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LOCUS XM_070218418 14375 bp mRNA linear INV 09-DEC-2024 (trol), transcript variant X1, mRNA. ACCESSION XM_070218418 VERSION XM_070218418.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14375 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14375 /gene="trol" /note="terribly reduced optic lobes; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 9 Proteins" /db_xref="GeneID:108055788" CDS 209..13702 /gene="trol" /codon_start=1 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X1" /protein_id="XP_070074519.1" /db_xref="GeneID:108055788" /translation="MGSPGSQAPAIAIGISNGRRGHTGSLLLRLLLVAFVLNACHVPP TNAKQITKSKVDDQDFILADTQSLQGSVDLDDDEAFLIPPDSEEKLDKKFTPEGNWWS QGLHRVRRSLNSFFGSDDDDQEKERERQRQRQNNRDAANRQKELRRQQKESQNREKQL RLERQERQRLAKRNNHVVFNRVTDPRKRASDLYDENEASGLNEEETTTYRTYFVVNEP YSDDYKERDSLQFQNLQKLLDEDLRNFFNRNFENNDDEEQEIHSTLERVDQTKDHFKI RVQLRVDLPSSINDFGSKLEQQLNVYKRIDRLGASTDGVFTFTESSVYKYEHQYDIVT PRVIVSGQPITEKPVEAPQEFDEDPIEVALPTDEVEGSGQDSGSCRGDATFQCRRSGK TICDEMRCDGSRDCPDAEDEEGCEVCNELQFKCDNKCLPLNKRCDNRYDCEDQTDEAG CQRYEVEESQPQPQPQPQPEPEPEPEPEPEPEPEPEPEPEEPITDNEQPEQNSECRAT EFRCNNGDCIDIRKRCDHISDCSEGEDENEECPAACSGMEYQCRDGTRCISLSQQCDG HSDCSDADDEEHCDGSGNDGEDCRFDEFRCGTGECIPMRQVCDNIYDCNDYSDEVSCA EEEEDSVGIPIGRPPQRPAPKHDWLDELDANEYHVYHPSNVYELANSKNPCASNQFRC ATTNVCIPLHLRCDNFYHCNDMSDEKDCEQYQRRTTTTTRRPSTSARPSFTFTFTTQG PGLLERRNSTTSRTTAGSTTRATEAPQWPWATRPTETTTTNPITTVGVASSSPQSSCL ENIEFACHNRDCIPIESVCDGTPDCGRSEDEDDALCKCTADKYKCQHGGGCIPKTQVC DGKPQCRDRSDESACHLNGRLNKTRLGVQCQENQYQCGDGSCISGYKRCNGINDCADD ADEYNCIYTYNEDYVDPDDNPLNECDILEFECDYSLCLPLEKKCDGYADCEDLSDEFE CQSYTENCLLSEFECDGYCLPRDQLCNGIINCQDGSDERNCTFCREDAYLCTTGECVA VNQRCNGIVECADGSDERHCVVNTTETNYHYPTHNPKPKTCRTHEWQCTNLECIEMRL KCDDVPDCSDGSDEDLSICFGTATTRLKPSDCGPDQFFCDDLCYNRSIRCNGHMDCSD GSDEIACSSLSVLPCPQHQCPSGRCYSESERCDRHRHCEDGSDEANCCYADQFRCNNG DCIAESAHCDGNIDCSDQSDELDCGGDSQCLPNQFRCKNGQCVSSTARCNKRSDCLDG SDEQNCANEPNNSGRGTNQLKLKTYPDNQIIKESREVIFRCRDEGPNRAKVKWSRPGG RPLPPGFTDRNGRLEIPNIRVEDAGAYVCEAVGYANYIPGQHVTVNLNVERLNEREIR PDSACTEYQATCMNGECIDKSGICDGHPDCSDGSDEHSCSLGLKCQPNQFMCSNSKCV DRTWRCDGENDCGDNSDETSCDPEPSDAPCRYDEFQCRSGHCIPKSFQCDYMNDCTDG TDEIGCSVPSPMTLPAPSIVVMEYEVLELTCVGTGVPTPTIVWRLNWGHVPEKCESKS YGGTGTLRCPNMRPQDSGAYSCEFINTRGTFYPKTNSIVTVTPVRSDVCKAGFFNMLA RKSEECVQCFCFGVSTNCDSANLFTYAIQPPILSHRVVSVELSPFRQIVINEASPGQD LLTLHHGVQFRASNVHYNGRETPFLALPAEYMGNQLKSYGGNLRYEVRYNGNGRPVSG PDVIITGNSFTLTHRVRTHPGQNNRVTIPFLPGGWTKPDGRKGTREDIMMILANVDNI LIRLGYLDSTAREVDLINIALDSAGSADQGLGSASLVEKCTCPPGYVGDSCESCASGY VRQARGPWLGHCVPFTPEPCPAGTYGNPRLGVPCQECPCPHAGANNFASGCQQSPDGD VICRCNEGYAGKRCEHCAQGYQGNPLAPGGVCRKIPDSSCNVDGTYNIYSNGTCQCKD SVIGEQCDTCAPKSFHLNSFTYTGCIECFCSGVGLDCDSSSWYRNQVTSTFGRTRVNH GFALISDYMRNTPVTVPVSMSTQANALSFVGSAEQAGNTLYWSLPAAFLGNKLTSYGG KLSYTLSYSPLPSGIMSRNSAPDVVIKSGEDLRLIHYRKSQVSPSVANTYAVEIKESA WQRGDELVPNREHVLMALSNITAIYIKATYTTSTKEASLRSVTLDTATATNLGTARAV EVEQCRCPEGYLGLSCEQCAPGYTRDPEAGIYLGLCRPCECNGHSKYCNSETGECESC SDNTEGFNCDRCAAGYVGDATRGTSYDCQYDDGGYPTSRPPAPGNQTAECLVNCQQEG TAGCRGYQCECKRNVAGDRCDQCRPGTYGLSAQNPDGCKECYCSGLTNQCRSASLYRQ LIPVDFISTPPLITDEFGDIMDRDNLVPDVPRNVYTYKHTSYTPKYWSLRGSVLGNQL LSYGGRLEYSLIVESVGRDHRGKDVVLIGNGLKLIWSRPDGHDNEQEYHVRLHEDEQW TVEDRGSARQATRADFMTVLSDLQHILILATPKVPTVSTSISNVILESSITTRAPGAT HASDIELCQCPSGYTGTSCESCAPLHYRDASGRCSQCPCDASNTESCGLVSGGNVECQ CRPRWRGDRCREIDTSPIIEEPPQICDLSRGFCCSGFQFDIAPNETISFNDTLQIYKG NRIIGNMTKLRYGCPSRETNEPTPEPDTSTDDPVRTQIIVSIARPEITILPVGGSLTL SCTGRMRWTNSPVFVNWYKQGSHLPEGVEVQGGNLQLFNLQISDSGIYICQAVSNETG HSFTDHVSITVSQEDQRSPAHIVDLPNDVTFEEYVSNEIVCEVEGNPPPTVTWTRVDG HADAQSTRTDNNRLVFDSPRKSDEGRYRCQAENSLSREEKYVVVYVRSNPPQPPPQQD RLYITPQEVNGVAGDSFQLSCQFTSAASLRYDWSHDGRSLSASSPRNVVVRGNVLEVR DANVRDSGTYTCVAFDLRTRRNFTESARVYIEQPNEPGILGDKPHILTLEQNIIIVQG EDLSITCEASGTPYPSIKWTKVQENLAENVRISGNVLTIYGGRSENRGLYSCIAENSH GSDQSSTSIDIEPRERPSLTIDTATQKVSVGSQASLYCAAQGIPEPTVEWVRTDGQPL SPRHKVQAPGYVVIDDIVLDDSGTYECRASNIAGQVSGLATINVQEPTLVRIEPDRQH HIVTQGDELSLSCVGSGVPTPSVFWSFEGRDVDRMGVPEGAVFAQPFRTNTADVKIFR VSKENEGIYVCHGSNDAGEDQQYIRVEVQPRRGDVGAGGDDNGDVDTRQPPNRPQIQP NPLSNERLTTELGNNVTLICNVDNVNTEWERVDGTPLPHNAYTVRNTLVIVFVEPQNL GQYRCNGIGRDGRVEAHVVRELVLLPLPRITFYPNIPLTVELGQNLDVYCQVENVRPE DVHWTTDNNRPLPSSVRIEGNVLRFASITQAAAGEYRCSATNQYGSRSKNARVVVKQP