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LOCUS XM_070219000 16458 bp mRNA linear INV 09-DEC-2024 containing E3 ubiquitin protein ligase 1 (HUWE1), transcript variant X2, mRNA. ACCESSION XM_070219000 VERSION XM_070219000.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..16458 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..16458 /gene="HUWE1" /note="HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 Proteins" /db_xref="GeneID:108068620" CDS 326..15694 /gene="HUWE1" /codon_start=1 /product="E3 ubiquitin-protein ligase HUWE1 isoform X1" /protein_id="XP_070075101.1" /db_xref="GeneID:108068620" /translation="MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTIHV WIYGKCELYHWIEILDRFDKILEEASRHVNANEFVLQCDTNFQETDVTLLLHVLNFTT LLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELL IVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDL CHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSIL IYSNALQDNTDKVLYAGFGEELCELIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPS RAGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHGLTERYPLILATSLFSLLYHLA SYEMGGSALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNIDIARFHQNNG LNVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDNSLEQVDDDVEETGENTSVA SGGGSPRRENSSDGLTGAGSSAYRAYHEHSGGGAGSGAGLLDIGGARSAGGGSSGGAS AAPIIGLINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQR AALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVV TVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFE FLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADAT EAIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGGSHHVASTPSPMAVMVA GSGGSTSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQSGGATTPRTQQPGGGVATPQ AVKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDHCREFVLHGGLKPILQLLSLP NLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGG SVLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRAILLKRW GVNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPDLIWDEIAAQMSAAAGTA DPLTEAELSRKLERAAEFRTKYSPEEQFRYIKSLLAASSRLGRALAELLGTLVKLSVG SPQTRQRRINDLISNINKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLI CSVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFDFDQWAS MEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYLPDSVP FEPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHT RMKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDYLLNNP EASALSTTTGGSAAPPPPPPPPPSTMDIDMDLPADGGEKSSSSSANSSYDYKHLKLMP SIIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQVFVTNFVRNIIQ WVDFTLQLFEPSKTAASKASRLEECLTGLTATRLFVRLKTSTRLLEENYSDLHRPLVE AITAQDAMVSLVKLLDCMSQWMLEQSVDSRATVPRWVQNLVDLIDSIDSISHILQRKA NMRAVSSEVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLHINIGRQRCTVSLNCM TQVSEASGTHRPVCPALKLSEAITALNSPVSLHKVEHLLNRVVRTSPDGSGTVHSDEL ISLRQLINFSDGQQPQENPANEEGTNEDSGSPLAAMTTRSKSRQKSAAAAAAAQKKSS SHGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHLMLNETKLSLLRLCA RLTRNYDNAQVFIRRGGVKMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERV LGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLLNTNSTTLADD ARVMVKSKFGQQPTAAAGGATPNSQTSTPPDEQLKDDPQVQSSVAVLKDLLHGLVQPC WHYGGTGSLDRGPGAAELLQPDQPPGTAAQGGHDEELYFRFQETPAPASSKKQSSGGG ASAGQPQTTEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVLL SHIYTPADSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCYQQPG VQVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYR VLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGG GGGGAGGANGAGSGNSAVGGGSGTGPGSGNTYGTIINRRLYPRLAARTAVSAAVERSN AMGGEHVLRDIIRNVLSDRRHAFEFIFNSDEMAVDSEDSAAPAVGGNGSGAGGIGAGG SGAAVIDVVEERSNGGDTSDPPGNVNSGSGTGAVQSSTSGGPVRPVLNFDQLWDDFLQ SEGLRLASRSGGGAGSGAGSTGAGSTGQQNGGNATGGSANSGSNSVSGDPRLRTNPDV DVGGGGNGGGQSSNSGVVNDNGIGGGGGSDGASTSSDTGAPGGERRDLNASLLGDVST SESDSDASTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERPRQFIEVFDHIYEPES SETASNDADVDNDDDDDEDEDDVDDDDDDDEDNDDEDREEGQSVMDAELENQIDIALA LVSSNNRPRRSAAVNASGDASANRDPNPDEEVDDEDDDVDADPDGDPDVDPIGGPSAA QAEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNGGGGSGGSGAGVTGTA GGSGRGSSSGGTTASIGAIASAALRPSSGSWMAPDFNFIGVSGGGGASGSGGASGSNA NGGEVNAFLTPAMSQLERSGGASGSGQNMSNLLDEQPSVSGNGGGGGGSGGGSASGNG GVSGGGGANGGGTAGQHPNATLCANGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFT QDALHWWLEEATVLDMESQTDACLYAAHFLLPHLIKELKTAHQQRKQEEAARQTATNT TTPASSASSSAGAPATSILSNTAAPTATASIASSLLANAVAAGSGGSSSSGSGLVVPP VAASATGGTRRSSIPVLIPSSFGGPGSATTGDATATTGGTTSSSSYTTTSISGSGSLE SQTTTRAPRQRGGLRQHSQLPFNIYAEIDLTNEQDSQGATSTGSAPNDGAESQAQQPQ QQQQQQNSSAPSLAQGAVLQHQRHPPVPLLPSSGRPSRPHSRLDEAELLLLQLADRQA VRSRLQVSSGHTNSSRTSGSALINARPNRDLPARLQRLVQAHGSLSSRINASAASTPA PTLVSMPTPMSSAALEQLNVTPAGPDVVGPDRNFALPPSLEVDVDVLPGILDRILPQQ QQEQQEAQQQEEEEEQLLLPPPPPPPPSETAPLLLTEEDMWQGTREEEEDSTSTVAVA GSSEAANESNQSDQTPESSESVSPNPQAPPPAAESGEGGAGGAGGAASASTQTPATAE ESAVGGTTATATTTAATVTDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEH LRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTAN PEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMD AHPPSNALSRFQTTLQSLDEARWHSSIWYDASGNAQPQHHQHTTIVHHHAHAHHAPTM GKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWII SALISIVQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSIS INPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNREVKARRILSAVFGMPSPTGGASTAG AGAPARNIDDFPPPGGTLDFRSRFCRYQVANRLRGILDDHPAAAPKPQSATPLDEAPS TSKAAAAKAAATAKVSSQSSQSVPYQTNAKNFWDVVLNIDRQTQVRLANVAQFPLTSQ PAWEWQANSADFLSFSDSPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEE QLPLSDQMPTLIPINQAAAAAADSPANPSEIGDGLAANVEQEATPASGNPASGDSNAA AKRTQLPTLSVALPVAPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVN LTQCSQASNAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNSHHGVTASTSGAAAAG ATVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQP YFLRTLKIFMQVRDMYEAQNGLSTGGGLAGAAGDNDDDIIDIEGDGGASGGSSSDMAP GSASTISPPPPPPMETNQNINDEEEDEDGEEEEDDDDAARASPAAASAGKSSKPTLSQ ILCLDVLWHTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRAGAKKSGRGGVVG SGLRAAGGLGAAASAAQEHSPSMDDTSSANTLSSASFEDEPRMQDASTNTPLSSNSSA ATTVLSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDF DVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFED EEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFV GRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTL GYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAF LEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRA LRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCF NQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA" misc_feature 593..1303 /gene="HUWE1" /note="Domain of Unknown Function (DUF908); Region: DUF908; pfam06012" /db_xref="CDD:428721" misc_feature 2192..3256 /gene="HUWE1" /note="Domain of Unknown Function (DUF913); Region: DUF913; pfam06025" /db_xref="CDD:461803" misc_feature 4688..4807 /gene="HUWE1" /note="UBA domain-like superfamily; Region: UBA_like_SF; cl21463" /db_xref="CDD:473871" misc_feature 5528..5746 /gene="HUWE1" /note="Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; Region: WWE; smart00678" /db_xref="CDD:128922" misc_feature 11342..11434 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 11489..11572 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 14624..15685 /gene="HUWE1" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(14636..14638,14726..14728,14759..14761,14942..14944, 15464..15466,15572..15577,15584..15598,15656..15658, 15680..15682) /gene="HUWE1" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(15026..15028,15035..15040,15044..15049,15056..15058, 15077..15079,15083..15085,15095..15100,15104..15106, 15119..15121,15134..15136,15185..15187,15197..15199) /gene="HUWE1" /note="E2 interaction site [active]" /db_xref="CDD:238033" polyA_site 16458 /gene="HUWE1" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 acacacactc gcacaaacgg gcacacgcac acatacagtc gcatcgctca cccactgcat 61 tgtttctgtt ctgacttttt tctgttgtat tacagctacg tttattgaac acgctgacgt 121 atacgtttaa accgcaactc gatgcccaac ctataaacaa tcgacgcccg acgccttttc 181 accacgaacc acccaatcta cacaagccgc ccactcgaca aacagccgga ggaagaggag 241 gaggaggagg aggaaggagg aggagcacca ccaccccaag tggtggccac ctgctgctcc 301 attagctcca ctagctccac gaacaatgaa ggtggacacg gtgaagctga agaagggctc 361 ctcggagctc accgccgagt gccgcgagct catcgacgag ctcaccaagc ggcggacgcg 421 ggccgagctg ctcgagttcc tcgacaccat ccacgtctgg atctacggca agtgcgagct 481 ctaccactgg atcgagatcc tcgaccggtt cgacaagatc ctcgaggagg cgtcgcgcca 541 tgtcaacgcc aacgagttcg tgctgcagtg cgacaccaat ttccaggaaa cggatgtcac 601 actgctgttg cacgttctta acttcaccac actgctgatc gagcactcgt tctcgcggca 661 cctctacaac tccatcgaac acctgacggt gctgctctcc tcccagaaca tggacatcgt 721 cctggccgtc ctcaatctgc tgtacatgtt ctccaagcgc agcaacttca taccccgcct 781 gccgttcgag aagaaggaac tgctgattgt caagctgttt aacatagccg agcgctgggg 841 cgatcccaac tacggactgt cgctcaagga ctgctgcatt ggcgagccga agctggaatt 901 cctttaccag ctgtgcatcg actatgtgga cgagcacggt catgccgccc agctggaaat 961 cccggacatg atggacctct gccacacggc gtccgcgccc gaggtgatca agacgattgc 1021 cggacagatc tcaaagccca gcgaggcaat caagatgcgc attgctcatc gggtgcgctt 1081 gatctcaggc ttcaacaact acaagctgcg cctccagttc gtccaggctc gcctgcaggc 1141 cgtctccatt ctgatctact cgaatgccct gcaggacaac acggacaagg tgctgtatgc 1201 cggcttcggc gaggagctgt gcgagctgat cgacaaggag gacgtgcatc tcgtggagat 1261 acgggcggca gtgctgcgca cactcacctc gatgctgcac tttgaccgca atccgaatgt 1321 gcccagcagg gccggttcgc gactgatgaa gatcgttcac tacacaggag ccgagcggca 1381 gggcggcact ttgccactgc tggtgcgcga ctgcattgat aatttaacca cccatggact 1441 caccgaacgc tacccgctca tcctggccac gtcactcttc tcgctgctct accatttggc 1501 cagctacgaa atgggcggct ctgctctggt caaaagcggc atgatgcagt ccctcctgtg 1561 cgtcatcagc tggccgggag tcgacctcga gcacattacg ttcgtgacgc gggcggtgcg 1621 ggtgatcgac ctgataacca acatagatat cgcacggttc catcagaaca acggactcaa 1681 cgtgttcatt gaccgtctgg agaaggagat caagagctgc tgcaaggcac tggccgacat 1741 tggcatcacg ctgaaggagt cgacgctgcg cgatgaccac aagttggata actcgctgga 1801 gcaagtggac gatgatgtgg aagagaccgg agagaacacg tccgtggcca gtggaggtgg 1861 atcgccgcgt cgcgagaact cgagtgacgg gctcaccggt gccgggagca gcgcctacag 1921 agcctatcac gagcacagtg gaggaggagc gggctcagga gcgggactcc tggacattgg 1981 tggagcacgc agcgcaggag gaggatcatc gggtggtgct tcagccgcac cgatcattgg 2041 attaatcaac cgggacggaa gtgccgctcg tccgccggcc atcatgtacc ccacaaacag 2101 ttactacgcc cgtccgctgg ccgagcgcaa ggcggagctc tcctcgcagc tgccgagcag 2161 cctggcgccg aagaagccct cctgcgtcac ccagcgggcg