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LOCUS XM_070219215 14873 bp mRNA linear INV 09-DEC-2024 receptor-related protein megalin (mgl), transcript variant X2, mRNA. ACCESSION XM_070219215 VERSION XM_070219215.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14873 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14873 /gene="mgl" /note="low-density lipoprotein receptor-related protein megalin; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 20 Proteins" /db_xref="GeneID:108054711" CDS 448..14730 /gene="mgl" /codon_start=1 /product="low-density lipoprotein receptor-related protein 2" /protein_id="XP_070075316.1" /db_xref="GeneID:108054711" /translation="MNPTPMGIGFGFGRKPPNKARMRSRWRPPPPATTLLTPDPAEGD NPAADPLQVTEASASASAPSSPIGDHRHPQLDSSRAAEPRLQHQQQEAQHYRQHRGQL TTLALLLLALVALSNLETLLAVRTEGPRNRHGSPGGSLGSTGGINTECPTDSFRCNNG KCISHHWVCNYQKDCDDGEDEMQSCPPPECETPQLNCGQYVFNKTYCIPPHYRCDMIE DCEDKSDEAQCTYRKCQHTDVFCNAPNGAAPAEGARLAGPCVPKEKRCDGYLDCRTGK DEEGCSGVSCRLDQFRCANGHKCIDAALKCNHRDDCGDNSDEQGCNFPPCHHAQFRCS NALCIPYNFHCDGYHDCADKSDEANCTAIACPDNKHLCPRGGASGTPKCILKSQLCDG KRDCEDGSDEETNCSIASCPALSCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDLDEC AEWGHCDQLCTNTLGSYTCQCAQGYTLINDSKCIAPDANNLQLIFAHDRAIMQMKPHG SEPMVLANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWA PVALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAGLMFV ADGGQVLRAHMDGTHARSIVSEAAYKASGVTVDIIAKRVFWCDSLLDYIESVDYEGGH RVMVLRGQQVPSPSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTHKSKDIREPK GIIAVHALSQPRVSNPCGNNNGGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLKL CKPVSEFLMYSQQRFIKGKVLEPVIEGFSDAIMPVVSRRARFVGLDFDARDEFIYYSD VLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVT HRRTLLKNLKRPRAIVVHPNRGFIFFSEWDRPANITRANTDGSGLLVFKNVTLGWPNG LSIDFKEDRVYWCDALLDHVQHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRL DAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHEVQRIAETQPCHRNNGGCQKICFA VPIGGGNATTNGGTPSFGRLQSRCSCPYGERLAEDQMSCIPDPSAEPPVQPCPNSWDF TCNNQRCIPKSWVCDGDDDCLDNSDEEQNCTKPTCGSNEFQCRSGRCIPQNFRCDQEN DCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTCAY FQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCVEESYKC DGIPDCNDGSDEVGCPPMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQD CGQITCAQNFFKCNNTNCVFKAYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQWQCP GVSERCVNITSVCDDTADCPNGSDEGEGCDLAECEHQAGQCSSFCQKTPNGALCICPP GSEIGEDGYTCIDTNECDPPGLCSQQCTNTKGSYFCSCQEGYILEPNKHTCKAVNHTA AFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKISRLDR GMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQP RGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRV YFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANK FRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCASARCQHLCLLSPSASEGYSCKCK PGFKLLSEGRCIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDR KGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGTESGIVGAPYTIAFDWLGRNLYI GNRVASNIEAVRVDGKQKYRTIILANDGYANSVSRPKQIVLDPTDGKLFWIDEGVLEV PIKIGRVDMNGQNPIVVFQDFAHPESLAVDTEKKMLYYSASNPAVIGSMDYNGADHTL IVMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMI YKKRALMQHPCQTNNGGCKHLCIPGSGATRTCSCGIGYRKENEINCVAYKTFAVVSQL DMIRGYSLSDSAEAMVPVSGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGT DLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTD APRELAVNPVKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDI YWVDSKLDTIQKISFNGANRKVIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSA NETATRVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPEGGATGPS GRNFRCECATGKLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNV VGLDFDFADNRMLYTQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQSKI YWTDSSNNSIYAMNLDGSELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRT TMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATI YPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSADRQKCN VNPCRINNGGCAQSCHPAPNGKAECKCDDNTKVVNEGRMCAPRNNTCEASKFYCKNGR CISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDG SDELGCTYPPCVDGEFTCGNGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPAN HLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYC DGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNR HQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQP CGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRN QSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDEP AHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACS QHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNL MHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLE GIAIDWVGRKLYWLDRHSKNLDVSELDGTKRKTLRSGVVDPRAIVVHPGIGYLYFTSW HLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEG RHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYD LHINHPLRQLPYTNPCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQ FYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAARHCRA GTFQCKNTNCTPSATICDGVDDCGDRSDEQNCDLPCPLSDFKCKSSGRCILDSWRCDG DADCKDGSDEDPAVCFKRTCDPKTEFACKNGRCIPQLWMCDFDNDCGDDSDEPAYMCR QRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKCGNNR CIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCG DNSDEMHCEGYQCKNGTFQCASGHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCP ESRFQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCSNHRCVARYQ ICDGVDNCGDGSDENNMTLCASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGDASD ELGCHHTSSCSEQNRGGCQHHCHNLTDGGYICTCYPGYIIAGDNKKKCSDVDECLTRQ HTCSHQCHNLNGTYSCSCREGFHLTDGSSGVCRAEKEDVILVFANGQEIRGLDLQKRE EFDVIAEEKRIEALDYDAQQQIVFWADSYDKTIKRSYMVNAIDGRAKIGFAQDLNMKG GSKPTAVAVDWLASNLYWTEMDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAV NPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEQIRHPAGLTIDYSQDHIIYWVDTK LNAIESMRADGSRRKAIVKGDQLRHPVSLDLFESNMFWMTRDTGELVRQDKFGRGVQV VLHRNLVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLLVPGGHRCACPDASGPPPSH RSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELVCDCLAEFRGEHCETSTTGA FGHGGANVTAVVVPIMVILLVMMAAAGAWYVIRKRPFGKLARMPAMTSSQSVTFRHGS NVEFSESGFPGASAPGAGDVAPIEGYNLQTVNANKARDFANPMYDAVQSGTTADPGMG NGSGIYDVPGEPSAKGKAMGHHAGGSFTEPASAIIAPSSITHKASPQLQLRTRELDPS ADTGKDTQFLVEEDKSEC" misc_feature 895..993 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(910..912,934..936,967..972) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(946..948,955..957,967..969,985..990) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 976..990 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <1066..1134 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1081..1083,1090..1092,1102..1104,1120..1125) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1111..1125 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1303..1410 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1318..1320,1345..1347,1378..1383) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1357..1359,1366..1368,1378..1380,1396..1401) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1387..1401 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1423..1527 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1438..1440,1462..1464,1495..1500) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1474..1476,1483..1485,1495..1497,1513..1518) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1504..1518 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1540..1665 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1555..1557,1597..1599,1630..1635) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1609..1611,1618..1620,1630..1632,1648..1653) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1639..1653 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <1768..1893 /gene="mgl" /note="Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057" /db_xref="CDD:469594" misc_feature <1903..2331 /gene="mgl" /note="DNA-binding beta-propeller fold protein YncE [General function prediction only]; Region: YncE; COG3391" /db_xref="CDD:442618" misc_feature 2146..>2577 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 2146..2259 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2275..2391 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2398..2508 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2716..2844 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 2989..>3405 /gene="mgl" /note="Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Region: YvrE; COG3386" /db_xref="CDD:442613" misc_feature 3193..3321 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 3346..3450 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 3883..3963 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3883..3885,3907..3909,3940..3945) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3919..3921,3928..3930,3940..3942,3958..3963) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3949..3963 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3985..4092 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: Ldl_recept_a; pfam00057" /db_xref="CDD:395011" misc_feature order(4003..4005,4027..4029,4060..4065) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4039..4041,4048..4050,4060..4062,4078..4083) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4069..4083 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4102..4200 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4120..4122,4144..4146,4177..4182) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4156..4158,4165..4167,4177..4179,4195..4200) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4186..4200 