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Candida albicans SC5314 Mdr1p (MDR1), partial mRNA.


LOCUS       XM_714072               1695 bp    mRNA    linear   PLN 18-APR-2022
ACCESSION   XM_714072
VERSION     XM_714072.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (bases 1 to 1695)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (bases 1 to 1695)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NC_032094).
            
            On Dec 8, 2016 this sequence version replaced XM_714072.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Candida albicans SC5314"
                     /mol_type="mRNA"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     gene            <1..>1695
                     /gene="MDR1"
                     /locus_tag="CAALFM_C603170CA"
                     /db_xref="GeneID:3639260"
     CDS             1..1695
                     /gene="MDR1"
                     /locus_tag="CAALFM_C603170CA"
                     /note="Plasma membrane MDR/MFS multidrug efflux pump;
                     methotrexate is preferred substrate; overexpression in
                     drug-resistant clinical isolates confers fluconazole
                     resistance; repressed in young biofilms; rat catheter
                     biofilm induced"
                     /codon_start=1
                     /transl_table=12
                     /product="Mdr1p"
                     /protein_id="XP_719165.2"
                     /db_xref="CGD:CAL0000173998"
                     /db_xref="GeneID:3639260"
                     /translation="MHYRFLRDSFVGRVTYHLSKHKYFAHPEEAKDYIVPEKYLADYK
                     PTLADDTSINFEKEEIDNQGEPNSSQSSSSNNTIVDNNNNNDNDVDGDKIVVTWDGDD
                     DPENPQNWPTLQKAFFIFQISFLTTSVYMGSAVYTPGIEELMHDFGIGRVVATLPLTL
                     FVIGYGVGPLVFSPMSENAIFGRTSIYIITLFLFVILQIPTALVNNIAGLCILRFLGG
                     FFASPCLATGGASVADVVKFWNLPVGLAAWSLGAVCGPSFGPFFGSILTVKASWRWTF
                     WFMCIISGFSFVMLCFTLPETFGKTLLYRKAKRLRAITGNDRITSEGEVENSKMTSHE
                     LIIDTLWRPLEITVMEPVVLLINIYIAMVYSILYLFFEVFPIYFVGVKHFTLVELGTT
                     YMSIVIGIVIAAFIYIPVIRQKFTKPILRQEQVFPEVFIPIAIVGGILLTSGLFIFGW
                     SANRTTHWVGPLFGAATTASGAFLIFQTLFNFMGASFKPHYIASVFASNDLFRSVIAS
                     VFPLFGAPLFDNLATPEYPVAWGSSVLGFITLVMIAIPVLFYLNGPKLRARSKYAN"
     misc_feature    355..1671
                     /gene="MDR1"
                     /locus_tag="CAALFM_C603170CA"
                     /note="Yeast Polyamine transporter 1 (Tpo1) and similar
                     multidrug resistance (MDR) transporters of the Major
                     Facilitator Superfamily; Region: MFS_Tpo1_MDR_like;
                     cd17323"
                     /db_xref="CDD:340881"
     misc_feature    order(385..390,397..402,409..411,505..507,661..666,
                     670..678,685..687,745..747,754..759,766..768,1078..1080,
                     1087..1092,1099..1107,1114..1116,1186..1188,1198..1200,
                     1411..1416,1426..1428,1438..1440,1486..1488,1495..1500,
                     1507..1512,1519..1521)
                     /gene="MDR1"
                     /locus_tag="CAALFM_C603170CA"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:340881"
ORIGIN      
        1 atgcattaca gatttttgag agatagtttt gttggtagag tgacttatca tttatcaaaa
       61 cataaatact ttgcccatcc agaagaagct aaagattata ttgtccccga gaaatattta
      121 gccgattaca aaccaactct tgctgatgat acaagtataa attttgaaaa agaagaaata
      181 gataatcaag gtgaacccaa ttcaagtcaa tcatcatctt ccaataacac aatagtcgac
      241 aacaacaaca ataatgataa tgatgttgat ggagataaaa tagttgtcac ttgggatggt
      301 gatgatgatc ccgaaaaccc tcaaaattgg ccaactttac aaaaagcatt tttcattttc
      361 caaatttcat ttttgacaac ttcagtttat atgggatcag cagtatatac ccctggtatt
      421 gaagaattaa tgcatgattt tggtattgga agagtcgtag ctacattgcc attaacatta
      481 tttgttattg gttatggtgt tggcccattg gttttcagtc cgatgtcaga aaatgctata
      541 tttggtcgta catccatata tatcataaca ttatttttat ttgtcatact acaaattccc
      601 actgctttgg ttaataatat tgctggttta tgtatattga gatttttggg tggattcttt
      661 gctagtcctt gtttggccac tggtggtgca agtgttgctg atgtggttaa attttggaat
      721 ttaccagttg ggttagccgc ttggagtttg ggtgctgttt gtggtcctag ttttggtcca
      781 ttctttggtt caattttaac tgtcaaagcc agttggagat ggactttttg gttcatgtgt
      841 atcatttctg ggttttcatt tgttatgttg tgtttcactt tacctgaaac ttttggcaaa
      901 acattattat atcgcaaggc taaaagattg agagccatca ccggtaacga cagaatcaca
      961 agtgagggag aagttgaaaa tagcaaaatg acaagtcatg aattgatcat tgatacatta
     1021 tggagaccat tagaaatcac tgttatggaa ccagttgttc ttttgattaa catttacatt
     1081 gccatggtgt acagtattct ttacttgttt ttcgaagttt tcccaattta tttcgttgga
     1141 gttaaacatt tcaccctcgt tgaattgggt accacatata tgtcaattgt tattggtatt
     1201 gtcattgctg cctttattta tattccagtt attagacaaa aattcaccaa accaattttg
     1261 cgtcaagaac aggttttccc cgaagtgttt attccaattg ccattgttgg tggtatcttg
     1321 ttaacttcag gtcttttcat ttttggttgg tcagcaaata gaaccactca ttgggttggt
     1381 ccattgtttg gtgctgctac tactgcttct ggtgcatttt tgattttcca aacattattc
     1441 aatttcatgg gtgcttcatt taagcctcac tatattgctt cagtttttgc atcaaatgat
     1501 ttgttcagat cagtcattgc atcagtgttc ccattatttg gtgctccttt gtttgacaat
     1561 ttggccaccc ctgaatatcc agttgcttgg ggtagttccg tgttgggttt catcaccctt
     1621 gttatgattg ctattccagt tttgttttac ttgaacggac caaagttgag agcaagatct
     1681 aagtatgcta attag