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E3 ubiquitin-protein ligase HUWE1 isoform X4 [Drosophila


LOCUS       XP_070075104            5115 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_070075104
VERSION     XP_070075104.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070219003.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5115
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..5115
                     /product="E3 ubiquitin-protein ligase HUWE1 isoform X4"
                     /calculated_mol_wt=552254
     Region          90..326
                     /region_name="DUF908"
                     /note="Domain of Unknown Function (DUF908); pfam06012"
                     /db_xref="CDD:428721"
     Region          622..976
                     /region_name="DUF913"
                     /note="Domain of Unknown Function (DUF913); pfam06025"
                     /db_xref="CDD:461803"
     Region          1454..1493
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          1734..1806
                     /region_name="WWE"
                     /note="Domain in Deltex and TRIP12 homologues. Possibly
                     involved in regulation of ubiquitin-mediated proteolysis;
                     smart00678"
                     /db_xref="CDD:128922"
     Region          3666..3696
                     /region_name="UBM"
                     /note="Ubiquitin binding region; pfam14377"
                     /db_xref="CDD:464159"
     Region          3715..3742
                     /region_name="UBM"
                     /note="Ubiquitin binding region; pfam14377"
                     /db_xref="CDD:464159"
     Region          4760..5113
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4764,4794,4805,4866,5040,5076..5077,5080..5084,5104,
                     5112)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4894,4897..4898,4900..4901,4904,4911,4913,
                     4917..4918,4920,4925,4930,4947,4951)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..5115
                     /gene="HUWE1"
                     /coded_by="XM_070219003.1:468..15815"
                     /db_xref="GeneID:108068620"
ORIGIN      
        1 mkvdtvklkk gsseltaecr elideltkrr traellefld tihvwiygkc elyhwieild
       61 rfdkileeas rhvnanefvl qcdtnfqetd vtlllhvlnf ttlliehsfs rhlynsiehl
      121 tvllssqnmd ivlavlnlly mfskrsnfip rlpfekkell ivklfniaer wgdpnyglsl
      181 kdccigepkl eflyqlcidy vdehghaaql eipdmmdlch tasapevikt iagqiskpse
      241 aikmriahrv rlisgfnnyk lrlqfvqarl qavsiliysn alqdntdkvl yagfgeelce
      301 lidkedvhlv eiraavlrtl tsmlhfdrnp nvpragsrlm kivhytgaer qggtlpllvr
      361 dcidnltthg lteryplila tslfsllyhl asyemggsal vksgmmqsll cviswpgvdl
      421 ehitfvtrav rvidlitnid iarfhqnngl nvfidrleke ikscckalad igitlkestl
      481 rddhkldnsl eqvdddveet gentsvasgg gsprrenssd gltgagssay rayhehsggg
