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LOCUS XM_070218447 14426 bp mRNA linear INV 09-DEC-2024 (trol), transcript variant X38, mRNA. ACCESSION XM_070218447 VERSION XM_070218447.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14426 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14426 /gene="trol" /note="terribly reduced optic lobes; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 9 Proteins" /db_xref="GeneID:108055788" CDS 209..13753 /gene="trol" /codon_start=1 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X37" /protein_id="XP_070074548.1" /db_xref="GeneID:108055788" /translation="MGSPGSQAPAIAIGISNGRRGHTGSLLLRLLLVAFVLNACHVPP TNAKQITKSKVDDQDFILADTQSLQGSVDLDDDEAFLIPPDSEEKLDKKFTPEGNWWS QGLHRVRRSLNSFFGSDDDDQEKERERQRQRQNNRDAANRQKELRRQQKESQNREKQL RLERQERQRLAKRNNHVVFNRVTDPRKRASDLYDENEASGLNEEETTTYRTYFVVNEP YSDDYKERDSLQFQNLQKLLDEDLRNFFNRNFENNDDEEQEIHSTLERVDQTKDHFKI RVQLRVDLPSSINDFGSKLEQQLNVYKRIDRLGASTDGVFTFTESSVYKYEHQYDIVT PRVIVSGQPITEKPVEAPQEFDEDPIEVALPTDEVEGSGQDSGSCRGDATFQCRRSGK TICDEMRCDGSRDCPDAEDEEGCEVCNELQFKCDNKCLPLNKRCDNRYDCEDQTDEAG CQRYEVEESQPQPQPQPQPEPEPEPEPEPEPEPEPEPEPEEPITDNEQPEQNSECRAT EFRCNNGDCIDIRKRCDHISDCSEGEDENEECPAACSGMEYQCRDGTRCISLSQQCDG HSDCSDADDEEHCDGSGNDGEDCRFDEFRCGTGECIPMRQVCDNIYDCNDYSDEVSCA EEEEDSVGIPIGRPPQRPAPKHDWLDELDANEYHVYHPSNVYELANSKNPCASNQFRC ATTNVCIPLHLRCDNFYHCNDMSDEKDCEQYQRRTTTTTRRPSTSARPSFTFTFTTQG PGLLERRNSTTSRTTAGSTTRATEAPQWPWATRPTETTTTNPITTVGVASSSPQSSCL ENIEFACHNRDCIPIESVCDGTPDCGRSEDEDDALCKCTADKYKCQHGGGCIPKTQVC DGKPQCRDRSDESACHLNGRLNKTRLGVQCQENQYQCGDGSCISGYKRCNGINDCADD ADEYNCIYTYNEDYVDPDDNPLNECDILEFECDYSLCLPLEKKCDGYADCEDLSDEFE CQSYTENCLLSEFECDGYCLPRDQLCNGIINCQDGSDERNCTFCREDAYLCTTGECVA VNQRCNGIVECADGSDERHCARIYCPPNRLACNGRCVSRRIRCDGKRDCLDGYDEMYC PETNYHYPTHNPKPKTCRTHEWQCTNLECIEMRLKCDDVPDCSDGSDEDLSICFGTAT TRLKPSDCGPDQFFCDDLCYNRSIRCNGHMDCSDGSDEIACSSLSVLPCPQHQCPSGR CYSESERCDRHRHCEDGSDEANCCYADQFRCNNGDCIAESAHCDGNIDCSDQSDELDC GGDSQCLPNQFRCKNGQCVSSTARCNKRSDCLDGSDEQNCGHHHVEVSPGSTGSTSTT TSTTAMTPLRIICPPTSFKCENGPCISLGLKCNGHVDCPYDSSDEADCGQISNDIDPN EPNNSGRGTNQLKLKTYPDNQIIKESREVIFRCRDEGPNRAKVKWSRPGGRPLPPGFT DRNGRLEIPNIRVEDAGAYVCEAVGYANYIPGQHVTVNLNVERLNEREIRPDSACTEY QATCMNGECIDKSGICDGHPDCSDGSDEHSCSLGLKCQPNQFMCSNSKCVDRTWRCDG ENDCGDNSDETSCDPEPSDAPCRYDEFQCRSGHCIPKSFQCDYMNDCTDGTDEIGCSV PSPMTLPAPSIVVMEYEVLELTCVGTGVPTPTIVWRLNWGHVPEKCESKSYGGTGTLR CPNMRPQDSGAYSCEFINTRGTFYPKTNSIVTVTPVRSDVCKAGFFNMLARKSEECVQ CFCFGVSTNCDSANLFTYAIQPPILSHRVVSVELSPFRQIVINEASPGQDLLTLHHGV QFRASNVHYNGRETPFLALPAEYMGNQLKSYGGNLRYEVRYNGNGRPVSGPDVIITGN SFTLTHRVRTHPGQNNRVTIPFLPGGWTKPDGRKGTREDIMMILANVDNILIRLGYLD STAREVDLINIALDSAGSADQGLGSASLVEKCTCPPGYVGDSCESCASGYVRQARGPW LGHCVPFTPEPCPAGTYGNPRLGVPCQECPCPHAGANNFASGCQQSPDGDVICRCNEG YAGKRCEHCAQGYQGNPLAPGGVCRKIPDSSCNVDGTYNIYSNGTCQCKDSVIGEQCD TCAPKSFHLNSFTYTGCIECFCSGVGLDCDSSSWYRNQVTSTFGRTRVNHGFALISDY MRNTPVTVPVSMSTQANALSFVGSAEQAGNTLYWSLPAAFLGNKLTSYGGKLSYTLSY SPLPSGIMSRNSAPDVVIKSGEDLRLIHYRKSQVSPSVANTYAVEIKESAWQRGDELV PNREHVLMALSNITAIYIKATYTTSTKEASLRSVTLDTATATNLGTARAVEVEQCRCP EGYLGLSCEQCAPGYTRDPEAGIYLGLCRPCECNGHSKYCNSETGECESCSDNTEGFN CDRCAAGYVGDATRGTSYDCQYDDGGYPTSRPPAPGNQTAECLVNCQQEGTAGCRGYQ CECKRNVAGDRCDQCRPGTYGLSAQNPDGCKECYCSGLTNQCRSASLYRQLIPVDFIS TPPLITDEFGDIMDRDNLVPDVPRNVYTYKHTSYTPKYWSLRGSVLGNQLLSYGGRLE YSLIVESVGRDHRGKDVVLIGNGLKLIWSRPDGHDNEQEYHVRLHEDEQWTVEDRGSA RQATRADFMTVLSDLQHILILATPKVPTVSTSISNVILESSITTRAPGATHASDIELC QCPSGYTGTSCESCAPLHYRDASGRCSQCPCDASNTESCGLVSGGNVECQCRPRWRGD RCREIETNEPTPEPDTSTDDPVRTQIIVSIARPEITILPVGGSLTLSCTGRMRWTNSP VFVNWYKQGSHLPEGVEVQGGNLQLFNLQISDSGIYICQAVSNETGHSFTDHVSITVS QEDQRSPAHIVDLPNDVTFEEYVSNEIVCEVEGNPPPTVTWTRVDGHADAQSTRTDNN RLVFDSPRKSDEGRYRCQAENSLSREEKYVVVYVRSNPPQPPPQQDRLYITPQEVNGV AGDSFQLSCQFTSAASLRYDWSHDGRSLSASSPRNVVVRGNVLEVRDANVRDSGTYTC VAFDLRTRRNFTESARVYIEQPNEPGILGDKPHILTLEQNIIIVQGEDLSITCEASGT PYPSIKWTKVQENLAENVRISGNVLTIYGGRSENRGLYSCIAENSHGSDQSSTSIDIE PRERPSLTIDTATQKVSVGSQASLYCAAQGIPEPTVEWVRTDGQPLSPRHKVQAPGYV VIDDIVLDDSGTYECRASNIAGQVSGLATINVQEPTLVRIEPDRQHHIVTQGDELSLS CVGSGVPTPSVFWSFEGRDVDRMGVPEGAVFAQPFRTNTADVKIFRVSKENEGIYVCH GSNDAGEDQQYIRVEVQPRRGDVGAGGDDNGDVDTRQPPNRPQIQPNPLSNERLTTEL GNNVTLICNVDNVNTEWERVDGTPLPHNAYTVRNTLVIVFVEPQNLGQYRCNGIGRDG RVEAHVVRELVLLPLPRITFYPNIPLTVELGQNLDVYCQVENVRPEDVHWTTDNNRPL PSSVRIEGNVLRFASITQAAAGEYRCSATNQYGSRSKNARVVVKQPSGFQPVPHSQVQ QRQVGDSIQLRCRLTTQYGDEVRGNIQFNWYREDGSPLPRGVRPDSQVLQLVKLQPED EGRYICNSYDLGSGQQLPPVSIDLQVLTVPAAPQNPIYLPPVAPPRSPERILEPQLSL SVQSSNLPAGDGTTVECFSSDDSYPDVVWERADGAPLSENVQQVGNNLVISNVASTDA GNYVCKCKTDEGDLYTTSYKLEVEEQPHELKSSKIVYAKVGGNADLQCGADEDRQPSY RWSRQYGQLQAGRSLQNEKLSLDRVQANDAGTYVCSAQYSDGETVDFPNILVVTGAIP QFRQEPRSYMSFPTLSNSSFKFNFELTFRPENADGLLLFNGQTRGSGDYIALSLKDRY AEFRFDFGGKPLLVRAEEPLALDEWHTVRVSRFKRDGYIQVDDQHPVAFPTSQHQQIP QLELIEDLYIGGVPNWEFLPAEAVGQQSGFVGCISRLTLQGRTVELIREAKFKEGITD CRPCAQGPCQNKGVCLESQTEQAYTCVCQPGWTGRDCAIEGTQCTAGVCGSGRCENTE NDMECLCPLNRAGDRCQYNEILNEQSLNFKSNSFAAYGTPKVTKVNITLSVRPASLED SVILYTAESTLPSGDYLALVLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIR RRLGEGILKVGDGPERKAKAPGSDRILSLKTHLFVGGVDRSTVKINRDVNITKGFDGC ISKLYNSQKSVNLLGDIRDAANVQNCGEANEIDDDEYEMPVALPSPKVAENERQLMAP CASDPCENGGSCSEQEDMAICSCPFGFSGKHCQNHLQLSFNASFRGDGYVELNRSHFQ PALEQTYSHIGIVFTTNKPNGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGE EAVIRNSDIRVDNGERHIVIAKRDENTAMLELDQILDTGDTRPTINKAMKLPGNVFVG GAPDVAAFTGFRYKDNFNGCIVVVEGETVGQINLSSAAINGVNANVCPANDEPLGGTE PPVV" misc_feature 458..>715 /gene="trol" /note="Coiled-coil domain-containing protein 66; Region: CCDC66; pfam15236" /db_xref="CDD:434558" misc_feature 1460..1561 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1475..1477,1496..1498,1529..1534) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1508..1510,1517..1519,1529..1531,1547..1552) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1538..1552 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1718..1816 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(1736..1738,1760..1762,1793..1798) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1772..1774,1781..1783,1793..1795,1811..1816) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1802..1816 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1838..1945 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1853..1855,1880..1882,1913..1918) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1892..1894,1901..1903,1913..1915,1931..1936) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1922..1936 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1973..2077 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1988..1990,2012..2014,2045..2050) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2024..2026,2033..2035,2045..2047,2063..2068) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2054..2068 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2231..2338 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2246..2248,2273..2275,2306..2311) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2285..2287,2294..2296,2306..2308,2324..2329) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2315..2329 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2597..2701 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2615..2617,2639..2641,2672..2677) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2651..2653,2660..2662,2672..2674,2690..2695) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2681..2695 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2714..2821 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2729..2731,2756..2758,2789..2794) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2768..2770,2777..2779,2789..2791,2807..2812) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2798..2812 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2864..2968 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2879..2881,2903..2905,2936..2941) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2915..2917,2924..2926,2936..2938,2954..2959) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2945..2959 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3023..3127 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3038..3040,3062..3064,3095..3100) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3074..3076,3083..3085,3095..3097,3113..3118) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3104..3118 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3146..3247 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3161..3163,3182..3184,3215..3220) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3194..3196,3203..3205,3215..3217,3233..3238) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3224..3238 