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4225..4332 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4240..4242,4267..4269,4300..4305) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4279..4281,4288..4290,4300..4302,4318..4323) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4309..4323 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4345..4452 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4360..4362,4387..4389,4420..4425) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4399..4401,4408..4410,4420..4422,4438..4443) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4429..4443 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4489..4584 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4492..4494,4519..4521,4552..4557) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4531..4533,4540..4542,4552..4554,4570..4575) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4561..4575 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4594..4692 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4612..4614,4636..4638,4669..4674) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4648..4650,4657..4659,4669..4671,4687..4692) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4678..4692 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4726..4830 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4744..4746,4774..4776,4807..4812) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4786..4788,4795..4797,4807..4809,4825..4830) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4816..4830 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4987..5082 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 5296..5418 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 5422..5556 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 5491..5610 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 5557..5685 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 6457..6585 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 6874..>6960 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 7198..7338 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 7399..7521 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 7477..7599 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 8155..>8553 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 8197..8286 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8320..8454 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8431..8559 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 9019..9123 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9034..9036,9058..9060,9091..9096) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9070..9072,9079..9081,9091..9093,9109..9114) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9100..9114 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9136..9243 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9151..9153,9175..9177,9208..9213) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9187..9189,9196..9198,9208..9210,9232..9237) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature order(9217..9222,9229..9237) /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9268..9369 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9283..9285,9310..9312,9343..9348) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9322..9324,9331..9333,9343..9345,9361..9366) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9352..9366 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9520..9618 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(9538..9540,9562..9564,9595..9600) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9574..9576,9583..9585,9595..9597,9613..9618) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9604..9618 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9658..9765 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(9667..9669,9709..9711,9742..9747) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9721..9723,9730..9732,9742..9744,9760..9765) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9751..9765 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9802..9897 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9817..9819,9841..9843,9874..9879) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9853..9855,9862..9864,9874..9876,9892..9897) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9883..9897 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9928..10032 