glycine hydroxymethyltransferase [Candida albicans SC5314].

LOCUS       XP_718086                470 aa            linear   PLN 18-APR-2022
ACCESSION   XP_718086
VERSION     XP_718086.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_712993.1
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 470)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 470)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 470)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 470)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 470)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 470)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30303.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..470
                     /product="glycine hydroxymethyltransferase"
                     /calculated_mol_wt=51907
     Region          17..467
                     /region_name="PLN03226"
                     /note="serine hydroxymethyltransferase; Provisional"
                     /db_xref="CDD:215639"
     Site            order(22,24,31..32,41,46,64,82..83,91,110,117,157..158,
                     297,315)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:99733"
     Site            order(45,65,75,112..113,140,195,220,223,248..249,255,394)
                     /site_type="other"
                     /note="glycine-pyridoxal phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99733"
     Site            order(45,140,249,394)
                     /site_type="active"
                     /db_xref="CDD:99733"
     Site            order(67,74,135,139,141,289,379)
                     /site_type="other"
                     /note="folate binding site [chemical binding]"
                     /db_xref="CDD:99733"
     CDS             1..470
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /coded_by="XM_712993.1:1..1413"
                     /note="Cytoplasmic serine hydroxymethyltransferase;
                     complements glycine auxotrophy of S. cerevisiae shm1 shm2
                     gly1-1 mutant; antigenic; farnesol-upregulated in biofilm;
                     stationary-phase enriched protein; rat catheter and Spider
                     biofilm repressed"
                     /transl_table=12
                     /db_xref="CGD:CAL0000189123"
                     /db_xref="GeneID:3640306"
ORIGIN      
        1 msayalsqsh rqlteghlkd tdpevdqiik deidrqqhsi vliasenftt tavfdalgtp
       61 mcnkysegyp garyyggneh idrmellcqe ralkafgltp dkwgvnvqtl sgspanlqvy
      121 qaimkpherl mgldlphggh lshgyqtdsr kisavstyfe tmpyrvdlet glidydmlek
      181 tavlyrpkvl vagtsaycrl idykrmreia dkvgaylvvd mahisgliaa gvipspfeya
      241 divtttthks lrgprgamif frrgvrsvnp ktgqeilydl enpinfsvfp ghqggphnht
      301 iaalatalkq antpefkeyq eqvlknakal eseftkkgyk lvsdgtdshm vlvslkdkqi
      361 dgarvetvce kinialnkns ipgdksalvp ggvrigapam ttrglgeedf kkivsyidfa
      421 vnyakevqsq lpkdanklkd fknavsgdse klkavrdeiy qwagsfplav