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LOCUS XP_070074548 4514 aa linear INV 09-DEC-2024 protein isoform X37 [Drosophila takahashii]. ACCESSION XP_070074548 VERSION XP_070074548.1 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_070218447.1 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..4514 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..4514 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X37" /calculated_mol_wt=499177 Region 84..>169 /region_name="CCDC66" /note="Coiled-coil domain-containing protein 66; pfam15236" /db_xref="CDD:434558" Region 418..451 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(423,430,441..442) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(434,437,441,447..448) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 444..448 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 504..536 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(510,518,529..530) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(522,525,529,535..536) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 532..536 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 544..579 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(549,558,569..570) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(562,565,569,575..576) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 572..576 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 589..623 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(594,602,613..614) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(606,609,613,619..620) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 616..620 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 675..710 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(680,689,700..701) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(693,696,700,706..707) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 703..707 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 797..831 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(803,811,822..823) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(815,818,822,828..829) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 825..829 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 836..871 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(841,850,861..862) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(854,857,861,867..868) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 864..868 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 886..920 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(891,899,910..911) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(903,906,910,916..917) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 913..917 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 939..973 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(944,952,963..964) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(956,959,963,969..970) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 966..970 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 980..1013 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(985,992,1003..1004) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(996,999,1003,1009..1010) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1006..1010 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1016..1050 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1021,1029,1040..1041) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1033,1036,1040,1046..1047) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1043..1047 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1055..1088 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1060,1067,1078..1079) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1071,1074,1078,1084..1085) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1081..1085 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1104..1136 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1110,1118,1129..1130) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1122,1125,1129,1135..1136) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1132..1136 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1154..1187 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1159,1166,1177..1178) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1170,1173,1177,1183..1184) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1180..1184 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1197..1227 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1198,1206,1217..1218) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1210,1213,1217,1223..1224) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1220..1224 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1228..1262 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1233,1241,1252..1253) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1245,1248,1252,1258..1259) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1255..1259 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1268..1302 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1273,1281,1292..1293) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1285,1288,1292,1298..1299) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1295..1299 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1333..1368 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1338,1346,1357..1358) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1350,1353,1357,1364..1365) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1361..1365 