for Moleclular
            Virology and Genetic Engineering, Microbial Genome Center of
            Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA,
            Beijing 100176, P.R.China
  REMARK    Sequence update by submitter
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B.,
            Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y.,
            Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y.,
            Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2001) State Key Laboratory for Moleclular
            Virology and Genetic Engineering, Microbial Genome Center of
            Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA,
            Beijing 100176, P.R.China
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence is identical to AAN45799.
            RefSeq Category: Reference Genome
                        CLI: Clinical Isolate
                        FGS: First Genome sequenced
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Shigella flexneri 2a str. 301"
                     /strain="301"
                     /serotype="2a"
                     /db_xref="taxon:198214"
     Protein         1..488
                     /product="5-carboxymethyl-2-hydroxymuconate semialdehyde
                     dehydrogenase"
                     /calculated_mol_wt=52969
     Region          21..476
                     /region_name="ALDH_F8_HMSADH"
                     /note="Human aldehyde dehydrogenase family 8 member
                     A1-like; cd07093"
                     /db_xref="CDD:143412"
     Site            order(145..147,153,171,173..174,204,208..209,223..225,228,
                     231,244..245,278,382,384,448)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143412"
     Site            order(148,244,275,278)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143412"
     CDS             1..488
                     /gene="hpaE"
                     /locus_tag="SF4383"
                     /coded_by="complement(NC_004337.2:4554355..4555821)"
                     /note="Code: C; COG: COG1012"
                     /transl_table=11
                     /db_xref="GeneID:1025220"
CONTIG      join(WP_000757498.1:1..488)
ORIGIN      
        1 mkkvnhwing knvagndyfq ttnpatgevl advasggeae inqavaaake afpkwadlpm
       61 kerarlmrrl gdlidqnvpe iaametadtg lpihqtknvl iprashnfef faevcqqmng
      121 ktypvddkml nytlvqpvgv calaspwnvp fmtatwkvap clalgntavl kmselsplta
      181 drlgelalea gipagvlnvv qgygatagda lvrhhdvrav sftggtatgr nimknaglkk
      241 ysmelggksp vlifedadie raldaalfti fsingercta gsrifiqqsi ypefvkrfae
      301 ranrlrvgdp ndpntqvral isqqhwekvs gyirlgieeg atllaggpdk psdlpahlkg
      361 gnflrptvla dvdnrmrvaq eeifgpvacl lpfkdeaegl rlandveygl asyiwtqdvs
      421 kvlrlargie agmvfvntqn vrdlrqpfgg vkasgtgreg geysfevfae mknvcismgd
      481 hpipkwgv