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LOCUS XM_070219002 16597 bp mRNA linear INV 09-DEC-2024 containing E3 ubiquitin protein ligase 1 (HUWE1), transcript variant X4, mRNA. ACCESSION XM_070219002 VERSION XM_070219002.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..16597 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..16597 /gene="HUWE1" /note="HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 Protein" /db_xref="GeneID:108068620" CDS 468..15833 /gene="HUWE1" /codon_start=1 /product="E3 ubiquitin-protein ligase HUWE1 isoform X2" /protein_id="XP_070075103.1" /db_xref="GeneID:108068620" /translation="MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTIHV WIYGKCELYHWIEILDRFDKILEEASRHVNANEFVLQCDTNFQETDVTLLLHVLNFTT LLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELL IVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDL CHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSIL IYSNALQDNTDKVLYAGFGEELCELIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPR AGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHGLTERYPLILATSLFSLLYHLAS YEMGGSALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNIDIARFHQNNGL NVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDNSLEQVDDDVEETGENTSVAS GGGSPRRENSSDGLTGAGSSAYRAYHEHSGGGAGSGAGLLDIGGARSAGGGSSGGASA APIIGLINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQRA ALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVVT VYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFEF LSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADATE AIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGGSHHVASTPSPMAVMVAG SGGSTSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQSGGATTPRTQQPGGGVATPQA VKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDHCREFVLHGGLKPILQLLSLPN LPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGGS VLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRAILLKRWG VNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPDLIWDEIAAQMSAAAGTAD PLTEAELSRKLERAAEFRTKYSPEEQFRYIKSLLAASSRLGRALAELLGTLVKLSVGS PQTRQRRINDLISNINKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLIC SVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFDFDQWASM EDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYLPDSVPF EPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHTR MKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDYLLNNPE ASALSTTTGGSAAPPPPPPPPPSTMDIDMDLPADGGEKSSSSSANSSYDYKHLKLMPS IIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQVFVTNFVRNIIQW VDFTLQLFEPSKTAASKASRLEECLTGLTATRLFVRLKTSTRLLEENYSDLHRPLVEA ITAQDAMVSLVKLLDCMSQWMLEQSVDSRATVPRWVQNLVDLIDSIDSISHILQRKAN MRAVSSEVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLHINIGRQRCTVSLNCMT QVSEASGTHRPVCPALKLSEAITALNSPVSLHKVEHLLNRVVRTSPDGSGTVHSDELI SLRQLINFSDGQQPQENPANEEGTNEDSGSPLAAMTTRSKSRQKSAAAAAAAQKKSSS HGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHLMLNETKLSLLRLCAR LTRNYDNAQVFIRRGGVKMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERVL GMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLLNTNSTTLADDA RVMVKSKFGQQPTAAAGGATPNSQTSTPPDEQLKDDPQVQSSVAVLKDLLHGLVQPCW HYGGTGSLDRGPGAAELLQPDQPPGTAAQGGHDEELYFRFQETPAPASSKKQSSGGGA SAGQPQTTEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVLLS HIYTPADSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCYQQPGV QVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYRV LLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGGG