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LOCUS XP_070075101 5122 aa linear INV 09-DEC-2024 takahashii]. ACCESSION XP_070075101 VERSION XP_070075101.1 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_070219000.1 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..5122 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..5122 /product="E3 ubiquitin-protein ligase HUWE1 isoform X1" /calculated_mol_wt=553196 Region 90..326 /region_name="DUF908" /note="Domain of Unknown Function (DUF908); pfam06012" /db_xref="CDD:428721" Region 623..977 /region_name="DUF913" /note="Domain of Unknown Function (DUF913); pfam06025" /db_xref="CDD:461803" Region 1455..1494 /region_name="UBA_like_SF" /note="UBA domain-like superfamily; cl21463" /db_xref="CDD:473871" Region 1735..1807 /region_name="WWE" /note="Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; smart00678" /db_xref="CDD:128922" Region 3673..3703 /region_name="UBM" /note="Ubiquitin binding region; pfam14377" /db_xref="CDD:464159" Region 3722..3749 /region_name="UBM" /note="Ubiquitin binding region; pfam14377" /db_xref="CDD:464159" Region 4767..5120 /region_name="HECTc" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; cd00078" /db_xref="CDD:238033" Site order(4771,4801,4812,4873,5047,5083..5084,5087..5091,5111, 5119) /site_type="active" /note="catalytic cleft [active]" /db_xref="CDD:238033" Site order(4901,4904..4905,4907..4908,4911,4918,4920, 4924..4925,4927,4932,4937,4954,4958) /site_type="active" /note="E2 interaction site [active]" /db_xref="CDD:238033" CDS 1..5122 /gene="HUWE1" /coded_by="XM_070219000.1:326..15694" /db_xref="GeneID:108068620" ORIGIN 1 mkvdtvklkk gsseltaecr elideltkrr traellefld tihvwiygkc elyhwieild 61 rfdkileeas rhvnanefvl qcdtnfqetd vtlllhvlnf ttlliehsfs rhlynsiehl 121 tvllssqnmd ivlavlnlly mfskrsnfip rlpfekkell ivklfniaer wgdpnyglsl 181 kdccigepkl eflyqlcidy vdehghaaql eipdmmdlch tasapevikt iagqiskpse 241 aikmriahrv rlisgfnnyk lrlqfvqarl qavsiliysn alqdntdkvl yagfgeelce 301 lidkedvhlv eiraavlrtl tsmlhfdrnp nvpsragsrl mkivhytgae rqggtlpllv 361 rdcidnltth glteryplil atslfsllyh lasyemggsa lvksgmmqsl lcviswpgvd 421 lehitfvtra vrvidlitni diarfhqnng lnvfidrlek eikscckala digitlkest 481 lrddhkldns leqvdddvee tgentsvasg ggsprrenss dgltgagssa yrayhehsgg 541 gagsgaglld iggarsaggg ssggasaapi iglinrdgsa arppaimypt nsyyarplae 601 rkaelssqlp sslapkkpsc vtqraallks mlnflkksiq dhahfsnmrn imetsltqsl 661 rhiianaeyy gpslfllatd vvtvyvfnep sllsslqdlg itsvmlkall qkdvpatrev 721 lgslpnvfsa lclnerglfe flsydpfdkv lkvllspdyl vamrrrrssd plgdtatnlg 781 