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Candida albicans SC5314 DNA topoisomerase 1 (TOP1), partial mRNA.


LOCUS       XM_709212               2343 bp    mRNA    linear   PLN 18-APR-2022
ACCESSION   XM_709212
VERSION     XM_709212.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (bases 1 to 2343)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2343)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (bases 1 to 2343)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NC_032094).
            
            On Dec 8, 2016 this sequence version replaced XM_709212.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Candida albicans SC5314"
                     /mol_type="mRNA"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     gene            <1..>2343
                     /gene="TOP1"
                     /locus_tag="CAALFM_C600950CA"
                     /db_xref="GeneID:3644034"
     CDS             1..2343
                     /gene="TOP1"
                     /locus_tag="CAALFM_C600950CA"
                     /note="DNA topoisomerase I; required for wild-type growth
                     and for wild-type mouse virulence; sensitive to
                     camptothecin; induced upon adherence to polystyrene; rat
                     catheter biofilm induced"
                     /codon_start=1
                     /transl_table=12
                     /product="DNA topoisomerase 1"
                     /protein_id="XP_714305.1"
                     /db_xref="CGD:CAL0000177495"
                     /db_xref="GeneID:3644034"
                     /translation="MSSSDEEDIALSRLAKKSSSITSASTYEDDEDDDIPLAKKSRKK
                     RVESDYEEDEDEVPLKKRKLSNGRAKKQVKTETKVKKEPKSANKSKSTSKKDTKVKKE
                     KTTVKKESKATSTKVKEESKTQSDSQASVKSETPEEDQGYKWWEVNQEEEGDGYIKWQ
                     TLEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQK
                     NFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFEKLREEKKAMSREEKKRIKEEKE
                     KEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVPEQVTLNLGKDA
                     KIPEPPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETAR
                     KLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSL
                     RYEHVTLKPPNKVIFDFLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDLFDRIN
                     PSLVNRQLQNYMKGLTAKVFRTYNASKTMQDQIDIIENEGTVAEKVAKFNAANRTVAI
                     LCNHQRTVSKTHGDSVQRINDKLKEFMWQKIRLKKMILQLEPKLKKKDPKYFEEIDDL
                     IKEDIEHIHHTIIKRQREQAKKKLERDNEKLKLEGKPLLTESDIKDKLDKIDELEKEY
                     QKELKTGKPIVTKNATVEKLKQQIETLENKILNVSIQLKDKEDNSEVSLGTSKMNYID
                     PRLIVMFSKKFDVPIEKLFTKTLREKFIWAIESADENWRF"
     misc_feature    469..1119
                     /gene="TOP1"
                     /locus_tag="CAALFM_C600950CA"
                     /note="Eukaryotic DNA topoisomerase I, DNA binding
                     fragment; Region: Topoisom_I_N; pfam02919"
                     /db_xref="CDD:460746"
     misc_feature    910..2256
                     /gene="TOP1"
                     /locus_tag="CAALFM_C600950CA"
                     /note="DNA Topoisomerase I (eukaryota); Region: TOPEUc;
                     smart00435"
                     /db_xref="CDD:214661"
ORIGIN      
        1 atgagttcat cagacgaaga agacattgcc ttgtctagac tcgctaaaaa atcatcctcg
       61 atcacttcag cttccactta tgaagacgat gaagatgatg atatcccttt agctaaaaaa
      121 tccaggaaaa agagggttga atctgattat gaagaagatg aagacgaagt cccattgaaa
      181 aagagaaaat tgtctaatgg tagagcaaaa aaacaagtta aaaccgaaac taaagttaaa
      241 aaggaaccta aaagtgccaa taaatccaaa tctacatcta aaaaggacac caaagttaag
      301 aaagagaaaa ctacagtcaa gaaggaatct aaagccacaa gcactaaagt gaaagaagaa
      361 tccaaaactc aatcagattc acaagcatcg gttaaatctg aaactcctga agaagatcaa
      421 gggtacaaat ggtgggaagt gaatcaagaa gaggaaggtg atggttatat caaatggcaa
      481 acactagaac ataacggtgt tatgttccca ccaccatatg aaccattacc atctcatgtc
      541 aaattatatt ataacaataa accagttaat ttacctccag aagcagaaga agttgccgga
      601 ttttatggag caatgttaga aactgatcat gctaaaaacc cagttttcca aaagaatttt
      661 ttcaatgatt ttttggaagt tttaaaagaa tgtggtggtt gtggtgttga aattaaaaaa
      721 tttgaaaaat tagattttag taaaatgtat gctcattttg aaaaattacg tgaagagaaa
      781 aaggccatga gtagggaaga aaagaaaaga atcaaagaag aaaaagaaaa agaagaagaa
      841 ccttatagga cttgttatct taatggtaga aaagaattag tggggaattt ccgtattgaa
      901 cctccaggtt tattccgtgg tcgtggtgca catcctaaaa ctgggaaatt aaaacgtcga
      961 gtagtgccgg aacaagtgac tttgaattta ggtaaagatg ctaaaatacc tgaaccacct
     1021 gcaggccatc aatgggggga aattagacat gataatgaag tcacttggtt agccatgtgg
     1081 aaagaaaata tttctgattc attgaaatac gttagatttg ctaataattc ttcagttaaa
     1141 ggtcaatccg atttcaaaaa atttgaaacg gcgagaaaat taagagatca cgttgattct
     1201 attagaaaag attataccaa aatgttaaaa tcagagaaaa tgcaagatag acaaatggcc
     1261 acggctatgt atcttattga tgtttttgca ttgagggctg gtggtgaaaa aggtgaggat
     1321 gaagccgata ccgttggttg ttgttcatta cgatatgaac atgtaacttt aaaaccaccc
     1381 aacaaggtta ttttcgattt tttgggtaaa gattcaatta gattttatca agaagttgaa
     1441 gttgataaac aagttttcaa aaatctacga attttcaaaa aatctcctaa acaacctggt
     1501 gatgatttat ttgatcgtat aaacccttca ttagtcaatc gacaattaca aaattatatg
     1561 aaaggattaa cagcaaaagt tttccgtaca tataatgcct cgaaaaccat gcaagatcaa
     1621 attgatataa ttgaaaatga aggtacagtg gcggaaaaag tggctaaatt caatgctgcc
     1681 aatagaacgg tggctatttt atgtaatcac cagcgtacgg tcagtaaaac ccatggtgat
     1741 agtgttcaga gaattaatga caaattaaaa gaattcatgt ggcaaaagat tagattaaag
     1801 aagatgattt tacaattaga acccaaatta aaaaagaaag atccgaaata ttttgaagaa
     1861 attgatgatt taatcaaaga agatattgaa catattcatc atactataat taaaagacaa
     1921 cgagaacaag ctaaaaaaaa attagaacgt gataatgaaa aattgaaact tgaaggtaaa
     1981 ccattattaa ctgaatcaga tataaaagat aaattagata aaattgatga attagaaaaa
     2041 gaatatcaaa aagaattgaa aactggtaaa ccaatagtca ccaaaaatgc taccgttgaa
     2101 aaattaaaac aacaaattga aactcttgaa aataaaattc ttaatgtttc aattcaatta
     2161 aaagataaag aagataattc tgaagtttct ttaggaactt caaaaatgaa ttatattgat
     2221 ccaagattaa ttgttatgtt ttctaaaaaa tttgatgttc ctattgaaaa attatttacc
     2281 aaaactttaa gagaaaagtt catttgggct attgaatcag ctgatgaaaa ttggagattc
     2341 taa