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1391..1459 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 1491..1525 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1496,1504,1515..1516) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1508,1511,1515,1521..1522) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1518..1522 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1531..1565 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1536,1544,1555..1556) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1548,1551,1555,1561..1562) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1558..1562 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1574..1608 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1579,1587,1598..1599) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1591,1594,1598,1604..1605) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1601..1605 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1626..1701 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 1629..1633 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 1642..1646 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 1665..1669 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 1679..1684 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 1693..1696 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 1800..1930 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 1987..2040 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Site order(1987,1989,2001,2011,2013,2022) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region 2165..2301 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region <2302..2328 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Region 2336..2385 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(2337,2339,2346,2353,2356,2365) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region <2422..2452 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Region 2518..2652 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 2745..2827 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2756..2760 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2772..2776 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2791..2795 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2805..2810 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2820..2823 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region <2854..2907 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2938..3021 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2949..2953 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2962..2966 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2985..2989 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2999..3004 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3034..3114 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3051..3055 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409570" Region 3064..3068 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409570" Region 3083..3087 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409570" Region 3097..3102 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409570" Region 3110..3113 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409570" Region 3132..3208 /region_name="I-set" /note="Immunoglobulin I-set domain; pfam07679" /db_xref="CDD:400151" Region 3140..3144 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3153..3157 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3174..3178 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3188..3193 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3201..3204 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3221..3308 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3231..3235 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3244..3248 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3288..3293 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3433..3509 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3442..3446 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3455..3459 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3475..3479 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3489..3494 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3521..>3588 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3532..3536 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3548..3555 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3571..3575 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3642..3710 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3666..3670 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3687..3690 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3700..3705 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3734..3800 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3742..3746 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3755..3759 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3774..3778 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3788..3793 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3822..3969 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3992..4024 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 4072..4225 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 4279..4311 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 4320..4473 