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9943..9945,9967..9969,10000..10005) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9979..9981,9988..9990,10000..10002,10018..10023) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10009..10023 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10048..10146 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(10066..10068,10090..10092,10123..10128) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10102..10104,10111..10113,10123..10125,10141..10146) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10132..10146 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10195..10281 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 10297..10407 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 10504..10602 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 10636..10764 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 10822..10953 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 10912..11028 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11026..11154 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11239..11397 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 11407..11508 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(11422..11424,11452..11454,11485..11490) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11464..11466,11473..11475,11485..11487,11503..11508) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11494..11508 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11533..11637 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(11548..11550,11572..11574,11605..11610) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11584..11586,11593..11595,11605..11607,11623..11628) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11614..11628 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11647..11745 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11662..11664,11689..11691,11722..11727) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11701..11703,11710..11712,11722..11724,11740..11745) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11731..11745 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11770..11871 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11791..11793,11815..11817,11848..11853) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11827..11829,11836..11838,11848..11850,11866..11871) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11857..11871 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11899..12003 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11914..11916,11947..11949,11980..11985) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11959..11961,11968..11970,11980..11982,11998..12003) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11989..12003 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12031..12123 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12043..12045,12067..12069,12100..12105) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12079..12081,12088..12090,12100..12102,12118..12123) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12109..12123 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12157..12261 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12172..12174,12196..12198,12229..12234) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12208..12210,12217..12219,12229..12231,12247..12252) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12238..12252 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12274..12378 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12289..12291,12313..12315,12346..12351) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12325..12327,12334..12336,12346..12348,12364..12369) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12355..12369 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12406..12501 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12421..12423,12445..12447,12478..12483) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12457..12459,12466..12468,12478..12480,12496..12501) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12487..12501 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12547..12633 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12547..12549,12571..12573,12604..12609) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12583..12585,12592..12594,12604..12606,12622..12627) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12613..12627 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12676..12771 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12682..12684,12706..12708,12739..12744) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12718..12720,12727..12729,12739..12741,12757..12762) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12748..12762 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12787..12897 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 12907..13002 /gene="mgl" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(12907..12909,12916..12918,12958..12960) /gene="mgl" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 13246..