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putative serine--tRNA ligase [Candida albicans SC5314].


LOCUS       XP_712318                496 aa            linear   PLN 18-APR-2022
ACCESSION   XP_712318
VERSION     XP_712318.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_707225.1
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 496)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 496)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 496)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 496)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 496)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 496)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW29988.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..496
                     /product="putative serine--tRNA ligase"
                     /calculated_mol_wt=55727
     Region          64..169
                     /region_name="Seryl_tRNA_N"
                     /note="Seryl-tRNA synthetase N-terminal domain; pfam02403"
                     /db_xref="CDD:426757"
     Region          205..487
                     /region_name="class_II_aaRS-like_core"
                     /note="Class II tRNA amino-acyl synthetase-like catalytic
                     core domain. Class II amino acyl-tRNA synthetases (aaRS)
                     share a common fold and generally attach an amino acid to
                     the 3' OH of ribose of the appropriate tRNA. PheRS is an
                     exception in that it attaches...; cl00268"
                     /db_xref="CDD:444800"
     Site            256..260
                     /site_type="other"
                     /note="motif 1"
                     /db_xref="CDD:238391"
     Site            order(257..258,260,306..307,330,332,376)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238391"
     Site            order(299,301,331,350,352,354..356,418..419,423,452..453,
                     456..457,460)
                     /site_type="active"
                     /db_xref="CDD:238391"
     Site            330..332
                     /site_type="other"
                     /note="motif 2"
                     /db_xref="CDD:238391"
     Site            order(457,460)
                     /site_type="other"
                     /note="motif 3"
                     /db_xref="CDD:238391"
     CDS             1..496
                     /locus_tag="CAALFM_C600390WA"
                     /coded_by="XM_707225.1:1..1491"
                     /note="Ortholog(s) have serine-tRNA ligase activity, role
                     in invasive growth in response to glucose limitation,
                     mitochondrial seryl-tRNA aminoacylation, pseudohyphal
                     growth and mitochondrion localization"
                     /transl_table=12
                     /db_xref="CGD:CAL0000178091"
                     /db_xref="GeneID:3646086"
ORIGIN      
        1 mlctgnriil vqfstvsark kmtytlhyst nrsnikarls smlntirryi stgknsstll
       61 raqidindil srpkeyessi hrrqlpqeli eninfitsnr plqaqlfsqi ndmkkertil
      121 aerlksnvgd lqqfkerlkq lkselkplek qvktiqekiy akaeslpnli dvtvptdplk
      181 eevvqfincq seedakvsns savhdhkeig vnfnildfsv asrvsgpswy yligdgalle
      241 qaliqyalsk arrrgylmlt ppsivkseiv gacgfkpndq nnekqiyelk gehksltgta
      301 eiplaafhss tvfpsgtqfp ikyvgvsray raeagasgkd tkglyrvhef tkvelfhftt
      361 eekaaqeled lkdmqveivt elglsaklln mpssdlgapa mkkydieawm pgrgswgelt
      421 scsncgdyqs rrlgiryndd qegrlkhvst lngtcmavpr vivalieqnf naekneisip
      481 evlqpfmdgk dkivpn