Sap1p [Candida albicans SC5314].

LOCUS       XP_718053                391 aa            linear   PLN 18-APR-2022
ACCESSION   XP_718053
VERSION     XP_718053.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_712960.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 391)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 391)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 391)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 391)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 391)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 391)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30279.
            
            On Dec 8, 2016 this sequence version replaced XP_718053.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..391
                     /product="Sap1p"
                     /calculated_mol_wt=41471
     Region          62..379
                     /region_name="SAP_like"
                     /note="SAPs, pepsin-like proteinases secreted from
                     pathogens to degrade host proteins; cd05474"
                     /db_xref="CDD:133141"
     Site            order(63,130,133,138,144,179,348,352)
                     /site_type="active"
                     /note="inhibitor binding site [active]"
                     /db_xref="CDD:133141"
     Site            order(82..85,267..270)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133141"
     Site            order(82,267)
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:133141"
     Site            order(131..136,138..142)
                     /site_type="active"
                     /note="Active site flap [active]"
                     /db_xref="CDD:133141"
     CDS             1..391
                     /gene="SAP1"
                     /locus_tag="CAALFM_C603490CA"
                     /coded_by="XM_712960.2:1..1176"
                     /note="Secreted aspartyl proteinase; acts in utilization
                     of protein as nitrogen source; assessment of virulence
                     role complicated by URA3 effects; regulated by growth
                     phase, alpha-pheromone; produced by opaque cells"
                     /transl_table=12
                     /db_xref="CGD:CAL0000189556"
                     /db_xref="GeneID:3640256"
ORIGIN      
        1 mflknifial aiallvdasp akrspgfvtl dfdviktpvn atgqegkvkr qaipvtlnne
       61 hvsyaaditi gsnkqkfnvi vdtgssdlwv pdasvtcdkp rpgqsadfck gkgiytpkss
      121 ttsqnlgtpf yigygdgsss qgtlykdtvg fggasitkqv faditktsip qgilgigykt
      181 neaagdydnv pvtlknqgvi aknayslyln spnaatgqii fggvdkakys gsliavpvts
      241 drelritlns lkavgkning nidvlldsgt titylqqdva qdiidafqae lksdgqghtf
      301 yvtdcqtsgt vdfnfdnnak isvpasefta plsyangqpy pkcqlllgis danilgdnfl
      361 rsaylvydld ddkislaqvk ytsasniaal t