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High-molecular-weight nonribosomal peptide/polyketide synthetase 2


LOCUS       YP_005227766            2035 aa            linear   CON 02-JUN-2020
            (HMWP2) [Klebsiella pneumoniae subsp. pneumoniae HS11286].
ACCESSION   YP_005227766
VERSION     YP_005227766.1
DBLINK      BioProject: PRJNA84387
            Assembly: GCF_000240185.1
DBSOURCE    REFSEQ: accession NC_016845.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae subsp. pneumoniae HS11286
  ORGANISM  Klebsiella pneumoniae subsp. pneumoniae HS11286
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 2035)
  AUTHORS   Liu,P., Li,P., Jiang,X., Bi,D., Xie,Y., Tai,C., Deng,Z.,
            Rajakumar,K. and Ou,H.Y.
  TITLE     Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
            HS11286, a multidrug-resistant strain isolated from human sputum
  JOURNAL   J. Bacteriol. 194 (7), 1841-1842 (2012)
   PUBMED   22408243
REFERENCE   2  (residues 1 to 2035)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2012) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 2035)
  AUTHORS   Ou,H.-Y., Jiang,X., Liu,P. and Li,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2011) State Key Laboratory of Microbial
            Metabolism, Shanghai Jiaotong University, 1954 Huashan Road,
            Shanghai 200030, China
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence is identical to AEW62164.
            RefSeq Category: Reference Genome
                        CLI: Clinical Isolate
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Klebsiella pneumoniae subsp. pneumoniae
                     HS11286"
                     /strain="HS11286"
                     /sub_species="pneumoniae"
                     /db_xref="taxon:1125630"
     Protein         1..2035
                     /product="High-molecular-weight nonribosomal
                     peptide/polyketide synthetase 2 (HMWP2)"
                     /calculated_mol_wt=228463
     Region          <5..95
                     /region_name="AcpA"
                     /note="Acyl carrier protein/domain [Lipid transport and
                     metabolism, Secondary metabolites biosynthesis, transport
                     and catabolism]; COG3433"
                     /db_xref="CDD:442659"
     Region          95..1445
                     /region_name="EntF"
                     /note="seryl-AMP synthase component of non-ribosomal
                     peptide synthetase [Secondary metabolites biosynthesis,
                     transport and catabolism]; COG1020"
                     /db_xref="CDD:440643"
     Region          580..1063
                     /region_name="A_NRPS_TlmIV_like"
                     /note="The adenylation domain of nonribosomal peptide
                     synthetases (NRPS), including Streptoalloteichus
                     tallysomycin biosynthesis genes; cd12114"
                     /db_xref="CDD:341279"
     Site            order(709,712..717,719..720)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341279"
     Site            order(712..713,831..832,853..858,881,943,955,958,1058)
                     /site_type="other"
                     /note="AMP binding site [chemical binding]"
                     /db_xref="CDD:341279"
     Region          1495..1906