      541 agsgaglldi ggarsagggs sggasaapii glinrdgsaa rppaimyptn syyarplaer
      601 kaelssqlps slapkkpscv tqraallksm lnflkksiqd hahfsnmrni metsltqslr
      661 hiianaeyyg pslfllatdv vtvyvfneps llsslqdlgi tsvmlkallq kdvpatrevl
      721 gslpnvfsal clnerglfef lsydpfdkvl kvllspdylv amrrrrssdp lgdtatnlgn
      781 amddlikhhp ylradateai vrllnelvrl gsdpsficwr ankessgsgs gsgshggggs
      841 hhvastpspm avmvagsggs tsvlqgaadt ndssgddddd ddemssasqq qqqsggattp
      901 rtqqpgggva tpqavkvvtp pereaiplid yilnvmkfie aifsnspngd hcrefvlhgg
      961 lkpilqllsl pnlpvdspvs ttsqavanvc kailsqaqet kvldvalkql adivaqlkpl
     1021 ikhftfpggs vllaelvccq rledgfanae ytpilhnmsf vhgyvvmlvh lcrnasndmr
     1081 aillkrwgvn retgvqllqq lvqlyislvw estillnlcs deptqhpdli wdeiaaqmsa
     1141 aagtadplte aelsrklera aefrtkyspe eqfryiksll aassrlgral aellgtlvkl
     1201 svgspqtrqr rindlisnin kvptpearei arilssilvn gfshesilpk pvpklkltfl
     1261 icsvgftgpm lfddkrsafh lmisqfcaen glkaffemfy walsldnvsq kfdfdqwasm
     1321 edlmqshedd krdcpegtge fldawlqlle kmvnpramld spytmsprln ylpdsvpfep
     1381 vfylihihql amqalrriwa rrpipnygps mfetmililk hlikshqtll dryhtrmkei
     1441 kfenlyirst ddglnadhik tltdmgfmhy hviealrtna sleeatdyll nnpeasalst
     1501 ttggsaappp ppppppstmd idmdlpadgg eksssssans sydykhlklm psiifdrfcd
     1561 eaisrafefm eaipdtvnsa adliavlyrr hnhlnkqvfv tnfvrniiqw vdftlqlfep
     1621 sktaaskasr leecltglta trlfvrlkts trlleenysd lhrplveait aqdamvslvk
     1681 lldcmsqwml eqsvdsratv prwvqnlvdl idsidsishi lqrkanmrav ssevwrwyda
     1741 stgkwnayse annelirnay aagerwlhin igrqrctvsl ncmtqvseas gthrpvcpal
     1801 klseaitaln spvslhkveh llnrvvrtsp dgsgtvhsde lislrqlinf sdgqqpqenp
     1861 aneegtneds gsplaamttr sksrqksaaa aaaaqkksss hgsppipkrt qkiilneeqv
     1921 glskfdcgri igsivdllqp shlmlnetkl sllrlcarlt rnydnaqvfi rrggvkmllh
     1981 lqqacsfmgf ptyaniilrh vleappvlqe amervlgmra agivpvghrd liyvltqvss
     2041 avsrnpqifv aaakemlkge yllntnsttl addarvmvks kfgqqptaaa ggatpnsqts
     2101 tppdeqlkdd pqvqssvavl kdllhglvqp cwhyggtgsl drgpgaaell qpdqppgtaa
     2161 qgghdeeetp apasskkqss gggasagqpq ttekfepccc twhiptsght hakptisrat
     2221 llklladstr ayqslvprvl lshiytpads plisapqqtf lgvlldrflp itqrhhvpev
     2281 stmtrvlics lsdcyqqpgv qvhvaeelha avaralaqpd saekhtrlqv lmslfpnlie
     2341 spmlydkvhm hrnnmyrvll rqgvmtyltk vaqykdlsnh ntlstlaail rpmeillrfs
     2401 vstttlgskr ilfgggggga ggangagsgn savgggsgtg pgsgntygti inrrlyprla
     2461 artavsaave rsnamggehv lrdiirnvls drrhafefif nsdemavdse dsaapavggn
     2521 gsgaggigag gsgaavidvv eersnggdts dppgnvnsgs gtgavqssts ggpvrpvlnf
     2581 dqlwddflqs eglrlasrsg ggagsgagst gagstgqqng gnatggsans gsnsvsgdpr
     2641 lrtnpdvdvg gggngggqss nsgvvndngi gggggsdgas tssdtgapgg errdlnasll
     2701 gdvstsesds dastendern eedededdda pdedvdehse tdvdeerprq fievfdhiye
     2761 pessetasnd advdnddddd ededdvdddd dddedndded reegqsvmda elenqidial