gcgctgctca agtcgatgct 2221 gaatttcctg aagaagagca tccaggatca tgcgcacttt agcaacatgc gcaacatcat 2281 ggagaccagc ttaacgcagt cgcttcgcca catcatagcc aatgcggagt actacgggcc 2341 gtcgctcttc ctgctggcca ccgatgtggt caccgtgtac gtgttcaacg agccctcgct 2401 gctctcctcg ctgcaggatc tgggcatcac gagtgtcatg ctgaaggcgc tgctccagaa 2461 ggatgtgccg gccacgcggg aagtgctggg ctccctgccg aatgtctttt ccgccctgtg 2521 cctgaatgag cgtggccttt ttgagttcct ctcctatgat ccttttgaca aggtgctgaa 2581 ggtgctgctc tcgccggact atctggtggc catgcgcagg cgccgctcct cggatccgct 2641 gggcgatacg gccaccaatt tgggcaatgc catggacgat ctgatcaagc atcatccgta 2701 tttgcgagcc gatgccacgg aggcgattgt gaggcttttg aatgagctgg ttcgccttgg 2761 ttccgatccc agtttcattt gctggcgggc caacaaggag agcagtggct ctggctcggg 2821 ttcaggcagc catggcggcg gcggttcgca tcacgtggcc tccacaccct cgcccatggc 2881 cgtcatggtg gctggctcgg gaggatcgac gtcggtgctc cagggagccg cggatacgaa 2941 cgacagcagc ggcgacgatg acgacgatga tgatgaaatg agctcggctt cgcagcaaca 3001 gcagcaaagt ggaggagcca ccacacccag gacgcaacaa ccaggaggag gagtagccac 3061 cccgcaggcc gtcaaggtgg tgacgccccc ggaacgagag gcaatacccc taatcgacta 3121 tatcttgaat gtgatgaagt tcatcgaggc gattttcagc aacagtccga atggcgatca 3181 ctgccgggag tttgtcctcc acggcggact aaagcccatt ctgcaactgc tgtcgctgcc 3241 caatctgccg gtggattcac ccgtttccac cacctcacag gcggtggcca atgtctgcaa 3301 ggccatactc agccaggcgc aggaaacgaa ggttctcgat gtggcgctca agcagctggc 3361 tgatattgtg gcccagctga agccgctgat caagcacttt acctttcccg gcggcagtgt 3421 cctcctcgca gagctcgtct gctgtcagcg gctggaggat ggcttcgcca atgccgaata 3481 cacaccgata ctgcacaaca tgagctttgt gcacggctat gtggtgatgc tggtgcatct 3541 ctgtcgcaac gcctccaacg acatgcgagc gattctgctc aagcgttggg gcgtcaatcg 3601 cgagactgga gtgcaattgc tgcagcagct ggtccagctg tacatttcgc tggtgtggga 3661 gagcaccata ctgctgaatc tctgctcgga tgagcccacc cagcatccgg atctcatttg 3721 ggacgagatt gcggcccaga tgtcggcggc agcgggcacc gcggatcccc tgaccgaagc 3781 ggagctctcg cggaagctgg agcgtgcggc ggaattccgg acgaagtact cgcccgagga 3841 gcagttccgg tacatcaaat ccctgctggc ggcgagctct cggctcggca gggcgctcgc 3901 cgagctgctg ggcacgctgg tgaagctatc ggtgggttcg ccgcagacgc gacagcgacg 3961 catcaacgat ctgatcagca atatcaacaa agttcctacg cccgaggctc gcgaaatagc 4021 ccgcatcctc agctcgattc tggtgaatgg cttcagtcac gagagcattc taccgaagcc 4081 tgtgcccaag ttgaagctca ccttcctcat ctgctcggtg ggattcaccg gtccaatgct 4141 gttcgacgac aagcgcagcg cctttcacct gatgatatcg caattctgcg cagagaatgg 4201 attgaaagcc ttctttgaga tgttctactg ggcgctgtcg ctggataatg tctcgcagaa 4261 gttcgatttc gatcagtggg cctcgatgga ggatctgatg cagtcgcacg aggacgacaa 4321 gcgcgattgc cccgagggca cgggcgagtt tctcgacgcc tggctgcagc tgctcgagaa 4381 gatggtgaat ccgcgtgcca tgctcgattc gccgtatacg atgagtccgc ggctgaatta 4441 cctgcccgat tcggtgccct tcgagccggt cttttacctc attcacatcc accagctggc 4501 catgcaggca ctgcgcagga tctgggcacg tcgcccgatt cccaactatg gacccagtat 4561 gttcgagacc atgatactga tcctgaagca tctgatcaag tcgcatcaaa cgctgctcga 4621 tcgctatcac acgcggatga aggagatcaa gttcgagaac ctctacatcc gcagcacgga 4681 cgatggccta aatgcggatc acatcaagac gctgacggac atgggcttca tgcattacca 4741 cgttattgag gctctccgca cgaatgcctc gctggaggag gccaccgatt atctgctgaa 4801 taacccagaa gccagtgctt tgtccacaac gactggtggt tctgctgctc ctccgccgcc 4861 gccaccgcca ccgccttcca ccatggacat tgacatggat ttgccagcgg atgggggaga 4921 gaaatctagc tctagttcgg cgaactccag ctatgactac aagcacctca aactgatgcc 4981 gtcgatcatc ttcgatcgct tctgcgacga ggccatttcg cgggcctttg agttcatgga 5041 ggccattccg gatacggtga acagtgccgc