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probable citrate synthase, mitochondrial isoform X1 [Drosophila


LOCUS       XP_070075188             517 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_070075188
VERSION     XP_070075188.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070219087.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..517
                     /product="probable citrate synthase, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=57552
     Region          87..514
                     /region_name="ScCit1-2_like"
                     /note="Saccharomyces cerevisiae (Sc) citrate synthases
                     Cit1-2_like. Citrate synthases (CS) catalyzes the
                     condensation of acetyl coenzyme A (AcCoA) with
                     oxaloacetate (OAA) to form citrate and coenzyme A (CoA),
                     the first step in the citric acid cycle (TCA or...;
                     cd06105"
                     /db_xref="CDD:99858"
     Site            order(125..126,129..135,220,224,227,319,324,327..328,
                     331..332,335..337,341,348..349,352..354,402,499..507)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:99858"
     Site            order(127,319,323,353..356,358,361,395..402,405,410,451,
                     454,456,478,482,499,502)
                     /site_type="active"
                     /db_xref="CDD:99858"
     Site            order(127,353..355,358,361,395..402,405,451,454,456,499)
                     /site_type="other"
                     /note="coenzyme A binding site [chemical binding]"
                     /db_xref="CDD:99858"
     Site            order(127,319,323,354..355,395..396,398..402,410,454,482)
                     /site_type="other"
                     /note="citrylCoA binding site [chemical binding]"
                     /db_xref="CDD:99858"
     Site            order(319,323,355..356,401..402,410,456,478,482,502)
                     /site_type="other"
                     /note="oxalacetate/citrate binding site [chemical
                     binding]"
                     /db_xref="CDD:99858"
     Site            order(355,401,456)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:99858"
     CDS             1..517
                     /gene="kdn"
                     /coded_by="XM_070219087.1:81..1634"
                     /db_xref="GeneID:108054783"
ORIGIN      
        1 mfvlrlvsas srqyfsmqhr slakksiwda kpfgfqrlrs kqeddttgql keqqqpspes
       61 lgkvseaqkl pnvgayvrmi sadgkslrdv ltakvpqeqe rvknfrkqhg atkmgettid
      121 mmyggmrgik alvtetsvld adegirfrgl sipecqkvlp aadggteplp eglfwllltg
      181 evptksqvqq lsrewaeraa lpqhvvtmln nmpttlhpms qfaaavtaln hdskfakays
      241 dgvhkskywe yvyedsmdli aklpvvaati ycntyrggkg srsidssldw sanfvkmlgy
      301 dnapftelmr lyltihsdhe ggnvsahtvh lvgsalsdpy lsfaaglngl agplhglanq
      361 evlvwlrklq keagnnpsee qlkeyiwktl ksgqvvpgyg havlrktdpr ytcqrefalk
      421 hlpddetfql vskiykvvpp iltetgkvkn pwpnvdahsg vllqyygmke mnyytvlfgv
      481 sralgvlasl vwdralglpi erpksfstdl lvkmvqk