GGGAGGANGAGSGNSAVGGGSGTGPGSGNTYGTIINRRLYPRLAARTAVSAAVERSNA MGGEHVLRDIIRNVLSDRRHAFEFIFNSDEMAVDSEDSAAPAVGGNGSGAGGIGAGGS GAAVIDVVEERSNGGDTSDPPGNVNSGSGTGAVQSSTSGGPVRPVLNFDQLWDDFLQS EGLRLASRSGGGAGSGAGSTGAGSTGQQNGGNATGGSANSGSNSVSGDPRLRTNPDVD VGGGGNGGGQSSNSGVVNDNGIGGGGGSDGASTSSDTGAPGGERRDLNASLLGDVSTS ESDSDASTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERPRQFIEVFDHIYEPESS ETASNDADVDNDDDDDEDEDDVDDDDDDDEDNDDEDREEGQSVMDAELENQIDIALAL VSSNNRPRRSAAVNASGDASANRDPNPDEEVDDEDDDVDADPDGDPDVDPIGGPSAAQ AEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNGGGGSGGSGAGVTGTAG GSGRGSSSGGTTASIGAIASAALRPSSGSWMAPDFNFIGVSGGGGASGSGGASGSNAN GGEVNAFLTPAMSQLERSGGASGSGQNMSNLLDEQPSVSGNGGGGGGSGGGSASGNGG VSGGGGANGGGTAGQHPNATLCANGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFTQ DALHWWLEEATVLDMESQTDACLYAAHFLLPHLIKELKTAHQQRKQEEAARQTATNTT TPASSASSSAGAPATSILSNTAAPTATASIASSLLANAVAAGSGGSSSSGSGLVVPPV AASATGGTRRSSIPVLIPSSFGGPGSATTGDATATTGGTTSSSSYTTTSISGSGSLES QTTTRAPRQRGGLRQHSQLPFNIYAEIDLTNEQDSQGATSTGSAPNDGAESQAQQPQQ QQQQQNSSAPSLAQGAVLQHQRHPPVPLLPSSGRPSRPHSRLDEAELLLLQLADRQAV RSRLQVSSGHTNSSRTSGSALINARPNRDLPARLQRLVQAHGSLSSRINASAASTPAP TLVSMPTPMSSAALEQLNVTPAGPDVVGPDRNFALPPSLEVDVDVLPGILDRILPQQQ QEQQEAQQQEEEEEQLLLPPPPPPPPSETAPLLLTEEDMWQGTREEEEDSTSTVAVAG SSEAANESNQSDQTPESSESVSPNPQAPPPAAESGEGGAGGAGGAASASTQTPATAEE SAVGGTTATATTTAATVTDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHL RMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANP EDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMDA HPPSNALSRFQTTLQSLDEARWHSSIWYDASGNAQPQHHQHTTIVHHHAHAHHAPTMG KPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIIS ALISIVQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISI NPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNREVKARRILSAVFGMPSPTGGASTAGA GAPARNIDDFPPPGGTLDFRSRFCRYQVANRLRGILDDHPAAAPKPQSATPLDEAPST SKAAAAKAAATAKVSSQSSQSVPYQTNAKNFWDVVLNIDRQTQVRLANVAQFPLTSQP AWEWQANSADFLSFSDSPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEEQ LPLSDQMPTLIPINQAAAAAADSPANPSEIGDGLAANVEQEATPASGNPASGDSNAAA KRTQLPTLSVALPVAPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNL TQCSQASNAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNSHHGVTASTSGAAAAGA TVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPY FLRTLKIFMQVRDMYEAQNGLSTGGGLAGAAGDNDDDIIDIEGDGGASGGSSSDMAPG SASTISPPPPPPMETNQNINDEEEDEDGEEEEDDDDAARASPAAASAGKSSKPTLSQI LCLDVLWHTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRAGAKKSGRGGVVGS GLRAAGGLGAAASAAQEHSPSMDDTSSANTLSSASFEDEPRMQDASTNTPLSSNSSAA TTVLSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFD VKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDE EGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVG RVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLG YELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFL EGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRAL RSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFN QLDLPMYKSYDKLRSCLLKAIHECSEGFGFA" misc_feature 735..1445 /gene="HUWE1" /note="Domain of Unknown Function (DUF908); Region: DUF908; pfam06012" /db_xref="CDD:428721" misc_feature 2331..3395 /gene="HUWE1" /note="Domain of Unknown Function (DUF913); Region: DUF913; pfam06025" /db_xref="CDD:461803" misc_feature 4827..4946 /gene="HUWE1" /note="UBA domain-like superfamily; Region: UBA_like_SF; cl21463" /db_xref="CDD:473871" misc_feature 5667..5885 /gene="HUWE1" /note="Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; Region: