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B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase


LOCUS       NP_463053               1256 aa            linear   CON 08-SEP-2022
            [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2].
ACCESSION   NP_463053
VERSION     NP_463053.3
DBLINK      BioProject: PRJNA57799
            BioSample: SAMN02604315
DBSOURCE    REFSEQ: accession NC_003197.2
KEYWORDS    RefSeq.
SOURCE      Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
  ORGANISM  Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Salmonella.
REFERENCE   1  (residues 1 to 1256)
  AUTHORS   McClelland,M., Sanderson,K.E., Spieth,J., Clifton,S.W.,
            Latreille,P., Courtney,L., Porwollik,S., Ali,J., Dante,M., Du,F.,
            Hou,S., Layman,D., Leonard,S., Nguyen,C., Scott,K., Holmes,A.,
            Grewal,N., Mulvaney,E., Ryan,E., Sun,H., Florea,L., Miller,W.,
            Stoneking,T., Nhan,M., Waterston,R. and Wilson,R.K.
  TITLE     Complete genome sequence of Salmonella enterica serovar Typhimurium
            LT2
  JOURNAL   Nature 413 (6858), 852-856 (2001)
   PUBMED   11677609
REFERENCE   2  (residues 1 to 1256)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 1256)
  AUTHORS   McClelland,M., Jain,A., Saraogi,P., Mendelson,R., Westerman,R.,
            SanMiguel,P. and Csonka,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2016) Department of Microbiology and Molecular
            Genetics, University of California, Irvine, CA 92697, USA
  REMARK    Sequence update by submitter
REFERENCE   4  (residues 1 to 1256)
  CONSRTM   The Salmonella typhimurium Genome Sequencing Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2001) Genome Sequencing Center, Department of
            Genetics, Washington University School of Medicine, 4444 Forest
            Park Boulevard, St. Louis, MO 63108, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAL23012.
            
            On Dec 2, 2016 this sequence version replaced NP_463053.2.
            Supported by NIH grant 5U 01 AI43283
            
            Coding sequences below are predicted from manually evaluated
            computer analysis, using similarity information and the programs;
            GLIMMER; http://www.tigr.org/softlab/glimmer/glimmer.html and
            GeneMark; http://opal.biology.gatech.edu/GeneMark/
            
            EC numbers were kindly provided by Junko Yabuzaki and the Kyoto
            Encyclopedia of Genes and Genomes; http://www.genome.ad.jp/kegg/,
            and Pedro Romero and Peter Karp at EcoCyc;
            http://ecocyc.PangeaSystems.com/ecocyc/
            
            The analyses of ribosome binding sites and promoter binding sites
            were kindly provided by Heladia Salgado, Julio Collado-Vides and
            ReguonDB;
            http://kinich.cifn.unam.mx:8850/db/regulondb_intro.frameset
            
            This sequence was finished as follows unless otherwise noted: all
            regions were double stranded, sequenced with an alternate
            chemistries or covered by high quality data (i.e., phred quality >=
            30); an attempt was made to resolve all sequencing problems, such
            as compressions and repeats; all regions were covered by sequence
            from more than one m13 subclone.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Salmonella enterica subsp. enterica serovar
                     Typhimurium str. LT2"
                     /strain="LT2"
                     /serovar="Typhimurium"
                     /sub_species="enterica"
                     /culture_collection="ATCC:700720"
                     /culture_collection="SGSC:1412"
                     /type_material="type strain of Salmonella enterica"
                     /db_xref="taxon:99287"
                     /focus
     Protein         1..1256
                     /product="B12-dependent
                     homocysteine-N5-methyltetrahydrofolate transmethylase"
                     /EC_number="2.1.1.13"
                     /calculated_mol_wt=138931
     Region          28..1252
                     /region_name="metH"
                     /note="B12-dependent methionine synthase; Provisional;
                     PRK09490"
                     /db_xref="CDD:236539"
     CDS             1..1256
                     /gene="metH"
                     /locus_tag="STM4188"
                     /coded_by="NC_003197.2:4408265..4412035"
                     /note="repressor of metE and metF;
                     5-methyltetrahydrofolate--homocysteine methyltransferase.
                     (SW:METH_SALTY)"
                     /transl_table=11
                     /db_xref="GeneID:1255714"
CONTIG      join(WP_014343933.1:1..1256)
ORIGIN      
        1 mshvarcslf rqhalcqygs lrgalsgasv sskveqlraq lnerilvldg gmgtmiqsyr
       61 lheedfrger fadwpcdlkg nndllvlskp eviaaihnay feagadiiet ntfnsttiam
      121 adyrmeslsa einyaaakla racadewtar tpekprfvag vlgptnrtas ispdvndpaf
      181 rnitfdqlva ayrestkalv eggadlilie tvfdtlnaka avfavkeefe algvdlpimi
      241 sgtitdasgr tlsgqtteaf ynslrhaeal tfglncalgp delrqyvqel sriaecyvta
      301 hpnaglpnaf geydldadtm akqirewaea gflnivggcc gttpehiaam sravagllpr
      361 qlpdipvacr lsgleplnig ddslfvnvge rtnvtgsakf krlikeekys ealdvarqqv
      421 esgaqiidin mdegmldaea amvrflslia gepdiarvpi midsskwevi ekglkciqgk
      481 givnsismke gveafihhak llrrygaavv vmafdeqgqa dtrarkieic rraykiltee
      541 vgfppediif dpnifavatg ieehnnyaqd figacedikr elphalisgg vsnvsfsfrg
      601 ndpvreaiha vflyyairng mdmgivnagq laiyddlpae lrdavedvil nrrddgterl
      661 ldlaekyrgs ktdeaanaqq aewrswdvkk rleyslvkgi tefieqdtee arqqaarpie
      721 viegplmdgm nvvgdlfgeg kmflpqvvks arvmkqavay lepfieaske kgssngkmvi
      781 atvkgdvhdi gknivgvvlq cnnyeivdlg vmvpaekilr tarevnadli glsglitpsl
      841 demvnvakem erqgftipll iggattskah tavkieqnys gptvyvqnas rtvgvvaall
      901 sdtqrddfva rtrkeyetvr iqharkkprt ppvtleaard ndlafdwery tppvahrlgv
      961 qeveasietl rnyidwtpff mtwslagkyp riledevvgv eaqrlfkdan dmldklsaek
     1021 llnprgvvgl fpanrvgddi eiyrdetrth vltvshhlrq qtekvgfany cladfvapkl
     1081 sgkadyigaf avtggleeda ladafeaqhd dynkimvkai adrlaeafae ylhervrkvy
     1141 wgyapnesls ndelirenyq girpapgypa cpehtekgti wqlldvekht gmkltesfam
     1201 wpgasvsgwy fshpeskyfa vaqiqrdqvt dyafrkgmsv edverwlapn lgydad