SGFQPVPHSQVQQRQVGDSIQLRCRLTTQYGDEVRGNIQFNWYREDGSPLPRGVRPDS QVLQLVKLQPEDEGRYICNSYDLGSGQQLPPVSIDLQVLRTTTQYPFNRFKGGVSLKD TPCMVLYICAAVPAAPQNPIYLPPVAPPRSPERILEPQLSLSVQSSNLPAGDGTTVEC FSSDDSYPDVVWERADGAPLSENVQQVGNNLVISNVASTDAGNYVCKCKTDEGDLYTT SYKLEVEEQPHELKSSKIVYAKVGGNADLQCGADEDRQPSYRWSRQYGQLQAGRSLQN EKLSLDRVQANDAGTYVCSAQYSDGETVDFPNILVVTGAIPQFRQEPRSYMSFPTLSN SSFKFNFELTFRPENADGLLLFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPLLVRAE EPLALDEWHTVRVSRFKRDGYIQVDDQHPVAFPTSQHQQIPQLELIEDLYIGGVPNWE FLPAEAVGQQSGFVGCISRLTLQGRTVELIREAKFKEGITDCRPCAQGPCQNKGVCLE SQTEQAYTCVCQPGWTGRDCAIEGTQCTAGVCGSGRCENTENDMECLCPLNRAGDRCQ YNEILNEQSLNFKSNSFAAYGTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGDYL ALVLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILKVGDGPERK AKAPGSDRILSLKTHLFVGGVDRSTVKINRDVNITKGFDGCISKLYNSQKSVNLLGDI RDAANVQNCGEANEIDDDEYEMPVALPSPKVAENERQLMAPCASDPCENGGSCSEQED MAICSCPFGFSGKHCQNHLQLSFNASFRGDGYVELNRSHFQPALEQTYSHIGIVFTTN KPNGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVDNGERH IVIAKRDENTAMLELDQILDTGDTRPTINKAMKLPGNVFVGGAPDVAAFTGFRYKDNF NGCIVVVEGETVGQINLSSAAINGVNANVCPANDEPLGGTEPPVV" misc_feature 458..>715 /gene="trol" /note="Coiled-coil domain-containing protein 66; Region: CCDC66; pfam15236" /db_xref="CDD:434558" misc_feature 1460..1561 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1475..1477,1496..1498,1529..1534) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1508..1510,1517..1519,1529..1531,1547..1552) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1538..1552 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1718..1816 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(1736..1738,1760..1762,1793..1798) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1772..1774,1781..1783,1793..1795,1811..1816) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1802..1816 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1838..1945 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1853..1855,1880..1882,1913..1918) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1892..1894,1901..1903,1913..1915,1931..1936) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1922..1936 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1973..2077 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1988..1990,2012..2014,2045..2050) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2024..2026,2033..2035,2045..2047,2063..2068) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2054..2068 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2231..2338 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2246..2248,2273..2275,2306..2311) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2285..2287,2294..2296,2306..2308,2324..2329) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2315..2329 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2597..2701 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2615..2617,2639..2641,2672..2677) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2651..2653,2660..2662,2672..2674,2690..2695) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2681..2695 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2714..2821 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2729..2731,2756..2758,2789..2794) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2768..2770,2777..2779,2789..2791,2807..2812) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2798..2812 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2864..2968 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2879..2881,2903..2905,2936..2941) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2915..2917,2924..2926,2936..2938,2954..2959) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2945..2959 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3023..3127 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3038..3040,3062..3064,3095..3100) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3074..3076,3083..3085,3095..3097,3113..3118) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3104..3118 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3146..3247 