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Candida albicans SC5314 RNA-DNA hybrid ribonuclease


LOCUS       XM_714081                858 bp    mRNA    linear   PLN 18-APR-2022
            (CAALFM_C603260WA), partial mRNA.
ACCESSION   XM_714081
VERSION     XM_714081.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (bases 1 to 858)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (bases 1 to 858)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (bases 1 to 858)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NC_032094).
            
            On Dec 8, 2016 this sequence version replaced XM_714081.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Candida albicans SC5314"
                     /mol_type="mRNA"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     gene            <1..>858
                     /locus_tag="CAALFM_C603260WA"
                     /db_xref="GeneID:3639183"
     CDS             1..858
                     /locus_tag="CAALFM_C603260WA"
                     /note="Putative ribonuclease H1; possibly an essential
                     gene, disruptants not obtained by UAU1 method; flow model
                     biofilm induced; Spider biofilm induced"
                     /codon_start=1
                     /transl_table=12
                     /product="RNA-DNA hybrid ribonuclease"
                     /protein_id="XP_719174.2"
                     /db_xref="CGD:CAL0000187941"
                     /db_xref="GeneID:3639183"
                     /translation="MPYYAVAKGSKTGVYSNWGDCKEQVHGYSGASYKKFSTAAEANA
                     FVQSGGKSGSSSSYSSGGRSSGGISGSSRSSGGYSGGYSGGYSGGYSGGYSGGSSKRS
                     SSSSTSSSSTTTNRVYVDGASRGNGQTSKAPSGYGVYYGPNDSRNVAVPLDRVDKNTS
                     YKPTNQRAELHGVKHALKNIHNDLQSGKATGKTEIHSDSKYAIQSVNEWSSNWAKNGW
                     KNSKGETVANKDLIQETVALKNSINKTYQDKNWGNLEFVHVKGHAGDPGNEAADRLAN
                     QGADQYGKK"
     misc_feature    4..135
                     /locus_tag="CAALFM_C603260WA"
                     /note="Caulimovirus viroplasmin; Region: Cauli_VI;
                     pfam01693"
                     /db_xref="CDD:460297"
     misc_feature    346..840
                     /locus_tag="CAALFM_C603260WA"
                     /note="Eukaryotic RNase H is essential and is longer and
                     more complex than their prokaryotic counterparts; Region:
                     RNase_HI_eukaryote_like; cd09280"
                     /db_xref="CDD:260012"
     misc_feature    order(358..369,373..381,490..498,505..507,592..594,
                     598..603,679..684,772..774,781..783,826..828)
                     /locus_tag="CAALFM_C603260WA"
                     /note="RNA/DNA hybrid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:260012"
ORIGIN      
        1 atgccatatt acgctgttgc taaaggatca aaaactggtg tatacagtaa ttggggtgat
       61 tgtaaagaac aagtccacgg ttatagtggc gcatcttata agaaattcag tactgctgct
      121 gaagccaatg cattcgtgca aagtgggggc aaatcaggat caagttcatc ttatagttcc
      181 ggaggtagat catcaggtgg aatttctggt tctagtcgct catcaggtgg ttattctggt
      241 ggttattccg gtggttattc cggtggctat tccggtggct actctggtgg tagctcaaag
      301 cgttcttctt cctcttcaac atcttcttct tctactacta ctaatcgtgt ttatgttgat
      361 ggtgcttcaa gaggaaatgg acaaaccagc aaggctccat caggatatgg tgtttattat
      421 ggtcctaatg attcaagaaa tgttgctgtt cccttggata gagtagataa aaacacttca
      481 tataaaccta caaatcaacg tgctgaatta catggtgtga aacatgcatt gaaaaatatc
      541 cacaatgatt tacaactggg taaagctacg gggaaaaccg aaattcatag tgattcgaaa
      601 tatgctattc aaagtgttaa tgaatggtcc agtaattggg caaagaatgg ttggaagaat
      661 tccaaagggg aaactgttgc taataaagat ttgattcagg aaactgttgc attaaaaaat
      721 agtattaaca aaacttatca agataaaaat tggggaaatt tggaatttgt tcatgttaaa
      781 ggtcatgctg gtgatcctgg taatgaagct gctgatagat tggcaaatca aggagctgat
      841 caatatggca agaagtag