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LOCUS NP_248764 1032 aa linear CON 24-JAN-2019 ACCESSION NP_248764 VERSION NP_248764.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 1032) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 1032) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 1032) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 1032) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 1032) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 1032) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 1032) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 1032) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 1032) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 1032) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 1032) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 1032) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 1032) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 1032) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 1032) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 1032) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG03464. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1032 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..1032 /product="serine/threonine protein kinase PpkA" /calculated_mol_wt=109887 Region 7..261 /region_name="STKc_PknB_like" /note="Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; cd14014" /db_xref="CDD:270916" Site order(7,31..32,61,66,71..74,86) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:270916" Site order(14..15,17..20,22,35,37,69,85..88,92,94,129,131, 133..134,136,146..147,150,168..171) /site_type="active" /db_xref="CDD:270916" Site order(14..15,17..20,22,35,37,69,85..88,92,131,133..134, 136,146..147) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270916" Site order(18,92,94,129,131,133,150,168..171) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270916" Site order(146..154,164..171) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270916" Region 616..797 /region_name="vWFA" /note="Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cd00198" /db_xref="CDD:238119" Site order(621,705,736) /site_type="other" /note="metal ion-dependent adhesion site (MIDAS)" /db_xref="CDD:238119" CDS 1..1032 /gene="ppkA" /locus_tag="PA0074" /coded_by="complement(NC_002516.2:87000..90098)" /note="Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa." /transl_table=11 /db_xref="GeneID:879361" /db_xref="PseudoCap:PA0074" CONTIG join(WP_003147051.1:1..1032) ORIGIN 1 mdielpgfdi erelgegama tvylatqrsl qrkvalkvma aalaadpsfa erflregrtl 61 arlshpntvt ihdignvgsc yymameylpn gtlkeriqqg ldpeqglayv rqvaaalgya 121 hsqglvhrdv kpanilfrad gtavlsdfgi aksiedntqf tqvgfavgtp symspeqarg 181 qeidgradly algvvlyeil tgklpyngkd slstalahlt eplpelpieq gryqdilrql 241 lakdpaerfp tagaliaald rlapsaleat qirplatpqg sprasnpppa epaplppadl 301 gglqpvsiql ppvtpsagga tppppppsqa akppsppppp lppakpragg srtpliaaaa 361 aavllaiggg awwllgsgda psaadpaplg qtpadkpqqq tpvadaeqdg gerpllmpgk 421 ktlfqrvltk pgaaisaeag gppragavpa fsvlyvyark qvggspwlrv gassngegdg 481 wlpasavsdw kqslvlkfte rsgrapvmfl nsaeqverll gdtraardtl tqavdhkgdp 541 qvvavepndr aipqdqfyll pifdskesfd adgqpaqlle vasidpggsa aapqapgqag 601 qggasgaasd tfrtgivlvv dtsvsmqpyi drvrevidgl qrqigergdl dkvsfglvgf 661 rnntdktpgl eyvsktlvpl qpgndaqrfa elssqvratd vsshsfneda fagimqavde 721 mdwspyagrv vllvtdagal rkndplgrtq mneaevrqaa lrkgvkiyal hlrtpagknn 781 hgyaeqqyrs ltadanpkia dlyipvagge vnafgntvke igtvfadlvh dagnrkpqap 841 rfdaapsvas ksaaigyamq meflgrrdpv rapqvvtawt adrdltnpal pafqvcvlls 901 klqlnelqqs lklivdaakr tqtspkdffq eiasasayms rdpaqlvkgs nlaqsgvlge 961 yleglpyrsk slnmtqdlwl slsvaeqqdf ideleskirl yetfhndvan wvrfgdadag 1021 dalyrvplst lp