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3161..3163,3182..3184,3215..3220) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3194..3196,3203..3205,3215..3217,3233..3238) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3224..3238 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3254..3358 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3269..3271,3293..3295,3326..3331) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3305..3307,3314..3316,3326..3328,3344..3349) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3335..3349 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3416..3514 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3434..3436,3458..3460,3491..3496) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3470..3472,3479..3481,3491..3493,3509..3514) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3500..3514 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3566..3667 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3581..3583,3602..3604,3635..3640) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3614..3616,3623..3625,3635..3637,3653..3658) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3644..3658 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3695..3787 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3698..3700,3722..3724,3755..3760) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3734..3736,3743..3745,3755..3757,3773..3778) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3764..3778 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3788..3892 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3803..3805,3827..3829,3860..3865) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3839..3841,3848..3850,3860..3862,3878..3883) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3869..3883 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3908..4012 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3923..3925,3947..3949,3980..3985) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3959..3961,3968..3970,3980..3982,3998..4003) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3989..4003 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4055..4261 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 4355..4459 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4370..4372,4394..4396,4427..4432) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4406..4408,4415..4417,4427..4429,4445..4450) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4436..4450 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4475..4579 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4490..4492,4514..4516,4547..4552) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4526..4528,4535..4537,4547..4549,4565..4570) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4556..4570 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4604..4708 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4619..4621,4643..4645,4676..4681) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4655..4657,4664..4666,4676..4678,4694..4699) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4685..4699 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4760..4987 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 4769..4783 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 4808..4822 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 4877..4891 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 4919..4936 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 4961..4972 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 5282..5674 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 5843..6004 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature order(5843..5845,5849..5851,5885..5887,5915..5917, 5921..5923,5948..5950) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature 6377..6787 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature <6788..6868 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature 6890..7039 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature order(6893..6895,6899..6901,6920..6922,6941..6943, 6950..6952,6977..6979) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature <7148..7240 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature 7436..7840 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 8303..8551 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8336..8350 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8384..8398 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8441..8455 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8483..8500 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8528..8539 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature <8630..8791 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 8882..9133 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8915..8929 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8954..8968 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9023..9037 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9065..9082 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9170..9412 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 9221..9235 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409570" misc_feature 9260..9274 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409570" misc_feature 9317..9331 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409570" misc_feature 9359..9376 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409570" misc_feature 9398..9409 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409570" misc_feature 9464..9694 /gene="trol" /note="Immunoglobulin I-set domain; Region: I-set; pfam07679" /db_xref="CDD:400151" misc_feature 9488..9502 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9527..9541 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9590..9604 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9632..9649 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9671..9682 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 9731..9994 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9761..9775 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9800..9814 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9932..9949 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10367..10597 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10394..10408 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10433..10447 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10493..10507 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10535..10552 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10631..>10834 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10664..10678 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10712..10735 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10781..10795 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11081..11287 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 11153..11167 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11216..11227 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11255..11272 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11357..11557 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 11381..11395 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 11420..11434 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11477..11491 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11519..11536 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11621..12064 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12131..12229 /gene="trol" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 12371..12832 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12992..13090 /gene="trol" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 13115..13576 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" polyA_site 14375 /gene="trol" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaggttgc gcgccatcgt tccaggcggt cgcacattcc acgtgccata gccgtaacaa 61 caacctgcca accgcttaaa accaaactca aatacgaacc gaaactgcct tcacacacac 121 aagtacctaa accaaatcta aatagctgcc aaaagaaacc aaaaattcca gagacgtcgt 181 agcatccgtt ccccggaaga agaagaagat gggatcgccg ggatcccaag cgcccgcgat 241 cgcgatcggg atcagtaacg ggcggagagg tcacacgggg tcgctgctcc tgcgcctcct 301 tctcgtggcc ttcgtcctca acgcctgcca cgtacccccg accaatgcca agcaaattac 361 gaaaagtaaa gttgatgacc aggactttat actggccgac acacaatcgc