WWE; smart00678" /db_xref="CDD:128922" misc_feature 11481..11573 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 11628..11711 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 14763..15824 /gene="HUWE1" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(14775..14777,14865..14867,14898..14900,15081..15083, 15603..15605,15711..15716,15723..15737,15795..15797, 15819..15821) /gene="HUWE1" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(15165..15167,15174..15179,15183..15188,15195..15197, 15216..15218,15222..15224,15234..15239,15243..15245, 15258..15260,15273..15275,15324..15326,15336..15338) /gene="HUWE1" /note="E2 interaction site [active]" /db_xref="CDD:238033" polyA_site 16597 /gene="HUWE1" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 catttgcctt caatttgcca aaaagaataa acgccagcgc ctatcgatag ccatcgatag 61 gcagagtcga ttgcaattct tcgttgccgt ggattggagc ggtgcgtggt cacactaatg 121 cttgcatttt ttttgtctgt ggaaatttca tttcacaaaa accgagatag ttaaattaac 181 caaattatag cgtttcagat cgaaataaca atagcagcaa tatgctgcag ttaaatataa 241 tttttattga acacgctgac gtatacgttt aaaccgcaac tcgatgccca acctataaac 301 aatcgacgcc cgacgccttt tcaccacgaa ccacccaatc tacacaagcc gcccactcga 361 caaacagccg gaggaagagg aggaggagga ggaggaagga ggaggagcac caccacccca 421 agtggtggcc acctgctgct ccattagctc cactagctcc acgaacaatg aaggtggaca 481 cggtgaagct gaagaagggc tcctcggagc tcaccgccga gtgccgcgag ctcatcgacg 541 agctcaccaa gcggcggacg cgggccgagc tgctcgagtt cctcgacacc atccacgtct 601 ggatctacgg caagtgcgag ctctaccact ggatcgagat cctcgaccgg ttcgacaaga 661 tcctcgagga ggcgtcgcgc catgtcaacg ccaacgagtt cgtgctgcag tgcgacacca 721 atttccagga aacggatgtc acactgctgt tgcacgttct taacttcacc acactgctga 781 tcgagcactc gttctcgcgg cacctctaca actccatcga acacctgacg gtgctgctct 841 cctcccagaa catggacatc gtcctggccg tcctcaatct gctgtacatg ttctccaagc 901 gcagcaactt cataccccgc ctgccgttcg agaagaagga actgctgatt gtcaagctgt 961 ttaacatagc cgagcgctgg ggcgatccca actacggact gtcgctcaag gactgctgca 1021 ttggcgagcc gaagctggaa ttcctttacc agctgtgcat cgactatgtg gacgagcacg 1081 gtcatgccgc ccagctggaa atcccggaca tgatggacct ctgccacacg gcgtccgcgc 1141 ccgaggtgat caagacgatt gccggacaga tctcaaagcc cagcgaggca atcaagatgc 1201 gcattgctca tcgggtgcgc ttgatctcag gcttcaacaa ctacaagctg cgcctccagt 1261 tcgtccaggc tcgcctgcag gccgtctcca ttctgatcta ctcgaatgcc ctgcaggaca 1321 acacggacaa ggtgctgtat gccggcttcg gcgaggagct gtgcgagctg atcgacaagg 1381 aggacgtgca tctcgtggag atacgggcgg cagtgctgcg cacactcacc tcgatgctgc 1441 actttgaccg caatccgaat gtgcccaggg ccggttcgcg actgatgaag atcgttcact 1501 acacaggagc cgagcggcag ggcggcactt tgccactgct ggtgcgcgac tgcattgata 1561 atttaaccac ccatggactc accgaacgct acccgctcat cctggccacg tcactcttct 1621 cgctgctcta ccatttggcc agctacgaaa tgggcggctc tgctctggtc aaaagcggca 1681 tgatgcagtc cctcctgtgc gtcatcagct ggccgggagt cgacctcgag cacattacgt 1741 tcgtgacgcg ggcggtgcgg gtgatcgacc tgataaccaa catagatatc gcacggttcc 1801 atcagaacaa cggactcaac gtgttcattg accgtctgga gaaggagatc aagagctgct 1861 gcaaggcact ggccgacatt ggcatcacgc tgaaggagtc gacgctgcgc gatgaccaca 1921 agttggataa ctcgctggag caagtggacg atgatgtgga agagaccgga gagaacacgt 1981 ccgtggccag tggaggtgga tcgccgcgtc gcgagaactc gagtgacggg ctcaccggtg 2041 ccgggagcag cgcctacaga gcctatcacg agcacagtgg aggaggagcg ggctcaggag 2101 cgggactcct ggacattggt ggagcacgca gcgcaggagg aggatcatcg ggtggtgctt 2161 cagccgcacc gatcattgga ttaatcaacc gggacggaag tgccgctcgt ccgccggcca 2221 tcatgtaccc cacaaacagt tactacgccc gtccgctggc