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3254..3358 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3269..3271,3293..3295,3326..3331) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3305..3307,3314..3316,3326..3328,3344..3349) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3335..3349 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3371..3472 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3386..3388,3407..3409,3440..3445) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3419..3421,3428..3430,3440..3442,3458..3463) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3449..3463 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3518..3616 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3536..3538,3560..3562,3593..3598) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3572..3574,3581..3583,3593..3595,3611..3616) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3602..3616 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3668..3769 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3683..3685,3704..3706,3737..3742) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3716..3718,3725..3727,3737..3739,3755..3760) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3746..3760 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3797..3889 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3800..3802,3824..3826,3857..3862) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3836..3838,3845..3847,3857..3859,3875..3880) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3866..3880 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3890..3994 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3905..3907,3929..3931,3962..3967) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3941..3943,3950..3952,3962..3964,3980..3985) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3971..3985 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4010..4114 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4025..4027,4049..4051,4082..4087) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4061..4063,4070..4072,4082..4084,4100..4105) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4091..4105 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4205..4312 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4220..4222,4244..4246,4277..4282) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4256..4258,4265..4267,4277..4279,4298..4303) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4289..4303 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4379..4585 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 4679..4783 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4694..4696,4718..4720,4751..4756) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4730..4732,4739..4741,4751..4753,4769..4774) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4760..4774 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4799..4903 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4814..4816,4838..4840,4871..4876) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4850..4852,4859..4861,4871..4873,4889..4894) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4880..4894 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4928..5032 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4943..4945,4967..4969,5000..5005) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4979..4981,4988..4990,5000..5002,5018..5023) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 5009..5023 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 5084..5311 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 5093..5107 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 5132..5146 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 5201..5215 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 5243..5260 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 5285..5296 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 5606..5998 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 6167..6328 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature order(6167..6169,6173..6175,6209..6211,6239..6241, 6245..6247,6272..6274) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature 6701..7111 