tgcagggcag 421 cgttgacctt gacgatgacg aagcgttcct gattcctccg gattccgaag agaagttgga 481 taagaagttc acgccggagg gcaactggtg gagccagggg ctccatcgtg ttcgccgctc 541 cctaaatagc ttcttcggct ccgacgacga tgatcaggaa aaggaacgtg agcgtcagag 601 gcaaaggcaa aataatcgcg atgccgccaa ccggcaaaag gaacttcggc gccagcaaaa 661 ggagagccag aaccgcgaga agcagctgcg attggagcgc caggagaggc agcgccttgc 721 caagcggaac aatcacgtgg tcttcaatcg cgtcaccgat ccccgcaagc gggcatccga 781 cctttacgac gagaacgagg catctggcct aaacgaggag gaaaccacca cctatcgcac 841 ctactttgtt gttaatgagc catattcaga cgactacaag gagcgggaca gcctccagtt 901 ccagaatctg caaaaacttc ttgacgagga cctgcgcaac ttcttcaatc gcaatttcga 961 aaataacgat gatgaagagc aggaaatcca tagcacccta gagcgagtcg atcaaaccaa 1021 ggaccatttt aaaattcgcg tgcaacttag ggtagatctg cccagttcaa tcaacgactt 1081 tggaagtaag ttggagcaac aactgaatgt ctacaagcga atcgatcgtt tgggtgccag 1141 taccgatggc gtcttcacct ttaccgaatc gagcgtctac aaatacgaac accaatacga 1201 tattgtgaca ccgagagtaa ttgtatctgg acaaccgata actgaaaaac cagtcgaagc 1261 accccaagaa ttcgatgagg atcctatcga agttgcattg cccacggatg aggtggaggg 1321 ctccggccaa gattccggta gctgtcgcgg cgatgccacc ttccagtgtc gaaggagtgg 1381 aaagactatt tgcgatgaaa tgcgatgcga tggatctcgc gattgtcccg atgccgagga 1441 cgaggaaggc tgcgaggttt gcaacgaact tcagttcaag tgcgataaca agtgtctgcc 1501 gctcaataag cgctgcgata atcgatacga ttgtgaggat cagacggacg aggctggttg 1561 tcaacggtac gaagtagaag agtctcagcc tcagccgcag ccgcaacctc agcctgaacc 1621 ggaacctgaa cctgaacctg agcctgagcc tgaacctgaa ccagaaccag aacctgaaga 1681 gcctataaca gacaatgaac agcctgagca aaactcagaa tgccgggcca ccgagttcag 1741 atgcaacaat ggggactgca tcgatattag aaagcgttgc gatcacattt cggactgtag 1801 cgaaggcgag gacgagaacg aggagtgccc cgccgcctgc agcggaatgg agtatcaatg 1861 tcgcgacggc acgcgctgca taagtttgag tcagcagtgc gacggtcatt ccgattgcag 1921 cgacgccgac gacgaggagc attgcgacgg aagtggtaac gatggtgagg attgtcggtt 1981 cgatgagttc cgttgcggaa ctggtgagtg cataccgatg cgtcaggtgt gcgataacat 2041 ctacgattgc aacgattatt ccgatgaggt cagctgcgcc gaggaggagg aagatagtgt 2101 gggcataccc attggccgtc caccgcagag gccagcgccc aaacacgact ggctggacga 2161 attggacgcc aatgagtacc acgtctatca tccaagtaat gtctatgagt tggccaattc 2221 caagaatccc tgtgccagca atcaatttcg ctgcgccacc acgaatgtgt gcatccccct 2281 gcatttgcgt tgcgataatt tctatcactg caacgatatg agcgatgaga aggactgcga 2341 gcagtatcaa cgacgcacca ccaccaccac ccgacgacct tcgacctcgg cccggccctc 2401 cttcaccttc accttcacga cccaggggcc aggcttgctg gagcgtcgca atagcaccac 2461 cagtagaacc accgcaggca gcaccaccag agccaccgaa gcaccacaat ggccatgggc 2521 aaccagaccc accgagacca cgaccactaa cccaataaca acagttggcg tagcgagcag 2581 ctcacctcag tcctcctgtc tcgaaaacat cgaattcgcg tgtcacaatc gcgattgcat 2641 tccgattgag agcgtctgcg atggcacccc cgactgcgga cgcagtgaag acgaggacga 2701 cgctctttgc aagtgcaccg ccgacaagta caaatgccaa cacggcggag gctgcattcc 2761 gaaaacccag gtgtgcgatg gcaaacctca gtgccgcgac cgcagcgacg agagcgcctg 2821 ccatctcaat ggaagattaa ataagactcg tttgggggtc cagtgccagg aaaaccagta 2881 tcaatgtggc gatggaagct gcatctccgg ctacaaacgc tgcaatggca tcaacgattg 2941 cgccgatgac gccgacgaat ataactgcat ctacacctac aacgaagact acgtagaccc 3001 ggacgacaat ccattgaatg aatgtgatat ccttgagttt gaatgtgact acagtctgtg 3061 tttaccgcta gagaagaaat gcgatggcta tgcagactgt gaagacttga gcgacgagtt 3121 cgagtgtcag tcgtacacag agaattgtct attgtctgag ttcgaatgcg atggctactg 3181 cctgccccgc gatcagttat gcaacggaat aatcaattgc caagatggca gcgacgagcg 3241 caactgtacc ttttgccggg aagatgccta cctctgcacc accggcgagt gtgtggccgt 3301 aaatcagaga tgcaacggca tcgtcgaatg cgccgatggc agcgacgagc gtcactgcgt 3361 agtcaacacc acagagacca actaccatta tcccacacac aatcctaaac caaaaacctg 3421 ccgaacccac gagtggcagt gtacgaatct cgagtgcatc gagatgagat tgaagtgcga 3481 tgatgttccg gattgctcgg atggatccga tgaggacctc agcatttgct tcggcacggc 3541 caccacacga ctaaagccca gcgactgcgg tccggatcag ttcttctgcg atgatttatg 3601 ctataatcgc tctattcgat gcaatggcca tatggattgc tcagatggca gtgatgagat 3661 cgcttgtagc tcgctgtcag tgcttccatg tccacagcac cagtgtccca gtggcaggtg 3721 ttattcggaa agtgagcgat gcgatcgcca caggcactgc gaggatggct ccgatgaggc 3781 caactgctgt tacgcggatc aattccgctg caataatggt gactgcattg cggaatcggc 3841 tcattgcgat ggaaatatcg attgtagcga ccagtccgat gaactcgact gcggaggaga 3901 ctcgcagtgt ctgcccaacc