>13698 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 13291..13428 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 13438..13539 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 13468..13593 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 13540..13671 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 13561..13686 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" ORIGIN 1 cagtcgctcg cggagcgtcg tcgtgaacgg tcagccagcg cggctaataa ctaactaact 61 ttggtgacag tgcgccatac tgactctgat ccgaacccga atcgaggccc acagcagcca 121 gaacatatta ccaacaatat atcagagcgg aaagtaaacg gagctactct gaacgaaaga 181 aagaccttct ctaagataaa tcctgttgag tgtttcgagt tttttttcga cagcccacca 241 aacaaaaacc aaacaaaaat atttcgaaaa agaatagaga aatcaagcca gaagagaggg 301 aattctcaaa ggcagaagac agaagaccgg tgggcagaga agaggtcacc agaaggtcac 361 cgaaacccca aaaaagaatc caaacctaaa cccacggata agaagcaaag gagcgaagga 421 gccagcgaag cgaccaacga accaaaaatg aatccgacgc ccatgggcat tggattcgga 481 tttggtcgca agccgcccaa caaggccaga atgcgttccc gctggcgacc accgccgccg 541 gcgacaaccc tgctgacccc tgaccccgcc gagggcgaca acccggcagc cgatccgctg 601 caggtcacag aggcctccgc ctcagcttcg gcgccatcct cgcccatcgg cgaccaccgc 661 catccgcagc tggacagcag cagagctgcc gagccgaggc tgcagcacca gcaacaggaa 721 gcacagcact accgccagca ccgcggccag ttgacaaccc tggcgctgct gctactggcc 781 ctcgtagccc tcagcaacct ggaaaccctg ctcgccgtgc gcaccgaagg accgcgcaac 841 cgccatggat caccaggtgg cagcttgggc agcacaggcg gcatcaatac cgagtgtccg 901 acggactcct tccgctgcaa caacggcaag tgcatctcgc accactgggt ctgcaattac 961 caaaaggact gcgacgatgg cgaggacgag atgcagtcgt gccccccacc ggaatgcgaa 1021 actccccagc tgaactgcgg gcagtatgtg ttcaacaaga cctattgcat ccctccgcac 1081 tatcgttgcg atatgatcga ggattgcgag gacaaatcgg acgaggccca gtgcacttac 1141 cgcaagtgcc agcacacgga cgtcttctgc aacgccccca atggagccgc ccccgcggag 1201 ggcgcccgcc tggccggacc ctgtgtgccg aaggagaaac gctgcgacgg ctacctggac 1261 tgccgcaccg ggaaggacga ggagggctgc agcggcgtct cctgtcgcct cgaccagttc 1321 cgctgcgcca atggacacaa gtgcatcgat gccgctctga agtgcaacca ccgcgacgac 1381 tgtggcgata attccgacga acagggatgc aacttcccgc cctgccacca cgcccagttc 1441 cggtgctcga acgccctatg cattccgtac aacttccact gcgatggcta ccacgactgc 1501 gccgacaaga gcgacgaggc caactgcacg gccatcgcct gtccggacaa caagcacctc 1561 tgtccacgag gaggcgccag cggaacaccc aagtgcatcc tgaagtccca actgtgcgac 1621 ggcaagcggg actgcgagga tggtagcgac gaggagacca actgttcgat tgcctcttgc 1681 ccagctctga gttgtgagtt caagtgcgga ccctcgctga ccggaggcgt gtgctactgc 1741 aaacctggtc aatcgctggc cccggacaac cgaacttgtg tggacctcga cgagtgcgcc 1801 gagtggggtc actgcgacca gctgtgcacg aacaccctgg gctcgtacac ctgccagtgt 1861 gcccagggct acacgctgat caacgactcc aagtgcattg ccccggatgc gaataacctg 1921 cagctgatct tcgcccacga tcgtgccata atgcaaatga agccgcatgg cagtgaacct 1981 atggtactgg ccaatgccac cgctgcggcc ggagtgacct tccattatgc gaggaatacg 2041 ctctactggt cggacatcaa gacaaggaag gttcaatctc tgcctctgga tgcacagaac 2101 aaggctgtct cgccattcga tcaaacgcta cccggaacct gggctcccgt agctctggcc 2161 gtcgattggg tgggcgataa gatatatgtg gccgatttgg tgggtcagaa gatcgatgtc 2221 ttcgagctga gtggtcaatg gcatgccgtg gtcctaggtt caaacctcac ctcgcccgcc 2281 gacctcgctt tggatcccac ggctggtctg atgttcgtgg cggatggtgg tcaagtgctc 2341 cgtgcccaca tggatggaac ccatgcccgt tcgattgtct cggaggctgc ctacaaggcg 2401 agcggcgtga cggtggacat cattgccaag cgcgtcttct ggtgcgactc cctgctggat 2461 tatattgagt cggtagacta tgagggtggt catagggtta tggtccttcg aggacagcaa 2521 gtgcctagtc cctcgcgact cgctctgttc gaaaaccgca tctactggac ggatgccacc 2581 aagcagggca tcatgtcggt ggacaagttc gagggtccca cctccattca ggtgacccac 2641 aagtccaagg acattcggga gcccaaaggc atcattgcgg tgcatgcact gagtcaaccg 2701 agggtctcga atccatgtgg caataacaat ggtggctgca atcatatgtg catcgtcacc 2761 gcggtcaagg gagctcccac gggattgggt ttccgttgcg cctgctcgac gggctatcaa 2821 ctggagacgg acttgaagct ttgcaaaccg gttagcgagt tcctcatgta ctcgcaacag 2881 cgatttatca agggcaaagt attagagccc gtgatcgagg gcttcagcga tgccattatg 2941 ccagtggttt cccgccgagc tcgtttcgtt ggcctggatt tcgatgcccg cgatgagttc 3001 atctactact cggacgttct gcaggatgtg atctataggg tgcatcgaaa tggaacaggt 3061 cgcgagattg ttttggcctc ccaaaatgag ggcgtcgagg gactggctgt cgattgggcc 3121 tctaagaatc tctactacat cgattcacgc aagggcacct tgaatgtctt gtccacgagg 3181 aatgtcactc atcgcaggac tctgctgaag aatttgaaac gtccaagggc cattgtggtc 3241 caccctaatc gcggcttcat