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E3 ubiquitin-protein ligase HUWE1 isoform X2 [Drosophila


LOCUS       XP_070075103            5121 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_070075103
VERSION     XP_070075103.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070219002.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5121
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..5121
                     /product="E3 ubiquitin-protein ligase HUWE1 isoform X2"
                     /calculated_mol_wt=553109
     Region          90..326
                     /region_name="DUF908"
                     /note="Domain of Unknown Function (DUF908); pfam06012"
                     /db_xref="CDD:428721"
     Region          622..976
                     /region_name="DUF913"
                     /note="Domain of Unknown Function (DUF913); pfam06025"
                     /db_xref="CDD:461803"
     Region          1454..1493
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          1734..1806
                     /region_name="WWE"
                     /note="Domain in Deltex and TRIP12 homologues. Possibly
                     involved in regulation of ubiquitin-mediated proteolysis;
                     smart00678"
                     /db_xref="CDD:128922"
     Region          3672..3702
                     /region_name="UBM"
                     /note="Ubiquitin binding region; pfam14377"
                     /db_xref="CDD:464159"
     Region          3721..3748
                     /region_name="UBM"
                     /note="Ubiquitin binding region; pfam14377"
                     /db_xref="CDD:464159"
     Region          4766..5119
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4770,4800,4811,4872,5046,5082..5083,5086..5090,5110,
                     5118)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4900,4903..4904,4906..4907,4910,4917,4919,
                     4923..4924,4926,4931,4936,4953,4957)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..5121
                     /gene="HUWE1"
                     /coded_by="XM_070219002.1:468..15833"
                     /db_xref="GeneID:108068620"
ORIGIN      
        1 mkvdtvklkk gsseltaecr elideltkrr traellefld tihvwiygkc elyhwieild
       61 rfdkileeas rhvnanefvl qcdtnfqetd vtlllhvlnf ttlliehsfs rhlynsiehl
      121 tvllssqnmd ivlavlnlly mfskrsnfip rlpfekkell ivklfniaer wgdpnyglsl
      181 kdccigepkl eflyqlcidy vdehghaaql eipdmmdlch tasapevikt iagqiskpse
      241 aikmriahrv rlisgfnnyk lrlqfvqarl qavsiliysn alqdntdkvl yagfgeelce
      301 lidkedvhlv eiraavlrtl tsmlhfdrnp nvpragsrlm kivhytgaer qggtlpllvr
      361 dcidnltthg lteryplila tslfsllyhl asyemggsal vksgmmqsll cviswpgvdl
      421 ehitfvtrav rvidlitnid iarfhqnngl nvfidrleke ikscckalad igitlkestl
      481 rddhkldnsl eqvdddveet gentsvasgg gsprrenssd gltgagssay rayhehsggg