namddlikhh pylradatea ivrllnelvr lgsdpsficw rankessgsg sgsgshgggg 841 shhvastpsp mavmvagsgg stsvlqgaad tndssgdddd dddemssasq qqqqsggatt 901 prtqqpgggv atpqavkvvt ppereaipli dyilnvmkfi eaifsnspng dhcrefvlhg 961 glkpilqlls lpnlpvdspv sttsqavanv ckailsqaqe tkvldvalkq ladivaqlkp 1021 likhftfpgg svllaelvcc qrledgfana eytpilhnms fvhgyvvmlv hlcrnasndm 1081 raillkrwgv nretgvqllq qlvqlyislv westillnlc sdeptqhpdl iwdeiaaqms 1141 aaagtadplt eaelsrkler aaefrtkysp eeqfryiksl laassrlgra laellgtlvk 1201 lsvgspqtrq rrindlisni nkvptpeare iarilssilv ngfshesilp kpvpklkltf 1261 licsvgftgp mlfddkrsaf hlmisqfcae nglkaffemf ywalsldnvs qkfdfdqwas 1321 medlmqshed dkrdcpegtg efldawlqll ekmvnpraml dspytmsprl nylpdsvpfe 1381 pvfylihihq lamqalrriw arrpipnygp smfetmilil khlikshqtl ldryhtrmke 1441 ikfenlyirs tddglnadhi ktltdmgfmh yhviealrtn asleeatdyl lnnpeasals 1501 tttggsaapp pppppppstm didmdlpadg geksssssan ssydykhlkl mpsiifdrfc 1561 deaisrafef meaipdtvns aadliavlyr rhnhlnkqvf vtnfvrniiq wvdftlqlfe 1621 psktaaskas rleecltglt atrlfvrlkt strlleenys dlhrplveai taqdamvslv 1681 klldcmsqwm leqsvdsrat vprwvqnlvd lidsidsish ilqrkanmra vssevwrwyd 1741 astgkwnays eannelirna yaagerwlhi nigrqrctvs lncmtqvsea sgthrpvcpa 1801 lklseaital nspvslhkve hllnrvvrts pdgsgtvhsd elislrqlin fsdgqqpqen 1861 paneegtned sgsplaamtt rsksrqksaa aaaaaqkkss shgsppipkr tqkiilneeq 1921 vglskfdcgr iigsivdllq pshlmlnetk lsllrlcarl trnydnaqvf irrggvkmll 1981 hlqqacsfmg fptyaniilr hvleappvlq eamervlgmr aagivpvghr dliyvltqvs 2041 savsrnpqif vaaakemlkg eyllntnstt laddarvmvk skfgqqptaa aggatpnsqt 2101 stppdeqlkd dpqvqssvav lkdllhglvq pcwhyggtgs ldrgpgaael lqpdqppgta 2161 aqgghdeely frfqetpapa sskkqssggg asagqpqtte kfepccctwh iptsghthak 2221 ptisratllk lladstrayq slvprvllsh iytpadspli sapqqtflgv lldrflpitq 2281 rhhvpevstm trvlicslsd cyqqpgvqvh vaeelhaava ralaqpdsae khtrlqvlms 2341 lfpnliespm lydkvhmhrn nmyrvllrqg vmtyltkvaq ykdlsnhntl stlaailrpm 2401 eillrfsvst ttlgskrilf ggggggagga ngagsgnsav gggsgtgpgs gntygtiinr 2461 rlyprlaart avsaaversn amggehvlrd iirnvlsdrr hafefifnsd emavdsedsa 2521 apavggngsg aggigaggsg aavidvveer snggdtsdpp gnvnsgsgtg avqsstsggp 2581 vrpvlnfdql wddflqsegl rlasrsggga gsgagstgag stgqqnggna tggsansgsn 2641 svsgdprlrt npdvdvgggg ngggqssnsg vvndngiggg ggsdgastss dtgapggerr 2701 dlnasllgdv stsesdsdas tenderneed ededddapde dvdehsetdv deerprqfie 2761 vfdhiyepes setasndadv dndddddede ddvddddddd ednddedree gqsvmdaele 2821 nqidialalv ssnnrprrsa avnasgdasa nrdpnpdeev ddedddvdad pdgdpdvdpi 2881 ggpsaaqaea ylyerlgsgl mptppvgfrv rmnssiaqpl didvnggngg ggsggsgagv 2941 tgtaggsgrg