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serine/threonine/tyrosine protein kinase [Candida albicans SC5314].


LOCUS       XP_712499                406 aa            linear   PLN 18-APR-2022
ACCESSION   XP_712499
VERSION     XP_712499.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_707406.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 406)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 406)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 406)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 406)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30154.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..406
                     /product="serine/threonine/tyrosine protein kinase"
                     /calculated_mol_wt=46397
     Region          27..365
                     /region_name="STKc_GSK3"
                     /note="The catalytic domain of the Serine/Threonine
                     Kinase, Glycogen Synthase Kinase 3; cd14137"
                     /db_xref="CDD:271039"
     Site            order(36..40,44,101,103,114,128,150..153,156,158..159,199,
                     201,203..204,206,218,221,232,234..237,239,277)
                     /site_type="active"
                     /db_xref="CDD:271039"
     Site            order(36..39,44,101,103,128,150..153,156,201,203..204,206,
                     218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271039"
     Site            order(40..41,230..238,246..247,278..282,284..285,289,
                     310..313)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:271039"
     Site            order(114,158,199,201,221,232,234..237,239,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271039"
     Site            order(217..227,229..239)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271039"
     Site            order(246,281..282,284..285,288..289,310..315)
                     /site_type="other"
                     /note="axin binding site [polypeptide binding]"
                     /db_xref="CDD:271039"
     CDS             1..406
                     /locus_tag="CAALFM_C602190CA"
                     /coded_by="XM_707406.2:1..1221"
                     /note="Putative serine/threonine/tyrosine
                     (dual-specificity) kinase; disruptants not obtained by
                     UAU1 method"
                     /transl_table=12
                     /db_xref="CGD:CAL0000199382"
                     /db_xref="GeneID:3645862"
ORIGIN      
        1 mpqssstfin eytlpdvven sssraskmti keykrigega fgtvveamlk yetnsskgnd
       61 gtgshllghf rhhshsdkdn nnttnnnnnn nkdgewlgpf aikrvpaqte yksreleilr
      121 fvshpnivsl rfffdkksss dnkvyqnlvm eclpsnlqse ikyyrqskyt ipyphmkayt
      181 fqlaramlyl hgygishrdi kpsnilvdpn tvrlkicdfg sakklepnqp svsyicsryy
      241 rapelivgcs lyttkidiwg lgcviaemfl gkpifqgqsp esqlkeiakl lgpppntfff
      301 ksnpqyrgnm yttrlfncsi eerfkqifsn spsdaidllm kilvydpdvr asprrvlihp
      361 ffdelkssqf kvyprgsstp ielhlfnfse yelellgslk nefvks