cttcttctcc gaatgggatc gaccggcgaa tatcacgcgg 3301 gcaaacaccg atggcagtgg tctgttggtc ttcaagaacg tcactttggg atggcccaat 3361 ggtctgtcta ttgacttcaa ggaggatagg gtttactggt gcgatgcctt gctagaccat 3421 gttcaacatg ccaatttgga tggcacggac atcaagacag tgaactcgcg actggtgcga 3481 catcccttct cgattgtcat ccacaacgat tggatgtata ttacggactg gcgattggat 3541 gccattatca ggctgcacaa gctgacgggc gagcaggagg agatgatggt gagggagccg 3601 cagaccaaca ggctgtatgg ggttaaggtg tacagtcacg aggttcagag gatcgcggag 3661 acgcaaccct gtcaccggaa caacggggga tgccagaaga tctgctttgc ggttccgatt 3721 ggaggaggga atgctacaac gaatggaggt acaccctcct ttggtcgcct gcagtcgcgg 3781 tgctcgtgtc cctatggcga gcggctggcc gaggatcaga tgagctgcat ccccgatccg 3841 agtgccgagc cgccggtgca gccgtgcccg aactcctggg acttcacgtg caacaaccag 3901 cggtgcattc ccaagtcgtg ggtctgcgat ggcgacgacg actgcctgga caacagcgat 3961 gaggagcaga actgcacgaa acccacctgc ggatcgaacg agttccagtg ccgatcgggc 4021 cgctgcattc cgcagaactt ccgctgcgac caggagaacg actgtggcga caactcggac 4081 gagcaggaat gcggcaacgt gacctgcggc acctcgcagt tcgcctgcgc caatgggcga 4141 tgcattccga atatgtggaa gtgcgacagc gagaacgatt gtggggatag cagcgatgag 4201 ggtgactttt gtgccgagaa gacctgcgcc tacttccagt tcacgtgtcc gcggacgggt 4261 cactgcatac cgcagagttg ggtgtgcgac ggcgacgacg attgcttcga caagcaggac 4321 gagaaggact gtccgccgat ctcctgtctg gccaatcagt tcaagtgcgc cgatctgcgg 4381 cagtgcgtcg aggagtcgta caaatgcgat ggcataccgg actgcaacga tggctccgac 4441 gaggtgggct gcccgcccat gggcccgaat cagtgtaatc tcgagaagca cttccgctgc 4501 aagtctactg gcttctgtat acccatcgcc tggcattgtg atggctcgaa tgattgctcg 4561 gatcattcgg atgagcagga ctgcggtcag atcacctgtg cccagaactt cttcaagtgc 4621 aacaacacga actgtgtgtt caaggcctac atttgcgacg gcaaggacga ttgtggtgat 4681 aactcggatg agggtgccga gcatgcctgt gttccgccgc ccttcaagtg tccccacggt 4741 cagtggcaat gtcccggggt ctcggagaga tgcgtgaaca taacctccgt ttgcgatgac 4801 accgccgatt gtcccaatgg ttccgatgag ggtgaaggtt gcgacctcgc cgagtgcgaa 4861 catcaggcgg gtcagtgctc cagtttctgt cagaagaccc cgaatggagc tctgtgcatc 4921 tgtccacctg gttcggagat cggagaagat ggctatacct gtatagacac taatgaatgc 4981 gatcccccgg gtctctgttc tcaacagtgt acgaacacca agggctcgta cttctgttcc 5041 tgccaagagg gttacatttt ggagcccaat aagcacacct gcaaggcagt caatcacacc 5101 gccgccttcc tgatcatctc caataggcat tctatcctag tggccgatct caaggaacag 5161 ggactggaaa gggtgcccat tatagtggag aatgtggtgg ccaccgcttc gaacatgcac 5221 acgggcacca ttttctggag cgacatgaag ctgaagaaga tctcgcgatt ggatagggga 5281 atggaaccgc aggagattat caacacggga ttggatctgg tggagggact ggcctacgat 5341 tggatagccc agaatctcta ctggctggac agcaagctga acacgatcga ggtgtcggcg 5401 gagaatggtt cgaatcgatt ggttcttgtt agagagaaca tcactcagcc cagaggcatg 5461 tgcatcgatc cgagtcccgg ggcaagatgg atcttctgga cggactgggg tgagaatccg 5521 cgggtggagc ggatcggcat ggatggaacg atgaggaaga cgatcatcaa tacgaagatc 5581 tattggccca atggtttgac cctggacata gccaccaagc gggtttactt tgcggattcc 5641 aagctggact ttatagactt ttgctactac aatggaaccg ggagacagca ggttttggcc 5701 agcagtcact acctcctgca tccgcactcg ctgtccctct tcgaggatac cctgtactgg 5761 acggacaggc aattgaatcg ggttctctcg gcgaataagt ttaggggcaa gaatcagacg 5821 gtggtttcgc acctgattag ccaaccgctg tccatccacg tgcatcatgc ctccctgcag 5881 ccgatgaccc cgaatccctg tgcctcagca cgctgccagc atctgtgtct gctgagtccc 5941 agcgcctcgg agggctactc gtgcaagtgc aagccgggct tcaagctgct cagcgagggt 6001 cgctgcatcg aggaggagaa tcccttcctg atggtcgtca agggcacgca gatagtggat 6061 cttccgctga atggtggcga tgcgagggca ggagccttgg ctccggtgat tggaatcgag 6121 agcagcactg gcctggactt tgatcgcaag ggagagaccc tctattgggt gcagggcagg 6181 gaggatgatg acgagaattg cactatctat acgacaccat acggaggtgg caacaagacc 6241 ctcttcctgg gcaccgaaag cggcattgtc ggagcaccct acaccattgc cttcgattgg 6301 ttgggtcgga atctctacat tggcaaccgg gtggccagta atatcgaggc agtgcgagtg 6361 gatggaaagc aaaagtaccg gacaatcatc ctagccaacg atggttatgc caactcggtg 6421 tcgcgaccca agcaaatagt gctcgatccc accgacggca agctcttctg gatcgacgag 6481 ggcgtgctgg aggtgcccat caagatcggc agggtggaca tgaatgggca gaaccccatt 6541 gtggtcttcc aggactttgc ccatcccgaa tcgctggccg tggacacgga gaagaagatg 6601 ctctactaca gtgccagcaa tccggcggtg attggttcga tggattataa cggagctgat 6661 cacacgctga ttgtgatgaa ggactcgcat ccgatggcca agccgaggag tctgggcatc 6721 ctggatcacc gactatacta tttggatccc ttgtacgagc ggattgtgcg aatcgatctg 6781 ccgcatggcg ataatcccaa gacaattgtg gataatgaat cggatttgag atcgatgatg 6841 atctacaaga agcgcgcttt gatgcagcat ccctgccaga cgaacaacgg cggctgcaag 6901 catctctgca ttccgggatc gggagctacg aggacctgct cctgcggcat tggttatcgc 6961 aaggagaacg agatcaattg cgtggcctac aagaccttcg cggtcgtctc ccagctggac 7021 atgatcaggg gatatagctt aagtgacagt gcagaggcca tggttccggt gagcggacct 7081 ggtcatcaca tcctccacgt ggacgtcatg tatcgggagc aatggatcta ctgggcggaa 7141 tacaatcggg