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LOCUS XP_070074519 4497 aa linear INV 09-DEC-2024 protein isoform X1 [Drosophila takahashii]. ACCESSION XP_070074519 VERSION XP_070074519.1 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_070218418.1 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..4497 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..4497 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X1" /calculated_mol_wt=497684 Region 84..>169 /region_name="CCDC66" /note="Coiled-coil domain-containing protein 66; pfam15236" /db_xref="CDD:434558" Region 418..451 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(423,430,441..442) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(434,437,441,447..448) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 444..448 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 504..536 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(510,518,529..530) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(522,525,529,535..536) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 532..536 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 544..579 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(549,558,569..570) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(562,565,569,575..576) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 572..576 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 589..623 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(594,602,613..614) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(606,609,613,619..620) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 616..620 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 675..710 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(680,689,700..701) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(693,696,700,706..707) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 703..707 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 797..831 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(803,811,822..823) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(815,818,822,828..829) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 825..829 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 836..871 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(841,850,861..862) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(854,857,861,867..868) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 864..868 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 886..920 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(891,899,910..911) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(903,906,910,916..917) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 913..917 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 939..973 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(944,952,963..964) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(956,959,963,969..970) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 966..970 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 980..1013 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(985,992,1003..1004) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(996,999,1003,1009..1010) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1006..1010 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1016..1050 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1021,1029,1040..1041) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1033,1036,1040,1046..1047) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1043..1047 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1070..1102 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1076,1084,1095..1096) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1088,1091,1095,1101..1102) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1098..1102 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1120..1153 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1125,1132,1143..1144) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1136,1139,1143,1149..1150) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1146..1150 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1163..1193 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1164,1172,1183..1184) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1176,1179,1183,1189..1190) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1186..1190 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1194..1228 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1199,1207,1218..1219) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1211,1214,1218,1224..1225) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1221..1225 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1234..1268 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1239,1247,1258..1259) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1251,1254,1258,1264..1265) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1261..1265 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1283..1351 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 1383..1417 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1388,1396,1407..1408) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1400,1403,1407,1413..1414) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1410..1414 