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LOCUS XM_070219003 16579 bp mRNA linear INV 09-DEC-2024 containing E3 ubiquitin protein ligase 1 (HUWE1), transcript variant X6, mRNA. ACCESSION XM_070219003 VERSION XM_070219003.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..16579 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..16579 /gene="HUWE1" /note="HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 Proteins" /db_xref="GeneID:108068620" CDS 468..15815 /gene="HUWE1" /codon_start=1 /product="E3 ubiquitin-protein ligase HUWE1 isoform X4" /protein_id="XP_070075104.1" /db_xref="GeneID:108068620" /translation="MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTIHV WIYGKCELYHWIEILDRFDKILEEASRHVNANEFVLQCDTNFQETDVTLLLHVLNFTT LLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELL IVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDL CHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSIL IYSNALQDNTDKVLYAGFGEELCELIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPR AGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHGLTERYPLILATSLFSLLYHLAS YEMGGSALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNIDIARFHQNNGL NVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDNSLEQVDDDVEETGENTSVAS GGGSPRRENSSDGLTGAGSSAYRAYHEHSGGGAGSGAGLLDIGGARSAGGGSSGGASA APIIGLINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQRA ALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVVT VYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFEF LSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADATE AIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGGSHHVASTPSPMAVMVAG SGGSTSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQSGGATTPRTQQPGGGVATPQA VKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDHCREFVLHGGLKPILQLLSLPN LPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGGS VLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRAILLKRWG VNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPDLIWDEIAAQMSAAAGTAD PLTEAELSRKLERAAEFRTKYSPEEQFRYIKSLLAASSRLGRALAELLGTLVKLSVGS PQTRQRRINDLISNINKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLIC SVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFDFDQWASM EDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYLPDSVPF EPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHTR MKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDYLLNNPE ASALSTTTGGSAAPPPPPPPPPSTMDIDMDLPADGGEKSSSSSANSSYDYKHLKLMPS IIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQVFVTNFVRNIIQW VDFTLQLFEPSKTAASKASRLEECLTGLTATRLFVRLKTSTRLLEENYSDLHRPLVEA ITAQDAMVSLVKLLDCMSQWMLEQSVDSRATVPRWVQNLVDLIDSIDSISHILQRKAN MRAVSSEVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLHINIGRQRCTVSLNCMT QVSEASGTHRPVCPALKLSEAITALNSPVSLHKVEHLLNRVVRTSPDGSGTVHSDELI SLRQLINFSDGQQPQENPANEEGTNEDSGSPLAAMTTRSKSRQKSAAAAAAAQKKSSS HGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHLMLNETKLSLLRLCAR LTRNYDNAQVFIRRGGVKMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERVL GMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLLNTNSTTLADDA RVMVKSKFGQQPTAAAGGATPNSQTSTPPDEQLKDDPQVQSSVAVLKDLLHGLVQPCW HYGGTGSLDRGPGAAELLQPDQPPGTAAQGGHDEEETPAPASSKKQSSGGGASAGQPQ TTEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVLLSHIYTPA DSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCYQQPGVQVHVAE ELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYRVLLRQGV MTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGGGGGGAGG ANGAGSGNSAVGGGSGTGPGSGNTYGTIINRRLYPRLAARTAVSAAVERSNAMGGEHV LRDIIRNVLSDRRHAFEFIFNSDEMAVDSEDSAAPAVGGNGSGAGGIGAGGSGAAVID VVEERSNGGDTSDPPGNVNSGSGTGAVQSSTSGGPVRPVLNFDQLWDDFLQSEGLRLA SRSGGGAGSGAGSTGAGSTGQQNGGNATGGSANSGSNSVSGDPRLRTNPDVDVGGGGN GGGQSSNSGVVNDNGIGGGGGSDGASTSSDTGAPGGERRDLNASLLGDVSTSESDSDA STENDERNEEDEDEDDDAPDEDVDEHSETDVDEERPRQFIEVFDHIYEPESSETASND ADVDNDDDDDEDEDDVDDDDDDDEDNDDEDREEGQSVMDAELENQIDIALALVSSNNR PRRSAAVNASGDASANRDPNPDEEVDDEDDDVDADPDGDPDVDPIGGPSAAQAEAYLY ERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNGGGGSGGSGAGVTGTAGGSGRGS SSGGTTASIGAIASAALRPSSGSWMAPDFNFIGVSGGGGASGSGGASGSNANGGEVNA FLTPAMSQLERSGGASGSGQNMSNLLDEQPSVSGNGGGGGGSGGGSASGNGGVSGGGG ANGGGTAGQHPNATLCANGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQDALHWW LEEATVLDMESQTDACLYAAHFLLPHLIKELKTAHQQRKQEEAARQTATNTTTPASSA SSSAGAPATSILSNTAAPTATASIASSLLANAVAAGSGGSSSSGSGLVVPPVAASATG GTRRSSIPVLIPSSFGGPGSATTGDATATTGGTTSSSSYTTTSISGSGSLESQTTTRA PRQRGGLRQHSQLPFNIYAEIDLTNEQDSQGATSTGSAPNDGAESQAQQPQQQQQQQN SSAPSLAQGAVLQHQRHPPVPLLPSSGRPSRPHSRLDEAELLLLQLADRQAVRSRLQV SSGHTNSSRTSGSALINARPNRDLPARLQRLVQAHGSLSSRINASAASTPAPTLVSMP TPMSSAALEQLNVTPAGPDVVGPDRNFALPPSLEVDVDVLPGILDRILPQQQQEQQEA QQQEEEEEQLLLPPPPPPPPSETAPLLLTEEDMWQGTREEEEDSTSTVAVAGSSEAAN ESNQSDQTPESSESVSPNPQAPPPAAESGEGGAGGAGGAASASTQTPATAEESAVGGT TATATTTAATVTDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIR QRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPEDPVDT AAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMDAHPPSNA LSRFQTTLQSLDEARWHSSIWYDASGNAQPQHHQHTTIVHHHAHAHHAPTMGKPLALL MMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIISALISIV QKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQ MIVRNCLDLLFVLAKHYPSSFVPFNREVKARRILSAVFGMPSPTGGASTAGAGAPARN IDDFPPPGGTLDFRSRFCRYQVANRLRGILDDHPAAAPKPQSATPLDEAPSTSKAAAA KAAATAKVSSQSSQSVPYQTNAKNFWDVVLNIDRQTQVRLANVAQFPLTSQPAWEWQA NSADFLSFSDSPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEEQLPLSDQ MPTLIPINQAAAAAADSPANPSEIGDGLAANVEQEATPASGNPASGDSNAAAKRTQLP TLSVALPVAPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQA SNAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNSHHGVTASTSGAAAAGATVSGAS LLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLK IFMQVRDMYEAQNGLSTGGGLAGAAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTIS PPPPPPMETNQNINDEEEDEDGEEEEDDDDAARASPAAASAGKSSKPTLSQILCLDVL WHTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRAGAKKSGRGGVVGSGLRAAG GLGAAASAAQEHSPSMDDTSSANTLSSASFEDEPRMQDASTNTPLSSNSSAATTVLSA HEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYF QTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAG GLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKA VHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFS TEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDI IPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQA DRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPM YKSYDKLRSCLLKAIHECSEGFGFA" misc_feature 735..1445 /gene="HUWE1" /note="Domain of Unknown Function (DUF908); Region: DUF908; pfam06012" /db_xref="CDD:428721" misc_feature 2331..3395 /gene="HUWE1" /note="Domain of Unknown Function (DUF913); Region: DUF913; pfam06025" /db_xref="CDD:461803" misc_feature 4827..4946 /gene="HUWE1" /note="UBA domain-like superfamily; Region: UBA_like_SF; cl21463" /db_xref="CDD:473871" misc_feature 5667..5885 /gene="HUWE1" /note="Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; Region: