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LOCUS XP_070075316 4760 aa linear INV 09-DEC-2024 takahashii]. ACCESSION XP_070075316 VERSION XP_070075316.1 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_070219215.1 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..4760 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..4760 /product="low-density lipoprotein receptor-related protein 2" /calculated_mol_wt=528845 Region 150..182 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(155,163,174..175) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(167,170,174,180..181) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 177..181 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region <207..229 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(212,215,219,225..226) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 222..226 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 286..321 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(291,300,311..312) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(304,307,311,317..318) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 314..318 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 326..360 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(331,339,350..351) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(343,346,350,356..357) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 353..357 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 365..406 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(370,384,395..396) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(388,391,395,401..402) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 398..402 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region <441..482 /region_name="vWFA" /note="Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057" /db_xref="CDD:469594" Region <486..628 /region_name="YncE" /note="DNA-binding beta-propeller fold protein YncE [General function prediction only]; COG3391" /db_xref="CDD:442618" Region 567..>710 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 567..604 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 610..648 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 651..687 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 757..799 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 848..>986 /region_name="YvrE" /note="Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; COG3386" /db_xref="CDD:442613" Region 916..958 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 967..1001 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1146..1172 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1146,1154,1165..1166) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1158,1161,1165,1171..1172) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1168..1172 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1180..1215 /region_name="Ldl_recept_a" /note="Low-density lipoprotein receptor domain class A; pfam00057" /db_xref="CDD:395011" Site order(1186,1194,1205..1206) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1198,1201,1205,1211..1212) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1208..1212 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1219..1251 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1225,1233,1244..1245) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1237,1240,1244,1250..1251) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1247..1251 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1260..1295 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1265,1274,1285..1286) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1278,1281,1285,1291..1292) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1288..1292 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1300..1335 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1305,1314,1325..1326) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1318,1321,1325,1331..1332) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1328..1332 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1348..1379 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1349,1358,1369..1370) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1362,1365,1369,1375..1376) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1372..1376 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1383..1415 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1389,1397,1408..1409) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1401,1404,1408,1414..1415) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1411..1415 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1427..1461 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1433,1443,1454..1455) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1447,1450,1454,1460..1461) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1457..1461 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1514..1545 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 1617..1657 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1659..1703 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1682..1721 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 1704..1746 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2004..2046 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 2143..>2171 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 2251..2297 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2318..2358 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 2344..2384 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2570..