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1423..1457 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1428,1436,1447..1448) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1440,1443,1447,1453..1454) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1450..1454 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1466..1500 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1471,1479,1490..1491) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1483,1486,1490,1496..1497) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1493..1497 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1518..1593 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 1521..1525 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 1534..1538 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 1557..1561 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 1571..1576 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 1585..1588 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 1692..1822 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 1879..1932 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Site order(1879,1881,1893,1903,1905,1914) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region 2057..2193 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region <2194..2220 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Region 2228..2277 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(2229,2231,2238,2245,2248,2257) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region <2314..2344 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Region 2410..2544 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 2699..2781 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2710..2714 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2726..2730 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2745..2749 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2759..2764 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2774..2777 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region <2808..2861 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2892..2975 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2903..2907 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2916..2920 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2939..2943 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2953..2958 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2988..3068 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3005..3009 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409570" Region 3018..3022 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409570" Region 3037..3041 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409570" Region 3051..3056 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409570" Region 3064..3067 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409570" Region 3086..3162 /region_name="I-set" /note="Immunoglobulin I-set domain; pfam07679" /db_xref="CDD:400151" Region 3094..3098 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3107..3111 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3128..3132 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3142..3147 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3155..3158 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3175..3262 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3185..3189 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3198..3202 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3242..3247 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3387..3463 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3396..3400 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3409..3413 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3429..3433 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3443..3448 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3475..>3542 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3486..3490 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3502..3509 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3525..3529 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3625..3693 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3649..3653 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3670..3673 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3683..3688 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3717..3783 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3725..3729 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3738..3742 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3757..3761 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3771..3776 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3805..3952 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3975..4007 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 4055..4208 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 4262..4294 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 4303..4456 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" CDS 1..4497 /gene="trol" /coded_by="XM_070218418.1:209..13702" /db_xref="GeneID:108055788" ORIGIN 1 mgspgsqapa iaigisngrr ghtgslllrl llvafvlnac