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature <7112..7192 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature 7214..7363 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature order(7217..7219,7223..7225,7244..7246,7265..7267, 7274..7276,7301..7303) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature <7472..7564 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature 7760..8164 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 8441..8689 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8474..8488 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8522..8536 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8579..8593 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8621..8638 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8666..8677 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature <8768..8929 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 9020..9271 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9053..9067 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9092..9106 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9161..9175 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9203..9220 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9308..9550 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 9359..9373 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409570" misc_feature 9398..9412 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409570" misc_feature 9455..9469 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409570" misc_feature 9497..9514 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409570" misc_feature 9536..9547 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409570" misc_feature 9602..9832 /gene="trol" /note="Immunoglobulin I-set domain; Region: I-set; pfam07679" /db_xref="CDD:400151" misc_feature 9626..9640 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9665..9679 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9728..9742 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9770..9787 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9809..9820 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 9869..10132 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9899..9913 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9938..9952 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10070..10087 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10505..10735 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10532..10546 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10571..10585 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10631..10645 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10673..10690 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10769..>10972 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10802..10816 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10850..10873 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10919..10933 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11132..11338 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 11204..11218 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11267..11278 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11306..11323 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11408..11608 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 11432..11446 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 11471..11485 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11528..11542 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11570..11587 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11672..12115 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12182..12280 /gene="trol" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 12422..12883 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 13043..13141 /gene="trol" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 13166..13627 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" polyA_site 14426 /gene="trol" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaggttgc gcgccatcgt tccaggcggt cgcacattcc acgtgccata gccgtaacaa 61 caacctgcca accgcttaaa accaaactca aatacgaacc gaaactgcct tcacacacac 121 aagtacctaa accaaatcta aatagctgcc aaaagaaacc aaaaattcca