WWE; smart00678" /db_xref="CDD:128922" misc_feature 11463..11555 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 11610..11693 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 14745..15806 /gene="HUWE1" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(14757..14759,14847..14849,14880..14882,15063..15065, 15585..15587,15693..15698,15705..15719,15777..15779, 15801..15803) /gene="HUWE1" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(15147..15149,15156..15161,15165..15170,15177..15179, 15198..15200,15204..15206,15216..15221,15225..15227, 15240..15242,15255..15257,15306..15308,15318..15320) /gene="HUWE1" /note="E2 interaction site [active]" /db_xref="CDD:238033" polyA_site 16579 /gene="HUWE1" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 catttgcctt caatttgcca aaaagaataa acgccagcgc ctatcgatag ccatcgatag 61 gcagagtcga ttgcaattct tcgttgccgt ggattggagc ggtgcgtggt cacactaatg 121 cttgcatttt ttttgtctgt ggaaatttca tttcacaaaa accgagatag ttaaattaac 181 caaattatag cgtttcagat cgaaataaca atagcagcaa tatgctgcag ttaaatataa 241 tttttattga acacgctgac gtatacgttt aaaccgcaac tcgatgccca acctataaac 301 aatcgacgcc cgacgccttt tcaccacgaa ccacccaatc tacacaagcc gcccactcga 361 caaacagccg gaggaagagg aggaggagga ggaggaagga ggaggagcac caccacccca 421 agtggtggcc acctgctgct ccattagctc cactagctcc acgaacaatg aaggtggaca 481 cggtgaagct gaagaagggc tcctcggagc tcaccgccga gtgccgcgag ctcatcgacg 541 agctcaccaa gcggcggacg cgggccgagc tgctcgagtt cctcgacacc atccacgtct 601 ggatctacgg caagtgcgag ctctaccact ggatcgagat cctcgaccgg ttcgacaaga 661 tcctcgagga ggcgtcgcgc catgtcaacg ccaacgagtt cgtgctgcag tgcgacacca 721 atttccagga aacggatgtc acactgctgt tgcacgttct taacttcacc acactgctga 781 tcgagcactc gttctcgcgg cacctctaca actccatcga acacctgacg gtgctgctct 841 cctcccagaa catggacatc gtcctggccg tcctcaatct gctgtacatg ttctccaagc 901 gcagcaactt cataccccgc ctgccgttcg agaagaagga actgctgatt gtcaagctgt 961 ttaacatagc cgagcgctgg ggcgatccca actacggact gtcgctcaag gactgctgca 1021 ttggcgagcc gaagctggaa ttcctttacc agctgtgcat cgactatgtg gacgagcacg 1081 gtcatgccgc ccagctggaa atcccggaca tgatggacct ctgccacacg gcgtccgcgc 1141 ccgaggtgat caagacgatt gccggacaga tctcaaagcc cagcgaggca atcaagatgc 1201 gcattgctca tcgggtgcgc ttgatctcag gcttcaacaa ctacaagctg cgcctccagt 1261 tcgtccaggc tcgcctgcag gccgtctcca ttctgatcta ctcgaatgcc ctgcaggaca 1321 acacggacaa ggtgctgtat gccggcttcg gcgaggagct gtgcgagctg atcgacaagg 1381 aggacgtgca tctcgtggag atacgggcgg cagtgctgcg cacactcacc tcgatgctgc 1441 actttgaccg caatccgaat gtgcccaggg ccggttcgcg actgatgaag atcgttcact 1501 acacaggagc cgagcggcag ggcggcactt tgccactgct ggtgcgcgac tgcattgata 1561 atttaaccac ccatggactc accgaacgct acccgctcat cctggccacg tcactcttct 1621 cgctgctcta ccatttggcc agctacgaaa tgggcggctc tgctctggtc aaaagcggca 1681 tgatgcagtc cctcctgtgc gtcatcagct ggccgggagt cgacctcgag cacattacgt 1741 tcgtgacgcg ggcggtgcgg gtgatcgacc tgataaccaa catagatatc gcacggttcc 1801 atcagaacaa cggactcaac gtgttcattg accgtctgga gaaggagatc aagagctgct 1861 gcaaggcact ggccgacatt ggcatcacgc tgaaggagtc gacgctgcgc gatgaccaca 1921 agttggataa ctcgctggag caagtggacg atgatgtgga agagaccgga gagaacacgt 1981 ccgtggccag tggaggtgga tcgccgcgtc gcgagaactc gagtgacggg ctcaccggtg 2041 ccgggagcag cgcctacaga gcctatcacg agcacagtgg aggaggagcg ggctcaggag 2101 cgggactcct ggacattggt ggagcacgca gcgcaggagg aggatcatcg ggtggtgctt 2161 cagccgcacc gatcattgga ttaatcaacc gggacggaag tgccgctcgt ccgccggcca 2221 tcatgtaccc cacaaacagt tactacgccc gtccgctggc cgagcgcaag