MULTISPECIES: histidinol dehydrogenase [Klebsiella].

LOCUS       WP_009307478             434 aa            linear   BCT 17-JUN-2024
ACCESSION   WP_009307478
VERSION     WP_009307478.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella
  ORGANISM  Klebsiella
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group.
COMMENT     REFSEQ: This record represents a single, non-redundant, protein
            sequence which may be annotated on many different RefSeq genomes
            from the same, or different, species.
            
            ##Evidence-For-Name-Assignment-START##
            Evidence Category  :: HMM
            Evidence Accession :: TIGR00069.1
            Evidence Source    :: JCVI
            ##Evidence-For-Name-Assignment-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Klebsiella"
                     /db_xref="taxon:570"
     gene            1..434
                     /gene="hisD"
     Protein         1..434
                     /product="histidinol dehydrogenase"
                     /EC_number="1.1.1.23"
                     /GO_function="GO:0004399 - histidinol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /calculated_mol_wt=45495
     Region          5..427
                     /region_name="hisD"
                     /note="bifunctional histidinal dehydrogenase/ histidinol
                     dehydrogenase; Reviewed; PRK00877"
                     /db_xref="CDD:234853"
     Site            order(58,130,132..133,141,162,185..186,188,209..211,
                     213..214,262)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(83..84,87..88,90,93..94,97..98,101..102,109,111,
                     115..119,122,124,136..140,204,219,223,250..251,254..255,
                     257..259,261..262,331,336,339..340,342..350,352,354..355,
                     357..361,363,365,375..376,378..382,384..385,388..395,
                     410..411,413..419)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119329"
     Site            order(138,140,237,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="active"
                     /note="product binding site [active]"
                     /db_xref="CDD:119329"
     Site            order(140,237,259,262,326..327,356,360..361,367,414,416,
                     419)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:119329"
     Site            order(259,262,360,419)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:119329"
     Site            326..327
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:119329"
ORIGIN      
        1 msfntiidwn gcsadqqqql ltrpaisasd sisktvteil nnvkangdaa lreysakfdk
       61 ttvaalqvse aeiaaagerl sdelkqamav avknietfhn aqqlqavdve tlpgvrcqqv
      121 trpiasvgly ipggsaplfs tvlmlatpar iagcqqvvlc spppiadeil yaaqlcgvkt
      181 ifnvggaqai aalalgtesv pkvdkifgpg nayvteakrq vsqrldgaai dmpagpsevl
      241 viadsganpd fvasdllsqa ehgpdsqvil ltpdadmgsr vaeaverqla alpraetarv
      301 alsasriiva rdlaqcvais nlygpehlii qtrqarelvd sitsagsvfl gdwspesagd
      361 yasgtnhvlp tygytatcss lgladfqkrm tvqelsrdgf aalastieil aaaerldahk
      421 navtlrvaal keqa