gagacgtcgt 181 agcatccgtt ccccggaaga agaagaagat gggatcgccg ggatcccaag cgcccgcgat 241 cgcgatcggg atcagtaacg ggcggagagg tcacacgggg tcgctgctcc tgcgcctcct 301 tctcgtggcc ttcgtcctca acgcctgcca cgtacccccg accaatgcca agcaaattac 361 gaaaagtaaa gttgatgacc aggactttat actggccgac acacaatcgc tgcagggcag 421 cgttgacctt gacgatgacg aagcgttcct gattcctccg gattccgaag agaagttgga 481 taagaagttc acgccggagg gcaactggtg gagccagggg ctccatcgtg ttcgccgctc 541 cctaaatagc ttcttcggct ccgacgacga tgatcaggaa aaggaacgtg agcgtcagag 601 gcaaaggcaa aataatcgcg atgccgccaa ccggcaaaag gaacttcggc gccagcaaaa 661 ggagagccag aaccgcgaga agcagctgcg attggagcgc caggagaggc agcgccttgc 721 caagcggaac aatcacgtgg tcttcaatcg cgtcaccgat ccccgcaagc gggcatccga 781 cctttacgac gagaacgagg catctggcct aaacgaggag gaaaccacca cctatcgcac 841 ctactttgtt gttaatgagc catattcaga cgactacaag gagcgggaca gcctccagtt 901 ccagaatctg caaaaacttc ttgacgagga cctgcgcaac ttcttcaatc gcaatttcga 961 aaataacgat gatgaagagc aggaaatcca tagcacccta gagcgagtcg atcaaaccaa 1021 ggaccatttt aaaattcgcg tgcaacttag ggtagatctg cccagttcaa tcaacgactt 1081 tggaagtaag ttggagcaac aactgaatgt ctacaagcga atcgatcgtt tgggtgccag 1141 taccgatggc gtcttcacct ttaccgaatc gagcgtctac aaatacgaac accaatacga 1201 tattgtgaca ccgagagtaa ttgtatctgg acaaccgata actgaaaaac cagtcgaagc 1261 accccaagaa ttcgatgagg atcctatcga agttgcattg cccacggatg aggtggaggg 1321 ctccggccaa gattccggta gctgtcgcgg cgatgccacc ttccagtgtc gaaggagtgg 1381 aaagactatt tgcgatgaaa tgcgatgcga tggatctcgc gattgtcccg atgccgagga 1441 cgaggaaggc tgcgaggttt gcaacgaact tcagttcaag tgcgataaca agtgtctgcc 1501 gctcaataag cgctgcgata atcgatacga ttgtgaggat cagacggacg aggctggttg 1561 tcaacggtac gaagtagaag agtctcagcc tcagccgcag ccgcaacctc agcctgaacc 1621 ggaacctgaa cctgaacctg agcctgagcc tgaacctgaa ccagaaccag aacctgaaga 1681 gcctataaca gacaatgaac agcctgagca aaactcagaa tgccgggcca ccgagttcag 1741 atgcaacaat ggggactgca tcgatattag aaagcgttgc gatcacattt cggactgtag 1801 cgaaggcgag gacgagaacg aggagtgccc cgccgcctgc agcggaatgg agtatcaatg 1861 tcgcgacggc acgcgctgca taagtttgag tcagcagtgc gacggtcatt ccgattgcag 1921 cgacgccgac gacgaggagc attgcgacgg aagtggtaac gatggtgagg attgtcggtt 1981 cgatgagttc cgttgcggaa ctggtgagtg cataccgatg cgtcaggtgt gcgataacat 2041 ctacgattgc aacgattatt ccgatgaggt cagctgcgcc gaggaggagg aagatagtgt 2101 gggcataccc attggccgtc caccgcagag gccagcgccc aaacacgact ggctggacga 2161 attggacgcc aatgagtacc acgtctatca tccaagtaat gtctatgagt tggccaattc 2221 caagaatccc tgtgccagca atcaatttcg ctgcgccacc acgaatgtgt gcatccccct 2281 gcatttgcgt tgcgataatt tctatcactg caacgatatg agcgatgaga aggactgcga 2341 gcagtatcaa cgacgcacca ccaccaccac ccgacgacct tcgacctcgg cccggccctc 2401 cttcaccttc accttcacga cccaggggcc aggcttgctg gagcgtcgca atagcaccac 2461 cagtagaacc accgcaggca gcaccaccag agccaccgaa gcaccacaat ggccatgggc 2521 aaccagaccc accgagacca cgaccactaa cccaataaca acagttggcg tagcgagcag 2581 ctcacctcag tcctcctgtc tcgaaaacat cgaattcgcg tgtcacaatc gcgattgcat 2641 tccgattgag agcgtctgcg atggcacccc cgactgcgga cgcagtgaag acgaggacga 2701 cgctctttgc aagtgcaccg ccgacaagta caaatgccaa cacggcggag gctgcattcc 2761 gaaaacccag gtgtgcgatg gcaaacctca gtgccgcgac cgcagcgacg agagcgcctg 2821 ccatctcaat ggaagattaa ataagactcg tttgggggtc cagtgccagg aaaaccagta 2881 tcaatgtggc gatggaagct gcatctccgg ctacaaacgc tgcaatggca tcaacgattg 2941 cgccgatgac gccgacgaat ataactgcat ctacacctac aacgaagact acgtagaccc 3001 ggacgacaat ccattgaatg aatgtgatat ccttgagttt gaatgtgact acagtctgtg 3061 tttaccgcta gagaagaaat gcgatggcta tgcagactgt gaagacttga gcgacgagtt 3121 cgagtgtcag tcgtacacag agaattgtct attgtctgag ttcgaatgcg atggctactg 3181 cctgccccgc gatcagttat gcaacggaat aatcaattgc caagatggca gcgacgagcg 3241 caactgtacc ttttgccggg aagatgccta cctctgcacc accggcgagt gtgtggccgt 3301 aaatcagaga tgcaacggca tcgtcgaatg cgccgatggc agcgacgagc gtcactgcgc 3361 caggatatat tgtccaccta ataggctggc ctgcaacggc cgatgcgtca gtcggagaat 3421 taggtgtgat ggcaaacgcg attgcctcga tggctacgac gagatgtatt gtccggagac 3481 caactaccat tatcccacac acaatcctaa accaaaaacc tgccgaaccc acgagtggca 3541 gtgtacgaat ctcgagtgca tcgagatgag attgaagtgc gatgatgttc cggattgctc 3601 ggatggatcc gatgaggacc tcagcatttg cttcggcacg gccaccacac gactaaagcc 3661 cagcgactgc ggtccggatc agttcttctg cgatgattta tgctataatc gctctattcg 3721 atgcaatggc catatggatt gctcagatgg cagtgatgag