agatctgata gccgtgctgt atagacgcca 5101 caatcacctg aacaagcagg tctttgtgac caactttgtg cgcaacatta tccagtgggt 5161 ggactttacc ctgcagctct ttgaaccatc gaaaacggca gcgtcgaagg cttcgcggtt 5221 ggaggaatgc ttgacgggat tgacggccac ccggttgttt gtgcggctca agacatcgac 5281 gcggctgctc gaggagaact acagtgattt gcatcgtccg ctggtggagg caataaccgc 5341 ccaggatgcc atggtgtcgc tggtcaagct gctcgactgc atgagccagt ggatgctgga 5401 gcaatcagtg gattctaggg ctacggtccc ccgatgggtg cagaacctgg tggatctaat 5461 cgattcgatc gacagcatca gccacattct gcagcgcaag gccaacatgc gggcggtgag 5521 cagcgaggtg tggcgctggt acgacgcctc cacgggcaag tggaatgcct attcggaggc 5581 caacaatgag ctcattcgga atgcctatgc cgccggcgag cggtggctgc acattaacat 5641 cggcaggcaa aggtgtacgg tgagcctgaa ctgcatgacg caggtgagcg aggcatccgg 5701 cacacatcgt cctgtttgtc cggctctcaa gctcagtgaa gccatcactg cgctcaacag 5761 tcccgtgtcg ctgcacaaag tggagcatct gctgaaccgc gtggtgcgaa cctcacccga 5821 tggctcggga accgtgcatt ccgacgaatt gatttccctg cgccagctga tcaacttttc 5881 ggatggtcag cagccgcagg agaacccggc gaatgaagag ggaacaaatg aagatagtgg 5941 atctcctctg gccgccatga ccacgcgcag caagtcgcgg caaaagagcg ccgccgctgc 6001 agccgctgcc cagaagaaat cctcgtcgca tggctcaccg cccataccca aacgcaccca 6061 gaagatcata ctcaacgagg agcaggtggg actgagtaaa ttcgactgcg gtcggataat 6121 tggcagcatt gtggatctcc tgcagccttc gcatctcatg ctcaacgaaa cgaagctttc 6181 gctgctgcgg ctgtgtgcaa gattaacccg aaactacgac aatgcccagg tgttcatccg 6241 gcggggcggc gttaagatgc tgctgcatct gcagcaggcc tgcagcttca tgggcttccc 6301 cacctatgcg aatatcatac tgcgtcacgt gctcgaggcg ccgccggtgc tgcaggaggc 6361 catggaacga gtgctgggca tgcgggcagc cggcattgtg cccgtggggc atcgggatct 6421 aatctatgta ctcacccagg tatcctcagc ggtttcgcgc aatccgcaga tctttgtggc 6481 cgccgccaag gagatgctca agggagagta cctcctgaac acgaacagca cgacgctggc 6541 ggacgatgcg cgggtgatgg tcaagtccaa gtttggtcaa caaccgacgg cagcggctgg 6601 cggagccacg ccaaattcgc agacgtccac gccgccggat gagcagctca aggacgatcc 6661 ccaggttcag tcatcggtgg ctgtgcttaa ggatctactg catggattgg tgcagccctg 6721 ctggcactac ggcggcacgg gatccttgga tcgcggccct ggcgccgccg agctgctgca 6781 accggaccag ccaccgggaa cggccgccca gggaggccac gacgaggagt tgtatttccg 6841 cttccaggaa acccccgcac ctgcgagcag caagaagcaa tcctcaggag gaggagcatc 6901 tgctgggcag ccacagacga cggagaagtt cgagccctgc tgctgcacgt ggcacatccc 6961 gaccagcggc cacacgcacg ccaagccgac catttcgcgg gcgacgctgc tcaagctgct 7021 ggcggattca acgagggcct atcagtcttt agtgccccgc gtgctgctat cccacattta 7081 cacgcccgcc gacagtccgc tgatctcggc gccgcagcag acgttcctgg gcgtcctcct 7141 cgatcgcttt ctgcccatca cgcagcggca tcatgtgccc gaggtgagca cgatgacgag 7201 ggtgctcatt tgctcccttt ctgactgcta ccagcagccg ggagtccagg tccatgtggc 7261 cgaggagctg cacgcggcgg tggccagggc tttggcccaa ccggactcgg cggagaagca 7321 cacgcgactc caggtgctga tgagcctgtt tcccaatctc atcgagtcgc cgatgctgta 7381 cgataaggtg cacatgcatc gcaacaacat gtaccgagtg ctgctgcgcc agggagtgat 7441 gacctacctg accaaggtgg cccagtacaa ggatctgtcc aatcacaaca cgctgagcac 7501 tctggcggcc atcctgcgac ccatggagat cttgctgagg tttagtgtgt ccaccacaac 7561 gctcggatcg aagaggattc tctttggcgg cggcggcgga ggagctggcg gagcaaatgg 7621 agcagggagc gggaacagtg ctgtcggagg aggcagtgga actggcccgg gatcgggcaa 7681 tacatatgga accatcatca atcgtcggct atatcctcgt ttggccgccc gcaccgcagt 7741 cagtgcggcc gtggagcgat ccaatgcgat gggtggcgag catgtgctgc gcgacattat 7801 acgcaatgtg ctctccgatc ggcggcacgc ctttgagttt atcttcaact cggacgagat 7861 ggccgtggac tcggaggact cggctgcccc ggcggtgggt ggtaatggat cgggagcagg 7921 cggaatagga gcaggaggat