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guanine nucleotide exchange factor [Candida albicans SC5314].


LOCUS       XP_719097                765 aa            linear   PLN 18-APR-2022
ACCESSION   XP_719097
VERSION     XP_719097.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_714004.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 765)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 765)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 765)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 765)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 765)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 765)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30196.
            
            On Dec 8, 2016 this sequence version replaced XP_719097.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..765
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..765
                     /product="guanine nucleotide exchange factor"
                     /calculated_mol_wt=86037
     Region          359..425
                     /region_name="DUF5601"
                     /note="Domain of unknown function (DUF5601); pfam18151"
                     /db_xref="CDD:465668"
     Region          489..590
                     /region_name="VPS9"
                     /note="Vacuolar sorting protein 9 (VPS9) domain;
                     pfam02204"
                     /db_xref="CDD:460489"
     Region          721..762
                     /region_name="CUE_VPS9_like"
                     /note="CUE domain found in vacuolar protein
                     sorting-associated protein 9 (VPS9) and similar proteins;
                     cd14369"
                     /db_xref="CDD:270552"
     Site            order(721,725,727..729,731..733,736,740,744..745,748..750,
                     754..756)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270552"
     CDS             1..765
                     /locus_tag="CAALFM_C602630CA"
                     /coded_by="XM_714004.2:1..2298"
                     /note="Ortholog(s) have guanyl-nucleotide exchange factor
                     activity, ubiquitin binding activity"
                     /transl_table=12
                     /db_xref="CGD:CAL0000186676"
                     /db_xref="GeneID:3639221"
ORIGIN      
        1 msfknqfnfn iskstpttst nntnttsnsn stsndnpqpt takpppfisn illksnfdss
       61 vstnnssktp pksssprlsa tgvvpavvti dngelignnt sntstdsskt dliglfdkfd
      121 inkddkeqtk peheehhpit ekheddevsh edklekmvsd ddgddeeshk ekevvsekeg
      181 tstkditssp sikqteqkns gttsfaalmt iqpyippeek evhekheesv nddnlidldd
      241 retsksknnn lhddpvqses tnvnqvesst pkgnfldiag sekeqsgvee lslkvgdses
      301 kttsdvpted vstsdanksh khrfqindss eqnkqshkpf dfqtflvqlr kksadpivry
      361 irsflssfir qghtftsdqr ikiisdfkif mnekftlyep fasmdqidle nsreglekli
      421 mnrlhdlcfp pevvkqnlsy ipepytldlq kdesfalqle kfswingnhl didmndlank
      481 ivkndqsfle yaitelnkin nyraprdkii cilnackiif sylklskqet nadsfipili
      541 lvifkaktdh lisnihyien frgqewllhg etsyylssiq gavefiqnit aedltisqae
      601 fdahmeawda qrkqkvqqlk lvqpiptipt tptdgtgetn lkpdmshtpn glspskvlfs
      661 saemftksit nflspsphls esepeefqpp pnspppsqdq ndpsaqyqpl ppreeeinae
      721 qmrkaydtli eifpsldtni lkdvifinrg nidvcidacl qlvdg