MULTISPECIES: GTP cyclohydrolase I FolE [Enterobacteriaceae].

LOCUS       WP_001139613             222 aa            linear   BCT 28-FEB-2022
ACCESSION   WP_001139613
VERSION     WP_001139613.1
KEYWORDS    RefSeq.
SOURCE      Enterobacteriaceae
  ORGANISM  Enterobacteriaceae
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF006824.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09347
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Enterobacteriaceae"
                     /db_xref="taxon:543"
     gene            1..222
                     /gene="folE"
     Protein         1..222
                     /product="GTP cyclohydrolase I FolE"
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /calculated_mol_wt=24700
     Site            order(35..36,39..40,43,47,50..51,53,55,57,59..61,63..64,
                     66,70,74,79,89,91,96..99,101..104,106,108,112..113,
                     116..117,119,121,128..129,131,135..137,140,150..152,154,
                     157,167,180..182,185..186,191..192,194..196,198..200,
                     205..206,209,211..213)
                     /site_type="other"
                     /note="homodecamer interface [polypeptide binding]"
                     /db_xref="CDD:238349"
     Region          40..220
                     /region_name="TFold"
                     /note="Tunnelling fold (T-fold). The five known T-folds
                     are found in five different enzymes with different
                     functions: dihydroneopterin-triphosphate epimerase
                     (DHNTPE), dihydroneopterin aldolase (DHNA), GTP
                     cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; cl00263"
                     /db_xref="CDD:469697"
     Site            order(66,69,111,113..114,133,135..136,140,151..153,180,
                     182,186)
                     /site_type="active"
                     /db_xref="CDD:238349"
     Site            order(111,113..114,180,182)
                     /site_type="active"
                     /note="putative catalytic site residues [active]"
                     /db_xref="CDD:238349"
     Site            order(111,113..114,182)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:238349"
     Site            order(161,164,170,172,201..203,205..209)
                     /site_type="active"
                     /note="GTP-CH-I/GFRP interaction surface [active]"
                     /db_xref="CDD:238349"
ORIGIN      
        1 mpslskeaal vhealvargl etplrppvhe mdnetrksli aghmteimql lnldladdsl
       61 metphriakm yvdeifsgld yanfpkitli enkmkvdemv tvrditltst cehhfvtidg
      121 katvayipkd sviglskinr ivqffaqrpq vqerltqqil ialqtllgtn nvavsidavh
      181 ycvkargird atsattttsl gglfkssqnt rheflravrh hn