uroporphyrinogen-III C-methyltransferase [Listeria monocytogenes].

LOCUS       WP_003721599             493 aa            linear   BCT 11-APR-2024
ACCESSION   WP_003721599
VERSION     WP_003721599.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes
  ORGANISM  Listeria monocytogenes
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR01469.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Listeria monocytogenes"
                     /db_xref="taxon:1639"
     gene            1..493
                     /gene="cobA"
     Protein         1..493
                     /product="uroporphyrinogen-III C-methyltransferase"
                     /EC_number="2.1.1.107"
                     /GO_function="GO:0004851 - uroporphyrin-III
                     C-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019354 - siroheme biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=54106
     Region          1..245
                     /region_name="CysG"
                     /note="Uroporphyrinogen-III methylase (siroheme synthase)
                     [Coenzyme transport and metabolism]; COG0007"
                     /db_xref="CDD:439778"
     Region          253..483
                     /region_name="HemD"
                     /note="Uroporphyrinogen-III synthase (HemD) catalyzes the
                     asymmetrical cyclization of tetrapyrrole (linear) to
                     uroporphyrinogen-III, the fourth step in the biosynthesis
                     of heme. This ubiquitous enzyme is present in eukaryotes,
                     bacteria and archaea. Mutations in...; cd06578"
                     /db_xref="CDD:119440"
     Site            order(257,306..308,338,380,403,405,424..428)
                     /site_type="active"
                     /db_xref="CDD:119440"
ORIGIN      
        1 mgkvmligag pgdaqlltvk glaalqkadv ivydrlvepa mlqerkasck liyvgkeplh
       61 hpipqdeier ilvreaatne lvvrlkagdp yvfgrggeeg etlhkagipf evipgitsai
      121 gglayagipv thrdfassfh vitghlkkgr dpldwealar legtlvflmg mtnlpnican
      181 llehgqkpet gvaivqwatr gkqltvtgnl qtieqkvaes gisspalivv gdvvslrpql
      241 nffeemplfh tkvllprara gksmlaeqir dlggevtmyp niqvldvapt ktkeqlsevs
      301 ellftskeav erffdylakl dldirslkns hltaigkqtk eafsekgiip dsfikrrste
      361 lilehlprlq knvsnliigs vvdttevnvi ladvkaiemm plydmrpvte rpfdlesfeq
      421 vcfsssrsvq nlldvltiee kailqtktil sigrftsatl asfgmnnfie aesatpesli
      481 eliqktkleg vpq