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bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease


LOCUS       XP_712310               1426 aa            linear   PLN 18-APR-2022
            [Candida albicans SC5314].
ACCESSION   XP_712310
VERSION     XP_712310.2
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_707217.2
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 1426)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 1426)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 1426)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 1426)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 1426)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 1426)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW29981.
            
            On Dec 8, 2016 this sequence version replaced XP_712310.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..1426
                     /product="bifunctional ATP-dependent DNA helicase/ssDNA
                     endodeoxyribonuclease"
                     /calculated_mol_wt=163306
     Region          402..603
                     /region_name="Dna2"
                     /note="DNA replication factor Dna2; pfam08696"
                     /db_xref="CDD:462565"
     Region          <564..711
                     /region_name="Cas4_I-A_I-B_I-C_I-D_II-B"
                     /note="CRISPR/Cas system-associated protein Cas4; cl00641"
                     /db_xref="CDD:469855"
     Region          968..1169
                     /region_name="DEXXQc_DNA2"
                     /note="DEXXQ-box helicase domain of DNA2; cd18041"
                     /db_xref="CDD:350799"
     Site            order(968,971,994..997,1029,1168..1169)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350799"
     Site            order(1018..1020,1080,1082,1133)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350799"
     Region          <1076..1375
                     /region_name="DNA2"
                     /note="Superfamily I DNA and/or RNA helicase [Replication,
                     recombination and repair]; COG1112"
                     /db_xref="CDD:440729"
     CDS             1..1426
                     /gene="DNA2"
                     /locus_tag="CAALFM_C600320CA"
                     /coded_by="XM_707217.2:1..4281"
                     /note="Protein similar to S. cerevisiae Dna2p, which is a
                     DNA replication factor involved in DNA repair; induced
                     under hydroxyurea treatment"
                     /transl_table=12
                     /db_xref="CGD:CAL0000193143"
                     /db_xref="GeneID:3646072"
ORIGIN      
        1 msginedass ttkrfkdsne aikpvkrlkk ttyfpvnnlt npqtnqsniq kspirpidin
       61 sittkvnpvq einrnntdnl tkvqkqseln flqensddsf dgirwkespe ikgshkqmei
      121 knsfgglpss plkninpese nvddrtsdvl nrygsdfenv skrrtplmsk trsditssss
      181 nhkkqtneis qlqraksgdv lkvksisgsi tdsfqntlnn winkfetdpq ddqnpnslpd
      241 tvemnktipk istppnpnts iqsedpfsdd ddliqllhsk tlpecpqsqp vsndntsikp
      301 pmenasddge ssddpftddd selmevlktq tpsvtsaftk sfqrgiqnfe klnienkyee
      361 qdiekvsdli ydrvttqrfr ivniieqyyg pksekqlile vvnssrdksk lvvrgeycel
      421 elekgdvihv iitdsarptl vddmhnlliw npdimlsatt isqqlncsrk tvilsrykfp
      481 gtstipiivg eivhfifqec icterwdmef msqvldqlls qymlaifgig kelkdvrdev
      541 vkhfdyletw fktyykqpls kknlidetse keqimfavee aldieeeigs pifgikgkid
      601 atitakfenk klkgqymipm eiktgkeyiy hhaqaslysl lfkdrydkni dsyllvytke
      661 kvtkkcniri selrslvnlr nrvsnyikdn lklpplvkns ncdrceirsa cmtlnhlten
      721 gtkeesgiee elyeaitrdi fendsyrkyf qhwdeliske edvmgravke lwtipaedqe
      781 fqgkcfsgmt itnsnetesn nflfssthhd ksqdqqfvyt fakaenpsrf nlaksqvtin
      841 dkviisdeeg hfalttgyvk qitkdfvvvs trrkiitsdy klknynkann qvfqsvirst
      901 qqnirtttkk rfridkdrmf yglglarynv lslflpngas qlrklvvdle kptftasswe
      961 ipdaetfnpd qiaalkkvfs addyslivgm pgtgkttvia qlikvlvaqr ksvlltsytn
     1021 savdnillkl kdldieflri gypqrvhkdi kdyipefkds ittyeqyvnt ymrpkvvatt
     1081 clsitdvcfn lrysfdyciv deasqitlpv slgplrfakk fvmvgdhdql qplvthpdkr
     1141 vkqelsrslf sllakehpds vshltyqyrm nsdimnvcnt liynnklkcg seqvaqnslk
     1201 iphpevlnsf igedvspdsq wihkifdekn nvlfldydav paveenvgem vintkealli
     1261 qqivnalvhg gvkedeigvm sfyraqlsvl kknlnnlkdl eiltadqyqg rdkeciiisl
     1321 vrsnerkfag dlmkeyrrln vattraktkl iilgsrftls tneltktfid ylenekwyyp
     1381 lpksahkiyk ipevngpspt rsqksqdspi lnrnpilknv vqditr