pyochelin non-ribosomal peptide synthetase PchF [Pseudomonas

LOCUS       WP_003148107            1809 aa            linear   BCT 11-OCT-2023
            aeruginosa].
ACCESSION   WP_003148107
VERSION     WP_003148107.1
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa
  ORGANISM  Pseudomonas aeruginosa
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 1809)
  AUTHORS   Chen,L., Yang,J., Yu,J., Yao,Z., Sun,L., Shen,Y. and Jin,Q.
  TITLE     VFDB: a reference database for bacterial virulence factors
  JOURNAL   Nucleic Acids Res 33 (Database issue), D325-D328 (2005)
   PUBMED   15608208
REFERENCE   2  (residues 1 to 1809)
  AUTHORS   Quadri,L.E., Keating,T.A., Patel,H.M. and Walsh,C.T.
  TITLE     Assembly of the Pseudomonas aeruginosa nonribosomal peptide
            siderophore pyochelin: In vitro reconstitution of aryl-4,
            2-bisthiazoline synthetase activity from PchD, PchE, and PchF
  JOURNAL   Biochemistry 38 (45), 14941-14954 (1999)
   PUBMED   10555976
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: BlastRule
            Evidence Accession :: NBR012852
            Evidence Source    :: NCBI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Pseudomonas aeruginosa"
                     /db_xref="taxon:287"
     gene            1..1809
                     /gene="pchF"
     Protein         1..1809
                     /product="pyochelin non-ribosomal peptide synthetase PchF"
                     /GO_function="GO:1904091 - non-ribosomal peptide
                     synthetase activity [Evidence IEA]"
                     /calculated_mol_wt=196954
     Region          5..53
                     /region_name="TubC_N"
                     /note="TubC N-terminal docking domain; pfam18563"
                     /db_xref="CDD:436580"
     Region          59..1360
                     /region_name="EntF"
                     /note="seryl-AMP synthase component of non-ribosomal
                     peptide synthetase [Secondary metabolites biosynthesis,
                     transport and catabolism]; COG1020"
                     /db_xref="CDD:440643"
     Region          528..1010
                     /region_name="A_NRPS_TlmIV_like"
                     /note="The adenylation domain of nonribosomal peptide
                     synthetases (NRPS), including Streptoalloteichus
                     tallysomycin biosynthesis genes; cd12114"
                     /db_xref="CDD:341279"
     Site            order(657,660..665,667..668)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341279"
     Site            order(660..661,779..780,801..806,829,892,904,907,1004)
                     /site_type="other"
                     /note="AMP binding site [chemical binding]"
                     /db_xref="CDD:341279"
     Region          <1351..1747
                     /region_name="PRK12467"
                     /note="peptide synthase; Provisional"
                     /db_xref="CDD:237108"
ORIGIN      
        1 mslgelletc rsrrielwse agrlryrapq galdaglaer lraerealle hleggpgwra
       61 epdmahqrfp ltpvqaayvl grqaafdygg nacqlyaeyd wpadtdparl eaawnamver
      121 hpmlravied nawqrvlpev pwqrltvhac agldeaafqa hlervrerld hacaaldqwp
      181 vlrpelsigr dacvlhcsvd ftlvdyaslq lllgewrrry ldpqwtaepl eatfrdyvgv
      241 eqrrrqspaw qrdrdwwlar ldalpgrpdl plrvqpdtrs trfrhfharl deaawqalga
      301 ragehglsaa gvalaafaet igrwsqapaf clnltvlnrp plhpqlaqvl gdftalslla
      361 vdsrhgdsfv erarrigeqm fddldhptfs gvdllrelar rrgrgadlmp vvftsgigsv
      421 qrllgdgeap raprymisqt pqvwldcqvt dqfggleigw dvrlglfpeg qaeamfddfv
      481 gllrrlaqsp rawtdgdate pveappqalp gsarsiaagf aeralltpda taihdaagsy
      541 syrqvaqhas alrrvleahg agrgrrvavm lpksaaqlva vigilqagaa yvpvdirqpp
      601 lrrqailasa evvalvcles dvpdvgcacv aidrlaadsa wppppaaeva addlayviyt
      661 sgstgtpkgv mlshaavsnt lldinqrygv dandrvlgla elsfdlsvyd ffgataagaq
      721 vvlpdpargs dpshwaelle rhaitlwnsv paqgqmlidy lesepqrhlp gprcvlwsgd
      781 wipvslptrw wrrwpdsalf slggateaai wsieqpirpq htelasipyg ralrgqsvev
      841 ldargrrcpp gvrgeihigg vglalgyagd pqrtaerfvr hpdgrrlyrt gdlgryladg
      901 sieflgredd qvkirghrie laeldaalca hpqvnlaatv vlgethersl asfvtlhapv
      961 eagedprtal davrqraaqa lrrdwgseeg iaaavaaldr aclaslaawl agsglfasat
     1021 pldlatlcqr lgiaearqrl lrhwlrqlee ggylraegeg wlgcaerpaq spedawtafa
     1081 gcapaalwpa elvaylrdsa qslgeqlagr ispaalmfpq gsariaeamy sqglhaqalh
     1141 eamaeaiaai verqpqrrwr llelgagtaa asrtviarla plvqrgaevd ylftdvssyf
     1201 laaarerfad qpwvrfgrfd mngdlldqgv aphsvdills sgalnnaldt pallaglrel
     1261 lsadawlviq eltrehneis vsqslmmenp rdlrderrql fvhtgqwlew laaqggdlac
     1321 gvvppgsald llgydvllar cktdrarlep aellafvear vprymlpaql rvlerlpvtg
     1381 ngkidrkalt gfarqpqadl rhgvaqapad elenallalw revldnpslg veqdffgagg
     1441 dslliaqlia rlrerlesar rhpfdrllrw alsqptprgl aerlrsapee grgpalaaar
     1501 gvapapagms raplaegava ldplvrlvpg egvprvlvhe glgtllpyrp llralgegrp
     1561 llglavhdsd aylaipaehl naclgrryae alhraglrev dllgycsggl valetakslv
     1621 qrgvrvrqld ivssyripyr vdderlllfs faatlgldta algfpaperl gqavqaalaq
     1681 tperlvaeal aglpgladlv alrgrvlqaa sgsadavsve rdtlyrlfch svrasqaeap
     1741 epyvgalrlf vpdagnplvp ryaealetqw raaalgacgi hevpgghfdc lgealaqsls
     1801 kpmpeeasr