caggagcagc cgtcatcgat gtggtggagg agcgcagcaa 7981 tggcggggat accagcgatc ccccaggtaa tgtaaactcc ggatctggaa cgggcgcagt 8041 tcaatcttca accagtggag gtcccgtgcg gccagttctg aactttgacc agctgtggga 8101 cgacttcctg cagagcgagg gactgcgatt ggcctcgcgg agcggcggag gcgcgggatc 8161 tggagcagga tccacaggag caggctcaac gggtcagcaa aacggtggca atgccactgg 8221 tggctctgca aactccggca gcaattcagt cagcggagat cctcgcctgc gcaccaatcc 8281 cgatgtggat gtgggcggcg gtggaaatgg cggtggtcag tcatccaatt cgggtgtggt 8341 aaacgataat ggaattggcg gcggcggcgg cagcgatggc gcctccacat cctcggacac 8401 tggagctccg ggcggcgaac gtcgcgattt gaatgcctcg ctgctgggcg atgtcagcac 8461 ctcggaatcc gattcggatg cctccacgga gaacgacgag cggaatgagg aggacgagga 8521 cgaggatgac gatgcccccg atgaagatgt ggacgagcat agcgaaacgg atgtggatga 8581 ggaaaggcca cgtcaattta tcgaggtctt tgatcacatc tacgaaccgg aatcctcgga 8641 aaccgcttcc aatgatgcgg atgtggataa cgacgacgat gatgacgagg atgaggacga 8701 tgtggacgac gacgatgatg atgacgagga taacgacgat gaggatcgcg aggagggcca 8761 gagtgtcatg gatgccgagt tggagaacca aatagacatt gccctcgcct tggtttcgtc 8821 caacaatcgt ccgcgacgca gtgcagcggt taatgcttcg ggcgatgcgt ccgccaatcg 8881 agatcccaat cccgacgagg aggtggacga cgaggacgac gatgtggacg ccgatcccga 8941 tggagatccc gatgtggacc ccattggcgg cccctcggct gcccaggcgg aggcctatct 9001 gtacgagcga ctgggcagcg gcctgatgcc cacgccaccg gtgggtttcc gcgtccgcat 9061 gaacagctcg attgcccagc ccctggacat tgatgtgaat ggcggaaatg gcggtggtgg 9121 atctggtgga tccggagcag gcgtcactgg aacggccggt ggatccggaa gaggctcctc 9181 gtcgggcgga acaacggcca gtattggagc cattgcctcc gctgccttgc gtccctcgtc 9241 cggttcttgg atggcgccgg actttaattt cattggagtc tcgggcggtg gaggagccag 9301 tggctctgga ggcgcctcag ggagcaatgc caacgggggc gaggtgaacg ccttcctcac 9361 gcccgccatg tcgcagctgg aacgcagtgg tggcgcctcg ggcagtggcc aaaacatgag 9421 caatctgctg gacgaacaac cgtcggtcag tggcaacggc ggcggaggag gaggaagtgg 9481 cggaggttcc gcctctggta acggcggcgt cagcggtgga ggaggagcca atggcggcgg 9541 taccgcagga cagcatccga atgccacgct ctgcgccaac ggagtgcgcc ggcggttgct 9601 ctatttggac cagcagtact gcgtctgcat gcccacgcat cagaatccca cggaagagac 9661 ccagatggag acgttcaccc aggatgctct gcattggtgg ctggaggagg ccacggtctt 9721 ggatatggag agccagactg acgcctgcct gtacgccgct cacttcctgc tgccgcatct 9781 catcaaggag ctgaagacgg cccaccagca gcgcaagcag gaggaggccg cccgccagac 9841 ggccacgaac accacaacac ctgcatcatc ggcttcgtct tcggccggag ctccggcgac 9901 ctccatccta tcgaacacag cggccccaac agcgacggcc tccattgcgt ccagtctact 9961 ggcgaatgcc gtggccgcgg gctcaggcgg cagcagcagc agcggcagcg gattggtggt 10021 gccaccggtg gcagcctccg ccacgggagg cacccggcgc agctcgattc ccgtgctgat 10081 tccctcgagc ttcggcggtc ctggtagtgc aaccactggc gatgccacgg ccacaacggg 10141 aggaaccacc agcagcagtt cctacacaac cacatccatt agcggcagtg gctccttgga 10201 gtcgcagacg acgactcgag cgcctcggca acgcggtgga ttgcgccagc acagccagct 10261 gcccttcaac atctacgcgg agatcgatct gaccaacgaa caggatagcc agggcgccac 10321 gtcaacgggc tctgctccaa acgatggagc ggaatcacag gcacagcagc cgcagcagca 10381 gcagcagcag caaaactcct ccgctccttc gttggcgcag ggggcggtcc ttcagcatca 10441 gcgtcatcca ccggtgccgc tcctgccgtc cagtggaagg ccttcgcgac ctcactcgcg 10501 tctcgacgag gcggagctgc ttctgttgca gttggccgat cgccaggctg ttcgcagtcg 10561 cctgcaagtg tccagcggtc acacgaattc ctcgcgcacc tcgggatcgg cgctgatcaa 10621 cgctcggccc aatcgcgatc tacccgcccg cctgcagcgc ctcgtccagg cacatggctc 10681 cctttccagt cgcatcaatg catccgccgc cagcacgccg gctccgacgc tcgtctccat 10741 gcccacgccc atgtccagtg cggcgctgga gcagctgaat gtcacgcccg ccggcccgga 