cgagcgcaag gcggagctct 2281 cctcgcagct gccgagcagc ctggcgccga agaagccctc ctgcgtcacc cagcgggcgg 2341 cgctgctcaa gtcgatgctg aatttcctga agaagagcat ccaggatcat gcgcacttta 2401 gcaacatgcg caacatcatg gagaccagct taacgcagtc gcttcgccac atcatagcca 2461 atgcggagta ctacgggccg tcgctcttcc tgctggccac cgatgtggtc accgtgtacg 2521 tgttcaacga gccctcgctg ctctcctcgc tgcaggatct gggcatcacg agtgtcatgc 2581 tgaaggcgct gctccagaag gatgtgccgg ccacgcggga agtgctgggc tccctgccga 2641 atgtcttttc cgccctgtgc ctgaatgagc gtggcctttt tgagttcctc tcctatgatc 2701 cttttgacaa ggtgctgaag gtgctgctct cgccggacta tctggtggcc atgcgcaggc 2761 gccgctcctc ggatccgctg ggcgatacgg ccaccaattt gggcaatgcc atggacgatc 2821 tgatcaagca tcatccgtat ttgcgagccg atgccacgga ggcgattgtg aggcttttga 2881 atgagctggt tcgccttggt tccgatccca gtttcatttg ctggcgggcc aacaaggaga 2941 gcagtggctc tggctcgggt tcaggcagcc atggcggcgg cggttcgcat cacgtggcct 3001 ccacaccctc gcccatggcc gtcatggtgg ctggctcggg aggatcgacg tcggtgctcc 3061 agggagccgc ggatacgaac gacagcagcg gcgacgatga cgacgatgat gatgaaatga 3121 gctcggcttc gcagcaacag cagcaaagtg gaggagccac cacacccagg acgcaacaac 3181 caggaggagg agtagccacc ccgcaggccg tcaaggtggt gacgcccccg gaacgagagg 3241 caatacccct aatcgactat atcttgaatg tgatgaagtt catcgaggcg attttcagca 3301 acagtccgaa tggcgatcac tgccgggagt ttgtcctcca cggcggacta aagcccattc 3361 tgcaactgct gtcgctgccc aatctgccgg tggattcacc cgtttccacc acctcacagg 3421 cggtggccaa tgtctgcaag gccatactca gccaggcgca ggaaacgaag gttctcgatg 3481 tggcgctcaa gcagctggct gatattgtgg cccagctgaa gccgctgatc aagcacttta 3541 cctttcccgg cggcagtgtc ctcctcgcag agctcgtctg ctgtcagcgg ctggaggatg 3601 gcttcgccaa tgccgaatac acaccgatac tgcacaacat gagctttgtg cacggctatg 3661 tggtgatgct ggtgcatctc tgtcgcaacg cctccaacga catgcgagcg attctgctca 3721 agcgttgggg cgtcaatcgc gagactggag tgcaattgct gcagcagctg gtccagctgt 3781 acatttcgct ggtgtgggag agcaccatac tgctgaatct ctgctcggat gagcccaccc 3841 agcatccgga tctcatttgg gacgagattg cggcccagat gtcggcggca gcgggcaccg 3901 cggatcccct gaccgaagcg gagctctcgc ggaagctgga gcgtgcggcg gaattccgga 3961 cgaagtactc gcccgaggag cagttccggt acatcaaatc cctgctggcg gcgagctctc 4021 ggctcggcag ggcgctcgcc gagctgctgg gcacgctggt gaagctatcg gtgggttcgc 4081 cgcagacgcg acagcgacgc atcaacgatc tgatcagcaa tatcaacaaa gttcctacgc 4141 ccgaggctcg cgaaatagcc cgcatcctca gctcgattct ggtgaatggc ttcagtcacg 4201 agagcattct accgaagcct gtgcccaagt tgaagctcac cttcctcatc tgctcggtgg 4261 gattcaccgg tccaatgctg ttcgacgaca agcgcagcgc ctttcacctg atgatatcgc 4321 aattctgcgc agagaatgga ttgaaagcct tctttgagat gttctactgg gcgctgtcgc 4381 tggataatgt ctcgcagaag ttcgatttcg atcagtgggc ctcgatggag gatctgatgc 4441 agtcgcacga ggacgacaag cgcgattgcc ccgagggcac gggcgagttt ctcgacgcct 4501 ggctgcagct gctcgagaag atggtgaatc cgcgtgccat gctcgattcg ccgtatacga 4561 tgagtccgcg gctgaattac ctgcccgatt cggtgccctt cgagccggtc ttttacctca 4621 ttcacatcca ccagctggcc atgcaggcac tgcgcaggat ctgggcacgt cgcccgattc 4681 ccaactatgg acccagtatg ttcgagacca tgatactgat cctgaagcat ctgatcaagt 4741 cgcatcaaac gctgctcgat cgctatcaca cgcggatgaa ggagatcaag ttcgagaacc 4801 tctacatccg cagcacggac gatggcctaa atgcggatca catcaagacg ctgacggaca 4861 tgggcttcat gcattaccac gttattgagg ctctccgcac gaatgcctcg ctggaggagg 4921 ccaccgatta tctgctgaat aacccagaag ccagtgcttt gtccacaacg actggtggtt 4981 ctgctgctcc tccgccgccg ccaccgccac cgccttccac catggacatt gacatggatt 5041 tgccagcgga tgggggagag aaatctagct ctagttcggc gaactccagc tatgactaca 5101 agcacctcaa actgatgccg tcgatcatct tcgatcgctt ctgcgacgag