gctactggaa tggcatcttc aggtcgcgac ccaatggcac cgatctgcag 7201 catgtggtca aggatgggat cggaagcaat ggcatccggg gactgaccat cgattgggtg 7261 gccggtaata tgtactttac caatgtctat ccgcatgaga attacgtgga ggtctgctgg 7321 ctggacggta gcaataggaa ggtgttggtc aagaccacca cggatgcacc gcgtgaactc 7381 gcggtgaatc ccgtgaagag gctgctctac tggatcgact atggtcagca tccgaggatt 7441 gggaaagctc tgctggacgg aagcaagtgg acgcctttgg tgacgtcggg gatctcgttg 7501 ccacgcgatc taaccatcga tatgcagacg catgacatct actgggtgga ctcgaaactg 7561 gacaccatcc agaagatctc ctttaatggg gccaatcgca aggtcattcg gagggatctg 7621 cccaatccca tgggcatcgc tgtctatctg aacgacgtgt actgggtgga caggaacctg 7681 atgaccgtgt tcaaggcctc caagcacagt gctaatgaga cggccaccag ggtgaggacg 7741 aatctggaga agctgaggga cattgcgatc tacaatatca acaatcagcc gcaggacgat 7801 accaatcctt gtgcccactt gggcaacggc ggctgcgatc agttgtgctt cagtttccca 7861 cccgaagggg gagccaccgg tccatcgggc aggaatttcc gttgcgagtg tgcgacgggt 7921 aagctgagtg ccgacgagcg aaagtgcgag gtggtcaacg agtatctggt ctttgccaca 7981 cgaaccgaaa ttcgagccgt taacctcgat ccccattcca cggaggtgcc ttttaccccg 8041 ctgactaatc tcacgaatgt cgtgggtctg gactttgatt tcgcggacaa tcgaatgttg 8101 tatacgcaga ttcgcccatg ggccaagatc gcctatacga aggcgaataa gccgggacac 8161 gatgacatca cggtggtgct gaacaagggc atcaatcccg agggcattgc gtacgattgg 8221 acgcagtcga agatctattg gacggacagc tcgaacaact cgatctatgc gatgaatctg 8281 gatggcagtg aactggtgat gattgcccgg gtggagcgtc cccgagcgat tgtcctggat 8341 ccctgcaatg gaacgctgtt cttcacggat tggggaagat tcggaacctc tggcaagata 8401 ttccgcacga cgatggcggg atctctgaag agagcgatcg tggataagga cctgtcgcag 8461 cccagtggcc tggccatcga ttacgatgag aggaggttgt attggacgga tgcggtgagg 8521 gagaagatcg agcgatccga tttggatggt cagaacaggg agctcctggt ggccgccacc 8581 atatatccct tcgcgatcac cgtgttccgt aactacatct actggacgga tctccagctg 8641 cgcggtgtct accgggcgga gaagcacacg ggtgcgaata tggtggagat ggtgaagcga 8701 ctggaggatt cgccgcgaga cattcgcatc tacagtgcgg atcggcagaa gtgcaatgtg 8761 aatccgtgca ggatcaacaa tgggggatgt gcccagagtt gtcacccggc gccgaatggc 8821 aaggccgagt gcaaatgcga tgataatacg aaggtggtga acgagggaag gatgtgtgca 8881 ccgaggaata atacgtgcga ggccagcaag ttctactgca agaatggcag gtgcatttcg 8941 aggatgtggt cctgcgatgg cgacgacgac tgtggggata attccgatga ggatcccaac 9001 tactgtgcct atcactcctg ctcgccgaat gagttccgtt gcaacaatgg tcggtgtatt 9061 ttcaagtctt ggaagtgcga tcacgagaac gattgcaagg atggctccga tgagctgggc 9121 tgcacctatc cgccctgcgt cgatggtgag ttcacctgcg gcaatggcag gtgtattccc 9181 caggcccagg tgtgcaatgg ggtgaacgat tgcaaggaca atgccacctc ggacgagacg 9241 cacgagaggt gtcccatgaa caccacctgt ccggcgaatc atctcaagtg cgagaagacg 9301 aatatctgtg tggagcccta ttggctgtgc gatggcgaca acgattgcgg cgacaactcc 9361 gacgaggatc ccctgcattg tggtcagaga acttgtccca cgaacagctt ccgctgcccc 9421 aaccaccgat gcattccggc cacctggtac tgcgatggcg acgatgattg cggcgatggc 9481 gccgacgagc caccagatta ctgcaagtcc gaaggacgca cttgcttcgg ggatctcttc 9541 acctgcgaca atggcaactg catacccaga atctacattt gcgacggtga caacgattgc 9601 ctggacaaca gtgacgagga caaccggcat cagtgcaatg accgaaagtg tgatgaggaa 9661 acggaattca cctgcgtgga gaacaagtcc tggcagcgag cccagtgcat ccccaaaaaa 9721 tggatctgcg acggagatcc ggattgtgta gatggagccg acgagaacac caccctgcac 9781 aactgtgcta cgcagcaacc ctgtggcgag gacatgttca cctgcggcaa cggacgctgc 9841 atcaataagg gatggatctg cgaccatgac aacgattgcg gcgacggcac cgacgagggc 9901 aagttctgca actccaagta caagacctgc tcggcccagg agttcacctg ccagaacttc 9961 aagtgcatcc gcaaccagtc gaggtgcgat ggcgaggacg actgcggcga tcactcggac 10021 gaggtgggct gcgccaagga gaacatcacc tgtccgcagg gacagttcgc ctgtacgaat 10081 ggccagtgca tcgactacaa tctggtgtgc aacaagtatc ccgactgtgc cgacgagtcc 10141 gatgagccgg cccactgcaa cgtggacgag tgcgccaagg tggagatcaa tcagtgcggc 10201 cacaagtgcg tggacacgct gacgggctac tactgtgact gcaatgaggg ctacaaactt 10261 ctggccgacg gcaaggcatg tgcggatgtg gacgagtgcc tggagcagcc gggcgcctgt 10321 tcccagcact gttcgaacac cccgggtgga ttctactgca agtgcgatga gacctactac 10381 gagcggcaga acgatgagca cacgtgcaag cgaaaggaca agataccacc ctggctgatc 10441 ttcaccaaca agtactatgt gcgaaatatg tcggtggatg gacatcagta caatttgatg 10501 caccaggatc tgatgaatgt ggtggccctg gactttgaca ttcgcgagga gtacatgtac 10561 ttctgcgacg tgacggccaa gacgatattc cgggccaagt atggggaggc agatgacgag 10621 atgccgccgg agcgggaggc tgtgatcagg cacgattccc atggactgga gggcatcgcc 10681 atcgattggg tgggtcgcaa gctctactgg ttggacaggc actccaagaa cctggatgtt 10741 tccgaactgg atggaaccaa acgcaagacc ctgaggagtg gtgtcgttga tccgcgtgcc 10801 attgtcgtgc atcctggcat cggttatctg tacttcacct cctggcatct gcaagcctac 10861 attgccaaaa tgggcatgga tggttcgaac ttctcgagga tcctgaactg gaacgacggt 10921 atcgcctggc cgaatgccct gtccattgac tacttcacgg atcgtattta ctgggcggac 10981 gcccacttgg actacatagc ctatgctgat ttggagggca ggcatcggca