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Nag1p [Candida albicans SC5314].


LOCUS       XP_712431                248 aa            linear   PLN 18-APR-2022
ACCESSION   XP_712431
VERSION     XP_712431.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_707338.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 248)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 248)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 248)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 248)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 248)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 248)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30375.
            
            On Dec 8, 2016 this sequence version replaced XP_712431.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..248
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..248
                     /product="Nag1p"
                     /calculated_mol_wt=27360
     Region          11..244
                     /region_name="GlcN6P_deaminase"
                     /note="Glucosamine-6-phosphate (GlcN6P) deaminase
                     subfamily; GlcN6P deaminase catalyzes the reversible
                     conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and
                     ammonium. The reaction is an aldo-keto isomerization
                     coupled with an amination or deamination. It...; cd01399"
                     /db_xref="CDD:238693"
     Site            order(37..40,67..68,133..134,139,141,168,205)
                     /site_type="active"
                     /db_xref="CDD:238693"
     Site            order(146,148..149,157,213..218,220,228..230)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238693"
     Site            order(147..148,154..157)
                     /site_type="active"
                     /note="allosteric site [active]"
                     /db_xref="CDD:238693"
     Site            order(159,162..172,176..178)
                     /site_type="active"
                     /note="active site lid [active]"
                     /db_xref="CDD:238693"
     Site            order(164,203,207,239,242..244)
                     /site_type="other"
                     /note="hexamer (dimer of trimers) interface [polypeptide
                     binding]"
                     /db_xref="CDD:238693"
     CDS             1..248
                     /gene="NAG1"
                     /locus_tag="CAALFM_C604590CA"
                     /coded_by="XM_707338.2:1..747"
                     /note="Glucosamine-6-phosphate deaminase; required for
                     normal hyphal growth and mouse virulence; converts
                     glucosamine 6-P to fructose 6-P; reversible reaction in
                     vitro; gene and protein is GlcNAc-induced; Spider biofilm
                     induced"
                     /transl_table=12
                     /db_xref="CGD:CAL0000199480"
                     /db_xref="GeneID:3645966"
ORIGIN      
        1 mrqaifsnpn daaeylanyi iakinstprt fvlglptgss pegiyaklie ankqgrvsfk
       61 nvvtfnmdey lglapsdlqs yhyfmydkff nhidipreni hilnglaani deecanyekk
      121 ikqygridlf lgglgpeghl afneagssrn sktrkvelve stikancrff gndeskvpky
      181 alsvgistil dnsdeiaiiv lgknkqfald ktvngkpndp kypssylqdh anvlivcdna
      241 aaglkskl