>2702 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 2584..2613 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 2625..2669 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 2662..2704 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2858..2892 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(2863,2871,2882..2883) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(2875,2878,2882,2888..2889) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 2885..2889 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 2897..2932 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(2902,2910,2921..2922) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(2914,2917,2921,2929..2930) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site order(2924..2925,2928..2930) /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 2941..2974 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(2946,2955,2966..2967) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(2959,2962,2966,2972..2973) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 2969..2973 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3025..3057 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3031,3039,3050..3051) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3043,3046,3050,3056..3057) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3053..3057 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3071..3106 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3074,3088,3099..3100) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3092,3095,3099,3105..3106) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3102..3106 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3119..3150 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3124,3132,3143..3144) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3136,3139,3143,3149..3150) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3146..3150 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3161..3195 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3166,3174,3185..3186) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3178,3181,3185,3191..3192) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3188..3192 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3201..3233 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3207,3215,3226..3227) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3219,3222,3226,3232..3233) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3229..3233 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3250..3278 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 3284..3320 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 3353..3385 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3397..3439 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3459..3502 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 3489..3527 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3527..3569 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3598..3650 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 3654..3687 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3659,3669,3680..3681) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3673,3676,3680,3686..3687) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3683..3687 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3696..3730 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3701,3709,3720..3721) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3713,3716,3720,3726..3727) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3723..3727 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3734..3766 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3739,3748,3759..3760) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3752,3755,3759,3765..3766) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3762..3766 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3775..3808 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3782,3790,3801..3802) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3794,3797,3801,3807..3808) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3804..3808 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3818..3852 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3823,3834,3845..3846) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3838,3841,3845,3851..3852) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3848..3852 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3862..3892 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3866,3874,3885..3886) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3878,3881,3885,3891..3892) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3888..3892 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3904..3938 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3909,3917,3928..3929) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3921,3924,3928,3934..3935) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3931..3935 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3943..3977 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3948,3956,3967..3968) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3960,3963,3967,3973..3974) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3970..3974 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3987..4018 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3992,4000,4011..4012) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(4004,4007,4011,4017..4018) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 4014..4018 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 4034..4062 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(4034,4042,4053..4054) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(4046,4049,4053,4059..4060) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 4056..4060 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 4077..4108 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(4079,4087,4098..4099) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(4091,4094,4098,4104..4105) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 4101..4105 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 4114..4150 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 4154..4185 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain; smart00179" /db_xref="CDD:214542" Site order(4154,4157,4171) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 4267..