gccatttcgc 5161 gggcctttga gttcatggag gccattccgg atacggtgaa cagtgccgca gatctgatag 5221 ccgtgctgta tagacgccac aatcacctga acaagcaggt ctttgtgacc aactttgtgc 5281 gcaacattat ccagtgggtg gactttaccc tgcagctctt tgaaccatcg aaaacggcag 5341 cgtcgaaggc ttcgcggttg gaggaatgct tgacgggatt gacggccacc cggttgtttg 5401 tgcggctcaa gacatcgacg cggctgctcg aggagaacta cagtgatttg catcgtccgc 5461 tggtggaggc aataaccgcc caggatgcca tggtgtcgct ggtcaagctg ctcgactgca 5521 tgagccagtg gatgctggag caatcagtgg attctagggc tacggtcccc cgatgggtgc 5581 agaacctggt ggatctaatc gattcgatcg acagcatcag ccacattctg cagcgcaagg 5641 ccaacatgcg ggcggtgagc agcgaggtgt ggcgctggta cgacgcctcc acgggcaagt 5701 ggaatgccta ttcggaggcc aacaatgagc tcattcggaa tgcctatgcc gccggcgagc 5761 ggtggctgca cattaacatc ggcaggcaaa ggtgtacggt gagcctgaac tgcatgacgc 5821 aggtgagcga ggcatccggc acacatcgtc ctgtttgtcc ggctctcaag ctcagtgaag 5881 ccatcactgc gctcaacagt cccgtgtcgc tgcacaaagt ggagcatctg ctgaaccgcg 5941 tggtgcgaac ctcacccgat ggctcgggaa ccgtgcattc cgacgaattg atttccctgc 6001 gccagctgat caacttttcg gatggtcagc agccgcagga gaacccggcg aatgaagagg 6061 gaacaaatga agatagtgga tctcctctgg ccgccatgac cacgcgcagc aagtcgcggc 6121 aaaagagcgc cgccgctgca gccgctgccc agaagaaatc ctcgtcgcat ggctcaccgc 6181 ccatacccaa acgcacccag aagatcatac tcaacgagga gcaggtggga ctgagtaaat 6241 tcgactgcgg tcggataatt ggcagcattg tggatctcct gcagccttcg catctcatgc 6301 tcaacgaaac gaagctttcg ctgctgcggc tgtgtgcaag attaacccga aactacgaca 6361 atgcccaggt gttcatccgg cggggcggcg ttaagatgct gctgcatctg cagcaggcct 6421 gcagcttcat gggcttcccc acctatgcga atatcatact gcgtcacgtg ctcgaggcgc 6481 cgccggtgct gcaggaggcc atggaacgag tgctgggcat gcgggcagcc ggcattgtgc 6541 ccgtggggca tcgggatcta atctatgtac tcacccaggt atcctcagcg gtttcgcgca 6601 atccgcagat ctttgtggcc gccgccaagg agatgctcaa gggagagtac ctcctgaaca 6661 cgaacagcac gacgctggcg gacgatgcgc gggtgatggt caagtccaag tttggtcaac 6721 aaccgacggc agcggctggc ggagccacgc caaattcgca gacgtccacg ccgccggatg 6781 agcagctcaa ggacgatccc caggttcagt catcggtggc tgtgcttaag gatctactgc 6841 atggattggt gcagccctgc tggcactacg gcggcacggg atccttggat cgcggccctg 6901 gcgccgccga gctgctgcaa ccggaccagc caccgggaac ggccgcccag ggaggccacg 6961 acgaggagtt gtatttccgc ttccaggaaa cccccgcacc tgcgagcagc aagaagcaat 7021 cctcaggagg aggagcatct gctgggcagc cacagacgac ggagaagttc gagccctgct 7081 gctgcacgtg gcacatcccg accagcggcc acacgcacgc caagccgacc atttcgcggg 7141 cgacgctgct caagctgctg gcggattcaa cgagggccta tcagtcttta gtgccccgcg 7201 tgctgctatc ccacatttac acgcccgccg acagtccgct gatctcggcg ccgcagcaga 7261 cgttcctggg cgtcctcctc gatcgctttc tgcccatcac gcagcggcat catgtgcccg 7321 aggtgagcac gatgacgagg gtgctcattt gctccctttc tgactgctac cagcagccgg 7381 gagtccaggt ccatgtggcc gaggagctgc acgcggcggt ggccagggct ttggcccaac 7441 cggactcggc ggagaagcac acgcgactcc aggtgctgat gagcctgttt cccaatctca 7501 tcgagtcgcc gatgctgtac gataaggtgc acatgcatcg caacaacatg taccgagtgc 7561 tgctgcgcca gggagtgatg acctacctga ccaaggtggc ccagtacaag gatctgtcca 7621 atcacaacac gctgagcact ctggcggcca tcctgcgacc catggagatc ttgctgaggt 7681 ttagtgtgtc caccacaacg ctcggatcga agaggattct ctttggcggc ggcggcggag 7741 gagctggcgg agcaaatgga gcagggagcg ggaacagtgc tgtcggagga ggcagtggaa 7801 ctggcccggg atcgggcaat acatatggaa ccatcatcaa tcgtcggcta tatcctcgtt 7861 tggccgcccg caccgcagtc agtgcggccg tggagcgatc caatgcgatg ggtggcgagc 7921 atgtgctgcg cgacattata cgcaatgtgc tctccgatcg gcggcacgcc tttgagttta 7981 tcttcaactc ggacgagatg gccgtggact cggaggactc ggctgccccg