10801 tgttgtgggc ccagacagga actttgcatt gccaccttcc ctggaggttg atgtggatgt 10861 gctgcctgga atactggatc gcatactgcc gcagcagcag caggagcagc aggaagcgca 10921 gcagcaggag gaggaggagg aacagctgtt gctaccaccg ccacctccgc cgccgcccag 10981 tgaaacggcg cccttgctcc tcaccgagga ggatatgtgg caagggacaa gagaggagga 11041 ggaggattcc acttccacag tggcagttgc cggcagcagc gaggctgcaa acgagtcaaa 11101 ccaatcggat cagacgccgg agagcagcga atctgtttcc ccgaacccgc aggctcctcc 11161 cccagcagca gaatccggcg aaggaggagc agggggagca ggaggagctg cctcggctag 11221 cacacaaacc ccggcaaccg cagaagaatc cgctgtaggt ggaacaacag caacagcaac 11281 aacgacagca gccaccgtaa cggacatgag tcccgaggtg cgggccgctc tcggggatct 11341 ggaggtgccc gagggcgtgg atccctcctt cctggccgcc ctgcccagcg agatgcgcga 11401 ggaggtgatc caggagcatc tgcggatgca gcgcattcgc cagcgggcgc agcagaatgc 11461 cattcagatt gcgcacgatt cgctcgtcga ggtgaatccc gagttcctcg ccgccctgcc 11521 gctgaacatt cagtccgagg tgctgatgca gcagcggatc gagcagcagc gccaggcggc 11581 gcagaccgcg aatcccgagg atcccgtcga cacggccgcc ttctttcaga acctgcccga 11641 gaatctgcgg caagcgatac tcaccgacat ggaggagtcg cagatagcca gtttgccgcc 11701 cgagttggcg gcggaggcgc agttcctgcg tcgcgactgg gagtcccgca atggcgcccg 11761 catggacgcc catccgccca gcaatgcgtt gtcccgcttc cagacgacgc tgcagagcct 11821 ggacgaggcc cgctggcaca gctccatttg gtacgacgcc agcggcaatg cccagccgca 11881 gcaccaccag cacaccacga ttgtgcacca ccatgcccac gcacatcacg cccccacgat 11941 gggcaaaccc ctagccctgc tgatgatgga ggacgagaac atcctgctcg atccggactc 12001 gctggccacc ctgctgctct tcctgttcgt cgaggatcag aaggtgaaca gcatgcggct 12061 gcatcgtgtg attcgcaacc tttgccacca cgaacccacg cgcgattgga tcatcagcgc 12121 tctgattagc atcgtccaaa agaccaacga ggataacgcc aactttggag ctggacaggc 12181 gggcggcaaa ccggagtggc tgaagctgcg cgtggacgcc gcctttggct acaagagcaa 12241 catcttcctc atcaatcggc tgtacgaggg cagtgcgcgg agcatcagca tcaatccgca 12301 ggccgcacag atgatagtgc gcaactgtct ggatctgctc ttcgtgctgg ccaagcacta 12361 tccgtccagc tttgtgccct tcaaccgcga ggtgaaggcc aggcgcatac tgagtgcggt 12421 atttggcatg ccatcgccca cgggtggtgc ttctactgct ggagctggag ctcctgcacg 12481 caatatagat gactttccac cgcccggcgg aactctggac tttcgctcgc gtttctgccg 12541 ctaccaggtg gccaatcgac tgcgcggcat actcgacgat catccggcgg cggccccgaa 12601 accccaaagt gcaactcccc tggatgaggc accctccaca tcgaaggcgg ctgctgccaa 12661 ggcagctgcc acggctaagg tttcgagtca gagcagtcag tcggtgccgt atcaaacgaa 12721 tgcgaagaat ttctgggatg tggtgctcaa catcgatcga cagacccaag tgcgtttggc 12781 caatgtggcc cagtttccac tcacctcgca gccagcttgg gaatggcaag cgaacagcgc 12841 cgacttcctg tcgttcagcg attcgccttt cggacagctg ctggaaatgc tgccctacaa 12901 ggtcatctgc cggtcgccac atctcaccga tatgctggtc aagttgctcg cctcgctgag 12961 caccgagttg cccaaggagg aggaacagtt gccgctgagc gatcaaatgc ccaccctgat 13021 acccattaat caggcggcgg cagcggcagc agattcccca gcgaatccat cagagattgg 13081 tgacggactg gccgcaaatg tggagcagga agccacgccg gccagcggta atccagcctc 13141 cggtgacagc aatgcggctg ccaagcgaac acagctgccc acattgagtg tagccctgcc 13201 agttgctccg tcgaagccgc ggcgcaagat ctactcgaag aacttctcgc aactgcagct 13261 ggtcatcgag gtgctgaccc accagtgcgg caccaccgag ggcctggaca acgtggccaa 13321 gctgattgtg aatctaacgc agtgctcgca ggcatccaat gcgattttca ttcagtacct 13381 gaccgctgcc atcctgggat tggccgagga ggtgcgccag gcgatacaga tgctgctgaa 13441 tgagatacgc atgtacaaca gtcatcatgg agtgacggcc tccacatccg gagcagcggc 13501 agcgggagcc accgtttcag gagccagtct gctgcctaac ctcgccgttc acgagggcat 13561 catgcaggat cgcttcaccg ccgagcatgt catcatttcg gcgccgaaga acgccaagcc 13621 cacctgcgaa