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histidinol dehydrogenase [Klebsiella pneumoniae subsp. pneumoniae


LOCUS       YP_005227837             434 aa            linear   CON 02-JUN-2020
            HS11286].
ACCESSION   YP_005227837
VERSION     YP_005227837.1
DBLINK      BioProject: PRJNA84387
            Assembly: GCF_000240185.1
DBSOURCE    REFSEQ: accession NC_016845.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae subsp. pneumoniae HS11286
  ORGANISM  Klebsiella pneumoniae subsp. pneumoniae HS11286
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 434)
  AUTHORS   Liu,P., Li,P., Jiang,X., Bi,D., Xie,Y., Tai,C., Deng,Z.,
            Rajakumar,K. and Ou,H.Y.
  TITLE     Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
            HS11286, a multidrug-resistant strain isolated from human sputum
  JOURNAL   J. Bacteriol. 194 (7), 1841-1842 (2012)
   PUBMED   22408243
REFERENCE   2  (residues 1 to 434)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2012) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 434)
  AUTHORS   Ou,H.-Y., Jiang,X., Liu,P. and Li,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2011) State Key Laboratory of Microbial
            Metabolism, Shanghai Jiaotong University, 1954 Huashan Road,
            Shanghai 200030, China
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence is identical to AEW62235.
            RefSeq Category: Reference Genome
                        CLI: Clinical Isolate
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Klebsiella pneumoniae subsp. pneumoniae
                     HS11286"
                     /strain="HS11286"
                     /sub_species="pneumoniae"
                     /db_xref="taxon:1125630"
     Protein         1..434
                     /product="histidinol dehydrogenase"
                     /calculated_mol_wt=45495
     Region          5..427
                     /region_name="hisD"
                     /note="bifunctional histidinal dehydrogenase/ histidinol
                     dehydrogenase; Reviewed; PRK00877"
                     /db_xref="CDD:234853"
     Site            order(58,130,132..133,141,162,185..186,188,209..211,
                     213..214,262)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(83..84,87..88,90,93..94,97..98,101..102,109,111,
                     115..119,122,124,136..140,204,219,223,250..251,254..255,
                     257..259,261..262,331,336,339..340,342..350,352,354..355,
                     357..361,363,365,375..376,378..382,384..385,388..395,
                     410..411,413..419)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119329"
     Site            order(138,140,237,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="active"
                     /note="product binding site [active]"
                     /db_xref="CDD:119329"
     Site            order(140,237,259,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(259,262,360,419)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:119329"
     Site            326..327
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:119329"
     CDS             1..434
                     /locus_tag="KPHS_35370"
                     /coded_by="NC_016845.1:3537825..3539129"
                     /transl_table=11
                     /db_xref="GeneID:11848568"
CONTIG      join(WP_009307478.1:1..434)
ORIGIN      
        1 msfntiidwn gcsadqqqql ltrpaisasd sisktvteil nnvkangdaa lreysakfdk
       61 ttvaalqvse aeiaaagerl sdelkqamav avknietfhn aqqlqavdve tlpgvrcqqv
      121 trpiasvgly ipggsaplfs tvlmlatpar iagcqqvvlc spppiadeil yaaqlcgvkt
      181 ifnvggaqai aalalgtesv pkvdkifgpg nayvteakrq vsqrldgaai dmpagpsevl
      241 viadsganpd fvasdllsqa ehgpdsqvil ltpdadmgsr vaeaverqla alpraetarv
      301 alsasriiva rdlaqcvais nlygpehlii qtrqarelvd sitsagsvfl gdwspesagd
      361 yasgtnhvlp tygytatcss lgladfqkrm tvqelsrdgf aalastieil aaaerldahk
      421 navtlrvaal keqa