methylglyoxal reductase (NADPH-dependent) [Candida albicans

LOCUS       XP_719172                343 aa            linear   PLN 18-APR-2022
            SC5314].
ACCESSION   XP_719172
VERSION     XP_719172.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_714079.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 343)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 343)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 343)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 343)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 343)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 343)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30254.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..343
                     /product="methylglyoxal reductase (NADPH-dependent)"
                     /calculated_mol_wt=37702
     Region          6..320
                     /region_name="AR_SDR_e"
                     /note="aldehyde reductase, extended (e) SDRs; cd05227"
                     /db_xref="CDD:187538"
     Site            order(11,13..16,36,62,84..88,127..129,167,171,197..200,
                     216..217)
                     /site_type="other"
                     /note="NADP binding site [chemical binding]"
                     /db_xref="CDD:187538"
     Site            order(88,90,129..131,134,167,197..199,220,232,239,310)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:187538"
     Site            order(129,167,171)
                     /site_type="active"
                     /db_xref="CDD:187538"
     CDS             1..343
                     /locus_tag="CAALFM_C603240WA"
                     /coded_by="XM_714079.2:1..1032"
                     /note="Predicted 3-methylbutanol:NAD(P) oxidoreductase and
                     methylglyoxal reductase (NADPH-dependent); role in
                     ergosterol metabolic process; early stage flow model
                     biofilm induced; Spider biofilm induced"
                     /transl_table=12
                     /db_xref="CGD:CAL0000179051"
                     /db_xref="GeneID:3639181"
ORIGIN      
        1 mstpitvivs gatgfiaqhv vkqllaknyq vigtvrstak gdhllklfnn pqnlsyeive
       61 dvgtkgafdk vlqkhgeakv flhlaspfhf nvtdvekell lpavdgtknv lqaiynfgnn
      121 iekvvitssy aaistaskea dknaiitekd wneiswqdal lnpvngyrgs kkfaekaawd
      181 fiksndnvkf slstinpsfv fgpqsfgsei kqslntssei insilklkpn dsipaskggw
      241 vdvrdvakah iiafenedak nqrillnsgr ftsqslvdii ndkfpdlkgk ipvdepgsdk
      301 sviaeslati ddtksrellg feyynleqsv ydtveqivna hkl