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LOCUS NP_708052 222 aa linear CON 24-AUG-2016 ACCESSION NP_708052 VERSION NP_708052.1 DBLINK BioProject: PRJNA62907 Assembly: GCF_000006925.2 DBSOURCE REFSEQ: accession NC_004337.2 KEYWORDS RefSeq. SOURCE Shigella flexneri 2a str. 301 ORGANISM Shigella flexneri 2a str. 301 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella. REFERENCE 1 (residues 1 to 222) AUTHORS Jin,Q., Yuan,Z., Xu,J., Wang,Y., Shen,Y., Lu,W., Wang,J., Liu,H., Yang,J., Yang,F., Zhang,X., Zhang,J., Yang,G., Wu,H., Qu,D., Dong,J., Sun,L., Xue,Y., Zhao,A., Gao,Y., Zhu,J., Kan,B., Ding,K., Chen,S., Cheng,H., Yao,Z., He,B., Chen,R., Ma,D., Qiang,B., Wen,Y., Hou,Y. and Yu,J. TITLE Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157 JOURNAL Nucleic Acids Res. 30 (20), 4432-4441 (2002) PUBMED 12384590 REFERENCE 2 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (26-AUG-2011) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 222) AUTHORS Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B., Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y., Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y., Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D. TITLE Direct Submission JOURNAL Submitted (03-AUG-2011) State Key Laboratory for Moleclular Virology and Genetic Engineering, Microbial Genome Center of Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA, Beijing 100176, P.R.China REMARK Sequence update by submitter REFERENCE 4 (residues 1 to 222) AUTHORS Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B., Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y., Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y., Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D. TITLE Direct Submission JOURNAL Submitted (06-DEC-2004) State Key Laboratory for Moleclular Virology and Genetic Engineering, Microbial Genome Center of Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA, Beijing 100176, P.R.China REMARK Sequence update by submitter REFERENCE 5 (residues 1 to 222) AUTHORS Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B., Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y., Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y., Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D. TITLE Direct Submission JOURNAL Submitted (21-MAY-2001) State Key Laboratory for Moleclular Virology and Genetic Engineering, Microbial Genome Center of Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA, Beijing 100176, P.R.China COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence is identical to AAN43759. RefSeq Category: Reference Genome CLI: Clinical Isolate FGS: First Genome sequenced Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Shigella flexneri 2a str. 301" /strain="301" /serotype="2a" /db_xref="taxon:198214" Protein 1..222 /product="GTP cyclohydrolase I" /calculated_mol_wt=24700 Site order(35..36,39..40,43,47,50..51,53,55,57,59..61,63..64, 66,70,74,79,89,91,96..99,101..104,106,108,112..113, 116..117,119,121,128..129,131,135..137,140,150..152,154, 157,167,180..182,185..186,191..192,194..196,198..200, 205..206,209,211..213) /site_type="other" /note="homodecamer interface [polypeptide binding]" /db_xref="CDD:238349" Region 40..220 /region_name="TFold" /note="Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA), GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; cl00263" /db_xref="CDD:469697" Site order(66,69,111,113..114,133,135..136,140,151..153,180, 182,186) /site_type="active" /db_xref="CDD:238349" Site order(111,113..114,180,182) /site_type="active" /note="putative catalytic site residues [active]" /db_xref="CDD:238349" Site order(111,113..114,182) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:238349" Site order(161,164,170,172,201..203,205..209) /site_type="active" /note="GTP-CH-I/GFRP interaction surface [active]" /db_xref="CDD:238349" CDS 1..222 /gene="folE" /locus_tag="SF2238" /coded_by="complement(NC_004337.2:2265462..2266130)" /note="Code: H; COG: COG0302" /transl_table=11 /db_xref="GeneID:1025439" CONTIG join(WP_001139613.1:1..222) ORIGIN 1 mpslskeaal vhealvargl etplrppvhe mdnetrksli aghmteimql lnldladdsl 61 metphriakm yvdeifsgld yanfpkitli enkmkvdemv tvrditltst cehhfvtidg 121 katvayipkd sviglskinr ivqffaqrpq vqerltqqil ialqtllgtn nvavsidavh 181 ycvkargird atsattttsl gglfkssqnt rheflravrh hn