2-oxoglutarate decarboxylase [Salmonella enterica subsp. enterica

LOCUS       NP_461251                556 aa            linear   CON 08-SEP-2022
            serovar Typhimurium str. LT2].
ACCESSION   NP_461251
VERSION     NP_461251.1
DBLINK      BioProject: PRJNA57799
            BioSample: SAMN02604315
DBSOURCE    REFSEQ: accession NC_003197.2
KEYWORDS    RefSeq.
SOURCE      Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
  ORGANISM  Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Salmonella.
REFERENCE   1  (residues 1 to 556)
  AUTHORS   McClelland,M., Sanderson,K.E., Spieth,J., Clifton,S.W.,
            Latreille,P., Courtney,L., Porwollik,S., Ali,J., Dante,M., Du,F.,
            Hou,S., Layman,D., Leonard,S., Nguyen,C., Scott,K., Holmes,A.,
            Grewal,N., Mulvaney,E., Ryan,E., Sun,H., Florea,L., Miller,W.,
            Stoneking,T., Nhan,M., Waterston,R. and Wilson,R.K.
  TITLE     Complete genome sequence of Salmonella enterica serovar Typhimurium
            LT2
  JOURNAL   Nature 413 (6858), 852-856 (2001)
   PUBMED   11677609
REFERENCE   2  (residues 1 to 556)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 556)
  AUTHORS   McClelland,M., Jain,A., Saraogi,P., Mendelson,R., Westerman,R.,
            SanMiguel,P. and Csonka,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2016) Department of Microbiology and Molecular
            Genetics, University of California, Irvine, CA 92697, USA
  REMARK    Sequence update by submitter
REFERENCE   4  (residues 1 to 556)
  CONSRTM   The Salmonella typhimurium Genome Sequencing Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2001) Genome Sequencing Center, Department of
            Genetics, Washington University School of Medicine, 4444 Forest
            Park Boulevard, St. Louis, MO 63108, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAL21210.
            Supported by NIH grant 5U 01 AI43283
            
            Coding sequences below are predicted from manually evaluated
            computer analysis, using similarity information and the programs;
            GLIMMER; http://www.tigr.org/softlab/glimmer/glimmer.html and
            GeneMark; http://opal.biology.gatech.edu/GeneMark/
            
            EC numbers were kindly provided by Junko Yabuzaki and the Kyoto
            Encyclopedia of Genes and Genomes; http://www.genome.ad.jp/kegg/,
            and Pedro Romero and Peter Karp at EcoCyc;
            http://ecocyc.PangeaSystems.com/ecocyc/
            
            The analyses of ribosome binding sites and promoter binding sites
            were kindly provided by Heladia Salgado, Julio Collado-Vides and
            ReguonDB;
            http://kinich.cifn.unam.mx:8850/db/regulondb_intro.frameset
            
            This sequence was finished as follows unless otherwise noted: all
            regions were double stranded, sequenced with an alternate
            chemistries or covered by high quality data (i.e., phred quality >=
            30); an attempt was made to resolve all sequencing problems, such
            as compressions and repeats; all regions were covered by sequence
            from more than one m13 subclone.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Salmonella enterica subsp. enterica serovar
                     Typhimurium str. LT2"
                     /strain="LT2"
                     /serovar="Typhimurium"
                     /sub_species="enterica"
                     /culture_collection="ATCC:700720"
                     /culture_collection="SGSC:1412"
                     /type_material="type strain of Salmonella enterica"
                     /db_xref="taxon:99287"
                     /focus
     Protein         1..556
                     /product="2-oxoglutarate decarboxylase"
                     /EC_number="4.1.3.-"
                     /note="SHCHC synthase"
                     /calculated_mol_wt=61392
     Region          2..556
                     /region_name="MenD"
                     /note="2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-
                     carboxylate synthase [Coenzyme transport and metabolism];
                     COG1165"
                     /db_xref="CDD:440779"
     CDS             1..556
                     /gene="menD"
                     /locus_tag="STM2309"
                     /coded_by="complement(NC_003197.2:2415625..2417295)"
                     /note="bifunctional; similar to E. coli 2-oxoglutarate
                     decarboxylase; SHCHC synthase (AAC75324.1); Blastp hit to
                     AAC75324.1 (556 aa), 91% identity in aa 1 - 556"
                     /transl_table=11
                     /db_xref="GeneID:1253831"
CONTIG      join(WP_000116392.1:1..556)
ORIGIN      
        1 msvsafnrrw aavilealtr hgvrhvciap gsrstpltla aaenpafihh thfderglgh
       61 lalglakvsq qpvavivtsg tavanlypal ieagltgekl illtadrppe lidcganqai
      121 rqagmfashp sqtlslprpt qdiparwlvs tidnalamlh agalhincpf aeplygdmnd
      181 tglvwqqrlg dwwqdekpwl rearrlesdk qrdwffwrqk rgvvvagrms aeegkkvaqw
      241 aqtlgwplig dvlsqtgqpl pcadlwlgna kavtelqqaq ivvqlgsslt gkrllqwqat
      301 cepeeywvid niegrldpah hrgrrlvaki adwlelhpae krkpwcveip rlaelawqrv
      361 vaqrdtfgea qlahrirdyl peqgqlfvgn slvvrlidal sqlpagypvy snrgasgidg
      421 llstaagvqr asakstlaiv gdlsalydln alallrqvsa pfvlivvnnn ggqifsllpt
      481 pqskrerfyl mpqnvhfdha aamfnlryhr penweelesa lagawrtpat tvielvvndt
      541 dgaqtlqqll aqvshl