uroporphyrinogen-III methyltransferase/uroporphyrinogen-III

LOCUS       NP_464726                493 aa            linear   CON 28-AUG-2016
            synthase [Listeria monocytogenes EGD-e].
ACCESSION   NP_464726
VERSION     NP_464726.1
DBLINK      BioProject: PRJNA61583
            Assembly: GCF_000196035.1
DBSOURCE    REFSEQ: accession NC_003210.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes EGD-e
  ORGANISM  Listeria monocytogenes EGD-e
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Toledo-Arana,A., Dussurget,O., Nikitas,G., Sesto,N.,
            Guet-Revillet,H., Balestrino,D., Loh,E., Gripenland,J., Tiensuu,T.,
            Vaitkevicius,K., Barthelemy,M., Vergassola,M., Nahori,M.A.,
            Soubigou,G., Regnault,B., Coppee,J.Y., Lecuit,M., Johansson,J. and
            Cossart,P.
  TITLE     The Listeria transcriptional landscape from saprophytism to
            virulence
  JOURNAL   Nature 459 (7249), 950-956 (2009)
   PUBMED   19448609
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Chatterjee,S.S., Hossain,H., Otten,S., Kuenne,C., Kuchmina,K.,
            Machata,S., Domann,E., Chakraborty,T. and Hain,T.
  TITLE     Intracellular gene expression profile of Listeria monocytogenes
  JOURNAL   Infect. Immun. 74 (2), 1323-1338 (2006)
   PUBMED   16428782
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Glaser,P., Frangeul,L., Buchrieser,C., Amend,A., Baquero,F.,
            Berche,P., Bloecker,H., Brandt,P., Chakraborty,T., Charbit,A.,
            Chetouani,F., Couve,E., de Daruvar,A., Dehoux,P., Domann,E.,
            Dominguez-Bernal,G., Duchaud,E., Durand,L., Dussurget,O.,
            Entian,K.-D., Fsihi,H., Garcia-Del Portillo,F., Garrido,P.,
            Gautier,L., Goebel,W., Gomez-Lopez,N., Hain,T., Hauf,J.,
            Jackson,D., Jones,L.-M., Karst,U., Kreft,J., Kuhn,M., Kunst,F.,
            Kurapkat,G., Madueno,E., Maitournam,A., Mata Vicente,J., Ng,E.,
            Nordsiek,G., Novella,S., de Pablos,B., Perez-Diaz,J.-C., Remmel,B.,
            Rose,M., Rusniok,C., Schlueter,T., Simoes,N., Tierrez,A.,
            Vazquez-Boland,J.-A., Voss,H., Wehland,J. and Cossart,P.
  TITLE     Comparative genomics of Listeria species
  JOURNAL   Science 294 (5543), 849-852 (2001)
   PUBMED   11679669
REFERENCE   4  (residues 1 to 493)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-NOV-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Glaser,P., Frangeul,L. and Rusniok,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2001) Glaser P., Institut Pasteur, Genomique des
            Microorganismes Pathogenes, 25 rue du Docteur Roux, 75724 Paris
            Cedex 15, FRANCE
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAC99279.
            RefSeq Category: Reference Genome
                        FGS: First Genome sequenced
                        MOD: Model Organism
                        UPR: UniProt Genome
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Listeria monocytogenes EGD-e"
                     /strain="EGD-e"
                     /db_xref="taxon:169963"
     Protein         1..493
                     /product="uroporphyrinogen-III
                     methyltransferase/uroporphyrinogen-III synthase"
                     /calculated_mol_wt=54106
     Region          1..245
                     /region_name="CysG"
                     /note="Uroporphyrinogen-III methylase (siroheme synthase)
                     [Coenzyme transport and metabolism]; COG0007"
                     /db_xref="CDD:439778"
     Region          253..483
                     /region_name="HemD"
                     /note="Uroporphyrinogen-III synthase (HemD) catalyzes the
                     asymmetrical cyclization of tetrapyrrole (linear) to
                     uroporphyrinogen-III, the fourth step in the biosynthesis
                     of heme. This ubiquitous enzyme is present in eukaryotes,
                     bacteria and archaea. Mutations in...; cd06578"
                     /db_xref="CDD:119440"
     Site            order(257,306..308,338,380,403,405,424..428)
                     /site_type="active"
                     /db_xref="CDD:119440"
     CDS             1..493
                     /locus_tag="lmo1201"
                     /coded_by="NC_003210.1:1225300..1226781"
                     /experiment="EXISTENCE:[PMID:19448609]"
                     /transl_table=11
                     /db_xref="GeneID:986081"
CONTIG      join(WP_003721599.1:1..493)
ORIGIN      
        1 mgkvmligag pgdaqlltvk glaalqkadv ivydrlvepa mlqerkasck liyvgkeplh
       61 hpipqdeier ilvreaatne lvvrlkagdp yvfgrggeeg etlhkagipf evipgitsai
      121 gglayagipv thrdfassfh vitghlkkgr dpldwealar legtlvflmg mtnlpnican
      181 llehgqkpet gvaivqwatr gkqltvtgnl qtieqkvaes gisspalivv gdvvslrpql
      241 nffeemplfh tkvllprara gksmlaeqir dlggevtmyp niqvldvapt ktkeqlsevs
      301 ellftskeav erffdylakl dldirslkns hltaigkqtk eafsekgiip dsfikrrste
      361 lilehlprlq knvsnliigs vvdttevnvi ladvkaiemm plydmrpvte rpfdlesfeq
      421 vcfsssrsvq nlldvltiee kailqtktil sigrftsatl asfgmnnfie aesatpesli
      481 eliqktkleg vpq