atcgcttgta gctcgctgtc 3781 agtgcttcca tgtccacagc accagtgtcc cagtggcagg tgttattcgg aaagtgagcg 3841 atgcgatcgc cacaggcact gcgaggatgg ctccgatgag gccaactgct gttacgcgga 3901 tcaattccgc tgcaataatg gtgactgcat tgcggaatcg gctcattgcg atggaaatat 3961 cgattgtagc gaccagtccg atgaactcga ctgcggagga gactcgcagt gtctgcccaa 4021 ccaattccgc tgcaagaatg gccaatgtgt gagctctaca gcgcgttgca acaagcgttc 4081 cgattgtttg gatggctccg atgagcagaa ttgtggtcat catcatgttg aggtcagccc 4141 aggaagcact ggaagtacca gcaccaccac tagcaccact gccatgacgc ctctgagaat 4201 catctgtcca ccaacctcat ttaaatgcga aaatggaccc tgtatttcgc tgggcctcaa 4261 gtgcaacgga cacgtcgatt gtccgtatga tagtagcgat gaggcggatt gtggccaaat 4321 cagcaatgac attgatccca atgaacctaa caactccgga cgtggaacga accaattgaa 4381 actcaagacc tatcccgaca accaaatcat taaggagagt cgtgaggtca tcttccgttg 4441 ccgtgacgaa ggtcccaacc gcgccaaggt caagtggtcg cgacccggcg gacgtcccct 4501 gccccccggt ttcaccgatc gcaatggccg cctggagatc cccaacatca gggtggagga 4561 tgctggcgcc tatgtctgcg aggccgtggg ctatgccaac tatattcccg gtcagcacgt 4621 caccgtaaac ctcaacgtcg agcgcttaaa cgaacgcgaa atccgtccgg actcagcctg 4681 tacggagtac caggccacct gcatgaacgg cgagtgtatc gataagtcgg gcatctgcga 4741 tggacatccg gactgttcgg atggctccga tgagcacagc tgcagtttgg gtttgaagtg 4801 tcagcccaac cagttcatgt gctccaattc caagtgtgtg gatcgcacct ggcgctgtga 4861 tggcgagaac gactgcggcg ataactccga tgagacctct tgcgatccgg aaccaagtga 4921 tgctccgtgc cgatacgacg aattccagtg ccgcagcggt cattgcattc ccaagagctt 4981 ccagtgcgac tatatgaacg attgtaccga tggtaccgat gaaattggat gctcggtgcc 5041 ctctccaatg accctacccg caccctcgat tgtcgtgatg gagtacgagg tcctcgagct 5101 gacctgcgtg ggcaccggcg tcccgacgcc gacgatcgtg tggcgtctca actggggcca 5161 tgtgcccgag aagtgtgaat cgaagagcta cggcggaacc ggaaccctgc gctgtccgaa 5221 catgaggccc caggacagtg gtgcctactc gtgcgagttc atcaacacac gcggcacctt 5281 ctatccgaaa acgaactcga ttgtcaccgt tacgccggtg cgctcggatg tctgcaaggc 5341 cggattcttc aatatgctgg cccgcaagtc ggaggaatgc gtccagtgct tctgctttgg 5401 cgtttcgacc aactgtgaca gtgccaattt gttcacctac gccattcagc caccgatcct 5461 ttcgcaccgc gtggtcagcg ttgaactcag tccgttccgt caaattgtca tcaatgaggc 5521 tagtccgggt caggatctgc tcaccttgca ccatggtgtt cagttcaggg catcgaacgt 5581 acactacaac ggccgggaga caccattctt ggccctgccc gctgagtata tgggcaacca 5641 gctgaagtcc tatggcggca atctgcgcta cgaggtcagg tacaatggca acggtagacc 5701 ggtcagcgga cccgatgtca tcatcaccgg caacagtttc acgctaaccc atcgcgttcg 5761 cactcatccg ggtcagaaca acagggtgac tattcccttc ctgccgggag gctggacgaa 5821 gccggatggt cgcaagggaa cgcgagagga catcatgatg atactggcca atgtggacaa 5881 tattctgatt cgactgggct acctggatag cacagctcgc gaagtggatc tgataaatat 5941 cgccttggat tcggccggaa gtgccgatca gggattgggc agtgcctcgc tcgtggagaa 6001 gtgcacctgt ccgcccggct atgttggtga ttcgtgcgag tcctgtgcct cgggctatgt 6061 tcgccaggcc cgcggacctt ggctgggtca ttgtgtgccc ttcaccccgg aaccgtgccc 6121 agcgggaacc tacggcaatc cccgacttgg tgttccctgc caggagtgtc cgtgccccca 6181 cgcgggcgcc aataactttg ccagcggctg ccaacagagt cccgatggcg atgtgatttg 6241 ccgctgcaac gaaggctatg ccggcaagag gtgcgagcac tgcgcccagg gttaccaggg 6301 taatccgttg gcaccgggag gagtctgtcg caagataccc gatagttcgt gcaatgtcga 6361 cggcacctac aacatctaca gcaatggaac gtgccagtgc aaggatagcg tgattggcga 6421 acagtgcgac acctgcgcgc cgaagagttt ccacctcaat tcgttcacct acaccggttg 6481 catcgagtgc ttctgcagtg gagtgggctt ggattgtgac agtagttcgt ggtatcgcaa 6541 ccaggtcacc agcacctttg gacgaacgcg cgtcaatcat ggattcgccc tgattagcga 6601 ctatatgcgc aataccccgg taacggtgcc cgtttccatg tccacccagg ccaatgcctt 6661 gagcttcgtg ggatccgccg agcaggccgg taatacgctc tactggagtc ttcccgccgc 6721 cttcctgggc aacaagctga cctcgtacgg aggcaagttg agctacacgc tcagctacag 6781 tcccctgccc agcggcatta tgtcgcgcaa cagtgccccc gatgtggtga tcaagagcgg 6841 cgaggatctg aggctcatcc attacaggaa gtcgcaggtc agtcccagtg tggccaacac 6901 ctatgccgtg gagatcaagg agagcgcatg gcagcgcggc gatgaactgg tgcctaaccg 6961 tgaacacgtc ctgatggccc tcagcaatat tacggccatc tatatcaagg ccacgtacac 7021 gactagcacc aaggaggcct cgctgcgatc ggtcacattg gatacggcca cggccaccaa 7081 tctgggcacc gcacgtgccg tcgaagtgga gcagtgccgc tgtcccgagg gctatttggg 7141 tctctcctgc gagcagtgtg ctcctggcta tacgcgcgat ccggaggcag gaatctatct 7201 gggtctctgc aggccctgcg agtgcaatgg acattccaag tattgcaaca gtgagacagg 7261 cgaatgcgaa agctgttccg acaacaccga aggattcaat tgtgaccgat gcgccgccgg 7321 ctatgtgggt