aattccgctg caagaatggc caatgtgtga gctctacagc 3961 gcgttgcaac aagcgttccg attgtttgga tggctccgat gagcagaatt gtgccaatga 4021 acctaacaac tccggacgtg gaacgaacca attgaaactc aagacctatc ccgacaacca 4081 aatcattaag gagagtcgtg aggtcatctt ccgttgccgt gacgaaggtc ccaaccgcgc 4141 caaggtcaag tggtcgcgac ccggcggacg tcccctgccc cccggtttca ccgatcgcaa 4201 tggccgcctg gagatcccca acatcagggt ggaggatgct ggcgcctatg tctgcgaggc 4261 cgtgggctat gccaactata ttcccggtca gcacgtcacc gtaaacctca acgtcgagcg 4321 cttaaacgaa cgcgaaatcc gtccggactc agcctgtacg gagtaccagg ccacctgcat 4381 gaacggcgag tgtatcgata agtcgggcat ctgcgatgga catccggact gttcggatgg 4441 ctccgatgag cacagctgca gtttgggttt gaagtgtcag cccaaccagt tcatgtgctc 4501 caattccaag tgtgtggatc gcacctggcg ctgtgatggc gagaacgact gcggcgataa 4561 ctccgatgag acctcttgcg atccggaacc aagtgatgct ccgtgccgat acgacgaatt 4621 ccagtgccgc agcggtcatt gcattcccaa gagcttccag tgcgactata tgaacgattg 4681 taccgatggt accgatgaaa ttggatgctc ggtgccctct ccaatgaccc tacccgcacc 4741 ctcgattgtc gtgatggagt acgaggtcct cgagctgacc tgcgtgggca ccggcgtccc 4801 gacgccgacg atcgtgtggc gtctcaactg gggccatgtg cccgagaagt gtgaatcgaa 4861 gagctacggc ggaaccggaa ccctgcgctg tccgaacatg aggccccagg acagtggtgc 4921 ctactcgtgc gagttcatca acacacgcgg caccttctat ccgaaaacga actcgattgt 4981 caccgttacg ccggtgcgct cggatgtctg caaggccgga ttcttcaata tgctggcccg 5041 caagtcggag gaatgcgtcc agtgcttctg ctttggcgtt tcgaccaact gtgacagtgc 5101 caatttgttc acctacgcca ttcagccacc gatcctttcg caccgcgtgg tcagcgttga 5161 actcagtccg ttccgtcaaa ttgtcatcaa tgaggctagt ccgggtcagg atctgctcac 5221 cttgcaccat ggtgttcagt tcagggcatc gaacgtacac tacaacggcc gggagacacc 5281 attcttggcc ctgcccgctg agtatatggg caaccagctg aagtcctatg gcggcaatct 5341 gcgctacgag gtcaggtaca atggcaacgg tagaccggtc agcggacccg atgtcatcat 5401 caccggcaac agtttcacgc taacccatcg cgttcgcact catccgggtc agaacaacag 5461 ggtgactatt cccttcctgc cgggaggctg gacgaagccg gatggtcgca agggaacgcg 5521 agaggacatc atgatgatac tggccaatgt ggacaatatt ctgattcgac tgggctacct 5581 ggatagcaca gctcgcgaag tggatctgat aaatatcgcc ttggattcgg ccggaagtgc 5641 cgatcaggga ttgggcagtg cctcgctcgt ggagaagtgc acctgtccgc ccggctatgt 5701 tggtgattcg tgcgagtcct gtgcctcggg ctatgttcgc caggcccgcg gaccttggct 5761 gggtcattgt gtgcccttca ccccggaacc gtgcccagcg ggaacctacg gcaatccccg 5821 acttggtgtt ccctgccagg agtgtccgtg cccccacgcg ggcgccaata actttgccag 5881 cggctgccaa cagagtcccg atggcgatgt gatttgccgc tgcaacgaag gctatgccgg 5941 caagaggtgc gagcactgcg cccagggtta ccagggtaat ccgttggcac cgggaggagt 6001 ctgtcgcaag atacccgata gttcgtgcaa tgtcgacggc acctacaaca tctacagcaa 6061 tggaacgtgc cagtgcaagg atagcgtgat tggcgaacag tgcgacacct gcgcgccgaa 6121 gagtttccac ctcaattcgt tcacctacac cggttgcatc gagtgcttct gcagtggagt 6181 gggcttggat tgtgacagta gttcgtggta tcgcaaccag gtcaccagca cctttggacg 6241 aacgcgcgtc aatcatggat tcgccctgat tagcgactat atgcgcaata ccccggtaac 6301 ggtgcccgtt tccatgtcca cccaggccaa tgccttgagc ttcgtgggat ccgccgagca 6361 ggccggtaat acgctctact ggagtcttcc cgccgccttc ctgggcaaca agctgacctc 6421 gtacggaggc aagttgagct acacgctcag ctacagtccc ctgcccagcg gcattatgtc 6481 gcgcaacagt gcccccgatg tggtgatcaa gagcggcgag gatctgaggc tcatccatta 6541 caggaagtcg caggtcagtc ccagtgtggc caacacctat gccgtggaga tcaaggagag 6601 cgcatggcag cgcggcgatg aactggtgcc taaccgtgaa cacgtcctga tggccctcag 6661 caatattacg gccatctata tcaaggccac gtacacgact agcaccaagg aggcctcgct 6721 gcgatcggtc acattggata cggccacggc caccaatctg ggcaccgcac gtgccgtcga 6781 agtggagcag tgccgctgtc ccgagggcta tttgggtctc tcctgcgagc agtgtgctcc 6841 tggctatacg cgcgatccgg aggcaggaat ctatctgggt ctctgcaggc cctgcgagtg 6901 caatggacat tccaagtatt gcaacagtga gacaggcgaa tgcgaaagct gttccgacaa 6961 caccgaagga ttcaattgtg accgatgcgc cgccggctat gtgggtgatg ccacccgagg 7021 aacttcgtac gactgtcaat acgatgacgg cggctatccg acgtcgcgtc caccggcacc 7081 gggcaatcag acggccgaat gcctggtgaa ttgccaacag gagggaaccg ccggttgccg 7141 cggctaccag tgcgagtgca agaggaatgt ggctggcgat cgatgcgatc agtgccgccc 7201 cggaacctat ggactgtcgg cccaaaatcc ggacggttgc aaggagtgct actgctccgg 7261 actgaccaac cagtgccgct cggcgtctct ctaccgccag ctgatacccg tggacttcat 7321 ttcgacgcca ccattgataa cagacgaatt cggcgacatc atggataggg ataaccttgt 7381 gcccgacgtg cccaggaatg tgtataccta caagcacacc tcctacacgc