      541 agsgaglldi ggarsagggs sggasaapii glinrdgsaa rppaimyptn syyarplaer
      601 kaelssqlps slapkkpscv tqraallksm lnflkksiqd hahfsnmrni metsltqslr
      661 hiianaeyyg pslfllatdv vtvyvfneps llsslqdlgi tsvmlkallq kdvpatrevl
      721 gslpnvfsal clnerglfef lsydpfdkvl kvllspdylv amrrrrssdp lgdtatnlgn
      781 amddlikhhp ylradateai vrllnelvrl gsdpsficwr ankessgsgs gsgshggggs
      841 hhvastpspm avmvagsggs tsvlqgaadt ndssgddddd ddemssasqq qqqsggattp
      901 rtqqpgggva tpqavkvvtp pereaiplid yilnvmkfie aifsnspngd hcrefvlhgg
      961 lkpilqllsl pnlpvdspvs ttsqavanvc kailsqaqet kvldvalkql adivaqlkpl
     1021 ikhftfpggs vllaelvccq rledgfanae ytpilhnmsf vhgyvvmlvh lcrnasndmr
     1081 aillkrwgvn retgvqllqq lvqlyislvw estillnlcs deptqhpdli wdeiaaqmsa
     1141 aagtadplte aelsrklera aefrtkyspe eqfryiksll aassrlgral aellgtlvkl
     1201 svgspqtrqr rindlisnin kvptpearei arilssilvn gfshesilpk pvpklkltfl
     1261 icsvgftgpm lfddkrsafh lmisqfcaen glkaffemfy walsldnvsq kfdfdqwasm
     1321 edlmqshedd krdcpegtge fldawlqlle kmvnpramld spytmsprln ylpdsvpfep
     1381 vfylihihql amqalrriwa rrpipnygps mfetmililk hlikshqtll dryhtrmkei
     1441 kfenlyirst ddglnadhik tltdmgfmhy hviealrtna sleeatdyll nnpeasalst
     1501 ttggsaappp ppppppstmd idmdlpadgg eksssssans sydykhlklm psiifdrfcd
     1561 eaisrafefm eaipdtvnsa adliavlyrr hnhlnkqvfv tnfvrniiqw vdftlqlfep
     1621 sktaaskasr leecltglta trlfvrlkts trlleenysd lhrplveait aqdamvslvk
     1681 lldcmsqwml eqsvdsratv prwvqnlvdl idsidsishi lqrkanmrav ssevwrwyda
     1741 stgkwnayse annelirnay aagerwlhin igrqrctvsl ncmtqvseas gthrpvcpal
     1801 klseaitaln spvslhkveh llnrvvrtsp dgsgtvhsde lislrqlinf sdgqqpqenp
     1861 aneegtneds gsplaamttr sksrqksaaa aaaaqkksss hgsppipkrt qkiilneeqv
     1921 glskfdcgri igsivdllqp shlmlnetkl sllrlcarlt rnydnaqvfi rrggvkmllh
     1981 lqqacsfmgf ptyaniilrh vleappvlqe amervlgmra agivpvghrd liyvltqvss
     2041 avsrnpqifv aaakemlkge yllntnsttl addarvmvks kfgqqptaaa ggatpnsqts
     2101 tppdeqlkdd pqvqssvavl kdllhglvqp cwhyggtgsl drgpgaaell qpdqppgtaa
     2161 qgghdeelyf rfqetpapas skkqssggga sagqpqttek fepccctwhi ptsghthakp
     2221 tisratllkl ladstrayqs lvprvllshi ytpadsplis apqqtflgvl ldrflpitqr
     2281 hhvpevstmt rvlicslsdc yqqpgvqvhv aeelhaavar alaqpdsaek htrlqvlmsl
     2341 fpnliespml ydkvhmhrnn myrvllrqgv mtyltkvaqy kdlsnhntls tlaailrpme
     2401 illrfsvstt tlgskrilfg gggggaggan gagsgnsavg ggsgtgpgsg ntygtiinrr
     2461 lyprlaarta vsaaversna mggehvlrdi irnvlsdrrh afefifnsde mavdsedsaa
     2521 pavggngsga ggigaggsga avidvveers nggdtsdppg nvnsgsgtga vqsstsggpv
     2581 rpvlnfdqlw ddflqseglr lasrsgggag sgagstgags tgqqnggnat ggsansgsns
     2641 vsgdprlrtn pdvdvggggn gggqssnsgv vndngigggg gsdgastssd tgapggerrd
     2701 lnasllgdvs tsesdsdast enderneede dedddapded vdehsetdvd eerprqfiev
     2761 fdhiyepess etasndadvd ndddddeded dvddddddde dnddedreeg qsvmdaelen
