N-chimaerin [Drosophila takahashii].

LOCUS       XP_070074919             481 aa            linear   INV 09-DEC-2024
ACCESSION   XP_070074919
VERSION     XP_070074919.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070218818.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..481
                     /product="N-chimaerin"
                     /calculated_mol_wt=54154
     Region          61..152
                     /region_name="SH2_a2chimerin_b2chimerin"
                     /note="Src homology 2 (SH2) domain found in
                     alpha2-chimerin and beta2-chimerin proteins; cd10352"
                     /db_xref="CDD:198215"
     Site            order(75,93,114,116)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198215"
     Site            order(115,140)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198215"
     Region          227..279
                     /region_name="C1_CHN"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in the chimaerin family; cd20806"
                     /db_xref="CDD:410356"
     Site            order(233..239,247..251,254)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410356"
     Region          288..477
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(327,367,371,440,443..444,463)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:239837"
     Site            327
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239837"
     CDS             1..481
                     /gene="RhoGAP5A"
                     /coded_by="XM_070218818.1:134..1579"
                     /db_xref="GeneID:108058452"
ORIGIN      
        1 mprnteagap epsspvqkvw kpelyklqle apapcplrcq rtlplppaks taeaveannl
       61 agrlygseyh glmghleaeq llanardgsy fvrrspqsdg yytlslrfnk rpkhykllyk
      121 tgcghylrgq dkrfdtvhdm vadglinfhm qlhaspiiqq inqqtkncyq qspymtlngr
      181 klralsnelg kqskeqpqpe eqqpeeeeel patastvdpm plvyekphhf kvhtfkglnw
      241 cefcanflwg ftaqgrkcea cgfvahskcs elvpakcvpd lkrirgvfgt dlttmvqlep
      301 hhqipfvvrr cveeveargm lqegiyrvsg fadeiealkl aldregertd msetaygnvn
      361 viagtlklyl rllpvplitf qaypsfmaag rsgkpaeqrq lmaeavrrlp pahhaclqym
      421 lehlkrvash yavnkmnehn latvfaptli atpqhmtnlt eeifmlssli ahcqtifatt
      481 s