Mdr1p [Candida albicans SC5314].

LOCUS       XP_719165                564 aa            linear   PLN 18-APR-2022
ACCESSION   XP_719165
VERSION     XP_719165.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_714072.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 564)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 564)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 564)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 564)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30248.
            
            On Dec 8, 2016 this sequence version replaced XP_719165.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..564
                     /product="Mdr1p"
                     /calculated_mol_wt=62773
     Region          119..557
                     /region_name="MFS_Tpo1_MDR_like"
                     /note="Yeast Polyamine transporter 1 (Tpo1) and similar
                     multidrug resistance (MDR) transporters of the Major
                     Facilitator Superfamily; cd17323"
                     /db_xref="CDD:340881"
     Site            order(129..130,133..134,137,169,221..222,224..226,229,249,
                     252..253,256,360,363..364,367..369,372,396,400,471..472,
                     476,480,496,499..500,503..504,507)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340881"
     CDS             1..564
                     /gene="MDR1"
                     /locus_tag="CAALFM_C603170CA"
                     /coded_by="XM_714072.2:1..1695"
                     /note="Plasma membrane MDR/MFS multidrug efflux pump;
                     methotrexate is preferred substrate; overexpression in
                     drug-resistant clinical isolates confers fluconazole
                     resistance; repressed in young biofilms; rat catheter
                     biofilm induced"
                     /transl_table=12
                     /db_xref="CGD:CAL0000173998"
                     /db_xref="GeneID:3639260"
ORIGIN      
        1 mhyrflrdsf vgrvtyhlsk hkyfahpeea kdyivpekyl adykptladd tsinfekeei
       61 dnqgepnssq ssssnntivd nnnnndndvd gdkivvtwdg dddpenpqnw ptlqkaffif
      121 qisflttsvy mgsavytpgi eelmhdfgig rvvatlpltl fvigygvgpl vfspmsenai
      181 fgrtsiyiit lflfvilqip talvnniagl cilrflggff aspclatgga svadvvkfwn
      241 lpvglaawsl gavcgpsfgp ffgsiltvka swrwtfwfmc iisgfsfvml cftlpetfgk
      301 tllyrkakrl raitgndrit segevenskm tsheliidtl wrpleitvme pvvlliniyi
      361 amvysilylf fevfpiyfvg vkhftlvelg ttymsivigi viaafiyipv irqkftkpil
      421 rqeqvfpevf ipiaivggil ltsglfifgw sanrtthwvg plfgaattas gaflifqtlf
      481 nfmgasfkph yiasvfasnd lfrsviasvf plfgaplfdn latpeypvaw gssvlgfitl
      541 vmiaipvlfy lngpklrars kyan