>4417 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 4282..4327 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 4331..4364 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 4341..4382 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 4365..4408 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 4372..4413 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" CDS 1..4760 /gene="mgl" /coded_by="XM_070219215.1:448..14730" /db_xref="GeneID:108054711" ORIGIN 1 mnptpmgigf gfgrkppnka rmrsrwrppp pattlltpdp aegdnpaadp lqvteasasa 61 sapsspigdh rhpqldssra aeprlqhqqq eaqhyrqhrg qlttlallll alvalsnlet 121 llavrtegpr nrhgspggsl gstggintec ptdsfrcnng kcishhwvcn yqkdcddged 181 emqscpppec etpqlncgqy vfnktycipp hyrcdmiedc edksdeaqct yrkcqhtdvf 241 cnapngaapa egarlagpcv pkekrcdgyl dcrtgkdeeg csgvscrldq frcanghkci 301 daalkcnhrd dcgdnsdeqg cnfppchhaq frcsnalcip ynfhcdgyhd cadksdeanc 361 taiacpdnkh lcprggasgt pkcilksqlc dgkrdcedgs deetncsias cpalscefkc 421 gpsltggvcy ckpgqslapd nrtcvdldec aewghcdqlc tntlgsytcq caqgytlind 481 skciapdann lqlifahdra imqmkphgse pmvlanataa agvtfhyarn tlywsdiktr 541 kvqslpldaq nkavspfdqt lpgtwapval avdwvgdkiy vadlvgqkid vfelsgqwha 601 vvlgsnltsp adlaldptag lmfvadggqv lrahmdgtha rsivseaayk asgvtvdiia 661 krvfwcdsll dyiesvdyeg ghrvmvlrgq qvpspsrlal fenriywtda tkqgimsvdk 721 fegptsiqvt hkskdirepk giiavhalsq prvsnpcgnn nggcnhmciv tavkgaptgl 781 gfrcacstgy qletdlklck pvseflmysq qrfikgkvle pviegfsdai mpvvsrrarf 841 vgldfdarde fiyysdvlqd viyrvhrngt greivlasqn egveglavdw asknlyyids 901 rkgtlnvlst rnvthrrtll knlkrpraiv vhpnrgfiff sewdrpanit rantdgsgll 961 vfknvtlgwp nglsidfked rvywcdalld hvqhanldgt diktvnsrlv rhpfsivihn 1021 dwmyitdwrl daiirlhklt geqeemmvre pqtnrlygvk vyshevqria etqpchrnng 1081 gcqkicfavp igggnattng gtpsfgrlqs rcscpygerl aedqmscipd psaeppvqpc 1141 pnswdftcnn qrcipkswvc dgdddcldns deeqnctkpt cgsnefqcrs grcipqnfrc 1201 dqendcgdns deqecgnvtc gtsqfacang rcipnmwkcd sendcgdssd egdfcaektc 1261 ayfqftcprt ghcipqswvc dgdddcfdkq dekdcppisc lanqfkcadl rqcveesykc 1321 dgipdcndgs devgcppmgp nqcnlekhfr ckstgfcipi awhcdgsndc sdhsdeqdcg 1381 qitcaqnffk cnntncvfka yicdgkddcg dnsdegaeha cvpppfkcph gqwqcpgvse 1441 rcvnitsvcd dtadcpngsd egegcdlaec ehqagqcssf cqktpngalc icppgseige 1501 dgytcidtne cdppglcsqq ctntkgsyfc scqegyilep nkhtckavnh taafliisnr 1561 hsilvadlke qglervpiiv envvatasnm htgtifwsdm klkkisrldr gmepqeiint 1621 gldlveglay dwiaqnlywl dsklntievs aengsnrlvl vrenitqprg mcidpspgar 1681 wifwtdwgen prverigmdg tmrktiintk iywpngltld iatkrvyfad skldfidfcy 1741 yngtgrqqvl asshyllhph slslfedtly wtdrqlnrvl sankfrgknq tvvshlisqp 1801 lsihvhhasl qpmtpnpcas arcqhlclls psasegysck ckpgfkllse grcieeenpf 1861 lmvvkgtqiv dlplnggdar agalapvigi esstgldfdr kgetlywvqg redddencti 1921 yttpygggnk tlflgtesgi vgapytiafd wlgrnlyign rvasnieavr vdgkqkyrti 1981 ilandgyans vsrpkqivld ptdgklfwid egvlevpiki grvdmngqnp ivvfqdfahp 2041 eslavdtekk mlyysasnpa vigsmdynga dhtlivmkds hpmakprslg ildhrlyyld 2101 plyerivrid lphgdnpkti vdnesdlrsm miykkralmq hpcqtnnggc khlcipgsga 2161 trtcscgigy rkeneincva yktfavvsql dmirgyslsd saeamvpvsg pghhilhvdv 2221 myreqwiywa eynrgywngi frsrpngtdl qhvvkdgigs ngirgltidw vagnmyftnv 2281 yphenyvevc wldgsnrkvl vktttdapre lavnpvkrll ywidygqhpr igkalldgsk 2341 wtplvtsgis lprdltidmq thdiywvdsk ldtiqkisfn ganrkvirrd lpnpmgiavy 2401 lndvywvdrn lmtvfkaskh sanetatrvr tnleklrdia iyninnqpqd dtnpcahlgn 2461 ggcdqlcfsf ppeggatgps grnfrcecat gklsaderkc evvneylvfa trteiravnl 2521 dphstevpft pltnltnvvg ldfdfadnrm lytqirpwak iaytkankpg hdditvvlnk 2581 ginpegiayd wtqskiywtd ssnnsiyamn ldgselvmia rverpraivl dpcngtlfft 2641 dwgrfgtsgk ifrttmagsl kraivdkdls qpsglaidyd errlywtdav rekiersdld 2701 gqnrellvaa tiypfaitvf rnyiywtdlq lrgvyraekh tganmvemvk rledsprdir 2761 iysadrqkcn vnpcrinngg caqschpapn gkaeckcddn tkvvnegrmc aprnntceas 2821 kfyckngrci srmwscdgdd dcgdnsdedp nycayhscsp nefrcnngrc ifkswkcdhe 2881 ndckdgsdel gctyppcvdg eftcgngrci pqaqvcngvn dckdnatsde thercpmntt 2941 cpanhlkcek tnicvepywl cdgdndcgdn sdedplhcgq rtcptnsfrc pnhrcipatw 3001 ycdgdddcgd gadeppdyck segrtcfgdl ftcdngncip riyicdgdnd cldnsdednr 3061 hqcndrkcde eteftcvenk swqraqcipk kwicdgdpdc vdgadenttl hncatqqpcg 3121 edmftcgngr cinkgwicdh dndcgdgtde gkfcnskykt csaqeftcqn fkcirnqsrc 3181 dgeddcgdhs devgcakeni tcpqgqfact ngqcidynlv cnkypdcade sdepahcnvd 3241 ecakveinqc ghkcvdtltg yycdcnegyk lladgkacad vdecleqpga csqhcsntpg 3301 gfyckcdety yerqndehtc krkdkippwl iftnkyyvrn msvdghqynl mhqdlmnvva 3361 ldfdireeym yfcdvtakti frakygeadd emppereavi rhdshglegi aidwvgrkly 3421 wldrhsknld vseldgtkrk tlrsgvvdpr aivvhpgigy lyftswhlqa yiakmgmdgs 3481 nfsrilnwnd giawpnalsi dyftdriywa dahldyiaya dlegrhrhtv lsgskvphvf 3541 alslfddyiy wsdwnlkaiv rankfhgany tvlrntthrp ydlhinhplr qlpytnpcgt 3601 nnggcshlcl iapppestyl niegyieega pifkcacpnq fylardmktc vanctagqhl 3661 cggrdekcip wfwkcdgekd ckdgsdepat caarhcragt fqckntnctp saticdgvdd 3721 cgdrsdeqnc dlpcplsdfk ckssgrcild swrcdgdadc kdgsdedpav cfkrtcdpkt 3781 efackngrci pqlwmcdfdn dcgddsdepa ymcrqrnctt gwqrcpgqsn yrcipkwlfc 3841 dgkddcrdns delpencpkc npetdfkcgn nrcipkqwmc dfaddcgdas deneavckgr 3901 yrecsesefr cgngkcissr wqcdheddcg dnsdemhceg yqckngtfqc asghciasyf 3961 rcdgdrdcrd msdevgcppr fpggrycpes rfqcnnnlcv slsdlcdgtd dcgdgsdedp 4021 svcsdfncdt lrrfqcsnhr cvaryqicdg vdncgdgsde nnmtlcaskq kpcdlytqyq 4081 cankhciers qvcdfsddcg dasdelgchh tsscseqnrg gcqhhchnlt dggyictcyp 4141 gyiiagdnkk kcsdvdeclt rqhtcshqch nlngtyscsc regfhltdgs sgvcraeked 4201 vilvfangqe irgldlqkre efdviaeekr iealdydaqq qivfwadsyd ktikrsymvn 4261 aidgrakigf aqdlnmkggs kptavavdwl asnlywtemd rtgskprgrv mvaktdgryr 4321 rsivnaglev ptsiavnpql griywsdags apkievswmd gskrrplite qirhpaglti 4381 dysqdhiiyw vdtklnaies mradgsrrka ivkgdqlrhp vsldlfesnm fwmtrdtgel 4441 vrqdkfgrgv qvvlhrnlvn psglkvyhdk ryntslpnpc dnstcshlcl lvpgghrcac 4501 pdasgpppsh rstaevicna aaehprpapr icpcqngglc kedaqgelvc dclaefrgeh 4561 cetsttgafg hgganvtavv vpimvillvm maaagawyvi rkrpfgklar mpamtssqsv 4621 tfrhgsnvef sesgfpgasa pgagdvapie gynlqtvnan kardfanpmy davqsgttad 4681 pgmgngsgiy dvpgepsakg kamghhaggs ftepasaiia pssithkasp qlqlrtreld 4741 psadtgkdtq flveedksec