methionine synthase [Salmonella enterica].

LOCUS       WP_014343933            1256 aa            linear   BCT 27-MAR-2023
ACCESSION   WP_014343933
VERSION     WP_014343933.1
KEYWORDS    RefSeq.
SOURCE      Salmonella enterica
  ORGANISM  Salmonella enterica
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Salmonella.
REFERENCE   1  (residues 1 to 1256)
  AUTHORS   Dixon,M.M., Huang,S., Matthews,R.G. and Ludwig,M.
  TITLE     The structure of the C-terminal domain of methionine synthase:
            presenting S-adenosylmethionine for reductive methylation of B12
  JOURNAL   Structure 4 (11), 1263-1275 (1996)
   PUBMED   8939751
REFERENCE   2  (residues 1 to 1256)
  AUTHORS   Drummond,J.T., Loo,R.R. and Matthews,R.G.
  TITLE     Electrospray mass spectrometric analysis of the domains of a large
            enzyme: observation of the occupied cobalamin-binding domain and
            redefinition of the carboxyl terminus of methionine synthase
  JOURNAL   Biochemistry 32 (36), 9282-9289 (1993)
   PUBMED   8369296
REFERENCE   3  (residues 1 to 1256)
  AUTHORS   Luschinsky,C.L., Drummond,J.T., Matthews,R.G. and Ludwig,M.L.
  TITLE     Crystallization and preliminary X-ray diffraction studies of the
            cobalamin-binding domain of methionine synthase from Escherichia
            coli
  JOURNAL   J Mol Biol 225 (2), 557-560 (1992)
   PUBMED   1593636
REFERENCE   4  (residues 1 to 1256)
  AUTHORS   Banerjee,R.V., Johnston,N.L., Sobeski,J.K., Datta,P. and
            Matthews,R.G.
  TITLE     Cloning and sequence analysis of the Escherichia coli metH gene
            encoding cobalamin-dependent methionine synthase and isolation of a
            tryptic fragment containing the cobalamin-binding domain
  JOURNAL   J Biol Chem 264 (23), 13888-13895 (1989)
   PUBMED   2668277
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: NF007024.0
            Evidence Source    :: NCBI Protein Cluster (PRK)
            Source Identifier  :: PRK09490
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Salmonella enterica"
                     /db_xref="taxon:28901"
     gene            1..1256
                     /gene="metH"
     Protein         1..1256
                     /product="methionine synthase"
                     /EC_number="2.1.1.13"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008705 - methionine synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=138931
     Region          28..1252
                     /region_name="metH"
                     /note="B12-dependent methionine synthase; Provisional;
                     PRK09490"
                     /db_xref="CDD:236539"
ORIGIN      
        1 mshvarcslf rqhalcqygs lrgalsgasv sskveqlraq lnerilvldg gmgtmiqsyr
       61 lheedfrger fadwpcdlkg nndllvlskp eviaaihnay feagadiiet ntfnsttiam
      121 adyrmeslsa einyaaakla racadewtar tpekprfvag vlgptnrtas ispdvndpaf
      181 rnitfdqlva ayrestkalv eggadlilie tvfdtlnaka avfavkeefe algvdlpimi
      241 sgtitdasgr tlsgqtteaf ynslrhaeal tfglncalgp delrqyvqel sriaecyvta
      301 hpnaglpnaf geydldadtm akqirewaea gflnivggcc gttpehiaam sravagllpr
      361 qlpdipvacr lsgleplnig ddslfvnvge rtnvtgsakf krlikeekys ealdvarqqv
      421 esgaqiidin mdegmldaea amvrflslia gepdiarvpi midsskwevi ekglkciqgk
      481 givnsismke gveafihhak llrrygaavv vmafdeqgqa dtrarkieic rraykiltee
      541 vgfppediif dpnifavatg ieehnnyaqd figacedikr elphalisgg vsnvsfsfrg
      601 ndpvreaiha vflyyairng mdmgivnagq laiyddlpae lrdavedvil nrrddgterl
      661 ldlaekyrgs ktdeaanaqq aewrswdvkk rleyslvkgi tefieqdtee arqqaarpie
      721 viegplmdgm nvvgdlfgeg kmflpqvvks arvmkqavay lepfieaske kgssngkmvi
      781 atvkgdvhdi gknivgvvlq cnnyeivdlg vmvpaekilr tarevnadli glsglitpsl
      841 demvnvakem erqgftipll iggattskah tavkieqnys gptvyvqnas rtvgvvaall
      901 sdtqrddfva rtrkeyetvr iqharkkprt ppvtleaard ndlafdwery tppvahrlgv
      961 qeveasietl rnyidwtpff mtwslagkyp riledevvgv eaqrlfkdan dmldklsaek
     1021 llnprgvvgl fpanrvgddi eiyrdetrth vltvshhlrq qtekvgfany cladfvapkl
     1081 sgkadyigaf avtggleeda ladafeaqhd dynkimvkai adrlaeafae ylhervrkvy
     1141 wgyapnesls ndelirenyq girpapgypa cpehtekgti wqlldvekht gmkltesfam
     1201 wpgasvsgwy fshpeskyfa vaqiqrdqvt dyafrkgmsv edverwlapn lgydad