                     /region_name="Cyc_NRPS"
                     /note="Cyc (heterocyclization) domain of nonribosomal
                     peptide synthetases (NRPSs); belongs to the
                     Condensation-domain family; cd19535"
                     /db_xref="CDD:380458"
     Region          1950..2008
                     /region_name="PP-binding"
                     /note="Phosphopantetheine attachment site; pfam00550"
                     /db_xref="CDD:425746"
     CDS             1..2035
                     /locus_tag="KPHS_34660"
                     /coded_by="NC_016845.1:3442686..3448793"
                     /transl_table=11
                     /db_xref="GeneID:11848495"
CONTIG      join(WP_014343269.1:1..2035)
ORIGIN      
        1 misgapsqds llpdnrhaad yqqlrerliq elnltpqqlh eesnliqagl dsirlmrwlh
       61 wfrkngyrlt lrelyaaptl aawnqlmlsr spenaeeetp pdesswpnmt estpfpltpv
      121 qhayltgrmp gqtlggvgch lyqefeghcl tasqleqait tllqrhpmlh iafrpdgqqv
      181 wlpqpywngv tvhdlshnda esrqayldal rqrlshrllr veigetfdfq ltllpdnrhr
      241 lhvnidllim dassftlffd elnallages lpaidtrydf rsyllhqqki nqtlrddara
      301 ywlakastlp papvlplace patlrevrnt rrrmivpatr whafsnrage ygvtptmala
      361 tcfsavlarw ggltrlllni tlfdrqplhp avgamladft nillldtacd gdtvsnlark
      421 nqltftedwe hrhwsgvell relkrqqryp hgapvvftsn lgrslyssra esplgepewg
      481 isqtpqvwid hlafehhgev wlqwdsndal fppalvetlf daycqlinql cddesawqkp
      541 fadmmpasqr airervnatg apipegllhe gifrialqqp qalavtdmry qwnyheltdy
      601 arrcagrlie cgvqpgdnva itmskgagql vavlavllag avyvpvsldq paarrekiya
      661 dasvrlvlic qhdtsagsdd ipvlawqqai eaepianpvv raptqpayii ytsgstgtpk
      721 gvvishrgal ntccdintry qvgphdrvla lsalhfdlsv ydifgvlrag galvmvmenq
      781 rrdphawcel iqrhqvtlwn svpalfdmll twcegfadat penlravmls gdwigldlpa
      841 ryrafrpqgq fiamggatea siwsnaceih dvpahwrsip ygfpltnqry rvvdeqgrdc
      901 pdwvpgelwi ggigvaegyf ndplrseqqf ltlpderwyr tgdlgcywpd gtieflgrrd
      961 kqvkvggyri elgeiesals qlagvkqatv laigekektl aayvvpqgea fcvtdhrnpa
     1021 lpqawhtlag tlpccaispe isaeqvadfl qhrllklkpg htagadplpl mnslaiqprw
     1081 qavvelwlaf lvtqrrlkpa aegyqvcage ehedehphfs ghdltlsqil rgarnelsll
     1141 ndaqwspesl afnhpasapy iqelaticqq laqrlqrpvr lldvgtrtgr aaesllaqln
     1201 agqieyvgle qsqemllsar qrlapwpgar lslwnadtla ahahsadiiw lnnalhrllp
     1261 edpgllatlq hlavpgally vmefrqltps allstllltn gqpeallhns adwaalfsaa
     1321 afncqhgdev aglqrflvqc pdrqvrrdpr qlqaalagrl pgwmvpqriv fldalpltan
     1381 gkidyqalkr rhtpeaenpa eadlpqgdie kqvaalwqql lstgnvtret dffqqggdsl
     1441 latrltgqlh qagyeaqlsd lfnhprladf aatlrktdvp veqpfvhspe eryqpfaltd
     1501 vqqaylvgrq pgfalggvgs hffvefeiad ldltrletvw nrliarhdml raivrdgqqq
     1561 vleqtppwvi pthtlhtpee alrvreklah qvlnpevwpv fdlqvgyvdg mparlwlcld
     1621 nllldglsmq illaelehgy rypqqllppl pvtfrdylqq pslqspnpds lawwqaqldd
     1681 ippapalplr clpqevetpr farlngalds trwhrlkkra adahltpsav llsvwstvls
     1741 awsaqpeftl nltlfdrrpl hpqinqilgd ftslmllswh pgeswlhsaq slqqrlsqnl
     1801 nhrdvsairv mrqlaqrqnv pavpmpvvft salgfeqdnf larrnllkpv wgisqtpqvw
     1861 ldhqiyeseg elrfnwdfva alfpagqver qfeqycalln rmaedesgwq lplaalvppv
     1921 khagqcaers prvcpehsqp hiaadestvs licdafrevv gesvtpaenf feagatslnl
     1981 vqlhvllqrh efstltlldl fthpspaala dylagvatve ktkrprpvrr rqrri