2-isopropylmalate synthase [Listeria monocytogenes EGD-e].

LOCUS       NP_465511                512 aa            linear   CON 28-AUG-2016
ACCESSION   NP_465511
VERSION     NP_465511.1
DBLINK      BioProject: PRJNA61583
            Assembly: GCF_000196035.1
DBSOURCE    REFSEQ: accession NC_003210.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes EGD-e
  ORGANISM  Listeria monocytogenes EGD-e
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 512)
  AUTHORS   Toledo-Arana,A., Dussurget,O., Nikitas,G., Sesto,N.,
            Guet-Revillet,H., Balestrino,D., Loh,E., Gripenland,J., Tiensuu,T.,
            Vaitkevicius,K., Barthelemy,M., Vergassola,M., Nahori,M.A.,
            Soubigou,G., Regnault,B., Coppee,J.Y., Lecuit,M., Johansson,J. and
            Cossart,P.
  TITLE     The Listeria transcriptional landscape from saprophytism to
            virulence
  JOURNAL   Nature 459 (7249), 950-956 (2009)
   PUBMED   19448609
REFERENCE   2  (residues 1 to 512)
  AUTHORS   Chatterjee,S.S., Hossain,H., Otten,S., Kuenne,C., Kuchmina,K.,
            Machata,S., Domann,E., Chakraborty,T. and Hain,T.
  TITLE     Intracellular gene expression profile of Listeria monocytogenes
  JOURNAL   Infect. Immun. 74 (2), 1323-1338 (2006)
   PUBMED   16428782
REFERENCE   3  (residues 1 to 512)
  AUTHORS   Glaser,P., Frangeul,L., Buchrieser,C., Amend,A., Baquero,F.,
            Berche,P., Bloecker,H., Brandt,P., Chakraborty,T., Charbit,A.,
            Chetouani,F., Couve,E., de Daruvar,A., Dehoux,P., Domann,E.,
            Dominguez-Bernal,G., Duchaud,E., Durand,L., Dussurget,O.,
            Entian,K.-D., Fsihi,H., Garcia-Del Portillo,F., Garrido,P.,
            Gautier,L., Goebel,W., Gomez-Lopez,N., Hain,T., Hauf,J.,
            Jackson,D., Jones,L.-M., Karst,U., Kreft,J., Kuhn,M., Kunst,F.,
            Kurapkat,G., Madueno,E., Maitournam,A., Mata Vicente,J., Ng,E.,
            Nordsiek,G., Novella,S., de Pablos,B., Perez-Diaz,J.-C., Remmel,B.,
            Rose,M., Rusniok,C., Schlueter,T., Simoes,N., Tierrez,A.,
            Vazquez-Boland,J.-A., Voss,H., Wehland,J. and Cossart,P.
  TITLE     Comparative genomics of Listeria species
  JOURNAL   Science 294 (5543), 849-852 (2001)
   PUBMED   11679669
REFERENCE   4  (residues 1 to 512)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-NOV-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 512)
  AUTHORS   Glaser,P., Frangeul,L. and Rusniok,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2001) Glaser P., Institut Pasteur, Genomique des
            Microorganismes Pathogenes, 25 rue du Docteur Roux, 75724 Paris
            Cedex 15, FRANCE
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAD00065.
            RefSeq Category: Reference Genome
                        FGS: First Genome sequenced
                        MOD: Model Organism
                        UPR: UniProt Genome
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Listeria monocytogenes EGD-e"
                     /strain="EGD-e"
                     /db_xref="taxon:169963"
     Protein         1..512
                     /product="2-isopropylmalate synthase"
                     /EC_number="2.3.3.13"
                     /calculated_mol_wt=55965
     Region          1..495
                     /region_name="PRK00915"
                     /note="2-isopropylmalate synthase; Validated"
                     /db_xref="CDD:234864"
     Site            order(12..13,16,43,74,96,138,140,168,170,201,203)
                     /site_type="active"
                     /db_xref="CDD:163678"
     Site            order(12..13,43)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:163678"
     Site            order(201,203)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:163678"
     CDS             1..512
                     /gene="leuA"
                     /locus_tag="lmo1987"
                     /coded_by="NC_003210.1:2059669..2061207"
                     /experiment="EXISTENCE:[PMID:19448609]"
                     /note="catalyzes the formation of 2-isopropylmalate from
                     acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis"
                     /transl_table=11
                     /db_xref="GeneID:984863"
CONTIG      join(WP_003723152.1:1..512)
ORIGIN      
        1 mkkiqffdtt lrdgeqtpgv nfdvkekiqi alqleklgid vieagfpiss pgdfecvkai
       61 akaikhcsvt glarcvegdi draeealkda vspqihifla tsdvhmeykl kmsraevlas
      121 ikhhisyarq kfevvqfspe datrsdrafl ieavqtaida gatvinipdt vgytnptefg
      181 qlfqdlrrei kqfdditfas hchddlgmat analaaieng arrvegting igeragntal
      241 eevavalhir kdfyqaetni vlnqfknssd lisrlsgmpv prnkaviggn ayahesgihq
      301 dgvlknpdty eiitpalvgv dknslplgkl sgkhafntrm eemgytlteq eqkdafkrfk
      361 qladakkevt eedlhalilg qssesaddfe lkhlqvqyvt ggvqgaivri eerdgalved
      421 aatgsgsiea iyntinrlmk qdieltdyri qaitagqdaq aevhvviknd kgaefhgigi
      481 dfdvltasak aylqasgksk taskqadfee vk