     2821 alvssnnrpr rsaavnasgd asanrdpnpd eevddedddv dadpdgdpdv dpiggpsaaq
     2881 aeaylyerlg sglmptppvg frvrmnssia qpldidvngg nggggsggsg agvtgtaggs
     2941 grgsssggtt asigaiasaa lrpssgswma pdfnfigvsg gggasgsgga sgsnanggev
     3001 nafltpamsq lersggasgs gqnmsnllde qpsvsgnggg gggsgggsas gnggvsgggg
     3061 angggtagqh pnatlcangv rrrllyldqq ycvcmpthqn pteetqmetf tqdalhwwle
     3121 eatvldmesq tdaclyaahf llphlikelk tahqqrkqee aarqtatntt tpassasssa
     3181 gapatsilsn taaptatasi assllanava agsggssssg sglvvppvaa satggtrrss
     3241 ipvlipssfg gpgsattgda tattggttss ssytttsisg sgslesqttt raprqrgglr
     3301 qhsqlpfniy aeidltneqd sqgatstgsa pndgaesqaq qpqqqqqqqn ssapslaqga
     3361 vlqhqrhppv pllpssgrps rphsrldeae llllqladrq avrsrlqvss ghtnssrtsg
     3421 salinarpnr dlparlqrlv qahgslssri nasaastpap tlvsmptpms saaleqlnvt
     3481 pagpdvvgpd rnfalppsle vdvdvlpgil drilpqqqqe qqeaqqqeee eeqlllpppp
     3541 ppppsetapl llteedmwqg treeeedsts tvavagssea anesnqsdqt pessesvspn
     3601 pqapppaaes geggaggagg aasastqtpa taeesavggt tatatttaat vtdmspevra
     3661 algdlevpeg vdpsflaalp semreeviqe hlrmqrirqr aqqnaiqiah dslvevnpef
     3721 laalplniqs evlmqqrieq qrqaaqtanp edpvdtaaff qnlpenlrqa iltdmeesqi
     3781 aslppelaae aqflrrdwes rngarmdahp psnalsrfqt tlqsldearw hssiwydasg
     3841 naqpqhhqht tivhhhahah haptmgkpla llmmedenil ldpdslatll lflfvedqkv
     3901 nsmrlhrvir nlchheptrd wiisalisiv qktnednanf gagqaggkpe wlklrvdaaf
     3961 gyksniflin rlyegsarsi sinpqaaqmi vrncldllfv lakhypssfv pfnrevkarr
     4021 ilsavfgmps ptggastaga gaparniddf pppggtldfr srfcryqvan rlrgilddhp
     4081 aaapkpqsat pldeapstsk aaaakaaata kvssqssqsv pyqtnaknfw dvvlnidrqt
     4141 qvrlanvaqf pltsqpawew qansadflsf sdspfgqlle mlpykvicrs phltdmlvkl
     4201 laslstelpk eeeqlplsdq mptlipinqa aaaaadspan pseigdglaa nveqeatpas
     4261 gnpasgdsna aakrtqlptl svalpvapsk prrkiysknf sqlqlvievl thqcgttegl
     4321 dnvaklivnl tqcsqasnai fiqyltaail glaeevrqai qmllneirmy nshhgvtast
     4381 sgaaaagatv sgasllpnla vhegimqdrf taehviisap knakptcelq lpsmkklmsn
     4441 ssaqpyflrt lkifmqvrdm yeaqnglstg gglagaagdn dddiidiegd ggasggsssd
     4501 mapgsastis ppppppmetn qnindeeede dgeeeedddd aaraspaaas agksskptls
     4561 qilcldvlwh tlseclvale eskdefavlv lqptveaffl ihashragak ksgrggvvgs
     4621 glraagglga aasaaqehsp smddtssant lssasfedep rmqdastntp lssnssaatt
     4681 vlsaheaqlr qdrqkflqfa ekhrtvlnqi lrqspthlsd gpfavlvdht rildfdvkrk
     4741 yfqtelerld egirreehtv svrrvtvfed sfrvlyrlgp eewknrfyiv fedeegqdag
     4801 gllrewyvii sreifnpmya lfcvspgdrv tyminpssha npnhlsyfkf vgrviakavh
     4861 dnkllecyft rsfykhilgk qvkhtdmesq dyefykgldy lmkndistlg yeltfstevq
     4921 efgvtqirdl kpngrdtavt eenkfeyvql vcqlkmsgsi rqqldafleg fydiipkhli
     4981 sifneqelel lisglpdidi edlkanteyh kytsksaqiq wfwralrsfd qadrakflqf
     5041 vtgtskvplq gfgslegmng iqkfqihrdd rstdrlpcah tcfnqldlpm yksydklrsc
     5101 llkaihecse gfgfa