gcggtgggtg 8041 gtaatggatc gggagcaggc ggaataggag caggaggatc aggagcagcc gtcatcgatg 8101 tggtggagga gcgcagcaat ggcggggata ccagcgatcc cccaggtaat gtaaactccg 8161 gatctggaac gggcgcagtt caatcttcaa ccagtggagg tcccgtgcgg ccagttctga 8221 actttgacca gctgtgggac gacttcctgc agagcgaggg actgcgattg gcctcgcgga 8281 gcggcggagg cgcgggatct ggagcaggat ccacaggagc aggctcaacg ggtcagcaaa 8341 acggtggcaa tgccactggt ggctctgcaa actccggcag caattcagtc agcggagatc 8401 ctcgcctgcg caccaatccc gatgtggatg tgggcggcgg tggaaatggc ggtggtcagt 8461 catccaattc gggtgtggta aacgataatg gaattggcgg cggcggcggc agcgatggcg 8521 cctccacatc ctcggacact ggagctccgg gcggcgaacg tcgcgatttg aatgcctcgc 8581 tgctgggcga tgtcagcacc tcggaatccg attcggatgc ctccacggag aacgacgagc 8641 ggaatgagga ggacgaggac gaggatgacg atgcccccga tgaagatgtg gacgagcata 8701 gcgaaacgga tgtggatgag gaaaggccac gtcaatttat cgaggtcttt gatcacatct 8761 acgaaccgga atcctcggaa accgcttcca atgatgcgga tgtggataac gacgacgatg 8821 atgacgagga tgaggacgat gtggacgacg acgatgatga tgacgaggat aacgacgatg 8881 aggatcgcga ggagggccag agtgtcatgg atgccgagtt ggagaaccaa atagacattg 8941 ccctcgcctt ggtttcgtcc aacaatcgtc cgcgacgcag tgcagcggtt aatgcttcgg 9001 gcgatgcgtc cgccaatcga gatcccaatc ccgacgagga ggtggacgac gaggacgacg 9061 atgtggacgc cgatcccgat ggagatcccg atgtggaccc cattggcggc ccctcggctg 9121 cccaggcgga ggcctatctg tacgagcgac tgggcagcgg cctgatgccc acgccaccgg 9181 tgggtttccg cgtccgcatg aacagctcga ttgcccagcc cctggacatt gatgtgaatg 9241 gcggaaatgg cggtggtgga tctggtggat ccggagcagg cgtcactgga acggccggtg 9301 gatccggaag aggctcctcg tcgggcggaa caacggccag tattggagcc attgcctccg 9361 ctgccttgcg tccctcgtcc ggttcttgga tggcgccgga ctttaatttc attggagtct 9421 cgggcggtgg aggagccagt ggctctggag gcgcctcagg gagcaatgcc aacgggggcg 9481 aggtgaacgc cttcctcacg cccgccatgt cgcagctgga acgcagtggt ggcgcctcgg 9541 gcagtggcca aaacatgagc aatctgctgg acgaacaacc gtcggtcagt ggcaacggcg 9601 gcggaggagg aggaagtggc ggaggttccg cctctggtaa cggcggcgtc agcggtggag 9661 gaggagccaa tggcggcggt accgcaggac agcatccgaa tgccacgctc tgcgccaacg 9721 gagtgcgccg gcggttgctc tatttggacc agcagtactg cgtctgcatg cccacgcatc 9781 agaatcccac ggaagagacc cagatggaga cgttcaccca ggatgctctg cattggtggc 9841 tggaggaggc cacggtcttg gatatggaga gccagactga cgcctgcctg tacgccgctc 9901 acttcctgct gccgcatctc atcaaggagc tgaagacggc ccaccagcag cgcaagcagg 9961 aggaggccgc ccgccagacg gccacgaaca ccacaacacc tgcatcatcg gcttcgtctt 10021 cggccggagc tccggcgacc tccatcctat cgaacacagc ggccccaaca gcgacggcct 10081 ccattgcgtc cagtctactg gcgaatgccg tggccgcggg ctcaggcggc agcagcagca 10141 gcggcagcgg attggtggtg ccaccggtgg cagcctccgc cacgggaggc acccggcgca 10201 gctcgattcc cgtgctgatt ccctcgagct tcggcggtcc tggtagtgca accactggcg 10261 atgccacggc cacaacggga ggaaccacca gcagcagttc ctacacaacc acatccatta 10321 gcggcagtgg ctccttggag tcgcagacga cgactcgagc gcctcggcaa cgcggtggat 10381 tgcgccagca cagccagctg cccttcaaca tctacgcgga gatcgatctg accaacgaac 10441 aggatagcca gggcgccacg tcaacgggct ctgctccaaa cgatggagcg gaatcacagg 10501 cacagcagcc gcagcagcag cagcagcagc aaaactcctc cgctccttcg ttggcgcagg 10561 gggcggtcct tcagcatcag cgtcatccac cggtgccgct cctgccgtcc agtggaaggc 10621 cttcgcgacc tcactcgcgt ctcgacgagg cggagctgct tctgttgcag ttggccgatc 10681 gccaggctgt tcgcagtcgc ctgcaagtgt ccagcggtca cacgaattcc tcgcgcacct 10741 cgggatcggc gctgatcaac gctcggccca atcgcgatct acccgcccgc ctgcagcgcc 10801 tcgtccaggc acatggctcc ctttccagtc gcatcaatgc atccgccgcc agcacgccgg 10861 ctccgacgct cgtctccatg cccacgccca tgtccagtgc ggcgctggag