gcggagctct 2281 cctcgcagct gccgagcagc ctggcgccga agaagccctc ctgcgtcacc cagcgggcgg 2341 cgctgctcaa gtcgatgctg aatttcctga agaagagcat ccaggatcat gcgcacttta 2401 gcaacatgcg caacatcatg gagaccagct taacgcagtc gcttcgccac atcatagcca 2461 atgcggagta ctacgggccg tcgctcttcc tgctggccac cgatgtggtc accgtgtacg 2521 tgttcaacga gccctcgctg ctctcctcgc tgcaggatct gggcatcacg agtgtcatgc 2581 tgaaggcgct gctccagaag gatgtgccgg ccacgcggga agtgctgggc tccctgccga 2641 atgtcttttc cgccctgtgc ctgaatgagc gtggcctttt tgagttcctc tcctatgatc 2701 cttttgacaa ggtgctgaag gtgctgctct cgccggacta tctggtggcc atgcgcaggc 2761 gccgctcctc ggatccgctg ggcgatacgg ccaccaattt gggcaatgcc atggacgatc 2821 tgatcaagca tcatccgtat ttgcgagccg atgccacgga ggcgattgtg aggcttttga 2881 atgagctggt tcgccttggt tccgatccca gtttcatttg ctggcgggcc aacaaggaga 2941 gcagtggctc tggctcgggt tcaggcagcc atggcggcgg cggttcgcat cacgtggcct 3001 ccacaccctc gcccatggcc gtcatggtgg ctggctcggg aggatcgacg tcggtgctcc 3061 agggagccgc ggatacgaac gacagcagcg gcgacgatga cgacgatgat gatgaaatga 3121 gctcggcttc gcagcaacag cagcaaagtg gaggagccac cacacccagg acgcaacaac 3181 caggaggagg agtagccacc ccgcaggccg tcaaggtggt gacgcccccg gaacgagagg 3241 caatacccct aatcgactat atcttgaatg tgatgaagtt catcgaggcg attttcagca 3301 acagtccgaa tggcgatcac tgccgggagt ttgtcctcca cggcggacta aagcccattc 3361 tgcaactgct gtcgctgccc aatctgccgg tggattcacc cgtttccacc acctcacagg 3421 cggtggccaa tgtctgcaag gccatactca gccaggcgca ggaaacgaag gttctcgatg 3481 tggcgctcaa gcagctggct gatattgtgg cccagctgaa gccgctgatc aagcacttta 3541 cctttcccgg cggcagtgtc ctcctcgcag agctcgtctg ctgtcagcgg ctggaggatg 3601 gcttcgccaa tgccgaatac acaccgatac tgcacaacat gagctttgtg cacggctatg 3661 tggtgatgct ggtgcatctc tgtcgcaacg cctccaacga catgcgagcg attctgctca 3721 agcgttgggg cgtcaatcgc gagactggag tgcaattgct gcagcagctg gtccagctgt 3781 acatttcgct ggtgtgggag agcaccatac tgctgaatct ctgctcggat gagcccaccc 3841 agcatccgga tctcatttgg gacgagattg cggcccagat gtcggcggca gcgggcaccg 3901 cggatcccct gaccgaagcg gagctctcgc ggaagctgga gcgtgcggcg gaattccgga 3961 cgaagtactc gcccgaggag cagttccggt acatcaaatc cctgctggcg gcgagctctc 4021 ggctcggcag ggcgctcgcc gagctgctgg gcacgctggt gaagctatcg gtgggttcgc 4081 cgcagacgcg acagcgacgc atcaacgatc tgatcagcaa tatcaacaaa gttcctacgc 4141 ccgaggctcg cgaaatagcc cgcatcctca gctcgattct ggtgaatggc ttcagtcacg 4201 agagcattct accgaagcct gtgcccaagt tgaagctcac cttcctcatc tgctcggtgg 4261 gattcaccgg tccaatgctg ttcgacgaca agcgcagcgc ctttcacctg atgatatcgc 4321 aattctgcgc agagaatgga ttgaaagcct tctttgagat gttctactgg gcgctgtcgc 4381 tggataatgt ctcgcagaag ttcgatttcg atcagtgggc ctcgatggag gatctgatgc 4441 agtcgcacga ggacgacaag cgcgattgcc ccgagggcac gggcgagttt ctcgacgcct 4501 ggctgcagct gctcgagaag atggtgaatc cgcgtgccat gctcgattcg ccgtatacga 4561 tgagtccgcg gctgaattac ctgcccgatt cggtgccctt cgagccggtc ttttacctca 4621 ttcacatcca ccagctggcc atgcaggcac tgcgcaggat ctgggcacgt cgcccgattc 4681 ccaactatgg acccagtatg ttcgagacca tgatactgat cctgaagcat ctgatcaagt 4741 cgcatcaaac gctgctcgat cgctatcaca cgcggatgaa ggagatcaag ttcgagaacc 4801 tctacatccg cagcacggac gatggcctaa atgcggatca catcaagacg ctgacggaca 4861 tgggcttcat gcattaccac gttattgagg ctctccgcac gaatgcctcg ctggaggagg 4921 ccaccgatta tctgctgaat aacccagaag ccagtgcttt gtccacaacg actggtggtt 4981 ctgctgctcc tccgccgccg ccaccgccac cgccttccac catggacatt gacatggatt 5041 tgccagcgga tgggggagag aaatctagct ctagttcggc gaactccagc tatgactaca 5101 agcacctcaa actgatgccg tcgatcatct tcgatcgctt ctgcgacgag