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cytochrome-b5 reductase [Candida albicans SC5314].


LOCUS       XP_710845                301 aa            linear   PLN 18-APR-2022
ACCESSION   XP_710845
VERSION     XP_710845.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_705753.1
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 301)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 301)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 301)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 301)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 301)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 301)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30140.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..301
                     /product="cytochrome-b5 reductase"
                     /calculated_mol_wt=33329
     Region          56..301
                     /region_name="cyt_b5_reduct_like"
                     /note="Cytochrome b5 reductase catalyzes the reduction of
                     2 molecules of cytochrome b5 using NADH as an electron
                     donor. Like ferredoxin reductases, these proteins have an
                     N-terminal FAD binding subdomain and a C-terminal NADH
                     binding subdomain, separated by a...; cd06183"
                     /db_xref="CDD:99780"
     Site            order(89,104..107,121..123,125,127..131,169,172..173,301)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99780"
     Site            order(104,106..107)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99780"
     Site            order(123,125,169..170,196..198,227,240,263..267)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99780"
     Site            order(128,131,134,140,148,150)
                     /site_type="other"
                     /note="phosphate binding motif [ion binding]"
                     /db_xref="CDD:99780"
     Site            order(164,168..171,173)
                     /site_type="other"
                     /note="beta-alpha-beta structure motif"
                     /db_xref="CDD:99780"
     CDS             1..301
                     /gene="MCR1"
                     /locus_tag="CAALFM_C602040WA"
                     /coded_by="XM_705753.1:1..906"
                     /note="NADH-cytochrome-b5 reductase; soluble in hyphae;
                     alkaline downregulated; farnesol, ketoconazole or
                     flucytosine induced; protein present in exponential and
                     stationary growth phase yeast; YNB biofilm induced; rat
                     catheter biofilm repressed"
                     /transl_table=12
                     /db_xref="CGD:CAL0000182452"
                     /db_xref="GeneID:3647561"
ORIGIN      
        1 mlthhlskla tpkflvpfag atalsiglal qystsnnyia netgktftds newvdlklsk
       61 sidlthntkh lvfklkdend vsglitascl ltkfvtpkgn nvirpytpvs dvnqsgeidf
      121 vikkydggkm sshifdlkeg etlsfkgpiv kwkwepnqfk sialigggtg itplyqllhq
      181 itsnpkdntk vnliygnltp edillkkeid aiaskhkdqv kvhyfvdkad ekkwegqigf
      241 itkeflqkel ekpgsdfkvf vcgppglyka isgpkvsptd qgeltgalkd lgfekehvfk
      301 f