cagctgaatg 10921 tcacgcccgc cggcccggat gttgtgggcc cagacaggaa ctttgcattg ccaccttccc 10981 tggaggttga tgtggatgtg ctgcctggaa tactggatcg catactgccg cagcagcagc 11041 aggagcagca ggaagcgcag cagcaggagg aggaggagga acagctgttg ctaccaccgc 11101 cacctccgcc gccgcccagt gaaacggcgc ccttgctcct caccgaggag gatatgtggc 11161 aagggacaag agaggaggag gaggattcca cttccacagt ggcagttgcc ggcagcagcg 11221 aggctgcaaa cgagtcaaac caatcggatc agacgccgga gagcagcgaa tctgtttccc 11281 cgaacccgca ggctcctccc ccagcagcag aatccggcga aggaggagca gggggagcag 11341 gaggagctgc ctcggctagc acacaaaccc cggcaaccgc agaagaatcc gctgtaggtg 11401 gaacaacagc aacagcaaca acgacagcag ccaccgtaac ggacatgagt cccgaggtgc 11461 gggccgctct cggggatctg gaggtgcccg agggcgtgga tccctccttc ctggccgccc 11521 tgcccagcga gatgcgcgag gaggtgatcc aggagcatct gcggatgcag cgcattcgcc 11581 agcgggcgca gcagaatgcc attcagattg cgcacgattc gctcgtcgag gtgaatcccg 11641 agttcctcgc cgccctgccg ctgaacattc agtccgaggt gctgatgcag cagcggatcg 11701 agcagcagcg ccaggcggcg cagaccgcga atcccgagga tcccgtcgac acggccgcct 11761 tctttcagaa cctgcccgag aatctgcggc aagcgatact caccgacatg gaggagtcgc 11821 agatagccag tttgccgccc gagttggcgg cggaggcgca gttcctgcgt cgcgactggg 11881 agtcccgcaa tggcgcccgc atggacgccc atccgcccag caatgcgttg tcccgcttcc 11941 agacgacgct gcagagcctg gacgaggccc gctggcacag ctccatttgg tacgacgcca 12001 gcggcaatgc ccagccgcag caccaccagc acaccacgat tgtgcaccac catgcccacg 12061 cacatcacgc ccccacgatg ggcaaacccc tagccctgct gatgatggag gacgagaaca 12121 tcctgctcga tccggactcg ctggccaccc tgctgctctt cctgttcgtc gaggatcaga 12181 aggtgaacag catgcggctg catcgtgtga ttcgcaacct ttgccaccac gaacccacgc 12241 gcgattggat catcagcgct ctgattagca tcgtccaaaa gaccaacgag gataacgcca 12301 actttggagc tggacaggcg ggcggcaaac cggagtggct gaagctgcgc gtggacgccg 12361 cctttggcta caagagcaac atcttcctca tcaatcggct gtacgagggc agtgcgcgga 12421 gcatcagcat caatccgcag gccgcacaga tgatagtgcg caactgtctg gatctgctct 12481 tcgtgctggc caagcactat ccgtccagct ttgtgccctt caaccgcgag gtgaaggcca 12541 ggcgcatact gagtgcggta tttggcatgc catcgcccac gggtggtgct tctactgctg 12601 gagctggagc tcctgcacgc aatatagatg actttccacc gcccggcgga actctggact 12661 ttcgctcgcg tttctgccgc taccaggtgg ccaatcgact gcgcggcata ctcgacgatc 12721 atccggcggc ggccccgaaa ccccaaagtg caactcccct ggatgaggca ccctccacat 12781 cgaaggcggc tgctgccaag gcagctgcca cggctaaggt ttcgagtcag agcagtcagt 12841 cggtgccgta tcaaacgaat gcgaagaatt tctgggatgt ggtgctcaac atcgatcgac 12901 agacccaagt gcgtttggcc aatgtggccc agtttccact cacctcgcag ccagcttggg 12961 aatggcaagc gaacagcgcc gacttcctgt cgttcagcga ttcgcctttc ggacagctgc 13021 tggaaatgct gccctacaag gtcatctgcc ggtcgccaca tctcaccgat atgctggtca 13081 agttgctcgc ctcgctgagc accgagttgc ccaaggagga ggaacagttg ccgctgagcg 13141 atcaaatgcc caccctgata cccattaatc aggcggcggc agcggcagca gattccccag 13201 cgaatccatc agagattggt gacggactgg ccgcaaatgt ggagcaggaa gccacgccgg 13261 ccagcggtaa tccagcctcc ggtgacagca atgcggctgc caagcgaaca cagctgccca 13321 cattgagtgt agccctgcca gttgctccgt cgaagccgcg gcgcaagatc tactcgaaga 13381 acttctcgca actgcagctg gtcatcgagg tgctgaccca ccagtgcggc accaccgagg 13441 gcctggacaa cgtggccaag ctgattgtga atctaacgca gtgctcgcag gcatccaatg 13501 cgattttcat tcagtacctg accgctgcca tcctgggatt ggccgaggag gtgcgccagg 13561 cgatacagat gctgctgaat gagatacgca tgtacaacag tcatcatgga gtgacggcct 13621 ccacatccgg agcagcggca gcgggagcca ccgtttcagg agccagtctg ctgcctaacc 13681 tcgccgttca cgagggcatc atgcaggatc gcttcaccgc cgagcatgtc atcatttcgg 13741 cgccgaagaa