RNA-DNA hybrid ribonuclease [Candida albicans SC5314].

LOCUS       XP_719174                285 aa            linear   PLN 18-APR-2022
ACCESSION   XP_719174
VERSION     XP_719174.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_714081.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 285)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 285)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 285)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 285)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 285)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 285)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30256.
            
            On Dec 8, 2016 this sequence version replaced XP_719174.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..285
                     /product="RNA-DNA hybrid ribonuclease"
                     /calculated_mol_wt=29780
     Region          2..45
                     /region_name="Cauli_VI"
                     /note="Caulimovirus viroplasmin; pfam01693"
                     /db_xref="CDD:460297"
     Region          116..280
                     /region_name="RNase_HI_eukaryote_like"
                     /note="Eukaryotic RNase H is essential and is longer and
                     more complex than their prokaryotic counterparts; cd09280"
                     /db_xref="CDD:260012"
     Site            order(120..123,125..127,164..166,169,198,200..201,
                     227..228,258,261,276)
                     /site_type="other"
                     /note="RNA/DNA hybrid binding site [nucleotide binding]"
                     /db_xref="CDD:260012"
     CDS             1..285
                     /locus_tag="CAALFM_C603260WA"
                     /coded_by="XM_714081.2:1..858"
                     /note="Putative ribonuclease H1; possibly an essential
                     gene, disruptants not obtained by UAU1 method; flow model
                     biofilm induced; Spider biofilm induced"
                     /transl_table=12
                     /db_xref="CGD:CAL0000187941"
                     /db_xref="GeneID:3639183"
ORIGIN      
        1 mpyyavakgs ktgvysnwgd ckeqvhgysg asykkfstaa eanafvqsgg ksgssssyss
       61 ggrssggisg ssrssggysg gysggysggy sggysggssk rssssstsss stttnrvyvd
      121 gasrgngqts kapsgygvyy gpndsrnvav pldrvdknts ykptnqrael hgvkhalkni
      181 hndlqsgkat gkteihsdsk yaiqsvnews snwakngwkn skgetvankd liqetvalkn
      241 sinktyqdkn wgnlefvhvk ghagdpgnea adrlanqgad qygkk