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LOCUS NP_252915 1809 aa linear CON 24-JAN-2019 ACCESSION NP_252915 VERSION NP_252915.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 1809) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 1809) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 1809) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 1809) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 1809) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 1809) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 1809) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 1809) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 1809) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 1809) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 1809) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 1809) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 1809) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 1809) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 1809) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 1809) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG07613. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1809 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..1809 /product="pyochelin synthetase" /calculated_mol_wt=196954 Region 5..53 /region_name="TubC_N" /note="TubC N-terminal docking domain; pfam18563" /db_xref="CDD:436580" Region 59..1360 /region_name="EntF" /note="seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism]; COG1020" /db_xref="CDD:440643" Region 528..1010 /region_name="A_NRPS_TlmIV_like" /note="The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; cd12114" /db_xref="CDD:341279" Site order(657,660..665,667..668) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341279" Site order(660..661,779..780,801..806,829,892,904,907,1004) /site_type="other" /note="AMP binding site [chemical binding]" /db_xref="CDD:341279" Region <1351..1747 /region_name="PRK12467" /note="peptide synthase; Provisional" /db_xref="CDD:237108" CDS 1..1809 /gene="pchF" /locus_tag="PA4225" /coded_by="complement(NC_002516.2:4731369..4736798)" /note="Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)" /transl_table=11 /db_xref="GeneID:880083" CONTIG join(WP_003148107.1:1..1809) ORIGIN 1 mslgelletc rsrrielwse agrlryrapq galdaglaer lraerealle hleggpgwra 61 epdmahqrfp ltpvqaayvl grqaafdygg nacqlyaeyd wpadtdparl eaawnamver 121 hpmlravied nawqrvlpev pwqrltvhac agldeaafqa hlervrerld hacaaldqwp 181 vlrpelsigr dacvlhcsvd ftlvdyaslq lllgewrrry ldpqwtaepl eatfrdyvgv 241 eqrrrqspaw qrdrdwwlar ldalpgrpdl plrvqpdtrs trfrhfharl deaawqalga 301 ragehglsaa gvalaafaet igrwsqapaf clnltvlnrp plhpqlaqvl gdftalslla 361 vdsrhgdsfv erarrigeqm fddldhptfs gvdllrelar rrgrgadlmp vvftsgigsv 421 qrllgdgeap raprymisqt pqvwldcqvt dqfggleigw dvrlglfpeg qaeamfddfv 481 gllrrlaqsp rawtdgdate pveappqalp gsarsiaagf aeralltpda taihdaagsy 541 syrqvaqhas alrrvleahg agrgrrvavm lpksaaqlva vigilqagaa yvpvdirqpp 601 lrrqailasa evvalvcles dvpdvgcacv aidrlaadsa wppppaaeva addlayviyt 661 sgstgtpkgv mlshaavsnt lldinqrygv dandrvlgla elsfdlsvyd ffgataagaq 721 vvlpdpargs dpshwaelle rhaitlwnsv paqgqmlidy lesepqrhlp gprcvlwsgd 781 wipvslptrw wrrwpdsalf slggateaai wsieqpirpq htelasipyg ralrgqsvev 841 ldargrrcpp gvrgeihigg vglalgyagd pqrtaerfvr hpdgrrlyrt gdlgryladg 901 sieflgredd qvkirghrie laeldaalca hpqvnlaatv vlgethersl asfvtlhapv 961 eagedprtal davrqraaqa lrrdwgseeg iaaavaaldr aclaslaawl agsglfasat 1021 pldlatlcqr lgiaearqrl lrhwlrqlee ggylraegeg wlgcaerpaq spedawtafa 1081 gcapaalwpa elvaylrdsa qslgeqlagr ispaalmfpq gsariaeamy sqglhaqalh 1141 eamaeaiaai verqpqrrwr llelgagtaa asrtviarla plvqrgaevd ylftdvssyf 1201 laaarerfad qpwvrfgrfd mngdlldqgv aphsvdills sgalnnaldt pallaglrel 1261 lsadawlviq eltrehneis vsqslmmenp rdlrderrql fvhtgqwlew laaqggdlac 1321 gvvppgsald llgydvllar cktdrarlep aellafvear vprymlpaql rvlerlpvtg 1381 ngkidrkalt gfarqpqadl rhgvaqapad elenallalw revldnpslg veqdffgagg 1441 dslliaqlia rlrerlesar rhpfdrllrw alsqptprgl aerlrsapee grgpalaaar 1501 gvapapagms raplaegava ldplvrlvpg egvprvlvhe glgtllpyrp llralgegrp 1561 llglavhdsd aylaipaehl naclgrryae alhraglrev dllgycsggl valetakslv 1621 qrgvrvrqld ivssyripyr vdderlllfs faatlgldta algfpaperl gqavqaalaq 1681 tperlvaeal aglpgladlv alrgrvlqaa sgsadavsve rdtlyrlfch svrasqaeap 1741 epyvgalrlf vpdagnplvp ryaealetqw raaalgacgi hevpgghfdc lgealaqsls 1801 kpmpeeasr