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LOCUS NP_250995 1249 aa linear CON 24-JAN-2019 ACCESSION NP_250995 VERSION NP_250995.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 1249) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 1249) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 1249) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 1249) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 1249) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 1249) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 1249) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 1249) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 1249) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 1249) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 1249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 1249) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 1249) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 1249) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 1249) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 1249) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG05693. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1249 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..1249 /product="protein AmbB" /calculated_mol_wt=134317 Region 192..>1236 /region_name="PRK12467" /note="peptide synthase; Provisional" /db_xref="CDD:237108" Region 241..721 /region_name="A_NRPS_Sfm_like" /note="The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; cd12115" /db_xref="CDD:341280" Site order(385,388..393,395..396) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341280" Site order(388..389,497..498,519..524,547,611,623,626,715) /site_type="other" /note="AMP binding site [chemical binding]" /db_xref="CDD:341280" CDS 1..1249 /gene="ambB" /locus_tag="PA2305" /coded_by="complement(NC_002516.2:2541197..2544946)" /note="Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa" /transl_table=11 /db_xref="GeneID:878073" CONTIG join(WP_003113094.1:1..1249) ORIGIN 1 mqerhglplr sfssgkalta gravrpevaq errylqgapl glelpgrial rdphcawqwf 61 epeaaaeafp aahwlaaflv llgrygneei tlgfpepitv rgrqapallr ssyramessa 121 ersarlaeel ddarrqlsad gqeraalagr cavqvlaarp tasspgwlal vlaadgsvgl 181 alrdpqydel rriaghlarl arglvdaqac vgrlpwldad eerrlqalrs epqaapsrgv 241 lhhlfeaqar rtpqriavha adrslsyael eresaalavr lraagvapeq rvgvclrrds 301 gllvgllgvl raggcyvpld paypeervay mlddadcllv lvdastrerv aalgrpcltl 361 eeggdqandl alpasevgad hlayiiytsg stgrpkgvai ehgsahaflr wagqhyaaee 421 wsgvlaatsv cfdlsvyelf gtlaeggtlh lvenlfslpd yprrdeisll ntvpsvcaal 481 lalgdlpggv rtlnlagepl rghlvrqirg qpqvrrlvnl ygptedttys tvheldlhae 541 aldeppigrp lpgttvevld gfeaplplgv agelylggig largyfgkpe qtaerfrvdp 601 gsgerryrtg drvrmredgv lehlgrlddq vkfngfriel geiasclasf pgvseacaml 661 tedsaglrrl vgylaapfap plqalnehlg qslphymlps afvvlaelpk tlngkidrka 721 lprpqatgae pqalpsdple qalhqawqaq lgappragqg fyaaggdslr avhllatlrq 781 rlsrrvplqa faggpatpea llellrqaap egdepepsag aaglslaerr lwvaqqlape 841 dtsynllahl rivgatadai eqalrqller hvalrrrvet gvdgpqphal aahavplqrl 901 lasdavhaer lledgvrreg arvfdlahea parlllvvtr dsaradllls vhhyafddvs 961 lavfaaelkt lldggrlgvl astpeqvaar eraalasgrl drvaerwaer llplakapga 1021 aparpeesgg ragqrlalpv saavhaacra laertsvspf saalqafaev lgaelgvddl 1081 lvgvalagrs rlemqglvgc fvnllplavg lrpeqsvewr lrqvghdlle llehqdvple 1141 cvtqalrqrg asglpiriac gahngraapa vdagvrvead fipvpgarld ltlwledqpq 1201 gwlavwtgvs aifdlhrier lhqawerrll anagepiskr mspegcnas