ccaagtactg 7441 gagcctgagg ggtagtgtgc tgggcaacca gctgttgtcg tacggcggcc gcttggagta 7501 cagcctgatt gtggagtccg ttggccggga ccatcgtggc aaggatgtgg tcctaattgg 7561 caacggactc aagctgatct ggtcgcgacc cgatggccat gacaacgagc aggaatacca 7621 tgtgcgtttg catgaggacg agcagtggac ggttgaggat cgtggatcgg cacgacaggc 7681 cacgcgggcc gacttcatga ctgtgctgtc ggatctgcag cacatcctga tcctggccac 7741 acccaaggtg cccacggtca gcacctcgat tagcaatgtc atcctggaga gttcgataac 7801 cacgagagcg cctggagcta cgcatgcctc cgatatcgag ttgtgccagt gtccatccgg 7861 ttatacgggc acttcctgtg agtcctgcgc accactgcac taccgcgacg cctctggacg 7921 ctgcagtcag tgtccttgcg acgcttccaa cacggaatcc tgcggcttgg tcagcggcgg 7981 taacgtcgaa tgccagtgca ggccacgctg gaggggtgat cgctgccggg aaattgacac 8041 atcgcccatt atcgaagaac cgccccagat atgtgattta agcaggggat tctgttgcag 8101 cggctttcag ttcgatatcg caccgaacga gacaatctcg tttaatgaca ccctgcagat 8161 atataagggc aacagaatca taggaaatat gaccaagctg cgctacggct gtccatcgcg 8221 agaaactaac gaaccgactc cggaaccgga taccagtacc gatgatcccg tgcgcaccca 8281 gatcatagtg tcgattgcca ggccagagat taccattctg cccgtgggtg gatcgctgac 8341 cctcagctgt accggtcgaa tgcgctggac caatagccca gtgtttgtga actggtacaa 8401 gcagggcagt cacctgcccg agggagtcga ggtgcaaggc ggtaatctgc agctgttcaa 8461 cctgcagatc agcgattctg gaatctacat ctgccaggcc gtaagcaacg agaccggcca 8521 cagctttacg gaccacgtct ccatcaccgt ttcccaggag gaccaacgct cgccggctca 8581 cattgtggat ttgcccaacg acgtgacctt cgaggagtac gtaagcaatg agatcgtctg 8641 cgaggtggag ggcaacccac cacccactgt cacctggact cgcgtggatg gccatgcgga 8701 cgcccaaagt acgcgaacgg acaacaatcg gctggtcttc gattcgccga ggaaatcgga 8761 cgagggtcgc tatcgctgcc aggcagagaa tagcctgagt cgggaggaga agtacgtagt 8821 cgtgtatgtc cggagcaatc ctccccagcc gccgccgcag caggatcgtt tgtacatcac 8881 accgcaggag gtgaacggtg tggccggtga ctccttccag ttgtcctgcc aattcaccag 8941 cgctgcctct ctgcgctacg attggtccca cgatggtcgc tccctgtccg cgtcgtcacc 9001 ccgaaatgtt gtggtccgcg gaaatgtcct ggaagtccgc gatgccaacg ttcgcgactc 9061 cggcacctac acctgtgtgg ccttcgacct gcgcacccga cgcaacttca ccgagagcgc 9121 acgggtctac atcgagcagc ccaacgagcc gggaatcctt ggcgacaagc cgcatatctt 9181 gaccttggag cagaacatca taattgtgca aggcgaggac ttgagcatca catgtgaggc 9241 aagtggaacg ccctatccct cgattaagtg gaccaaggtg caggagaatc tggccgaaaa 9301 tgtccgcatc agtggcaatg tgctcaccat ctacggaggc cgcagtgaga atcgtggtct 9361 ttactcctgc atcgccgaga actctcacgg cagcgatcag tccagcacaa gcatcgatat 9421 tgaaccccgg gagcggccga gtcttacgat tgatacggcc acccaaaagg tttcggttgg 9481 ctcccaggcg tccctttact gtgccgccca gggcattccc gaaccgaccg tcgagtgggt 9541 tcgaacggat ggtcagccac tgtcgccgcg tcacaaggtc caggcacccg gctatgttgt 9601 gatcgatgac attgtgctcg atgatagcgg tacctacgag tgccgggcga gcaacatagc 9661 tggccaggtg agcggcttgg ccaccattaa cgtccaggag ccaactcttg tgcggatcga 9721 accagatagg caacaccata tcgtcaccca gggcgacgaa ctctcgctca gctgcgtggg 9781 cagtggcgtc cctactcctt cggtcttttg gagtttcgag ggaagagacg ttgacaggat 9841 gggagtaccg gaaggtgctg tttttgcgca acctttccga accaacactg ccgacgtgaa 9901 aatcttccgg gtgagcaagg agaacgaagg catctacgtc tgtcacggat ccaatgacgc 9961 gggtgaagat caacaataca ttcgcgtgga ggtacaaccc agacggggtg acgtcggtgc 10021 aggaggagat gacaatggtg atgtcgatac ccgacagccc cccaatcggc cccaaatcca 10081 accgaatcca ttgagcaacg aacgcctgac caccgaattg ggcaacaatg tgaccctcat 10141 ctgcaacgtg gacaacgtga acacggaatg ggaacgcgtc gatggcacac ccctgccgca 10201 caatgcctac acggtgagaa atacgctggt gattgtcttc gtggagccgc agaatctggg 10261 tcagtaccgc tgcaatggaa tcggtcgcga tggacgtgtg gaggcccatg tggtgaggga 10321 gctggttctc ctgcccctgc ccaggatcac cttctatccc aacatcccgc tgaccgtgga 10381 gctgggccag aacttggatg tctactgcca ggtggagaac gtgcgtccgg aggacgtgca 10441 ttggaccacc gacaacaatc gaccactgcc cagttccgta cgcatcgagg gcaatgtcct 10501 caggttcgcg tccatcactc aggctgctgc cggtgaatac cgctgctcgg ccaccaatca 10561 atatggaagc cgatcgaaga acgccagggt ggtggtgaaa cagcccagtg gcttccagcc 10621 cgttccccac tcgcaggtgc aacagcgtca ggtgggcgac tccatccagt tgcgatgccg 10681 cctgaccacc cagtacggcg acgaggttcg cggcaatatc cagttcaact ggtaccgtga 10741 ggacggcagc cccttgcccc gcggtgtccg tccggatagc caggtgctgc agctggttaa 10801 attgcagccc gaggacgagg gccgctacat ctgcaactcg tacgatttgg gcagcgggca 10861 gcaactgccc cccgtctcca tcgacttgca agtactaaga actactaccc agtatccttt 