gatgccaccc gaggaacttc gtacgactgt caatacgatg acggcggcta 7381 tccgacgtcg cgtccaccgg caccgggcaa tcagacggcc gaatgcctgg tgaattgcca 7441 acaggaggga accgccggtt gccgcggcta ccagtgcgag tgcaagagga atgtggctgg 7501 cgatcgatgc gatcagtgcc gccccggaac ctatggactg tcggcccaaa atccggacgg 7561 ttgcaaggag tgctactgct ccggactgac caaccagtgc cgctcggcgt ctctctaccg 7621 ccagctgata cccgtggact tcatttcgac gccaccattg ataacagacg aattcggcga 7681 catcatggat agggataacc ttgtgcccga cgtgcccagg aatgtgtata cctacaagca 7741 cacctcctac acgcccaagt actggagcct gaggggtagt gtgctgggca accagctgtt 7801 gtcgtacggc ggccgcttgg agtacagcct gattgtggag tccgttggcc gggaccatcg 7861 tggcaaggat gtggtcctaa ttggcaacgg actcaagctg atctggtcgc gacccgatgg 7921 ccatgacaac gagcaggaat accatgtgcg tttgcatgag gacgagcagt ggacggttga 7981 ggatcgtgga tcggcacgac aggccacgcg ggccgacttc atgactgtgc tgtcggatct 8041 gcagcacatc ctgatcctgg ccacacccaa ggtgcccacg gtcagcacct cgattagcaa 8101 tgtcatcctg gagagttcga taaccacgag agcgcctgga gctacgcatg cctccgatat 8161 cgagttgtgc cagtgtccat ccggttatac gggcacttcc tgtgagtcct gcgcaccact 8221 gcactaccgc gacgcctctg gacgctgcag tcagtgtcct tgcgacgctt ccaacacgga 8281 atcctgcggc ttggtcagcg gcggtaacgt cgaatgccag tgcaggccac gctggagggg 8341 tgatcgctgc cgggaaattg aaactaacga accgactccg gaaccggata ccagtaccga 8401 tgatcccgtg cgcacccaga tcatagtgtc gattgccagg ccagagatta ccattctgcc 8461 cgtgggtgga tcgctgaccc tcagctgtac cggtcgaatg cgctggacca atagcccagt 8521 gtttgtgaac tggtacaagc agggcagtca cctgcccgag ggagtcgagg tgcaaggcgg 8581 taatctgcag ctgttcaacc tgcagatcag cgattctgga atctacatct gccaggccgt 8641 aagcaacgag accggccaca gctttacgga ccacgtctcc atcaccgttt cccaggagga 8701 ccaacgctcg ccggctcaca ttgtggattt gcccaacgac gtgaccttcg aggagtacgt 8761 aagcaatgag atcgtctgcg aggtggaggg caacccacca cccactgtca cctggactcg 8821 cgtggatggc catgcggacg cccaaagtac gcgaacggac aacaatcggc tggtcttcga 8881 ttcgccgagg aaatcggacg agggtcgcta tcgctgccag gcagagaata gcctgagtcg 8941 ggaggagaag tacgtagtcg tgtatgtccg gagcaatcct ccccagccgc cgccgcagca 9001 ggatcgtttg tacatcacac cgcaggaggt gaacggtgtg gccggtgact ccttccagtt 9061 gtcctgccaa ttcaccagcg ctgcctctct gcgctacgat tggtcccacg atggtcgctc 9121 cctgtccgcg tcgtcacccc gaaatgttgt ggtccgcgga aatgtcctgg aagtccgcga 9181 tgccaacgtt cgcgactccg gcacctacac ctgtgtggcc ttcgacctgc gcacccgacg 9241 caacttcacc gagagcgcac gggtctacat cgagcagccc aacgagccgg gaatccttgg 9301 cgacaagccg catatcttga ccttggagca gaacatcata attgtgcaag gcgaggactt 9361 gagcatcaca tgtgaggcaa gtggaacgcc ctatccctcg attaagtgga ccaaggtgca 9421 ggagaatctg gccgaaaatg tccgcatcag tggcaatgtg ctcaccatct acggaggccg 9481 cagtgagaat cgtggtcttt actcctgcat cgccgagaac tctcacggca gcgatcagtc 9541 cagcacaagc atcgatattg aaccccggga gcggccgagt cttacgattg atacggccac 9601 ccaaaaggtt tcggttggct cccaggcgtc cctttactgt gccgcccagg gcattcccga 9661 accgaccgtc gagtgggttc gaacggatgg tcagccactg tcgccgcgtc acaaggtcca 9721 ggcacccggc tatgttgtga tcgatgacat tgtgctcgat gatagcggta cctacgagtg 9781 ccgggcgagc aacatagctg gccaggtgag cggcttggcc accattaacg tccaggagcc 9841 aactcttgtg cggatcgaac cagataggca acaccatatc gtcacccagg gcgacgaact 9901 ctcgctcagc tgcgtgggca gtggcgtccc tactccttcg gtcttttgga gtttcgaggg 9961 aagagacgtt gacaggatgg gagtaccgga aggtgctgtt tttgcgcaac ctttccgaac 10021 caacactgcc gacgtgaaaa tcttccgggt gagcaaggag aacgaaggca tctacgtctg 10081 tcacggatcc aatgacgcgg gtgaagatca acaatacatt cgcgtggagg tacaacccag 10141 acggggtgac gtcggtgcag gaggagatga caatggtgat gtcgataccc gacagccccc 10201 caatcggccc caaatccaac cgaatccatt gagcaacgaa cgcctgacca ccgaattggg 10261 caacaatgtg accctcatct gcaacgtgga caacgtgaac acggaatggg aacgcgtcga 10321 tggcacaccc ctgccgcaca atgcctacac ggtgagaaat acgctggtga ttgtcttcgt 10381 ggagccgcag aatctgggtc agtaccgctg caatggaatc ggtcgcgatg gacgtgtgga 10441 ggcccatgtg gtgagggagc tggttctcct gcccctgccc aggatcacct tctatcccaa 10501 catcccgctg accgtggagc tgggccagaa cttggatgtc tactgccagg tggagaacgt 10561 gcgtccggag gacgtgcatt ggaccaccga caacaatcga ccactgccca gttccgtacg 10621 catcgagggc aatgtcctca ggttcgcgtc catcactcag gctgctgccg gtgaataccg 10681 ctgctcggcc accaatcaat atggaagccg atcgaagaac gccagggtgg tggtgaaaca 10741 gcccagtggc ttccagcccg ttccccactc gcaggtgcaa cagcgtcagg tgggcgactc 10801 catccagttg cgatgccgcc tgaccaccca gtacggcgac gaggttcgcg gcaatatcca 10861 gttcaactgg taccgtgagg acggcagccc cttgccccgc