gccatttcgc 5161 gggcctttga gttcatggag gccattccgg atacggtgaa cagtgccgca gatctgatag 5221 ccgtgctgta tagacgccac aatcacctga acaagcaggt ctttgtgacc aactttgtgc 5281 gcaacattat ccagtgggtg gactttaccc tgcagctctt tgaaccatcg aaaacggcag 5341 cgtcgaaggc ttcgcggttg gaggaatgct tgacgggatt gacggccacc cggttgtttg 5401 tgcggctcaa gacatcgacg cggctgctcg aggagaacta cagtgatttg catcgtccgc 5461 tggtggaggc aataaccgcc caggatgcca tggtgtcgct ggtcaagctg ctcgactgca 5521 tgagccagtg gatgctggag caatcagtgg attctagggc tacggtcccc cgatgggtgc 5581 agaacctggt ggatctaatc gattcgatcg acagcatcag ccacattctg cagcgcaagg 5641 ccaacatgcg ggcggtgagc agcgaggtgt ggcgctggta cgacgcctcc acgggcaagt 5701 ggaatgccta ttcggaggcc aacaatgagc tcattcggaa tgcctatgcc gccggcgagc 5761 ggtggctgca cattaacatc ggcaggcaaa ggtgtacggt gagcctgaac tgcatgacgc 5821 aggtgagcga ggcatccggc acacatcgtc ctgtttgtcc ggctctcaag ctcagtgaag 5881 ccatcactgc gctcaacagt cccgtgtcgc tgcacaaagt ggagcatctg ctgaaccgcg 5941 tggtgcgaac ctcacccgat ggctcgggaa ccgtgcattc cgacgaattg atttccctgc 6001 gccagctgat caacttttcg gatggtcagc agccgcagga gaacccggcg aatgaagagg 6061 gaacaaatga agatagtgga tctcctctgg ccgccatgac cacgcgcagc aagtcgcggc 6121 aaaagagcgc cgccgctgca gccgctgccc agaagaaatc ctcgtcgcat ggctcaccgc 6181 ccatacccaa acgcacccag aagatcatac tcaacgagga gcaggtggga ctgagtaaat 6241 tcgactgcgg tcggataatt ggcagcattg tggatctcct gcagccttcg catctcatgc 6301 tcaacgaaac gaagctttcg ctgctgcggc tgtgtgcaag attaacccga aactacgaca 6361 atgcccaggt gttcatccgg cggggcggcg ttaagatgct gctgcatctg cagcaggcct 6421 gcagcttcat gggcttcccc acctatgcga atatcatact gcgtcacgtg ctcgaggcgc 6481 cgccggtgct gcaggaggcc atggaacgag tgctgggcat gcgggcagcc ggcattgtgc 6541 ccgtggggca tcgggatcta atctatgtac tcacccaggt atcctcagcg gtttcgcgca 6601 atccgcagat ctttgtggcc gccgccaagg agatgctcaa gggagagtac ctcctgaaca 6661 cgaacagcac gacgctggcg gacgatgcgc gggtgatggt caagtccaag tttggtcaac 6721 aaccgacggc agcggctggc ggagccacgc caaattcgca gacgtccacg ccgccggatg 6781 agcagctcaa ggacgatccc caggttcagt catcggtggc tgtgcttaag gatctactgc 6841 atggattggt gcagccctgc tggcactacg gcggcacggg atccttggat cgcggccctg 6901 gcgccgccga gctgctgcaa ccggaccagc caccgggaac ggccgcccag ggaggccacg 6961 acgaggagga aacccccgca cctgcgagca gcaagaagca atcctcagga ggaggagcat 7021 ctgctgggca gccacagacg acggagaagt tcgagccctg ctgctgcacg tggcacatcc 7081 cgaccagcgg ccacacgcac gccaagccga ccatttcgcg ggcgacgctg ctcaagctgc 7141 tggcggattc aacgagggcc tatcagtctt tagtgccccg cgtgctgcta tcccacattt 7201 acacgcccgc cgacagtccg ctgatctcgg cgccgcagca gacgttcctg ggcgtcctcc 7261 tcgatcgctt tctgcccatc acgcagcggc atcatgtgcc cgaggtgagc acgatgacga 7321 gggtgctcat ttgctccctt tctgactgct accagcagcc gggagtccag gtccatgtgg 7381 ccgaggagct gcacgcggcg gtggccaggg ctttggccca accggactcg gcggagaagc 7441 acacgcgact ccaggtgctg atgagcctgt ttcccaatct catcgagtcg ccgatgctgt 7501 acgataaggt gcacatgcat cgcaacaaca tgtaccgagt gctgctgcgc cagggagtga 7561 tgacctacct gaccaaggtg gcccagtaca aggatctgtc caatcacaac acgctgagca 7621 ctctggcggc catcctgcga cccatggaga tcttgctgag gtttagtgtg tccaccacaa 7681 cgctcggatc gaagaggatt ctctttggcg gcggcggcgg aggagctggc ggagcaaatg 7741 gagcagggag cgggaacagt gctgtcggag gaggcagtgg aactggcccg ggatcgggca 7801 atacatatgg aaccatcatc aatcgtcggc tatatcctcg tttggccgcc cgcaccgcag 7861 tcagtgcggc cgtggagcga tccaatgcga tgggtggcga gcatgtgctg cgcgacatta 7921 tacgcaatgt gctctccgat cggcggcacg cctttgagtt tatcttcaac tcggacgaga 7981 tggccgtgga ctcggaggac tcggctgccc cggcggtggg tggtaatgga