DNA topoisomerase 1 [Candida albicans SC5314].

LOCUS       XP_714305                780 aa            linear   PLN 18-APR-2022
ACCESSION   XP_714305
VERSION     XP_714305.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_709212.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 780)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 780)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 780)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 780)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 780)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 780)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30041.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..780
                     /product="DNA topoisomerase 1"
                     /calculated_mol_wt=90638
     Region          157..373
                     /region_name="Topoisom_I_N"
                     /note="Eukaryotic DNA topoisomerase I, DNA binding
                     fragment; pfam02919"
                     /db_xref="CDD:460746"
     Region          304..752
                     /region_name="TOPEUc"
                     /note="DNA Topoisomerase I (eukaryota); smart00435"
                     /db_xref="CDD:214661"
     CDS             1..780
                     /gene="TOP1"
                     /locus_tag="CAALFM_C600950CA"
                     /coded_by="XM_709212.2:1..2343"
                     /note="DNA topoisomerase I; required for wild-type growth
                     and for wild-type mouse virulence; sensitive to
                     camptothecin; induced upon adherence to polystyrene; rat
                     catheter biofilm induced"
                     /transl_table=12
                     /db_xref="CGD:CAL0000177495"
                     /db_xref="GeneID:3644034"
ORIGIN      
        1 msssdeedia lsrlakksss itsastyedd edddiplakk srkkrvesdy eededevplk
       61 krklsngrak kqvktetkvk kepksanksk stskkdtkvk kekttvkkes katstkvkee
      121 sktqsdsqas vksetpeedq gykwwevnqe eegdgyikwq tlehngvmfp ppyeplpshv
      181 klyynnkpvn lppeaeevag fygamletdh aknpvfqknf fndflevlke cggcgveikk
      241 fekldfskmy ahfeklreek kamsreekkr ikeekekeee pyrtcylngr kelvgnfrie
      301 ppglfrgrga hpktgklkrr vvpeqvtlnl gkdakipepp aghqwgeirh dnevtwlamw
      361 kenisdslky vrfannssvk gqsdfkkfet arklrdhvds irkdytkmlk sekmqdrqma
      421 tamylidvfa lraggekged eadtvgccsl ryehvtlkpp nkvifdflgk dsirfyqeve
      481 vdkqvfknlr ifkkspkqpg ddlfdrinps lvnrqlqnym kgltakvfrt ynasktmqdq
      541 idiienegtv aekvakfnaa nrtvailcnh qrtvskthgd svqrindklk efmwqkirlk
      601 kmilqlepkl kkkdpkyfee iddlikedie hihhtiikrq reqakkkler dneklklegk
      661 plltesdikd kldkidelek eyqkelktgk pivtknatve klkqqietle nkilnvsiql
      721 kdkednsevs lgtskmnyid prlivmfskk fdvpieklft ktlrekfiwa iesadenwrf