hvpptnakqi tkskvddqdf 61 iladtqslqg svdldddeaf lippdseekl dkkftpegnw wsqglhrvrr slnsffgsdd 121 ddqekererq rqrqnnrdaa nrqkelrrqq kesqnrekql rlerqerqrl akrnnhvvfn 181 rvtdprkras dlydeneasg lneeetttyr tyfvvnepys ddykerdslq fqnlqkllde 241 dlrnffnrnf ennddeeqei hstlervdqt kdhfkirvql rvdlpssind fgskleqqln 301 vykridrlga stdgvftfte ssvykyehqy divtprvivs gqpitekpve apqefdedpi 361 evalptdeve gsgqdsgscr gdatfqcrrs gkticdemrc dgsrdcpdae deegcevcne 421 lqfkcdnkcl plnkrcdnry dcedqtdeag cqryeveesq pqpqpqpqpe pepepepepe 481 pepepepepe epitdneqpe qnsecratef rcnngdcidi rkrcdhisdc segedeneec 541 paacsgmeyq crdgtrcisl sqqcdghsdc sdaddeehcd gsgndgedcr fdefrcgtge 601 cipmrqvcdn iydcndysde vscaeeeeds vgipigrppq rpapkhdwld eldaneyhvy 661 hpsnvyelan sknpcasnqf rcattnvcip lhlrcdnfyh cndmsdekdc eqyqrrtttt 721 trrpstsarp sftftfttqg pgllerrnst tsrttagstt rateapqwpw atrptetttt 781 npittvgvas sspqssclen iefachnrdc ipiesvcdgt pdcgrseded dalckctadk 841 ykcqhgggci pktqvcdgkp qcrdrsdesa chlngrlnkt rlgvqcqenq yqcgdgscis 901 gykrcngind caddadeync iytynedyvd pddnplnecd ilefecdysl clplekkcdg 961 yadcedlsde fecqsytenc llsefecdgy clprdqlcng iincqdgsde rnctfcreda 1021 ylcttgecva vnqrcngive cadgsderhc vvnttetnyh ypthnpkpkt crthewqctn 1081 leciemrlkc ddvpdcsdgs dedlsicfgt attrlkpsdc gpdqffcddl cynrsircng 1141 hmdcsdgsde iacsslsvlp cpqhqcpsgr cysesercdr hrhcedgsde anccyadqfr 1201 cnngdciaes ahcdgnidcs dqsdeldcgg dsqclpnqfr ckngqcvsst arcnkrsdcl 1261 dgsdeqncan epnnsgrgtn qlklktypdn qiikesrevi frcrdegpnr akvkwsrpgg 1321 rplppgftdr ngrleipnir vedagayvce avgyanyipg qhvtvnlnve rlnereirpd 1381 sacteyqatc mngecidksg icdghpdcsd gsdehscslg lkcqpnqfmc snskcvdrtw 1441 rcdgendcgd nsdetscdpe psdapcryde fqcrsghcip ksfqcdymnd ctdgtdeigc 1501 svpspmtlpa psivvmeyev leltcvgtgv ptptivwrln wghvpekces ksyggtgtlr 1561 cpnmrpqdsg ayscefintr gtfypktnsi vtvtpvrsdv ckagffnmla rkseecvqcf 1621 cfgvstncds anlftyaiqp pilshrvvsv elspfrqivi neaspgqdll tlhhgvqfra 1681 snvhyngret pflalpaeym gnqlksyggn lryevryngn grpvsgpdvi itgnsftlth 1741 rvrthpgqnn rvtipflpgg wtkpdgrkgt redimmilan vdnilirlgy ldstarevdl 1801 inialdsags adqglgsasl vekctcppgy vgdscescas gyvrqargpw lghcvpftpe 1861 pcpagtygnp rlgvpcqecp cphagannfa sgcqqspdgd vicrcnegya gkrcehcaqg 1921 yqgnplapgg vcrkipdssc nvdgtyniys ngtcqckdsv igeqcdtcap ksfhlnsfty 1981 tgciecfcsg vgldcdsssw yrnqvtstfg rtrvnhgfal isdymrntpv tvpvsmstqa 2041 nalsfvgsae qagntlywsl paaflgnklt syggklsytl sysplpsgim srnsapdvvi 2101 ksgedlrlih yrksqvspsv antyaveike sawqrgdelv pnrehvlmal snitaiyika 2161 tyttstkeas lrsvtldtat atnlgtarav eveqcrcpeg ylglsceqca pgytrdpeag 2221 iylglcrpce cnghskycns etgecescsd ntegfncdrc aagyvgdatr gtsydcqydd 2281 ggyptsrppa pgnqtaeclv ncqqegtagc rgyqceckrn vagdrcdqcr pgtyglsaqn 2341 pdgckecycs gltnqcrsas lyrqlipvdf istpplitde fgdimdrdnl vpdvprnvyt 2401 ykhtsytpky wslrgsvlgn qllsyggrle yslivesvgr dhrgkdvvli gnglkliwsr 2461 pdghdneqey hvrlhedeqw tvedrgsarq atradfmtvl sdlqhilila tpkvptvsts 2521 isnvilessi ttrapgatha sdielcqcps gytgtscesc aplhyrdasg rcsqcpcdas 2581 ntescglvsg gnvecqcrpr wrgdrcreid tspiieeppq icdlsrgfcc sgfqfdiapn 2641 etisfndtlq iykgnriign mtklrygcps retneptpep dtstddpvrt qiivsiarpe 2701 itilpvggsl tlsctgrmrw tnspvfvnwy kqgshlpegv evqggnlqlf nlqisdsgiy 2761 icqavsnetg hsftdhvsit vsqedqrspa hivdlpndvt feeyvsneiv cevegnpppt 2821 vtwtrvdgha daqstrtdnn rlvfdsprks degryrcqae nslsreekyv vvyvrsnppq 2881 pppqqdrlyi tpqevngvag dsfqlscqft saaslrydws hdgrslsass prnvvvrgnv 2941 levrdanvrd sgtytcvafd lrtrrnftes arvyieqpne pgilgdkphi ltleqniiiv 3001 qgedlsitce asgtpypsik wtkvqenlae nvrisgnvlt iyggrsenrg lysciaensh 3061 gsdqsstsid ieprerpslt idtatqkvsv gsqaslycaa qgipeptvew vrtdgqplsp 3121 rhkvqapgyv viddivldds gtyecrasni agqvsglati nvqeptlvri epdrqhhivt 3181 qgdelslscv gsgvptpsvf wsfegrdvdr mgvpegavfa qpfrtntadv kifrvskene 3241 giyvchgsnd agedqqyirv evqprrgdvg aggddngdvd trqppnrpqi qpnplsnerl 3301 ttelgnnvtl icnvdnvnte wervdgtplp hnaytvrntl vivfvepqnl gqyrcngigr 3361 dgrveahvvr elvllplpri tfypnipltv elgqnldvyc qvenvrpedv hwttdnnrpl 3421 pssvriegnv lrfasitqaa ageyrcsatn qygsrsknar vvvkqpsgfq pvphsqvqqr 3481 qvgdsiqlrc rlttqygdev rgniqfnwyr edgsplprgv rpdsqvlqlv klqpedegry 3541 icnsydlgsg qqlppvsidl qvlrtttqyp fnrfkggvsl kdtpcmvlyi caavpaapqn 3601 piylppvapp rsperilepq lslsvqssnl pagdgttvec fssddsypdv vweradgapl 3661 senvqqvgnn lvisnvastd agnyvckckt degdlyttsy kleveeqphe lksskivyak 3721 vggnadlqcg adedrqpsyr wsrqygqlqa grslqnekls ldrvqandag tyvcsaqysd 3781 getvdfpnil vvtgaipqfr qeprsymsfp tlsnssfkfn feltfrpena dglllfngqt 3841 rgsgdyials lkdryaefrf dfggkpllvr aeeplaldew htvrvsrfkr dgyiqvddqh 3901 pvafptsqhq qipqlelied lyiggvpnwe flpaeavgqq sgfvgcisrl tlqgrtveli 3961 reakfkegit dcrpcaqgpc qnkgvclesq teqaytcvcq pgwtgrdcai egtqctagvc 4021 gsgrcenten dmeclcplnr agdrcqynei lneqslnfks nsfaaygtpk vtkvnitlsv 4081 rpasledsvi lytaestlps gdylalvlrg ghaellinta arldpvvvrs aeplplnrwt 4141 rieirrrlge gilkvgdgpe rkakapgsdr ilslkthlfv ggvdrstvki nrdvnitkgf 4201 dgcisklyns qksvnllgdi rdaanvqncg eaneidddey empvalpspk vaenerqlma 4261 pcasdpceng gscseqedma icscpfgfsg khcqnhlqls fnasfrgdgy velnrshfqp 4321 aleqtyshig ivfttnkpng llfwwgqeag eeytgqdfia aavvdgyvey smrldgeeav 4381 irnsdirvdn gerhiviakr dentamleld qildtgdtrp tinkamklpg nvfvggapdv 4441 aaftgfrykd nfngcivvve getvgqinls saaingvnan vcpandeplg gteppvv