tacggtgctc 11041 tctggcagca aggtgcctca tgtgtttgca ctgagtctct tcgacgacta catctactgg 11101 agtgactgga atctgaaggc cattgtgcgg gccaacaagt tccatggtgc caactacacg 11161 gtgctgagga ataccaccca tcgtccctac gacctgcaca tcaatcatcc gctgaggcaa 11221 ctgccctaca ccaatccctg tggcaccaac aacggcggtt gctcgcatct ctgcctgata 11281 gctccaccgc cggagtccac gtacctgaat atcgagggct atatcgagga gggagctccg 11341 atcttcaagt gcgcctgtcc caatcagttc tacttggccc gggacatgaa gacttgcgtg 11401 gccaattgca cggccgggca gcatttgtgc ggcggtcggg atgagaagtg cataccgtgg 11461 ttctggaagt gcgacgggga gaaggactgc aaggatggca gcgatgagcc agccacctgt 11521 gccgcgcgac actgccgggc cggaacgttc cagtgcaaga ataccaactg cacaccctcg 11581 gcgaccattt gcgatggcgt ggacgactgc ggtgatcgta gcgacgaaca gaattgcgat 11641 ctaccctgcc cgctgtccga tttcaagtgc aaatccagtg gtaggtgcat cctggacagc 11701 tggcgctgcg atggcgatgc cgactgcaag gatggcagcg acgaggaccc cgccgtgtgc 11761 ttcaagcgca cctgcgatcc caagacggag tttgcctgca agaatggccg ctgcattccg 11821 caactgtgga tgtgcgattt cgacaacgat tgcggcgatg attccgatga gccggcgtac 11881 atgtgccgcc agcgcaactg caccaccggc tggcagagat gccctggtca gtcgaactac 11941 cgctgcattc ccaagtggct gttctgcgac ggcaaggacg attgtcggga caacagcgac 12001 gagctgccag agaactgccc caagtgtaat cccgagacgg acttcaagtg cggcaacaac 12061 cgatgcatac ccaagcaatg gatgtgtgac tttgcggacg attgtggcga tgctagcgat 12121 gagaacgagg ctgtctgcaa gggtcgctat cgggagtgct ccgaatcgga gttccgctgc 12181 ggcaacggca agtgcatctc ctcccggtgg cagtgcgatc atgaggacga ctgcggcgac 12241 aactcggacg agatgcactg cgagggctat cagtgcaaaa acggcacctt ccagtgcgct 12301 tccggtcatt gcatagcctc ctacttccgt tgcgacggcg atcgcgattg ccgcgacatg 12361 tccgacgagg tgggctgtcc gccgcgcttc ccgggcggtc gctactgtcc cgagtcgcgt 12421 ttccagtgca acaacaacct gtgcgtctcg ctgtcggacc tctgtgacgg cacagatgat 12481 tgcggtgatg gcagcgacga ggatcccagc gtttgcagtg acttcaattg cgataccctg 12541 cggcgattcc agtgctccaa tcatcgatgc gtggctcgct atcaaatctg cgatggtgtg 12601 gacaactgcg gcgatggcag tgatgagaac aacatgaccc tgtgtgccag caaacagaag 12661 ccctgcgatc tgtacaccca gtaccagtgc gccaacaagc actgcatcga acgctcgcag 12721 gtgtgcgact tctccgacga ttgtggcgat gccagcgatg agttgggctg ccaccacacg 12781 agcagctgct ccgaacagaa tcgcggtggg tgtcagcatc actgccacaa tctcaccgac 12841 ggtgggtaca tatgcacctg ctatcccggc tacatcatag ccggcgacaa caagaagaag 12901 tgctccgacg tggacgagtg cctcacgcga cagcacacgt gttcgcatca gtgtcacaat 12961 ctcaatggca cctactcgtg cagttgccgc gagggtttcc atctgaccga cggctcgagt 13021 ggcgtttgtc gtgccgaaaa ggaggatgtc attttggtat ttgccaacgg tcaggagatc 13081 cgaggtttgg acctccagaa acgcgaggaa ttcgatgtga ttgcggagga gaagcggatc 13141 gaggcactgg actacgatgc ccagcagcag atcgtctttt gggcggatag ctatgacaag 13201 acgatcaagc gttcgtacat ggtgaatgcc atcgatggca gggccaagat tggctttgcc 13261 caggatctga acatgaaggg aggatcgaaa cccaccgccg tggccgtcga ttggctggcc 13321 tcgaatctct actggacgga aatggacagg acgggctcga agccgcgtgg tcgagtgatg 13381 gtggccaaga cggatggaag gtatcgcagg tcgattgtga atgccggtct ggaggtgccc 13441 acttcgatag cggttaatcc acagctgggc aggatctact ggtcggatgc gggctccgcg 13501 cccaagatag aggtctcctg gatggatggg tccaagcggc gaccgctgat caccgagcag 13561 attcgtcatc ccgccggcct gaccatcgat tactcgcagg atcacatcat ctactgggtg 13621 gacaccaagc tgaatgccat tgaatcgatg cgggccgatg gttcgcgtcg caaggccatt 13681 gtgaagggtg accagctgag gcatcccgtt tccctcgatc tcttcgaatc caacatgttc 13741 tggatgacac gcgacaccgg ggagctggtg cgccaggata agttcgggcg cggagtgcag 13801 gtggtgctgc atcgcaacct cgtcaatccg tccggcctga aggtctacca cgacaagcgg 13861 tacaacacct cgctgcccaa tccgtgcgac aactccacct gctcgcacct ctgcctcctg 13921 gtgcccggcg gccatcggtg cgcctgtccc gacgcctccg gtccgccgcc ctcgcatcgc 13981 agcaccgccg aggtgatctg taatgccgcc gccgagcatc cgcgtccggc gccgaggatt 14041 tgtccctgcc agaacggcgg gctctgcaag gaggatgccc agggtgagct cgtctgcgac 14101 tgtttggccg agttccgggg cgagcactgc gagacgagca ccaccggagc ctttggtcat 14161 gggggcgcca atgtcaccgc cgtcgtggtg cccatcatgg tcatcctgct ggtgatgatg 14221 gccgccgccg gcgcctggta cgtcatccgg aagagacctt ttggcaaatt ggctcgcatg 14281 ccggcgatga cctcgtcgca gagcgtgacc ttccgccacg ggtcgaatgt ggagttcagc 14341 gagagcggct tcccgggggc atccgcaccg ggggccggcg atgtggcgcc catcgagggc 14401 tacaacctgc agacggtgaa cgcgaacaag gcgcgcgact ttgccaatcc gatgtacgat 14461 gcagtgcagt cgggcaccac cgccgatcca ggcatgggca acggctcggg catctacgat 14521 gtgcccggcg aaccgtcggc caagggcaag gccatgggcc accatgcggg cggatccttc 14581 acggagcccg cctcggcgat catcgcgccc agcagcatca cgcacaaggc gtcgccgcag 14641 ctgcagctgc gcaccaggga gctggacccc tcggcggaca ccggcaagga cacccagttc 14701 ctggtggagg aggacaagtc cgagtgctga tatcaagccc gtcaatcggc tgcagttgcg 14761 atggccagct gtcgccggca gcagcagcag cagaagcagc agaagcatcc ggagaacagc 14821 tatccgctgc agacataaca cagactggtc aagcaaagga aggagcagca gca