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" CDS 1..4514 /gene="trol" /coded_by="XM_070218447.1:209..13753" /db_xref="GeneID:108055788" ORIGIN 1 mgspgsqapa iaigisngrr ghtgslllrl llvafvlnac hvpptnakqi tkskvddqdf 61 iladtqslqg svdldddeaf lippdseekl dkkftpegnw wsqglhrvrr slnsffgsdd 121 ddqekererq rqrqnnrdaa nrqkelrrqq kesqnrekql rlerqerqrl akrnnhvvfn 181 rvtdprkras dlydeneasg lneeetttyr tyfvvnepys ddykerdslq fqnlqkllde 241 dlrnffnrnf ennddeeqei hstlervdqt kdhfkirvql rvdlpssind fgskleqqln 301 vykridrlga stdgvftfte ssvykyehqy divtprvivs gqpitekpve apqefdedpi 361 evalptdeve gsgqdsgscr gdatfqcrrs gkticdemrc dgsrdcpdae deegcevcne 421 lqfkcdnkcl plnkrcdnry dcedqtdeag cqryeveesq pqpqpqpqpe pepepepepe 481 pepepepepe epitdneqpe qnsecratef rcnngdcidi rkrcdhisdc segedeneec 541 paacsgmeyq crdgtrcisl sqqcdghsdc sdaddeehcd gsgndgedcr fdefrcgtge 601 cipmrqvcdn iydcndysde vscaeeeeds vgipigrppq rpapkhdwld eldaneyhvy 661 hpsnvyelan sknpcasnqf rcattnvcip lhlrcdnfyh cndmsdekdc eqyqrrtttt 721 trrpstsarp sftftfttqg pgllerrnst tsrttagstt rateapqwpw atrptetttt 781 npittvgvas sspqssclen iefachnrdc ipiesvcdgt pdcgrseded dalckctadk 841 ykcqhgggci pktqvcdgkp qcrdrsdesa chlngrlnkt rlgvqcqenq yqcgdgscis 901 gykrcngind caddadeync iytynedyvd pddnplnecd ilefecdysl clplekkcdg 961 yadcedlsde fecqsytenc llsefecdgy clprdqlcng iincqdgsde rnctfcreda 1021 ylcttgecva vnqrcngive cadgsderhc ariycppnrl acngrcvsrr ircdgkrdcl 1081 dgydemycpe tnyhypthnp kpktcrthew qctnleciem rlkcddvpdc sdgsdedlsi 1141 cfgtattrlk psdcgpdqff cddlcynrsi rcnghmdcsd gsdeiacssl svlpcpqhqc 1201 psgrcysese rcdrhrhced gsdeanccya dqfrcnngdc iaesahcdgn idcsdqsdel 1261 dcggdsqclp nqfrckngqc vsstarcnkr sdcldgsdeq ncghhhvevs pgstgststt 1321 tsttamtplr iicpptsfkc engpcislgl kcnghvdcpy dssdeadcgq isndidpnep 1381 nnsgrgtnql klktypdnqi ikesrevifr crdegpnrak vkwsrpggrp lppgftdrng 1441 rleipnirve dagayvceav gyanyipgqh vtvnlnverl nereirpdsa cteyqatcmn 1501 gecidksgic dghpdcsdgs dehscslglk cqpnqfmcsn skcvdrtwrc dgendcgdns 1561 detscdpeps dapcrydefq crsghcipks fqcdymndct dgtdeigcsv pspmtlpaps 1621 ivvmeyevle ltcvgtgvpt ptivwrlnwg hvpekcesks yggtgtlrcp nmrpqdsgay 1681 scefintrgt fypktnsivt vtpvrsdvck agffnmlark seecvqcfcf gvstncdsan 1741 lftyaiqppi lshrvvsvel spfrqivine aspgqdlltl hhgvqfrasn vhyngretpf 1801 lalpaeymgn qlksyggnlr yevryngngr pvsgpdviit gnsftlthrv rthpgqnnrv 1861 tipflpggwt kpdgrkgtre dimmilanvd nilirlgyld starevdlin ialdsagsad 1921 qglgsaslve kctcppgyvg dscescasgy vrqargpwlg hcvpftpepc pagtygnprl 1981 gvpcqecpcp hagannfasg cqqspdgdvi crcnegyagk rcehcaqgyq gnplapggvc 2041 rkipdsscnv dgtyniysng tcqckdsvig eqcdtcapks fhlnsftytg ciecfcsgvg 2101 ldcdssswyr nqvtstfgrt rvnhgfalis dymrntpvtv pvsmstqana lsfvgsaeqa 2161 gntlywslpa aflgnkltsy ggklsytlsy splpsgimsr nsapdvviks gedlrlihyr 2221 ksqvspsvan tyaveikesa wqrgdelvpn rehvlmalsn itaiyikaty ttstkeaslr 2281 svtldtatat nlgtaravev eqcrcpegyl glsceqcapg ytrdpeagiy lglcrpcecn 2341 ghskycnset gecescsdnt egfncdrcaa gyvgdatrgt sydcqyddgg yptsrppapg 2401 nqtaeclvnc qqegtagcrg yqceckrnva gdrcdqcrpg tyglsaqnpd gckecycsgl 2461 tnqcrsasly rqlipvdfis tpplitdefg dimdrdnlvp dvprnvytyk htsytpkyws 2521 lrgsvlgnql lsyggrleys livesvgrdh rgkdvvlign glkliwsrpd ghdneqeyhv 2581 rlhedeqwtv edrgsarqat radfmtvlsd lqhililatp kvptvstsis nvilessitt 2641 rapgathasd ielcqcpsgy tgtscescap lhyrdasgrc sqcpcdasnt escglvsggn 2701 vecqcrprwr gdrcreietn eptpepdtst ddpvrtqiiv siarpeitil pvggsltlsc 2761 tgrmrwtnsp vfvnwykqgs hlpegvevqg gnlqlfnlqi sdsgiyicqa vsnetghsft 2821 dhvsitvsqe dqrspahivd lpndvtfeey vsneivceve gnppptvtwt rvdghadaqs 2881 trtdnnrlvf dsprksdegr yrcqaensls reekyvvvyv rsnppqpppq qdrlyitpqe 2941 vngvagdsfq lscqftsaas lrydwshdgr slsassprnv vvrgnvlevr danvrdsgty 3001 tcvafdlrtr rnftesarvy ieqpnepgil gdkphiltle qniiivqged lsitceasgt 3061 pypsikwtkv qenlaenvri sgnvltiygg rsenrglysc iaenshgsdq sstsidiepr 3121 erpsltidta tqkvsvgsqa slycaaqgip eptvewvrtd gqplsprhkv qapgyvvidd 3181 ivlddsgtye crasniagqv sglatinvqe ptlvriepdr qhhivtqgde lslscvgsgv 3241 ptpsvfwsfe grdvdrmgvp egavfaqpfr tntadvkifr vskenegiyv chgsndaged 3301 qqyirvevqp rrgdvgaggd dngdvdtrqp pnrpqiqpnp lsnerlttel gnnvtlicnv 3361 dnvntewerv dgtplphnay tvrntlvivf vepqnlgqyr cngigrdgrv eahvvrelvl 3421 lplpritfyp nipltvelgq nldvycqven vrpedvhwtt dnnrplpssv riegnvlrfa 3481 sitqaaagey rcsatnqygs rsknarvvvk qpsgfqpvph sqvqqrqvgd siqlrcrltt 3541 qygdevrgni qfnwyredgs plprgvrpds qvlqlvklqp edegryicns ydlgsgqqlp 3601 pvsidlqvlt vpaapqnpiy lppvapprsp erilepqlsl svqssnlpag dgttvecfss 3661 ddsypdvvwe radgaplsen vqqvgnnlvi snvastdagn yvckcktdeg dlyttsykle 3721 veeqphelks skivyakvgg nadlqcgade drqpsyrwsr qygqlqagrs lqneklsldr 3781 vqandagtyv csaqysdget vdfpnilvvt gaipqfrqep rsymsfptls nssfkfnfel 3841 tfrpenadgl llfngqtrgs gdyialslkd ryaefrfdfg gkpllvraee plaldewhtv 3901 rvsrfkrdgy iqvddqhpva fptsqhqqip qleliedlyi ggvpnweflp aeavgqqsgf 3961 vgcisrltlq grtvelirea kfkegitdcr pcaqgpcqnk gvclesqteq aytcvcqpgw 4021 tgrdcaiegt qctagvcgsg rcentendme clcplnragd rcqyneilne qslnfksnsf 4081 aaygtpkvtk vnitlsvrpa sledsvilyt aestlpsgdy lalvlrggha ellintaarl 4141 dpvvvrsaep lplnrwtrie irrrlgegil kvgdgperka kapgsdrils lkthlfvggv 4201 drstvkinrd vnitkgfdgc isklynsqks vnllgdirda anvqncgean eidddeyemp 4261 valpspkvae nerqlmapca sdpcenggsc seqedmaics cpfgfsgkhc qnhlqlsfna 4321 sfrgdgyvel nrshfqpale qtyshigivf ttnkpngllf wwgqeageey tgqdfiaaav 4381 vdgyveysmr ldgeeavirn sdirvdnger hiviakrden tamleldqil dtgdtrptin 4441 kamklpgnvf vggapdvaaf tgfrykdnfn gcivvveget vgqinlssaa ingvnanvcp 4501 andeplggte ppvv