ctccagctgc cgtcgatgaa gaagcttatg tccaactcat ccgcccagcc 13681 gtacttcctg cgcaccctga agatcttcat gcaggtgcgc gacatgtacg aggcgcagaa 13741 tggtttatcc acgggcggtg gtttggctgg agcagctggc gacaacgatg acgacatcat 13801 cgacattgag ggcgatggcg gagcttcggg cggcagcagt tcggatatgg cgcccggttc 13861 ggcgagcaca atatctccgc cgccgccgcc accgatggaa accaatcaga acattaacga 13921 tgaggaggag gatgaggatg gggaggagga ggaggacgat gatgatgcgg ccagggcatc 13981 gccagcggcg gcaagtgctg gcaagtcaag caagcccacg ctcagccaga tcctctgcct 14041 cgacgtcctt tggcacacgc tcagcgaatg cctggtggcg ctggaggagt ccaaggacga 14101 gttcgccgtc ctggtgctgc agcccaccgt ggaggccttc ttcctcatcc acgcctcgca 14161 tcgcgcgggg gctaagaagt cgggtcgcgg cggagttgtg ggctccggac tgcgggcagc 14221 tggaggattg ggagcagctg cgtcggcggc ccaggagcac agtccatcga tggacgacac 14281 cagcagcgcc aataccctta gttcggccag tttcgaagat gagccgcgaa tgcaggacgc 14341 ctccacaaac acgccgcttt cgagcaacag ctccgccgcc accactgtgc tgagcgcaca 14401 cgaggcgcag ctgcgacagg atcgccagaa gttcctgcag ttcgccgaga aacaccgcac 14461 cgtgctcaac caaatactgc gccagtcgcc cactcatctc tccgacggac ccttcgccgt 14521 tctcgtcgac cacacgcgca tcctggactt tgacgtcaag cggaagtact tccagacgga 14581 gctggagcgc ctggacgagg gcattcggcg cgaggagcac acggtcagtg tgcggcgcgt 14641 gaccgtcttc gaggattcgt tccgcgtgtt gtaccgcctg ggaccggagg agtggaagaa 14701 ccgcttctac attgtcttcg aggacgagga aggccaggat gctggcggcc tgctgcgcga 14761 atggtatgtg atcatatcgc gcgagatctt caatccgatg tatgccttgt tctgcgtatc 14821 gccgggcgat cgcgtcacct acatgatcaa tccctccagc catgccaatc cgaatcatct 14881 gagctacttc aagttcgtcg gccgcgtaat tgccaaggcc gtgcacgata acaagctgct 14941 ggagtgctac ttcacccgat ccttctacaa gcacatcctg ggcaagcagg tgaagcacac 15001 ggacatggag tcgcaggact acgagttcta caagggcctc gactatctga tgaagaacga 15061 catctccacc ctgggctacg agctgacctt ctccacggag gtgcaggagt tcggtgtcac 15121 ccagatccgt gatctcaagc caaacggacg cgacaccgcg gtgaccgagg aaaacaagtt 15181 cgagtatgtg cagctggtgt gccagctgaa gatgagcggc tccattcgac agcaattgga 15241 cgcattcctc gagggcttct acgacattat tccaaagcat ttaatttcga tattcaacga 15301 acaggaactg gaacttctca tatccggcct gccggatatt gacattgaag atctaaaggc 15361 gaacaccgag taccacaagt acacctccaa atcggcccag attcaatggt tctggcgtgc 15421 attgcgcagc ttcgaccaag cggaccgggc caagttcctg cagttcgtca ctggcacatc 15481 gaaggtgccg ctgcagggct tcggctccct ggagggcatg aacgggattc agaagttcca 15541 aatccatcgg gacgatcggt ccactgatcg attgccctgt gcacacacct gcttcaacca 15601 actggatctt ccgatgtaca agtcatacga caaactgcgg agctgcttgc tgaaggccat 15661 acacgagtgc tccgagggct ttggcttcgc ctaagcggga acatcagtgg ctttcggtcc 15721 tccagcctcc agcgaggcca gccaaccaag cagccaggaa cccatggacg caactctatt 15781 cctagttcgc ccaattcacg ggcgacacga cgagaaatgc ataattgatt tgaacagaac 15841 agaacagcca ctgctaattt gcgatagcgg caacagaaac tgcatacata cacagtacat 15901 atagttatat agtatatata aaaatgttga attaattatt aattttcgcg cctatatata 15961 tacaatatat attttcttaa attttcaaaa gaaaacggaa aaaagtctaa ggaaacctac 16021 aaaaaaaaaa taagatacaa acgcgaaaca gcatattcga tttaaatttg tctgcgtaac 16081 tcatccctat tatatatttt ctcggaatct atccctgtcg ttttgcacat tttcattaaa 16141 acaaaaggat ttatataaaa aaacatacac aatttgacat atttttattt acctaaacac 16201 gaaaccgaat agcaaaggat taaacgtagt ctatagaacg caaatgcaaa tgcacataaa 16261 cagatttctt gtttacttaa gtgaatttac cgaagatgag acggggaggc agcggaaata 16321 attaaatgga ttaaagtatt tcgatgtaag agataagtcc ttatgttatg cattttatgt 16381 ttacctttgg aataatgagc cgcagatgta acttaaagaa tgtggaataa agtaagagta 16441 agctcattta tcaaaata