tcgggagcag 8041 gcggaatagg agcaggagga tcaggagcag ccgtcatcga tgtggtggag gagcgcagca 8101 atggcgggga taccagcgat cccccaggta atgtaaactc cggatctgga acgggcgcag 8161 ttcaatcttc aaccagtgga ggtcccgtgc ggccagttct gaactttgac cagctgtggg 8221 acgacttcct gcagagcgag ggactgcgat tggcctcgcg gagcggcgga ggcgcgggat 8281 ctggagcagg atccacagga gcaggctcaa cgggtcagca aaacggtggc aatgccactg 8341 gtggctctgc aaactccggc agcaattcag tcagcggaga tcctcgcctg cgcaccaatc 8401 ccgatgtgga tgtgggcggc ggtggaaatg gcggtggtca gtcatccaat tcgggtgtgg 8461 taaacgataa tggaattggc ggcggcggcg gcagcgatgg cgcctccaca tcctcggaca 8521 ctggagctcc gggcggcgaa cgtcgcgatt tgaatgcctc gctgctgggc gatgtcagca 8581 cctcggaatc cgattcggat gcctccacgg agaacgacga gcggaatgag gaggacgagg 8641 acgaggatga cgatgccccc gatgaagatg tggacgagca tagcgaaacg gatgtggatg 8701 aggaaaggcc acgtcaattt atcgaggtct ttgatcacat ctacgaaccg gaatcctcgg 8761 aaaccgcttc caatgatgcg gatgtggata acgacgacga tgatgacgag gatgaggacg 8821 atgtggacga cgacgatgat gatgacgagg ataacgacga tgaggatcgc gaggagggcc 8881 agagtgtcat ggatgccgag ttggagaacc aaatagacat tgccctcgcc ttggtttcgt 8941 ccaacaatcg tccgcgacgc agtgcagcgg ttaatgcttc gggcgatgcg tccgccaatc 9001 gagatcccaa tcccgacgag gaggtggacg acgaggacga cgatgtggac gccgatcccg 9061 atggagatcc cgatgtggac cccattggcg gcccctcggc tgcccaggcg gaggcctatc 9121 tgtacgagcg actgggcagc ggcctgatgc ccacgccacc ggtgggtttc cgcgtccgca 9181 tgaacagctc gattgcccag cccctggaca ttgatgtgaa tggcggaaat ggcggtggtg 9241 gatctggtgg atccggagca ggcgtcactg gaacggccgg tggatccgga agaggctcct 9301 cgtcgggcgg aacaacggcc agtattggag ccattgcctc cgctgccttg cgtccctcgt 9361 ccggttcttg gatggcgccg gactttaatt tcattggagt ctcgggcggt ggaggagcca 9421 gtggctctgg aggcgcctca gggagcaatg ccaacggggg cgaggtgaac gccttcctca 9481 cgcccgccat gtcgcagctg gaacgcagtg gtggcgcctc gggcagtggc caaaacatga 9541 gcaatctgct ggacgaacaa ccgtcggtca gtggcaacgg cggcggagga ggaggaagtg 9601 gcggaggttc cgcctctggt aacggcggcg tcagcggtgg aggaggagcc aatggcggcg 9661 gtaccgcagg acagcatccg aatgccacgc tctgcgccaa cggagtgcgc cggcggttgc 9721 tctatttgga ccagcagtac tgcgtctgca tgcccacgca tcagaatccc acggaagaga 9781 cccagatgga gacgttcacc caggatgctc tgcattggtg gctggaggag gccacggtct 9841 tggatatgga gagccagact gacgcctgcc tgtacgccgc tcacttcctg ctgccgcatc 9901 tcatcaagga gctgaagacg gcccaccagc agcgcaagca ggaggaggcc gcccgccaga 9961 cggccacgaa caccacaaca cctgcatcat cggcttcgtc ttcggccgga gctccggcga 10021 cctccatcct atcgaacaca gcggccccaa cagcgacggc ctccattgcg tccagtctac 10081 tggcgaatgc cgtggccgcg ggctcaggcg gcagcagcag cagcggcagc ggattggtgg 10141 tgccaccggt ggcagcctcc gccacgggag gcacccggcg cagctcgatt cccgtgctga 10201 ttccctcgag cttcggcggt cctggtagtg caaccactgg cgatgccacg gccacaacgg 10261 gaggaaccac cagcagcagt tcctacacaa ccacatccat tagcggcagt ggctccttgg 10321 agtcgcagac gacgactcga gcgcctcggc aacgcggtgg attgcgccag cacagccagc 10381 tgcccttcaa catctacgcg gagatcgatc tgaccaacga acaggatagc cagggcgcca 10441 cgtcaacggg ctctgctcca aacgatggag cggaatcaca ggcacagcag ccgcagcagc 10501 agcagcagca gcaaaactcc tccgctcctt cgttggcgca gggggcggtc cttcagcatc 10561 agcgtcatcc accggtgccg ctcctgccgt ccagtggaag gccttcgcga cctcactcgc 10621 gtctcgacga ggcggagctg cttctgttgc agttggccga tcgccaggct gttcgcagtc 10681 gcctgcaagt gtccagcggt cacacgaatt cctcgcgcac ctcgggatcg gcgctgatca 10741 acgctcggcc caatcgcgat ctacccgccc gcctgcagcg cctcgtccag gcacatggct 10801 ccctttccag tcgcatcaat gcatccgccg ccagcacgcc ggctccgacg ctcgtctcca 10861 tgcccacgcc catgtccagt gcggcgctgg agcagctgaa