sssggttasi gaiasaalrp ssgswmapdf nfigvsgggg asgsggasgs 3001 nanggevnaf ltpamsqler sggasgsgqn msnlldeqps vsgngggggg sgggsasgng 3061 gvsggggang ggtagqhpna tlcangvrrr llyldqqycv cmpthqnpte etqmetftqd 3121 alhwwleeat vldmesqtda clyaahfllp hlikelktah qqrkqeeaar qtatntttpa 3181 ssasssagap atsilsntaa ptatasiass llanavaags ggssssgsgl vvppvaasat 3241 ggtrrssipv lipssfggpg sattgdatat tggttssssy tttsisgsgs lesqtttrap 3301 rqrgglrqhs qlpfniyaei dltneqdsqg atstgsapnd gaesqaqqpq qqqqqqnssa 3361 pslaqgavlq hqrhppvpll pssgrpsrph srldeaelll lqladrqavr srlqvssght 3421 nssrtsgsal inarpnrdlp arlqrlvqah gslssrinas aastpaptlv smptpmssaa 3481 leqlnvtpag pdvvgpdrnf alppslevdv dvlpgildri lpqqqqeqqe aqqqeeeeeq 3541 lllppppppp psetaplllt eedmwqgtre eeedststva vagsseaane snqsdqtpes 3601 sesvspnpqa pppaaesgeg gaggaggaas astqtpatae esavggttat atttaatvtd 3661 mspevraalg dlevpegvdp sflaalpsem reeviqehlr mqrirqraqq naiqiahdsl 3721 vevnpeflaa lplniqsevl mqqrieqqrq aaqtanpedp vdtaaffqnl penlrqailt 3781 dmeesqiasl ppelaaeaqf lrrdwesrng armdahppsn alsrfqttlq sldearwhss 3841 iwydasgnaq pqhhqhttiv hhhahahhap tmgkplallm medenilldp dslatlllfl 3901 fvedqkvnsm rlhrvirnlc hheptrdwii salisivqkt nednanfgag qaggkpewlk 3961 lrvdaafgyk sniflinrly egsarsisin pqaaqmivrn cldllfvlak hypssfvpfn 4021 revkarrils avfgmpsptg gastagagap arniddfppp ggtldfrsrf cryqvanrlr 4081 gilddhpaaa pkpqsatpld eapstskaaa akaaatakvs sqssqsvpyq tnaknfwdvv 4141 lnidrqtqvr lanvaqfplt sqpawewqan sadflsfsds pfgqllemlp ykvicrsphl 4201 tdmlvkllas lstelpkeee qlplsdqmpt lipinqaaaa aadspanpse igdglaanve 4261 qeatpasgnp asgdsnaaak rtqlptlsva lpvapskprr kiysknfsql qlvievlthq 4321 cgttegldnv aklivnltqc sqasnaifiq yltaailgla eevrqaiqml lneirmynsh 4381 hgvtastsga aaagatvsga sllpnlavhe gimqdrftae hviisapkna kptcelqlps 4441 mkklmsnssa qpyflrtlki fmqvrdmyea qnglstgggl agaagdnddd iidiegdgga 4501 sggsssdmap gsastisppp pppmetnqni ndeeededge eeeddddaar aspaaasagk 4561 sskptlsqil cldvlwhtls eclvaleesk defavlvlqp tveaffliha shragakksg 4621 rggvvgsglr aagglgaaas aaqehspsmd dtssantlss asfedeprmq dastntplss 4681 nssaattvls aheaqlrqdr qkflqfaekh rtvlnqilrq spthlsdgpf avlvdhtril 4741 dfdvkrkyfq telerldegi rreehtvsvr rvtvfedsfr vlyrlgpeew knrfyivfed 4801 eegqdaggll rewyviisre ifnpmyalfc vspgdrvtym inpsshanpn hlsyfkfvgr 4861 viakavhdnk llecyftrsf ykhilgkqvk htdmesqdye fykgldylmk ndistlgyel 4921 tfstevqefg vtqirdlkpn grdtavteen kfeyvqlvcq lkmsgsirqq ldaflegfyd 4981 iipkhlisif neqelellis glpdidiedl kanteyhkyt sksaqiqwfw ralrsfdqad 5041 rakflqfvtg tskvplqgfg slegmngiqk fqihrddrst drlpcahtcf nqldlpmyks 5101 ydklrscllk aihecsegfg fa