ggtgtccgtc cggatagcca 10921 ggtgctgcag ctggttaaat tgcagcccga ggacgagggc cgctacatct gcaactcgta 10981 cgatttgggc agcgggcagc aactgccccc cgtctccatc gacttgcaag tactaacggt 11041 accagcggct ccccagaacc ccatctacct gccgccagtg gcgccaccac gttcgcccga 11101 aaggatcctc gagccccaac tgagcctgag tgtacaatcc tcgaacctgc cagccggcga 11161 cggcaccacc gtcgagtgct tctcctccga tgactcctac ccagatgtcg tgtgggaacg 11221 cgccgatgga gctccactca gcgaaaatgt ccagcaagtg ggcaataacc tggtgattag 11281 taacgtggcc tccaccgatg ccggtaacta tgtgtgcaag tgcaagacgg acgagggaga 11341 tctgtatacc accagctaca aactggaggt cgaggagcag ccccatgaac tgaagagctc 11401 caagatagtc tacgccaagg ttggcggaaa tgccgacttg cagtgcggag ccgatgaaga 11461 tcgacagccc agctaccgtt ggtctcgcca atacggacaa cttcaggcgg gacgcagtct 11521 gcagaatgag aaactttcgt tggatcgcgt tcaggccaac gatgccggaa cttatgtttg 11581 ttcggcccaa tacagcgatg gcgagacggt tgacttcccc aacattctgg ttgtgaccgg 11641 ggcgattccc cagttccgcc aggagccccg cagctacatg agcttcccca cgctctcgaa 11701 ctcctcgttc aagttcaact tcgagctgac cttccggccg gaaaacgccg acggactgct 11761 gctcttcaat ggacagaccc gcggaagcgg tgactatatc gcactctcgc tgaaggatcg 11821 ctatgcggag ttccggttcg attttggcgg taaaccgttg ctggtgcgag cggaggagcc 11881 actggctttg gatgaatggc acacggtgcg cgtgagtcgc ttcaagcggg atggctacat 11941 ccaggtggac gaccagcatc cggtggcctt ccccacctcc cagcatcagc agatacccca 12001 gttggaactg attgaggatc tgtacattgg cggcgtgccc aactgggagt tcctgcccgc 12061 cgaggcggtg ggtcagcaat caggcttcgt gggctgcatt agccggctga ccctgcaggg 12121 acgcaccgtg gagctgatcc gggaggccaa gttcaaggag ggcatcaccg attgccggcc 12181 ctgcgcccag ggaccctgcc agaacaaggg cgtctgcctg gagagccaga cggagcaggc 12241 ctacacctgc gtctgccagc cgggctggac tggccgggat tgtgccatcg agggcaccca 12301 gtgcaccgca ggagtttgcg gctcgggacg ctgcgagaat acggagaacg acatggagtg 12361 cctgtgcccg ctgaacaggg caggcgatcg atgccagtac aatgagattc taaatgaaca 12421 gagcttgaat ttcaagagca acagctttgc ggcctacgga actcccaagg tcaccaaagt 12481 aaacatcaca ctctccgttc gtcccgcgag cctggaggac tctgtgatcc tgtacacggc 12541 ggaatccact ctgcccagcg gcgattacct ggctttggtc cttcgcggtg gccacgcgga 12601 gctgctgatc aacacggccg cccgcttgga tcccgtggtg gtgcgttcgg cggaaccgct 12661 gcccctcaat cgctggacca gaatcgagat caggcgtcgc ctgggcgagg gaatcctcaa 12721 ggtgggcgat ggacccgagc gaaaggccaa ggcaccggga tccgatcgca ttctgtcgct 12781 caagacccac ctctttgtgg gcggcgtcga tcggtcgacc gtaaagatca accgtgatgt 12841 gaacatcacc aagggcttcg atggctgcat ctcgaagctg tacaactcgc agaaatccgt 12901 caatctgctg ggtgacatca gggatgcggc gaatgtccag aactgtgggg aggcgaatga 12961 gatagatgac gatgagtatg agatgccagt agcgctgcca tcgcctaagg tcgccgagaa 13021 tgaacgtcag ctgatggcgc cgtgtgccag tgatccctgc gagaacgggg gaagctgcag 13081 cgagcaggag gacatggcca tctgctcctg tcccttcggc ttcagcggca aacactgcca 13141 gaatcacctc cagctgagct tcaatgcctc gttccgcggc gatggctacg tggagctgaa 13201 ccgcagccac ttccaacccg ccctggagca gacgtactcc cacattggca ttgtgttcac 13261 caccaacaag ccgaatggcc tgcttttctg gtggggccag gaggccgggg aggagtacac 13321 cggacaggac ttcattgccg ccgccgtggt cgatggctat gtggagtact cgatgaggct 13381 cgatggcgag gaggcggtca ttcggaacag cgatatccgc gtggacaatg gcgagcggca 13441 cattgtgatc gccaagcggg atgagaacac cgccatgctg gaactcgatc agatcctgga 13501 cacgggcgat acgcgaccca ccatcaacaa ggcaatgaag ctgccgggca atgtgtttgt 13561 cggtggcgct cctgatgtcg cggcattcac gggcttccgc tacaaggaca atttcaacgg 13621 ctgcattgtg gtcgtcgagg gcgaaaccgt gggccaaatt aaccttagtt cagctgccat 13681 caatggagtg aatgccaacg tgtgtcccgc taacgacgaa cctctgggag gaaccgaacc 13741 gccagtcgtc tgaggacaca accagcaacc gaaattagct ttttaattaa acattaacaa 13801 atgaaacaaa aagaaaaaca atttttatat atacaacata tgaataagcc ccaagcaaac 13861 ctacaaaaaa ttgaatatta tacgacgaac agataatata aaaacaaaaa aagagagaaa 13921 cgatcacttc tactacaatt gcttcttcga tccttaagtc taggttaaag attgtagcaa 13981 gaaaacaagc gaatatcaca aacatttatt taacaagaac gccatgcgag aagtgaaacg 14041 aaacagaaac aataatgcaa ttaatgcaga taatacagat aaagcctaga accctaagaa 14101 ctaactaact aactcgaaca agaacaacaa cgcatactag ccaactgcaa ccacaacaac 14161 cacaatagtg aaggcatttt aattataatt ttagtctcta gcttataact atgactacga 14221 ctcgtttttt ttgtgagccc agtgtaaaat gttggaaatc ggaaattggc cctacacaca 14281 aacacacaca agttattaat taaataccaa ttgataccat ataatgataa atgaaatact 14341 atgaatgcaa ctattgtgaa cgaacgaaaa ccgttgagtg gataaaaagc ataagcagaa 14401 gatatattaa aatgaaatca acaaca