     2821 qidialalvs snnrprrsaa vnasgdasan rdpnpdeevd dedddvdadp dgdpdvdpig
     2881 gpsaaqaeay lyerlgsglm ptppvgfrvr mnssiaqpld idvnggnggg gsggsgagvt
     2941 gtaggsgrgs ssggttasig aiasaalrps sgswmapdfn figvsgggga sgsggasgsn
     3001 anggevnafl tpamsqlers ggasgsgqnm snlldeqpsv sgnggggggs gggsasgngg
     3061 vsggggangg gtagqhpnat lcangvrrrl lyldqqycvc mpthqnptee tqmetftqda
     3121 lhwwleeatv ldmesqtdac lyaahfllph likelktahq qrkqeeaarq tatntttpas
     3181 sasssagapa tsilsntaap tatasiassl lanavaagsg gssssgsglv vppvaasatg
     3241 gtrrssipvl ipssfggpgs attgdatatt ggttssssyt ttsisgsgsl esqtttrapr
     3301 qrgglrqhsq lpfniyaeid ltneqdsqga tstgsapndg aesqaqqpqq qqqqqnssap
     3361 slaqgavlqh qrhppvpllp ssgrpsrphs rldeaellll qladrqavrs rlqvssghtn
     3421 ssrtsgsali narpnrdlpa rlqrlvqahg slssrinasa astpaptlvs mptpmssaal
     3481 eqlnvtpagp dvvgpdrnfa lppslevdvd vlpgildril pqqqqeqqea qqqeeeeeql
     3541 llpppppppp setaplllte edmwqgtree eedststvav agsseaanes nqsdqtpess
     3601 esvspnpqap ppaaesgegg aggaggaasa stqtpataee savggttata tttaatvtdm
     3661 spevraalgd levpegvdps flaalpsemr eeviqehlrm qrirqraqqn aiqiahdslv
     3721 evnpeflaal plniqsevlm qqrieqqrqa aqtanpedpv dtaaffqnlp enlrqailtd
     3781 meesqiaslp pelaaeaqfl rrdwesrnga rmdahppsna lsrfqttlqs ldearwhssi
     3841 wydasgnaqp qhhqhttivh hhahahhapt mgkplallmm edenilldpd slatlllflf
     3901 vedqkvnsmr lhrvirnlch heptrdwiis alisivqktn ednanfgagq aggkpewlkl
     3961 rvdaafgyks niflinrlye gsarsisinp qaaqmivrnc ldllfvlakh ypssfvpfnr
     4021 evkarrilsa vfgmpsptgg astagagapa rniddfpppg gtldfrsrfc ryqvanrlrg
     4081 ilddhpaaap kpqsatplde apstskaaaa kaaatakvss qssqsvpyqt naknfwdvvl
     4141 nidrqtqvrl anvaqfplts qpawewqans adflsfsdsp fgqllemlpy kvicrsphlt
     4201 dmlvkllasl stelpkeeeq lplsdqmptl ipinqaaaaa adspanpsei gdglaanveq
     4261 eatpasgnpa sgdsnaaakr tqlptlsval pvapskprrk iysknfsqlq lvievlthqc
     4321 gttegldnva klivnltqcs qasnaifiqy ltaailglae evrqaiqmll neirmynshh
     4381 gvtastsgaa aagatvsgas llpnlavheg imqdrftaeh viisapknak ptcelqlpsm
     4441 kklmsnssaq pyflrtlkif mqvrdmyeaq nglstgggla gaagdndddi idiegdggas
     4501 ggsssdmapg sastispppp ppmetnqnin deeededgee eeddddaara spaaasagks
     4561 skptlsqilc ldvlwhtlse clvaleeskd efavlvlqpt veafflihas hragakksgr
     4621 ggvvgsglra agglgaaasa aqehspsmdd tssantlssa sfedeprmqd astntplssn
     4681 ssaattvlsa heaqlrqdrq kflqfaekhr tvlnqilrqs pthlsdgpfa vlvdhtrild
     4741 fdvkrkyfqt elerldegir reehtvsvrr vtvfedsfrv lyrlgpeewk nrfyivfede
     4801 egqdaggllr ewyviisrei fnpmyalfcv spgdrvtymi npsshanpnh lsyfkfvgrv
     4861 iakavhdnkl lecyftrsfy khilgkqvkh tdmesqdyef ykgldylmkn distlgyelt
     4921 fstevqefgv tqirdlkpng rdtavteenk feyvqlvcql kmsgsirqql daflegfydi
     4981 ipkhlisifn eqelellisg lpdidiedlk anteyhkyts ksaqiqwfwr alrsfdqadr
     5041 akflqfvtgt skvplqgfgs legmngiqkf qihrddrstd rlpcahtcfn qldlpmyksy
     5101 dklrscllka ihecsegfgf a