10921 caatcggttt aagggcggtg tctccctgaa agacacgccc tgcatggttc tgtatatttg 10981 tgcagcggta ccagcggctc cccagaaccc catctacctg ccgccagtgg cgccaccacg 11041 ttcgcccgaa aggatcctcg agccccaact gagcctgagt gtacaatcct cgaacctgcc 11101 agccggcgac ggcaccaccg tcgagtgctt ctcctccgat gactcctacc cagatgtcgt 11161 gtgggaacgc gccgatggag ctccactcag cgaaaatgtc cagcaagtgg gcaataacct 11221 ggtgattagt aacgtggcct ccaccgatgc cggtaactat gtgtgcaagt gcaagacgga 11281 cgagggagat ctgtatacca ccagctacaa actggaggtc gaggagcagc cccatgaact 11341 gaagagctcc aagatagtct acgccaaggt tggcggaaat gccgacttgc agtgcggagc 11401 cgatgaagat cgacagccca gctaccgttg gtctcgccaa tacggacaac ttcaggcggg 11461 acgcagtctg cagaatgaga aactttcgtt ggatcgcgtt caggccaacg atgccggaac 11521 ttatgtttgt tcggcccaat acagcgatgg cgagacggtt gacttcccca acattctggt 11581 tgtgaccggg gcgattcccc agttccgcca ggagccccgc agctacatga gcttccccac 11641 gctctcgaac tcctcgttca agttcaactt cgagctgacc ttccggccgg aaaacgccga 11701 cggactgctg ctcttcaatg gacagacccg cggaagcggt gactatatcg cactctcgct 11761 gaaggatcgc tatgcggagt tccggttcga ttttggcggt aaaccgttgc tggtgcgagc 11821 ggaggagcca ctggctttgg atgaatggca cacggtgcgc gtgagtcgct tcaagcggga 11881 tggctacatc caggtggacg accagcatcc ggtggccttc cccacctccc agcatcagca 11941 gataccccag ttggaactga ttgaggatct gtacattggc ggcgtgccca actgggagtt 12001 cctgcccgcc gaggcggtgg gtcagcaatc aggcttcgtg ggctgcatta gccggctgac 12061 cctgcaggga cgcaccgtgg agctgatccg ggaggccaag ttcaaggagg gcatcaccga 12121 ttgccggccc tgcgcccagg gaccctgcca gaacaagggc gtctgcctgg agagccagac 12181 ggagcaggcc tacacctgcg tctgccagcc gggctggact ggccgggatt gtgccatcga 12241 gggcacccag tgcaccgcag gagtttgcgg ctcgggacgc tgcgagaata cggagaacga 12301 catggagtgc ctgtgcccgc tgaacagggc aggcgatcga tgccagtaca atgagattct 12361 aaatgaacag agcttgaatt tcaagagcaa cagctttgcg gcctacggaa ctcccaaggt 12421 caccaaagta aacatcacac tctccgttcg tcccgcgagc ctggaggact ctgtgatcct 12481 gtacacggcg gaatccactc tgcccagcgg cgattacctg gctttggtcc ttcgcggtgg 12541 ccacgcggag ctgctgatca acacggccgc ccgcttggat cccgtggtgg tgcgttcggc 12601 ggaaccgctg cccctcaatc gctggaccag aatcgagatc aggcgtcgcc tgggcgaggg 12661 aatcctcaag gtgggcgatg gacccgagcg aaaggccaag gcaccgggat ccgatcgcat 12721 tctgtcgctc aagacccacc tctttgtggg cggcgtcgat cggtcgaccg taaagatcaa 12781 ccgtgatgtg aacatcacca agggcttcga tggctgcatc tcgaagctgt acaactcgca 12841 gaaatccgtc aatctgctgg gtgacatcag ggatgcggcg aatgtccaga actgtgggga 12901 ggcgaatgag atagatgacg atgagtatga gatgccagta gcgctgccat cgcctaaggt 12961 cgccgagaat gaacgtcagc tgatggcgcc gtgtgccagt gatccctgcg agaacggggg 13021 aagctgcagc gagcaggagg acatggccat ctgctcctgt cccttcggct tcagcggcaa 13081 acactgccag aatcacctcc agctgagctt caatgcctcg ttccgcggcg atggctacgt 13141 ggagctgaac cgcagccact tccaacccgc cctggagcag acgtactccc acattggcat 13201 tgtgttcacc accaacaagc cgaatggcct gcttttctgg tggggccagg aggccgggga 13261 ggagtacacc ggacaggact tcattgccgc cgccgtggtc gatggctatg tggagtactc 13321 gatgaggctc gatggcgagg aggcggtcat tcggaacagc gatatccgcg tggacaatgg 13381 cgagcggcac attgtgatcg ccaagcggga tgagaacacc gccatgctgg aactcgatca 13441 gatcctggac acgggcgata cgcgacccac catcaacaag gcaatgaagc tgccgggcaa 13501 tgtgtttgtc ggtggcgctc ctgatgtcgc ggcattcacg ggcttccgct acaaggacaa 13561 tttcaacggc tgcattgtgg tcgtcgaggg cgaaaccgtg ggccaaatta accttagttc 13621 agctgccatc aatggagtga atgccaacgt gtgtcccgct aacgacgaac ctctgggagg 13681 aaccgaaccg ccagtcgtct gaggacacaa ccagcaaccg aaattagctt tttaattaaa 13741 cattaacaaa tgaaacaaaa agaaaaacaa tttttatata tacaacatat gaataagccc 13801 caagcaaacc tacaaaaaat tgaatattat acgacgaaca gataatataa aaacaaaaaa 13861 agagagaaac gatcacttct actacaattg cttcttcgat ccttaagtct aggttaaaga 13921 ttgtagcaag aaaacaagcg aatatcacaa acatttattt aacaagaacg ccatgcgaga 13981 agtgaaacga aacagaaaca ataatgcaat taatgcagat aatacagata aagcctagaa 14041 ccctaagaac taactaacta actcgaacaa gaacaacaac gcatactagc caactgcaac 14101 cacaacaacc acaatagtga aggcatttta attataattt tagtctctag cttataacta 14161 tgactacgac tcgttttttt tgtgagccca gtgtaaaatg ttggaaatcg gaaattggcc 14221 ctacacacaa acacacacaa gttattaatt aaataccaat tgataccata taatgataaa 14281 tgaaatacta tgaatgcaac tattgtgaac gaacgaaaac cgttgagtgg ataaaaagca 14341 taagcagaag atatattaaa atgaaatcaa caaca