tgtcacgccc gccggcccgg 10921 atgttgtggg cccagacagg aactttgcat tgccaccttc cctggaggtt gatgtggatg 10981 tgctgcctgg aatactggat cgcatactgc cgcagcagca gcaggagcag caggaagcgc 11041 agcagcagga ggaggaggag gaacagctgt tgctaccacc gccacctccg ccgccgccca 11101 gtgaaacggc gcccttgctc ctcaccgagg aggatatgtg gcaagggaca agagaggagg 11161 aggaggattc cacttccaca gtggcagttg ccggcagcag cgaggctgca aacgagtcaa 11221 accaatcgga tcagacgccg gagagcagcg aatctgtttc cccgaacccg caggctcctc 11281 ccccagcagc agaatccggc gaaggaggag cagggggagc aggaggagct gcctcggcta 11341 gcacacaaac cccggcaacc gcagaagaat ccgctgtagg tggaacaaca gcaacagcaa 11401 caacgacagc agccaccgta acggacatga gtcccgaggt gcgggccgct ctcggggatc 11461 tggaggtgcc cgagggcgtg gatccctcct tcctggccgc cctgcccagc gagatgcgcg 11521 aggaggtgat ccaggagcat ctgcggatgc agcgcattcg ccagcgggcg cagcagaatg 11581 ccattcagat tgcgcacgat tcgctcgtcg aggtgaatcc cgagttcctc gccgccctgc 11641 cgctgaacat tcagtccgag gtgctgatgc agcagcggat cgagcagcag cgccaggcgg 11701 cgcagaccgc gaatcccgag gatcccgtcg acacggccgc cttctttcag aacctgcccg 11761 agaatctgcg gcaagcgata ctcaccgaca tggaggagtc gcagatagcc agtttgccgc 11821 ccgagttggc ggcggaggcg cagttcctgc gtcgcgactg ggagtcccgc aatggcgccc 11881 gcatggacgc ccatccgccc agcaatgcgt tgtcccgctt ccagacgacg ctgcagagcc 11941 tggacgaggc ccgctggcac agctccattt ggtacgacgc cagcggcaat gcccagccgc 12001 agcaccacca gcacaccacg attgtgcacc accatgccca cgcacatcac gcccccacga 12061 tgggcaaacc cctagccctg ctgatgatgg aggacgagaa catcctgctc gatccggact 12121 cgctggccac cctgctgctc ttcctgttcg tcgaggatca gaaggtgaac agcatgcggc 12181 tgcatcgtgt gattcgcaac ctttgccacc acgaacccac gcgcgattgg atcatcagcg 12241 ctctgattag catcgtccaa aagaccaacg aggataacgc caactttgga gctggacagg 12301 cgggcggcaa accggagtgg ctgaagctgc gcgtggacgc cgcctttggc tacaagagca 12361 acatcttcct catcaatcgg ctgtacgagg gcagtgcgcg gagcatcagc atcaatccgc 12421 aggccgcaca gatgatagtg cgcaactgtc tggatctgct cttcgtgctg gccaagcact 12481 atccgtccag ctttgtgccc ttcaaccgcg aggtgaaggc caggcgcata ctgagtgcgg 12541 tatttggcat gccatcgccc acgggtggtg cttctactgc tggagctgga gctcctgcac 12601 gcaatataga tgactttcca ccgcccggcg gaactctgga ctttcgctcg cgtttctgcc 12661 gctaccaggt ggccaatcga ctgcgcggca tactcgacga tcatccggcg gcggccccga 12721 aaccccaaag tgcaactccc ctggatgagg caccctccac atcgaaggcg gctgctgcca 12781 aggcagctgc cacggctaag gtttcgagtc agagcagtca gtcggtgccg tatcaaacga 12841 atgcgaagaa tttctgggat gtggtgctca acatcgatcg acagacccaa gtgcgtttgg 12901 ccaatgtggc ccagtttcca ctcacctcgc agccagcttg ggaatggcaa gcgaacagcg 12961 ccgacttcct gtcgttcagc gattcgcctt tcggacagct gctggaaatg ctgccctaca 13021 aggtcatctg ccggtcgcca catctcaccg atatgctggt caagttgctc gcctcgctga 13081 gcaccgagtt gcccaaggag gaggaacagt tgccgctgag cgatcaaatg cccaccctga 13141 tacccattaa tcaggcggcg gcagcggcag cagattcccc agcgaatcca tcagagattg 13201 gtgacggact ggccgcaaat gtggagcagg aagccacgcc ggccagcggt aatccagcct 13261 ccggtgacag caatgcggct gccaagcgaa cacagctgcc cacattgagt gtagccctgc 13321 cagttgctcc gtcgaagccg cggcgcaaga tctactcgaa gaacttctcg caactgcagc 13381 tggtcatcga ggtgctgacc caccagtgcg gcaccaccga gggcctggac aacgtggcca 13441 agctgattgt gaatctaacg cagtgctcgc aggcatccaa tgcgattttc attcagtacc 13501 tgaccgctgc catcctggga ttggccgagg aggtgcgcca ggcgatacag atgctgctga 13561 atgagatacg catgtacaac agtcatcatg gagtgacggc ctccacatcc ggagcagcgg 13621 cagcgggagc caccgtttca ggagccagtc tgctgcctaa cctcgccgtt cacgagggca 13681 tcatgcagga tcgcttcacc gccgagcatg tcatcatttc ggcgccgaag aacgccaagc 