active breakpoint cluster region-related protein isoform X3

LOCUS       XP_070074978            1320 aa            linear   INV 09-DEC-2024
            [Drosophila takahashii].
ACCESSION   XP_070074978
VERSION     XP_070074978.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070218877.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1320
                     /product="active breakpoint cluster region-related protein
                     isoform X3"
                     /calculated_mol_wt=144133
     Region          591..773
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(594,598,695,724..725,728..729,731..732,735..736,
                     739..740,743,769,773)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          767..953
                     /region_name="PH_BCR_arthropod"
                     /note="Breakpoint Cluster Region-related pleckstrin
                     homology (PH) domain; cd13368"
                     /db_xref="CDD:270174"
     Region          995..>1060
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          1119..1314
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(1157,1196,1200,1272,1275..1276,1306)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:239852"
     Site            1157
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239852"
     CDS             1..1320
                     /gene="RhoGAP1A"
                     /coded_by="XM_070218877.1:275..4237"
                     /db_xref="GeneID:108055801"
ORIGIN      
        1 masfkekfkl wsrgksslnl resstssggk dkdrlslntd nkytthtnaa gsgsgggtaa
       61 gagagstsgp lhsapptgkr iaelnferee rdkdsgnekd tngalqqcit elaasikaqp
      121 dngasstggg gaggaggstd ggdkekqplr kstsqyvtvi qvkeakekeg ddggasdpqq
      181 sqqptppstf aryaeasapp lspsltsyaa hveakkkmpp rpppknirrv epptipsqqq
      241 qqlssspkre tpfvgssmpl psssggslss dspgnslern ikpsdilrqk ssenldskya
      301 anrkttpelg kfvnvnnpel meelgrkmvg ktdsleqakr ndsspsgggs lgrtastpgr
      361 sltpgrtgvg asptgslnkt aklaaadsss tsslekksrn clqasdaegg tgtnqrsvgs
      421 keslasqgis eviksyesvs slssesakaa ataaasqqsa adnepyydsv pldngdgeyv
      481 fikpgrtgss ssrddlstpg sstlplanpa dpespgrtsn yvnidyflqq snetrsssld
      541 sdgeyegppi lrtishdeqt tsqttpgalr knlvsailvs gnargakirs ilssiiqset
      601 iyveclnkmm qykkaihatl ntsqpvikee eentiffkid elhdlhtafl sdlktivshe
      661 ggdvligepf rrladmfdly saflhnykna ietvkkcsan npqfkkivst ivvnlqteqs
      721 ltledllhkp varvqinalv fndllretpm ahpdhqplrq aqkiiqmfln qfnvvnqrlp
      781 sesnrnlrrm vrnsfivelv dghrklrhlf lfndviacak ykalgrdrid yelkwfiplk
      841 eisiieeadp aaelkesspa nisqvkrnlr svrdqlamev ansggggvrs gdkyrrklad
      901 lesqlvlatp nlvlrlanka nnktmtffls sdfertqwid sitslkqkcn lpgantinsl
      961 evtafivamq kgmktemgsy lmrntndesl lvgdlhmavq glggleqaad lyicievdsy
     1021 ghyfrkattk mvcrsqtplw nesfmleleg sqnvrillye akerpllrak hilklslswl
     1081 tettqprtik lsetlelgcs frfvpgelcr attkpgalfg akmsqvlkre krdipfiisa
     1141 cireverrgm levgcyrvsg sasdlaklkk afesdayeae qllrevdihs vtgilktflr
     1201 elpealftdq lyprffdtfs afsnnnestr inellkvfee lpqvnkasin sildhlirvh
     1261 eketdnkmsl hnlamvfgpt llrpgqtqvk qkdplaastv dvmaqagily cflqarikkd