MULTISPECIES: 5-carboxymethyl-2-hydroxymuconate semialdehyde

LOCUS       WP_000757498             488 aa            linear   BCT 17-NOV-2023
            dehydrogenase [Shigella].
ACCESSION   WP_000757498
VERSION     WP_000757498.1
KEYWORDS    RefSeq.
SOURCE      Shigella
  ORGANISM  Shigella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Nordlund,I. and Shingler,V.
  TITLE     Nucleotide sequences of the meta-cleavage pathway enzymes
            2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic
            semialdehyde hydrolase from Pseudomonas CF600
  JOURNAL   Biochim. Biophys. Acta 1049 (2), 227-230 (1990)
   PUBMED   2194577
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR02299.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Shigella"
                     /db_xref="taxon:620"
     gene            1..488
                     /gene="hpaE"
     Protein         1..488
                     /product="5-carboxymethyl-2-hydroxymuconate semialdehyde
                     dehydrogenase"
                     /GO_function="GO:0018480 -
                     5-carboxymethyl-2-hydroxymuconic-semialdehyde
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:1901023 - 4-hydroxyphenylacetate catabolic
                     process [Evidence IEA]"
                     /calculated_mol_wt=52969
     Region          21..476
                     /region_name="ALDH_F8_HMSADH"
                     /note="Human aldehyde dehydrogenase family 8 member
                     A1-like; cd07093"
                     /db_xref="CDD:143412"
     Site            order(145..147,153,171,173..174,204,208..209,223..225,228,
                     231,244..245,278,382,384,448)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143412"
     Site            order(148,244,275,278)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143412"
ORIGIN      
        1 mkkvnhwing knvagndyfq ttnpatgevl advasggeae inqavaaake afpkwadlpm
       61 kerarlmrrl gdlidqnvpe iaametadtg lpihqtknvl iprashnfef faevcqqmng
      121 ktypvddkml nytlvqpvgv calaspwnvp fmtatwkvap clalgntavl kmselsplta
      181 drlgelalea gipagvlnvv qgygatagda lvrhhdvrav sftggtatgr nimknaglkk
      241 ysmelggksp vlifedadie raldaalfti fsingercta gsrifiqqsi ypefvkrfae
      301 ranrlrvgdp ndpntqvral isqqhwekvs gyirlgieeg atllaggpdk psdlpahlkg
      361 gnflrptvla dvdnrmrvaq eeifgpvacl lpfkdeaegl rlandveygl asyiwtqdvs
      421 kvlrlargie agmvfvntqn vrdlrqpfgg vkasgtgreg geysfevfae mknvcismgd
      481 hpipkwgv