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LOCUS NP_252017 2352 aa linear CON 24-JAN-2019 ACCESSION NP_252017 VERSION NP_252017.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 2352) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 2352) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 2352) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 2352) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 2352) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 2352) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 2352) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 2352) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 2352) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 2352) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 2352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 2352) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 2352) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 2352) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 2352) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 2352) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG06715. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2352 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..2352 /product="non-ribosomal peptide synthetase" /calculated_mol_wt=259276 Region 4..>2072 /region_name="PRK12467" /note="peptide synthase; Provisional" /db_xref="CDD:237108" Region 2077..2341 /region_name="alpha/beta hydrolases" /note="A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a...; cl21494" /db_xref="CDD:473884" CDS 1..2352 /locus_tag="PA3327" /coded_by="NC_002516.2:3730557..3737615" /note="'Product name confidence: class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene)'" /transl_table=11 /db_xref="GeneID:882492" CONTIG join(WP_003113143.1:1..2352) ORIGIN 1 mvrfarlpls pyqrdiwvaa aqfpeldqyt ifsydrftge vdtqaleral lqaardteaf 61 rlrlgetdgt pyqwldtdae fearhvdlra drdpeaavrs wlrdafrhay pldgrslvdl 121 allhsdqaly vyvrthhivs dawglqlfls rvragylgel gepqaqmpta sllaqletdd 181 ysgseqyrgd rayfaealeg lepalftrrr paglrrtarh rltlertlld airdrgespf 241 lflsaavaly larihqnddv vlgvpvlnra draakqvvgh fantlplrir tapeqtvdef 301 laqlreatrt llrhqkmplg dllrgasplf dttlsymrwp aaqaipnasv etvaqthahd 361 pdalaiwvse fdghsdaqvd feyacdvfda dfpmdaaarh ietflralve ggerrlgeld 421 plsaaereel ihtrnatdqa fpeqatlptl faeqvartpq rtalleadgg tlsyaeldak 481 vqavadalra agvrtderva llvargphll pailgvqrag gayvpinpdh plervrllle 541 dcgarvvlvd eraatlgesl getrvlhler lpqstgdlpa anvapgdlay viytsgstgm 601 pkgvmvehrs vvnrlnwmqr rypigerdvl lqktpvtfdv svwelfwwsf tgarlsllpp 661 gaekdpreml rsiqrdavtv ihfvpsmltp fldlldgdpt araaasslrl vfcsgealap 721 lqvarfrrlf gdavrlvnly gpteatvdvs dhecasdnpt rvpigrpidn lrlyvldral 781 rpqplgavge lyiggvgvar gylnrpelna erflvdpfva ggrlyrtgdl arwladgnle 841 ylgraddqvk irgnrvepde vrdrlaalpg vrdaavvard savrgthlvg yyvaaaeldp 901 gqlraglsat lpdfmlpaff vridslplsa ngkldrrqlp appeqvaava prtateaela 961 avwadvlgva evgvhddfya lggdsilmlr iraaaqrrgl gfeladlmrn ptvaglaerl 1021 vrplaersyq pfelvsevdk prlegledaf ptsrlslgll fhsrqrpdss vyhdvfhyrf 1081 dlawdeaafr haldrvvaay palrssfdls gaseplqlvh tqarseplil dlrgnpeagt 1141 vldehirqrr fhryslqqpg lflfaafvre dgldlvfsfh haildgwsva nlivalvaay 1201 rgeplpgpap alachvreel aalaspaavg ywtgllegar mtrldgfgah epqaaqgpas 1261 hrealpdgll erlkataaqr glplksllla ahcltlhlfs rsdsvvtgai sngrpelpda 1321 drmvglflnt vpvrseiagc swievadalf rqerdghahr ryplsaiqqi vgdelssafn 1381 yvnlhvlepl wqlrdfrvwe etnfallvnv iatpsdgmyl ridsdgrgis rsqaaligat 1441 fvellwrlad hpdeaadfaf laprrdaasq peplvdvvsl ferqvealpg saalafeeqr 1501 wtyrdldhva rcvatrlvra garrgdaigv alnrspemia tiwgilragl vcvpldvsyp 1561 aqrlalilet aqpfrvvahp ehahvaaaer vlpveelvad iepetfaapq ldelamllft 1621 sgstgrpkgv elshrmwany tqwqlrvasg vpglrtlqfa plsfdmafqe ifstlcggge 1681 lqlisnrerm dpsallhvle rrqvqrvllp fvalqrlaea snalgvrpga lrvvvssgeq 1741 lritedvraf caampgllle nqygptethq vtyhslsgdp ahypdlppig rpldgvevqv 1801 ldaalrpvpv gvtgelyfgg dclargyhra pkltaerfve hpwrpgarly rtgdlgrilg 1861 ngeivwlgra dtqvkvrgfr iepaevelai mrqaerqpgl rgaavvarer qgndaflaaf 1921 llgepeavdl aelkqalrse lpehmvpahf awvdgfaltp sgkrddaalr alplehgtni 1981 eylaprddye rtlagllgel ldrprvgird sffdlggtsl samrfmllie krygvdlpma 2041 alietptveg laerlrersa vrafdplvpi raggsrpplf lvhplgghvl cylplvralp 2101 pdqpvyalqa agtgqgstpl avlediaasy laairrvqpe gpyylggwsf ggfvayemar 2161 qlraldpqav aqlivldsit vdrnhagsas dealllffyw elvwfersdk eveplpegas 2221 leqkldhive raieagvlpa gtpratvqrl yelfraswqa ligyrpevsd qdmtllradg 2281 plplalkpmh daagthygdp kngwqhwtsg rldvidvpgd hlvlmkepyv etvaaeiaal 2341 lepstssert rp