Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Candida albicans SC5314 glycine hydroxymethyltransferase (SHM2),


LOCUS       XM_712993               1413 bp    mRNA    linear   PLN 18-APR-2022
            partial mRNA.
ACCESSION   XM_712993
VERSION     XM_712993.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (bases 1 to 1413)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (bases 1 to 1413)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NC_032094).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Candida albicans SC5314"
                     /mol_type="mRNA"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     gene            <1..>1413
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /db_xref="GeneID:3640306"
     CDS             1..1413
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /note="Cytoplasmic serine hydroxymethyltransferase;
                     complements glycine auxotrophy of S. cerevisiae shm1 shm2
                     gly1-1 mutant; antigenic; farnesol-upregulated in biofilm;
                     stationary-phase enriched protein; rat catheter and Spider
                     biofilm repressed"
                     /codon_start=1
                     /transl_table=12
                     /product="glycine hydroxymethyltransferase"
                     /protein_id="XP_718086.1"
                     /db_xref="CGD:CAL0000189123"
                     /db_xref="GeneID:3640306"
                     /translation="MSAYALSQSHRQLTEGHLKDTDPEVDQIIKDEIDRQQHSIVLIA
                     SENFTTTAVFDALGTPMCNKYSEGYPGARYYGGNEHIDRMELLCQERALKAFGLTPDK
                     WGVNVQTLSGSPANLQVYQAIMKPHERLMGLDLPHGGHLSHGYQTDSRKISAVSTYFE
                     TMPYRVDLETGLIDYDMLEKTAVLYRPKVLVAGTSAYCRLIDYKRMREIADKVGAYLV
                     VDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSVNPKTGQEI
                     LYDLENPINFSVFPGHQGGPHNHTIAALATALKQANTPEFKEYQEQVLKNAKALESEF
                     TKKGYKLVSDGTDSHMVLVSLKDKQIDGARVETVCEKINIALNKNSIPGDKSALVPGG
                     VRIGAPAMTTRGLGEEDFKKIVSYIDFAVNYAKEVQSQLPKDANKLKDFKNAVSGDSE
                     KLKAVRDEIYQWAGSFPLAV"
     misc_feature    49..1401
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /note="serine hydroxymethyltransferase; Provisional;
                     Region: PLN03226"
                     /db_xref="CDD:215639"
     misc_feature    order(64..66,70..72,91..96,121..123,136..138,190..192,
                     244..249,271..273,328..330,349..351,469..474,889..891,
                     943..945)
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:99733"
     misc_feature    order(133..135,193..195,223..225,334..339,418..420,
                     583..585,658..660,667..669,742..747,763..765,1180..1182)
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /note="glycine-pyridoxal phosphate binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:99733"
     misc_feature    order(133..135,418..420,745..747,1180..1182)
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /note="active site"
                     /db_xref="CDD:99733"
     misc_feature    order(199..201,220..222,403..405,415..417,421..423,
                     865..867,1135..1137)
                     /gene="SHM2"
                     /locus_tag="CAALFM_C603760CA"
                     /note="folate binding site [chemical binding]; other site"
                     /db_xref="CDD:99733"
ORIGIN      
        1 atgtctgctt acgctttatc tcaatctcat agacaattga ctgaaggtca tttaaaagat
       61 actgatcctg aagttgatca aatcattaaa gatgaaattg atagacaaca acattccatt
      121 gttttaattg cttcagaaaa tttcactact actgctgttt tcgatgcctt gggaactcca
      181 atgtgtaata aatattctga aggttatcct ggtgctagat attatggtgg taatgaacat
      241 attgatagaa tggaactttt gtgtcaagaa agagctttaa aagcttttgg tttgactcca
      301 gataaatggg gggttaatgt tcaaactttg agtggatctc cagctaattt acaagtttat
      361 caagccatta tgaaacctca tgaaagatta atggggttgg atttacccca tggtggtcat
      421 ttatctcatg gttatcaaac cgattcaaga aaaatttctg ctgtttccac ttattttgaa
      481 accatgcctt acagagttga tttagaaact ggattgattg attatgatat gttggaaaaa
      541 actgctgttt tgtatagacc aaaagtttta gttgctggta cttctgctta ttgtagatta
      601 attgattaca aaagaatgag agaaattgcc gataaagttg gtgcttacct tgttgttgat
      661 atggctcata tttccggttt aattgctgct ggtgttatcc catcaccatt tgaatacgct
      721 gatattgtca ccaccactac tcataaatca ttaagaggtc caagaggtgc catgattttc
      781 tttagaagag gggtaagatc agttaatcca aagactggtc aagaaatctt gtatgattta
      841 gaaaacccaa ttaacttctc agtgttccca ggtcatcaag gtggtccaca taatcatacc
      901 attgctgcct tggctactgc tttgaaacaa gctaatactc cagaatttaa agaatatcaa
      961 gaacaagttt tgaaaaatgc taaagcttta gaaagtgaat tcaccaaaaa aggttataaa
     1021 ttagtttctg acggtactga ttctcatatg gttttagtgt ctttaaaaga taaacaaatt
     1081 gatggtgcta gagttgaaac tgtttgtgaa aaaatcaata ttgctttgaa taagaattcc
     1141 attcctggag ataaatcagc tttagttcca ggtggagtta gaattggtgc cccagccatg
     1201 actacaagag gtttaggtga agaagatttc aagaaaatcg ttagttatat tgattttgct
     1261 gtcaattatg ctaaggaagt tcaatcacaa ttaccaaaag atgctaataa attgaaagat
     1321 ttcaaaaatg ctgtttctgg tgatctggaa aaacttaaag ctgttagaga tgaaatttat
     1381 caatgggctg gttctttccc attagcagta taa