13741 ccacctgcga actccagctg ccgtcgatga agaagcttat gtccaactca tccgcccagc 13801 cgtacttcct gcgcaccctg aagatcttca tgcaggtgcg cgacatgtac gaggcgcaga 13861 atggtttatc cacgggcggt ggtttggctg gagcagctgg cgacaacgat gacgacatca 13921 tcgacattga gggcgatggc ggagcttcgg gcggcagcag ttcggatatg gcgcccggtt 13981 cggcgagcac aatatctccg ccgccgccgc caccgatgga aaccaatcag aacattaacg 14041 atgaggagga ggatgaggat ggggaggagg aggaggacga tgatgatgcg gccagggcat 14101 cgccagcggc ggcaagtgct ggcaagtcaa gcaagcccac gctcagccag atcctctgcc 14161 tcgacgtcct ttggcacacg ctcagcgaat gcctggtggc gctggaggag tccaaggacg 14221 agttcgccgt cctggtgctg cagcccaccg tggaggcctt cttcctcatc cacgcctcgc 14281 atcgcgcggg ggctaagaag tcgggtcgcg gcggagttgt gggctccgga ctgcgggcag 14341 ctggaggatt gggagcagct gcgtcggcgg cccaggagca cagtccatcg atggacgaca 14401 ccagcagcgc caataccctt agttcggcca gtttcgaaga tgagccgcga atgcaggacg 14461 cctccacaaa cacgccgctt tcgagcaaca gctccgccgc caccactgtg ctgagcgcac 14521 acgaggcgca gctgcgacag gatcgccaga agttcctgca gttcgccgag aaacaccgca 14581 ccgtgctcaa ccaaatactg cgccagtcgc ccactcatct ctccgacgga cccttcgccg 14641 ttctcgtcga ccacacgcgc atcctggact ttgacgtcaa gcggaagtac ttccagacgg 14701 agctggagcg cctggacgag ggcattcggc gcgaggagca cacggtcagt gtgcggcgcg 14761 tgaccgtctt cgaggattcg ttccgcgtgt tgtaccgcct gggaccggag gagtggaaga 14821 accgcttcta cattgtcttc gaggacgagg aaggccagga tgctggcggc ctgctgcgcg 14881 aatggtatgt gatcatatcg cgcgagatct tcaatccgat gtatgccttg ttctgcgtat 14941 cgccgggcga tcgcgtcacc tacatgatca atccctccag ccatgccaat ccgaatcatc 15001 tgagctactt caagttcgtc ggccgcgtaa ttgccaaggc cgtgcacgat aacaagctgc 15061 tggagtgcta cttcacccga tccttctaca agcacatcct gggcaagcag gtgaagcaca 15121 cggacatgga gtcgcaggac tacgagttct acaagggcct cgactatctg atgaagaacg 15181 acatctccac cctgggctac gagctgacct tctccacgga ggtgcaggag ttcggtgtca 15241 cccagatccg tgatctcaag ccaaacggac gcgacaccgc ggtgaccgag gaaaacaagt 15301 tcgagtatgt gcagctggtg tgccagctga agatgagcgg ctccattcga cagcaattgg 15361 acgcattcct cgagggcttc tacgacatta ttccaaagca tttaatttcg atattcaacg 15421 aacaggaact ggaacttctc atatccggcc tgccggatat tgacattgaa gatctaaagg 15481 cgaacaccga gtaccacaag tacacctcca aatcggccca gattcaatgg ttctggcgtg 15541 cattgcgcag cttcgaccaa gcggaccggg ccaagttcct gcagttcgtc actggcacat 15601 cgaaggtgcc gctgcagggc ttcggctccc tggagggcat gaacgggatt cagaagttcc 15661 aaatccatcg ggacgatcgg tccactgatc gattgccctg tgcacacacc tgcttcaacc 15721 aactggatct tccgatgtac aagtcatacg acaaactgcg gagctgcttg ctgaaggcca 15781 tacacgagtg ctccgagggc tttggcttcg cctaagcggg aacatcagtg gctttcggtc 15841 ctccagcctc cagcgaggcc agccaaccaa gcagccagga acccatggac gcaactctat 15901 tcctagttcg cccaattcac gggcgacacg acgagaaatg cataattgat ttgaacagaa 15961 cagaacagcc actgctaatt tgcgatagcg gcaacagaaa ctgcatacat acacagtaca 16021 tatagttata tagtatatat aaaaatgttg aattaattat taattttcgc gcctatatat 16081 atacaatata tattttctta aattttcaaa agaaaacgga aaaaagtcta aggaaaccta 16141 caaaaaaaaa ataagataca aacgcgaaac agcatattcg atttaaattt gtctgcgtaa 16201 ctcatcccta ttatatattt tctcggaatc tatccctgtc gttttgcaca ttttcattaa 16261 aacaaaagga tttatataaa aaaacataca caatttgaca tatttttatt tacctaaaca 16321 cgaaaccgaa tagcaaagga ttaaacgtag tctatagaac gcaaatgcaa atgcacataa 16381 acagatttct tgtttactta agtgaattta ccgaagatga gacggggagg cagcggaaat 16441 aattaaatgg attaaagtat ttcgatgtaa gagataagtc cttatgttat gcattttatg 16501 tttacctttg gaataatgag ccgcagatgt aacttaaaga atgtggaata aagtaagagt 16561 aagctcattt atcaaaata