NADP-dependent alcohol dehydrogenase [Candida albicans SC5314].

LOCUS       XP_719082                369 aa            linear   PLN 18-APR-2022
ACCESSION   XP_719082
VERSION     XP_719082.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_713989.1
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 369)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 369)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 369)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 369)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 369)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 369)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30181.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..369
                     /product="NADP-dependent alcohol dehydrogenase"
                     /calculated_mol_wt=40123
     Region          11..361
                     /region_name="CAD1"
                     /note="Cinnamyl alcohol dehydrogenases (CAD); cd05283"
                     /db_xref="CDD:176186"
     Site            order(49..51,54,168,172,194..199,217..218,222,237,
                     257..258,260,282..283,308..310)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:176186"
     Site            order(49,51,72,98,168,310)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:176186"
     Site            order(49,72,168)
                     /site_type="other"
                     /note="catalytic Zn binding site [ion binding]"
                     /db_xref="CDD:176186"
     Site            order(103,106,109,117)
                     /site_type="other"
                     /note="structural Zn binding site [ion binding]"
                     /db_xref="CDD:176186"
     Site            order(116,175,179,276,281..283,285,296,298..299,302..309)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:176186"
     CDS             1..369
                     /locus_tag="CAALFM_C602480WA"
                     /coded_by="XM_713989.1:1..1110"
                     /note="Similar to alcohol dehydrogenases; induced by
                     benomyl treatment, nitric oxide; induced in core stress
                     response; oxidative stress-induced via Cap1; Spider
                     biofilm repressed"
                     /transl_table=12
                     /db_xref="CGD:CAL0000187810"
                     /db_xref="GeneID:3639170"
ORIGIN      
        1 mttdsvpakf qgfassnknt wnkpklvsyd rkqinphdvv lenevcglcy sdihtlqsnw
       61 geynrddlvv gheivgkvia vgdkvtefki gqrvgigaas sacrecnrck sdneqycaka
      121 astynapdvr snnyvtqggy sshsiadeqf vfpipddlps ayaaplmcag itvfspllrn
      181 lgsdakgktv giigigglgh lalqlakalg akvvafsrts skkdqalklg adefiatnee
      241 kdwsskyhdt fdfilncasg vdglnlqdyl svlkvdkkfi svglppateq fgvspftflk
      301 hgasfgssll gskvevleml klaakhnvkp wieevplsee ncskalnrch dgdvryrfvf
      361 tefdkafak