cgccaagccc acctgcgaac tccagctgcc gtcgatgaag aagcttatgt 13801 ccaactcatc cgcccagccg tacttcctgc gcaccctgaa gatcttcatg caggtgcgcg 13861 acatgtacga ggcgcagaat ggtttatcca cgggcggtgg tttggctgga gcagctggcg 13921 acaacgatga cgacatcatc gacattgagg gcgatggcgg agcttcgggc ggcagcagtt 13981 cggatatggc gcccggttcg gcgagcacaa tatctccgcc gccgccgcca ccgatggaaa 14041 ccaatcagaa cattaacgat gaggaggagg atgaggatgg ggaggaggag gaggacgatg 14101 atgatgcggc cagggcatcg ccagcggcgg caagtgctgg caagtcaagc aagcccacgc 14161 tcagccagat cctctgcctc gacgtccttt ggcacacgct cagcgaatgc ctggtggcgc 14221 tggaggagtc caaggacgag ttcgccgtcc tggtgctgca gcccaccgtg gaggccttct 14281 tcctcatcca cgcctcgcat cgcgcggggg ctaagaagtc gggtcgcggc ggagttgtgg 14341 gctccggact gcgggcagct ggaggattgg gagcagctgc gtcggcggcc caggagcaca 14401 gtccatcgat ggacgacacc agcagcgcca atacccttag ttcggccagt ttcgaagatg 14461 agccgcgaat gcaggacgcc tccacaaaca cgccgctttc gagcaacagc tccgccgcca 14521 ccactgtgct gagcgcacac gaggcgcagc tgcgacagga tcgccagaag ttcctgcagt 14581 tcgccgagaa acaccgcacc gtgctcaacc aaatactgcg ccagtcgccc actcatctct 14641 ccgacggacc cttcgccgtt ctcgtcgacc acacgcgcat cctggacttt gacgtcaagc 14701 ggaagtactt ccagacggag ctggagcgcc tggacgaggg cattcggcgc gaggagcaca 14761 cggtcagtgt gcggcgcgtg accgtcttcg aggattcgtt ccgcgtgttg taccgcctgg 14821 gaccggagga gtggaagaac cgcttctaca ttgtcttcga ggacgaggaa ggccaggatg 14881 ctggcggcct gctgcgcgaa tggtatgtga tcatatcgcg cgagatcttc aatccgatgt 14941 atgccttgtt ctgcgtatcg ccgggcgatc gcgtcaccta catgatcaat ccctccagcc 15001 atgccaatcc gaatcatctg agctacttca agttcgtcgg ccgcgtaatt gccaaggccg 15061 tgcacgataa caagctgctg gagtgctact tcacccgatc cttctacaag cacatcctgg 15121 gcaagcaggt gaagcacacg gacatggagt cgcaggacta cgagttctac aagggcctcg 15181 actatctgat gaagaacgac atctccaccc tgggctacga gctgaccttc tccacggagg 15241 tgcaggagtt cggtgtcacc cagatccgtg atctcaagcc aaacggacgc gacaccgcgg 15301 tgaccgagga aaacaagttc gagtatgtgc agctggtgtg ccagctgaag atgagcggct 15361 ccattcgaca gcaattggac gcattcctcg agggcttcta cgacattatt ccaaagcatt 15421 taatttcgat attcaacgaa caggaactgg aacttctcat atccggcctg ccggatattg 15481 acattgaaga tctaaaggcg aacaccgagt accacaagta cacctccaaa tcggcccaga 15541 ttcaatggtt ctggcgtgca ttgcgcagct tcgaccaagc ggaccgggcc aagttcctgc 15601 agttcgtcac tggcacatcg aaggtgccgc tgcagggctt cggctccctg gagggcatga 15661 acgggattca gaagttccaa atccatcggg acgatcggtc cactgatcga ttgccctgtg 15721 cacacacctg cttcaaccaa ctggatcttc cgatgtacaa gtcatacgac aaactgcgga 15781 gctgcttgct gaaggccata cacgagtgct ccgagggctt tggcttcgcc taagcgggaa 15841 catcagtggc tttcggtcct ccagcctcca gcgaggccag ccaaccaagc agccaggaac 15901 ccatggacgc aactctattc ctagttcgcc caattcacgg gcgacacgac gagaaatgca 15961 taattgattt gaacagaaca gaacagccac tgctaatttg cgatagcggc aacagaaact 16021 gcatacatac acagtacata tagttatata gtatatataa aaatgttgaa ttaattatta 16081 attttcgcgc ctatatatat acaatatata ttttcttaaa ttttcaaaag aaaacggaaa 16141 aaagtctaag gaaacctaca aaaaaaaaat aagatacaaa cgcgaaacag catattcgat 16201 ttaaatttgt ctgcgtaact catccctatt atatattttc tcggaatcta tccctgtcgt 16261 tttgcacatt ttcattaaaa caaaaggatt tatataaaaa aacatacaca atttgacata 16321 tttttattta cctaaacacg aaaccgaata gcaaaggatt aaacgtagtc tatagaacgc 16381 aaatgcaaat gcacataaac agatttcttg tttacttaag tgaatttacc gaagatgaga 16441 cggggaggca gcggaaataa ttaaatggat taaagtattt cgatgtaaga gataagtcct 16501 tatgttatgc attttatgtt tacctttgga ataatgagcc gcagatgtaa cttaaagaat 16561 gtggaataaa gtaagagtaa gctcatttat caaaata